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| 1 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 2 | A review of Pt-based electrocatalysts for oxygen reduction reaction显示文摘 | Changlin ZHANG Xiaochen SHEN Yanbo PAN Zhenmeng PENG | 2017 | Frontiers in Energy2017，11，3： | 3 |
| 3 | D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy显示文摘Near-infrared(NIR)small molecular organic dyes as photothermal agents for cancer photothermal therapy(PTT)have attracted considerable research attention.Herein,two donor-acceptor-donor(D-A-D)structured NIR dyes,BBTT and SeBTT,are rationally designed,where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium(Se).More importantly,SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency(PTCE≈65.3%).In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging(PAI)agent,and succeed in tumor suppression without noticeable damage to main organs under NIR photoirradiation.This study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT. | Zijin Cheng Tian Zhang Weili Wang Qing Shen Ying Hong Jinjun Shao Xiaoji Xie Zhenghao Fei Xiaochen Dong | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 4 | Predicting the degradation behavior of magnesium alloys with a diffusion-based theoretical model and in vitro corrosion testing显示文摘Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys in a quantitative manner. As such, controlling the degradation rate of the Mg alloys as per our needs is still hard, which greatly limits the practical application of the Mg alloys as a degradable biomaterial.This paper discussed a numerical model developed based on the diffusion theory, which can capture the experimental degradation behavior of the Mg alloys precisely. The numerical model is then implemented into a finite element scheme, where the model is calibrated with the data from our previous studies on the corrosion of the as-cast Mg-1 Ca and the as-rolled Mg-3 Ge binary alloys. The degradation behavior of a pin implant is predicted using the calibrated model to demonstrate the model’s capability. A standard flow is provided in a practical framework for obtaining the degradation behavior of any biomedical Mg alloys. This methodology was further verified via the comparison with enormous available experimental results. Lastly, the material parameters defined in this model were provided as a new kind of material property. | Zhenquan Shen Ming Zhao Dong Bian Danni Shen Xiaochen Zhou Jianing Liu Yang Liu Hui Guo Yufeng Zheng | 2019 | Journal of Materials Science & Technology2019，35，7： | 2 |
| 5 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 6 | Particle Image Velocimetry Experimental and Computational Investigation of a Blood Pump显示文摘Blood pumps have been adopted to treat heart failure over the past decades.A novel blood pump adopting the ro-tor with splitter blades and tandem cascade stator was developed recently.A particle image velocimetry (PIV) experiment was carried out to verify the design of the blood pump based on computational fluid dynamics (CFD) and further analyze the flow properties in the rotor and stator.The original sized pump model with an acrylic housing and an experiment loop were constructed to perform the optical measurement.The PIV testing was car-ried out at the rotational speed of 6952±50 r/min with the flow rate of 3.1 l/min and at 8186±50 r/min with 3.5 l/min,respectively.The velocity and the Reynolds shear stress distributions were investigated by PIV and CFD,and the comparisons between them will be helpful for the future blood pump design. | Xiaochen Yang Xingmin Gui Hui Huang Yongbin Shen Ziwen Yu Yan Zhang | 2012 | Journal of Thermal Science2012，21，3： | 2 |
| 7 | Propagation properties of foreshock cavitons: Cluster observations显示文摘Foreshock cavitons are transient phenomena observed in the terrestrial foreshock region.They are characterized by a simultaneous depression of magnetic field magnitude and plasma density,which are bounded with enhancements of these two parameters and surrounded by ultralow frequency(ULF)waves.Previous studies focused on the interplanetary magnetic field(IMF)conditions,solar wind(SW)conditions,and the growth of the foreshock waves related to the generation of foreshock cavitons.Previously,a multipoint spacecraft analysis method using Cluster data was applied to analyze only two foreshock cavitons,and this method did not consider uncertainties.In this study,multipoint spacecraft analysis methods,including the timing method,the minimum directional derivative(MDD)method,and the spatiotemporal difference(STD)method are applied to determine the velocity in both spacecraft and solar wind frames.The propagation properties show good agreement with previous results from simulations and observations that most cavitons move sunward in the solar wind frame,with the velocities larger than the Alfvén speed.The propagation properties of foreshock cavitons support the formation mechanism of cavitons in previous simulations,which suggested that cavitons are formed due to the nonlinear evolution of compressive ULF waves.We find that there is clear decreasing trend between the size of cavitons and their velocity in the solar wind frame.In addition,the timing method considering errors has been applied to study the evolution properties by comparing the velocities with errors of the leading and trailing edges,and we identify three stable cavitons and one contracting caviton,which has not been studied before.Most cavitons should remain stable when they travel toward the Earth’s bow shock.The relationship between the size of foreshock cavitons and their distance from the bow shock is also discussed. | WANG MengMeng YAO ShuTao SHI QuanQi ZHANG Hui TIAN AnMin DEGELING Alexander William ZHANG Shuai GUO RuiLong SUN WeiJie LIU Ji BAI ShiChen SHEN XiaoChen ZHU XiaoQiong FU SuiYan PU ZuYin | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 8 | Ternary phase interfacial polymerization of polypyrrole/MWCNT nanocomposites with core–shell structure显示文摘 | Yongqin Han Mingxia Shen Xiaochen Lin Bing Ding Luojiang Zhang Hao Tong Xiaogang Zhang | 2012 | Synthetic Metals . 2012 (9-10)2012，，9： | 1 |
| 9 | Neuropeptide Y stimulates food intake and regulates metabolism in grass carp, Ctenopharyngodon idellus显示文摘 | Yi Zhou Xu-Fang Liang Xiaochen Yuan Jie Li Yan He Liu Fang Xiaoze Guo Liwei Liu Bin Li Dan Shen | 2013 | Aquaculture2013，，： | 1 |
| 10 | A review on basic data-driven approaches for industrial process monitoring显示文摘 | YIN Shen DINGS X XIE Xiaochen | 2014 | IEEE Transactions on Industrial Electronics2014，61，11： | 1 |
| 11 | Analysis and elimination of tri-band beacon interference with the fluxgate sensors onboard CSES显示文摘High precision magnetometer(HPM)is a magnetic field detection payload onboard China Seismo-Electromagnetic Satellite(CSES),including two fluxgate magnetometers(FGM)and a coupled dark state magnetometer(CDSM).Observations show that FGM appears to be influenced when tri-band beacon(TBB)is powered on and emits electromagnetic waves.The interference phenomenon is further validated based on both in-orbit observation analysis and electromagnetic compatibility(EMC)tests on the ground.A joint correction algorithm based on the least square fitting and first-order difference method according to scalar magnetometer data is proposed to eliminate the interference.The algorithm significantly improves the consistency of HPM data.After correction,the average scalar deviation error could be reduced from 9.0 nT to around 0.7 nT. | TONG YuQi CHENG BingJun MIAO YuanQing ZHOU Bin ZHU XingHong YANG YanYan LIU Ji GOU XiaoChen ZHANG YiTeng WANG JinDong LI Lei MAGNES Werner LAMMEGGER Roland POLLINGER Andreas ZEREN Zhima SHEN XuHui | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 12 | High-temperature phase relations of ZrN–ZrO_2–Y_2O_3 ternary system显示文摘Zirconium nitride(ZrN) ceramics were prepared via hot pressed sintering(HP) at 1750 ℃ in N_2 atmosphere with ZrO_2–Y_2O_3 as sintering additive. X-ray diffraction was applied to analyze the phase composition of the as-prepared ceramics to study the high temperature phase relation in ZrN –ZrO_2–Y_2O_3 ternary system and establish ZrN –ZrO_2–Y_2O_3 ternary phase diagrams. The results show that ZrN and tetragonal ZrO_2(t-ZrO_2) solid solution, face-centered cubic ZrO_2(c-ZrO_2) solid solution, body-centered cubic Y_2O_3(c-Y_2O_3) solid solution coexist in the system of ZrN –ZrO_2–Y_2O_3. | Youjun LU Zhenxia YUAN Hongfang SHEN Xiaochen HUAI Zhenkun HUANG | 2018 | Journal of Advanced Ceramics2018，7，4： | 1 |
| 13 | Structure-based insights into recognition and regulation of SAM-sensing riboswitches显示文摘Riboswitches are highly conserved RNA elements that located in the 5’-UTR of m RNAs,which undergo real-time structure conformational change to achieve the regulation of downstream gene expression by sensing their cognate ligands.S-adenosylmethionine(SAM)is a ubiquitous methyl donor for transmethylation reactions in all living organisms.SAM riboswitch is one of the most abundant riboswitches that bind to SAM with high affinity and selectivity,serving as regulatory modules in multiple metabolic pathways.To date,seven SAM-specific riboswitch classes that belong to four families,one SAM/SAH riboswitch and one SAH riboswitch have been identified.Each SAM riboswitch family has a well-organized tertiary core scaffold to support their unique ligand-specific binding pocket.In this review,we summarize the current research progress on the distribution,structure,ligand recognition and gene regulation mechanism of these SAM-related riboswitch families,and further discuss their evolutionary prospects and potential applications. | Luqian Zheng Qianqian Song Xiaochen Xu Xin Shen Chunyan Li Hongcheng Li Hao Chen Aiming Ren | 2023 | Science China(Life Sciences)2023，66，1： | 0 |
| 14 | S/Se-embedded acenaphthylene-imide-containing polycyclic heteroaromatic hydrocarbon显示文摘Acenapththylene-imide(An I),similar to naphthalene diimide(NDI),is an outstanding building block for organic functional materials and has gained a lot of research attention.Herein,Sulphur and Selenium-embedded AnI-containing polycyclic aromatic hydrocarbon molecules,AnI-SQ and AnI-SeQ,with[1,2,5]thiadiazolo[3,4-g]quinoxaline(SQ)and[1,2,5]selenadiazolo[3,4-g]quinoxaline(Se Q)are designed and synthesized with low-lying LUMO energy levels.The absorption and emission of AnI-SQ and An I-Se Q displayed a bathochromic shift upon protonation of the C=N bond.Besides,theoretical calculation indicates remarkable rigid planar backbones for both An I-SQ and An I-Se Q.Through self-assembly with polymeric Pluronic?F-127,corresponding hydrophilic nanoparticles(NPs)were prepared with low cytotoxicity.And AnI-SQ NPs could be applied for in vitro two-photon fluorescence imaging. | Zhichao Wang Qianli Ma Xuan Huang Tian Zhang Jiawei Shao Xinglin Zhang Qian Shen Xiaochen Wang Jinjun Shao | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 15 | Nodeless superconducting gaps in Ca10(Pt(4-δ)As8)((Fe(1-x)Ptx)2As2)5 probed by quasiparticle heat transport显示文摘The in-plane thermal conductivity of the iron-based superconductor Ca10(Pt_(4-δ)As_8)((Fe_(1-x)Pt_x)_2As_2)_5 single crystal('10-4-8', T c= 22 K) was measured down to 80 m K. In a zero field, the residual linear term κ_0/T is negligible, suggesting the nodeless superconducting gaps in this multiband compound. In the magnetic fields, κ_0/T increases rapidly, which mimics the multiband superconductor Nb Se_2 and Lu Ni_2B_2 C with highly anisotropic gap. Such a field dependence of κ_0/T is an evidence for the multiple superconducting gaps with quite different magnitudes or highly anisotropic gap. Compared with the London penetration depth results of the Ca10(Pt_(4-δ)As_8)((Fe_(1-x)Pt_x)_2As_2)_5('10-3-8') compound, the 10-4-8 and 10-3-8 compounds may have a similar superconducting gap structure. | Xun Qiu LanPo He XiaoChen Hong ZhenZhang Jian Pan XiaoPing Shen DongLai Feng ShiYan Li | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，5： | 0 |
| 16 | Optimizing magnetic/dielectric matching in permalloy/carbonized cotton fiber composites by strain-tunable ferromagnetic resonance and defect-induced dielectric polarization显示文摘Electromagnetic losses in composites could be synergistically controlled by permeability and permittivity,associated with multiple ferromagnetic resonances and dielectric polarization.However,it is still challenging for simultaneous tunability for both the terms in a magnetic/dielectric composite system.Here,we demonstrate the tunable ferromagnetic resonances and the enhanced dielectric losses at gigahertz frequencies in permalloy/carbonized cotton fiber composites with different annealing temperatures.It is theoretically confirmed that the stress field acting on the magnetic permalloy layer increases with increasing temperature because of the shrinkage of the dielectric carbonized cotton fibers,resulting in multiple ferromagnetic resonances,in which there is a linear relationship(f=1.52×σ+9.38)between the resonance frequency(f)and the stress(σ).The present work provides a fundamental insight into understanding the micromagnetic dynamics of the magnetic/dielectric composite system. | Xiaochen Shen Chenglong Hu Wenling Ren Rongzhi Zhao Lianze Ji Xuefeng Zhang Xinglong Dong | 2022 | Journal of Materials Science & Technology2022，，29： | 0 |
| 17 | Correction to:Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘CORRECTION TO:PROTEIN CELL(2021)HTTPS://DOI.ORG/10.1007/S13238-021-00837-8 In the original publication of the article figure 1 is incorrectly published.The correct Figure 1 is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit https://creativecommons.org/licenses/by/4.0/. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2022 | Protein & Cell2022，13，6： | 0 |
| 18 | An Automatic HFO Detection Method Combining Visual Inspection Features with Multi-Domain Features显示文摘As an important promising biomarker,high frequency oscillations(HFOs)can be used to track epileptic activity and localize epileptogenic zones.However,visual marking of HFOs from a large amount of intracranial electroencephalogram(iEEG)data requires a great deal of time and effort from researchers,and is also very dependent on visual features and easily influenced by subjective factors.Therefore,we proposed an automatic epileptic HFO detection method based on visual features and non-intuitive multi-domain features.To eliminate the interference of continuous oscillatory activity in detected sporadic short HFO events,the iEEG signals adjacent to the detected events were set as the neighboring environmental range while the number of oscillations and the peak–valley differences were calculated as the environmental reference features.The proposed method was developed as a MatLab-based HFO detector to automatically detect HFOs in multi-channel,long-distance iEEG signals.The performance of our detector was evaluated on iEEG recordings from epileptic mice and patients with intractable epilepsy.More than 90%of the HFO events detected by this method were confirmed by experts,while the average missed-detection rate was<10%.Compared with recent related research,the proposed method achieved a synchronous improvement of sensitivity and specificity,and a balance between low false-alarm rate and high detection rate.Detection results demonstrated that the proposed method performs well in sensitivity,specificity,and precision.As an auxiliary tool,our detector can greatly improve the efficiency of clinical experts in inspecting HFO events during the diagnosis and treatment of epilepsy. | Xiaochen Liu Lingli Hu Chenglin Xu Shuai Xu Shuang Wang Zhong Chen Jizhong Shen | 2021 | Neuroscience Bulletin2021，37，6： | 0 |
| 19 | Light-responsive organic artificial enzymes:Material designs and bio-applications显示文摘As significant biocatalysts,natural enzymes have exhibited a vast range of applications in biocatalytic reactions.However,the“always-on”natural enzyme activity is not beneficial for the regulation of catalytic processes,which limits their bio-applications.Recently,it has been extensively reported that various organic artificial enzymes exhibit prominent absorption and controlled activity under illumination,which not only creates a series of light-responsive catalytic platforms but also plays a key role in biosensing and biomedical research.To provide novel ideas for the design of artificial enzymes,we conduct this review to highlight the recent progress of light-responsive organic artificial enzymes(LOA-Enz).The specific photoresponse mechanism and various bio-applications of LOA-Enz are also presented in detail.Furthermore,the remaining challenges and future perspectives in this field are discussed. | Weili Wang Qing Shen Hao Cai Leichen Wang Jinjun Shao Wenjun Wang Xiaochen Dong | 2023 | Nano Research2023，16，1： | 0 |
| 20 | Small Molecular NIR-II Fluorophores for Cancer Phototheranostics显示文摘Phototheranostics integrates deep-tissue imaging with phototherapy(containing photothermal therapy and photodynamic therapy),holding great promise in early diagnosis and precision treatment of cancers.Recently,second near-infrared(NIR-II)fluorescence imaging exhibits the merits of high accuracy and specificity,as well as real-time detection.Among the NIR-II fluorophores,organic small molecular fluorophores have shown superior properties in the biocompatibility,variable structure,and tunable emission wavelength than the inorganic NIR-II materials.What’s more,some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser.This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years,focusing on the molecular structures and phototheranostic performances.Furthermore,challenges and prospects of future development toward clinical translation are discussed. | Hanming Dai Qing Shen Jinjun Shao Wenjun Wang Fan Gao Xiaochen Dong | 2021 | The Innovation2021，2，1： | 0 |
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