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| 1 | Arabidopsis NIP3;1 Plays an Important Role in Arsenic Uptake and Root-to-Shoot Translocation under Arsenite Stress Conditions显示文摘在 Arabidopsis, nodulin 26-like 内在的蛋白质(捏) aquaporin 蛋白质的亚科由九个成员,组成哪个中的五个(NIP1; 1, NIP1; 2, NIP5; 1, NIP6; 1,并且 NIP7; 1 ) 以前被识别对亚砷酸盐可渗透。然而,角色在植物在亚砷酸盐的 root-to-shoot translocation 捏仍然保持糟糕理解。在这研究,用反向的基因策略, Arabidopsis NIP3; 1 被识别在亚砷酸盐压力条件下面在砷举起和 root-to-shoot 分发起一个重要作用。nip3; 1 loss-of-function 异种在亚砷酸盐忍耐显示了明显的改进为未葬生长和积累的更少砷在野类型的植物比那些射击,而 nip3; 1 nip1; 1 两倍异种显示出强壮的亚砷酸盐忍耐并且在亚砷酸盐压力条件下面改进了根和射击的生长。一个倡导者 -- glucuronidase 分析揭示了那 NIP3; 1 几乎专门在根被表示(与根尖端的异常) ,并且在酵母 Saccharomyces cerevisiae 的 heterologous 表示表明了那 NIP3; 1 能调停亚砷酸盐运输。一起拿,我们的结果建议那 NIP3; 1 在 Arabidopsis 涉及亚砷酸盐举起和 root-to-shoot translocation,可能作为被动、双向的亚砷酸盐 transporter。 | WenzhongXu Wentao Dai Huili Yan Sheng Li Hongling Shen Yanshan Chen Hua Xu Yangyang Sun Zhenyan He Mi Ma | 2015 | Molecular Plant2015，8，5： | 13 |
| 2 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 3 | Endometrial membrane organoids from human embryonic stem cell combined with the 3D Matrigel for endometrium regeneration in asherman syndrome显示文摘Asherman’s syndrome(AS),a leading cause of uterine infertility worldwide,is characterized by scarring of the uterine surfaces lacking endometrial epithelial cells,which prevents endometrial regeneration.Current research on cell therapy for AS focuses on mesenchymal and adult stem cells from the endometrium.However,insufficient number,lack of purity,and rapid senescence of endometrial epithelial progenitor cells(EEPCs)during experimental processes restrict their use in cell therapies.In this study,we induced human embryonic stem cells-9(H9-ESC)into EEPCs by optimizing the induction factors from the definitive endoderm.EEPCs,which act as endometrial epithelial cells,accompanied by human endometrial stromal cells provide a niche environment for the development of endometrial membrane organoids(EMOs)in an in vitro 3D culture model.To investigate the function of EMOs,we transplanted tissue-engineered constructs with EMOs into an in vivo rat AS model.The implantation of EMOs into the damaged endometrium facilitates endometrial regeneration and angiogenesis.Implanting EMOs developed from human embryonic stem cells into the endometrium might prove useful for“endometrial re-engineering”in the treatment of Asherman’s syndrome. | Xiuxiu Jiang Xingmiao Li Xiangwei Fei Jiajie Shen Jianhua Chen Meijun Guo Yangyang Li | 2021 | Bioactive Materials2021，6，11： | 11 |
| 4 | CO_2 absorption into a phase change absorbent: Water-lean potassium prolinate/ethanol solution显示文摘Phase change solvents are attractive energy-efficient absorbents for carbon dioxide(CO_2) capture due to CO_2-rich phase formation. Potassium prolinate + water + ethanol(ProK/W/Eth) solution has shown good capture characteristics as a promising one in our previous work. In this work, absorption rate of CO_2, solubility of N2 O,and heat of absorption for ProK/W/Eth solution were investigated using a stirred cell reactor and a CPA201 reaction calorimeter and these results were also compared with the aqueous ProK and 30 mass% MEA solutions.Using ethanol as a solvent can substantially increase the CO_2 physical solubility and the absorption rate of CO_2 in ProK/W/Eth solutions is far higher than that in aqueous 30 mass% MEA solutions especially at a low CO_2 loading range. Solid precipitation, obtained from the liquid-to-solid phase change absorption, was analyzed by13 C NMR and DSC-TGA. The enthalpy change for ProK/W/Eth solutions at various CO_2 loading was also discussed. | Yangyang Bian Shufeng Shen | 2018 | Chinese Journal of Chemical Engineering2018，26，11： | 7 |
| 5 | 3D morphology and formation mechanism of fractures developed by true triaxial stress显示文摘As main part of underground rock mass,the three-dimensional(3D)morphology of natural fractures plays an important role in rock mass stability.Based on previous studies on 3D morphology,this study probes into the law and mechanism regarding the influence of the confining pressure constraints on 3D morphological features of natural fractures.First,fracture surfaces were obtained by true triaxial compression test and 3D laser scanning.Then 3D morphological parameters of fractures were calculated by using Grasselli’s model.The results show that the failure mode of granites developed by true triaxial stress can be categorized into tension failure and shear failure.Based on the spatial position of fractures,they can be divided into tension fracture surface,S-1 shear fracture surface,and S-2 shear fracture surface.Micro-failure of the tension fracture surface is dominated by mainly intergranular fracture;the maximum height of asperities on the fracture surface and the 3D roughness of fracture surfaces are influenced by σ_(3) only and they are greater than those of shear fracture surfaces,a lower overall uniformity than tension fracture surface.S-1 shear fracture surface and S-2 shear fracture surface are dominated by intragranular and intergranular coupling fracture.The maximum height of asperities on the fracture surface and 3D roughness of fracture surface are affected by σ_(1),σ_(2),and σ_(3).With the increase of σ_(2) or σ_(3),the cutting off of asperities on the fracture surface becomes more common,the maximum height of asperities and 3D roughness of fracture surface further decrease,and the overall uniformity gets further improved.The experimental results are favorable for selecting technical parameters of enhanced geothermal development and the safety of underground mine engineering. | Bing Chen Baotang Shen Shichuan Zhang Yangyang Li Haiyang Jiang | 2022 | International Journal of Mining Science and Technology2022，32，6： | 4 |
| 6 | An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma显示文摘Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery. | Xingchen Li Yuan Cheng Yangyang Dong Boqiang Shen Xiao Yang Jiaqi Wang Jingyi Zhou Jianliu Wang | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 7 | Eliminating poverty through development:The dynamic evolution of multidimensional poverty in rural China显示文摘This paper measures intertemporal multidimensional poverty in rural China from 1988 to 2018 based on the China Household Income Project(CHIP)data and for that time period has the following findings.First,multidimensional poverty in rural China declines steadily when measured through the income poverty approach.Second,multidimensional poverty in rural areas presents demographic and regional heterogeneity,among which elderly poverty,child poverty,and poverty in the western Chinese region are the most prominent ones.Third,income poverty and multidimensional poverty have a low overlap ratio and show intertemporal synchronisation over time.Although increases in income can alleviate multidimensional poverty,this effect is very limited.This paper suggests that a suitable multidimensional poverty identification framework should be developed in the era of poverty alleviation after 2020 and that in the new poverty alleviation governance system of China,targeted development strategies should be formulated with an increased focus on the poverty of special groups such as children and the elderly. | Yangyang Shen Shi Li | 2022 | Economic and Political Studies2022，10，1： | 2 |
| 8 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 9 | Spatial and seasonal distribution of organochlorine pesticides in the sediments of the Yangtze Estuary显示文摘 | Yangyang Li Junfeng Niu Zhenyao Shen Chi Zhang Zhengzao Wang Tiande He | 2014 | Chemosphere2014，，： | 1 |
| 10 | Tailoring therapy to improve the treatment of children with obstructive sleep apnea according to grade of adenotonsillar hypertrophy显示文摘 | Ling Shen Bolu Zheng Zongtong Lin Yangyang Xu Zhongjie Yang | 2015 | International Journal of Pediatric Otorhinolaryng2015，，： | 1 |
| 11 | Molecular dynamics study of the influence of surfactant structure on surfactant - facilitated spreading of droplets on solid surfaces显示文摘 | SHEN YANGYANG COUZIS A KOPLIK J | 2005 | Langmuir2005，21，12： | 1 |
| 12 | Transplantation of human umbilical cord-derived mesenchymal stems cellsfor the treatment of Becker muscular dystrophy in affected pedigree members显示文摘 | Pang Li Kai Cui Bo Zhang Zhendan Wang Yangyang Shen Xiangyu Wang Jianbo Zhang Feng Tong Sheng Li | 2015 | International Journal of Molecular Medicine2015，，： | 1 |
| 13 | Toward the development of magnetic tweezers for high-throughput measurement of protein- protein interactions显示文摘 | Haowen Cao Yi Shen Yangyang Sun Sheng-Ce Tao Daniel M. Czajkowsky Zhifeng Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 0 |
| 14 | Epidermal growth factor receptor is overexpressed in neuroblastoma tissues and cells显示文摘Neuroblastoma 是在童年的最普通的腹的恶意的肿瘤。指向肿瘤房间表面受体的 Immunotoxin (信息技术) 是一条新增补治疗学的处理途径。如果信息技术治疗能被用来对待倔强的 neuroblastoma,这研究的目的是在 neuroblastoma 房间线和纸巾检测表皮的生长因素受体(EGFR ) 的表示,并且探索。在人的 neuroblastoma 织物样品的 EGFR 表示被 immunohistochemistry 检测 ? 染色。EGFR 表示的积极的率在 neuroblastoma 织物是 81.0% 并且 50.0% 在 gangliocytoma,分别地,但是没有在他们之间的统计意义(P ?>? 0.05 ) 。分别地,在有利类型和相反的类型的 EGFR 表示的积极的率是 62.5% 和 92.3% ,但是他们不是统计上不同的(P ?>? 0.05 ) 。从化疗前和化疗以后的样品的结果证明没有重要统计差别(P ?>? 0.05 ) 在他们之间在 EGFR 表示。而且,在五根 neuroblastoma 房间线的 EGFR 表示层次用基于房间的 ELISA 试金和西方的污点分析被测量。结果证明 EGFR 的表示在 KP-N-NS 是更高的并且是(2 )-C 在另外的房间比那些排队。我们的结果表明有在 neuroblastoma 纸巾以及在 neuroblastoma 房间线的 EGFR 的一致、普遍的表情,建议开发由在 EGFR 指向的 neuroblastoma 的未来处理策略是可能的。 | Chao Zheng Ruling Shen Kai Li Na Zheng Yuqing Zong Danrong Ye Qingcheng Wang Zuopeng Wang Lian Chen Yangyang Ma | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 0 |
| 15 | Recent advances in the development of in vitro liver models for hepatotoxicity testing显示文摘Liver injury is a common cause of drug approval withdrawal during drug development,pre-clinical research,and clinical treatment.If not properly treated,patients with severe liver injury can suffer from acute liver failure or even death.Thus,utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized medication.Biomaterials(e.g.,hydrogels,nanofibers,decellularized liver matrix)and bioengineering technologies(e.g.,microarrays,micropatterns,3D printing,and microfluidics)have been applied for in vitro hepatotoxicity assessment models.This review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment models.In addition,it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation. | Siming Lu Jingwei Zhang Sha Lin Danfeng Zheng Yan Shen Jiale Qin Yangyang Li Shuqi Wang | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
| 16 | Phenotype and metabolism alterations in PCB-degrading Rhodococcus biphenylivorans TG9^(T) under acid stress显示文摘Environmental acidification impairs microorganism diversity and their functions on substance transformation.Rhodococcus is a ubiquitously distributed genus for contaminant detoxification in the environment,and it can also adapt a certain range of pH.This work interpreted the acid responses from both phenotype and metabolism in strain Rhodococcus biphenylivorans TG9^(T)(TG9)induced at pH 3.The phenotype alterations were described with the number of culturable and viable cells,intracellular ATP concentrations,cell shape and entocyte,degradation efficiency of polychlorinated biphenyl(PCB)31 and biphenyl.The number of culturable cells maintained rather stable within the first 10 days,even though the other phenotypes had noticeable alterations,indicating that TG9 possesses certain capacities to survive under acid stress.The metabolism responses were interpreted based on transcription analyses with four treatments including log phase(LP),acid-induced(PER),early recovery after removing acid(RE)and later recovery(REL).With the overview on the expression regulations among the 4 treatments,the RE sample presented more upregulated and less downregulated genes,suggesting that its metabolism was somehow more active after recovering from acid stress.In addition,the response mechanism was interpreted on 10 individual metabolism pathways mainly covering protein modification,antioxidation,antipermeability,H+consumption,neutralization and extrusion.Furthermore,the transcription variations were verified with RT-qPCR on 8 genes with 24-hr,48-hr and 72-hr acid treatment.Taken together,TG9 possesses comprehensive metabolism strategies defending against acid stress.Consequently,a model was built to provide an integrate insight to understand the acid resistance/tolerance metabolisms in microorganisms. | Aili Li Jiahui Fan Yangyang Jia Xianjin Tang Jingwen Chen Chaofeng Shen | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 17 | Use of 1.32-μm and 1.06-μm wavelength lasers for vascular cutting in a porcine model of liver and stomach bleeding显示文摘Objective The aim of this study was to analyze and evaluate 1.32-μm and 1.06-μm neodymium-doped yttrium aluminum garnet(Nd:YAG) lasers for use in liver and gastroepiploic vessel vaporization and coagulation. Methods The effects of 1.32-μm and 1.06-μm Nd:YAG lasers were compared for gastroepiploic vessel hemostasis in porcine liver.Results The results were observed and measured under the same parameters and dose conditions. The 1.32-μm laser showed greater vaporization width and depth than the 1.06-μm laser. Both lasers controlled active bleeding. The coagulation band with the 1.32-μm laser was thinner than with the 1.06-μm laser, at nearly 3 mm. After cutting of 1-and 2-mm porcine vessels, no grossly visible bleeding was apparent. Intravascular thrombus was visible under the microscope. The length of vessel thrombosis in the experimental group was 2 mm and the diameter was 2 mm; the control group exhibited thrombi as 2.3–4.9 mm in length. Thrombosis completely blocked the blood vessels.Conclusion The 1.32-μm laser had greater vaporization capability than the 1.06-μm laser and achieved hemostasis requirements for vessels less than 2 mm in diameter. | Lu Han Wenyuan Gao Yangyang Shen Kai Pang Zhanjun Jiang Yonghui Gao Peng Xu Sheng Li | 2017 | Oncology and Translational Medicine2017，3，4： | 0 |
| 18 | Ru single atoms induce surface-mediated discharge in Na-O_(2)batteries显示文摘Sodium(Na)O_(2)batteries have high energy density and low cost.However,high polarization,complex discharge products,and low Coulombic efficiency(CE)lead to poor cyclability.Here,we proposed an atomically dispersed Ru catalyst on nitrogen-doped graphene for Na-O_(2)batteries.The catalysts enable the discharge to proceed via a surface-mediated route,which leads to uniform deposition of Na_(2-x)O_(2)and low polarization during recharge.The first-principle calculation revealed that Ru-N_(4)complex in the catalyst has strong chemical adsorption to intermediate superoxides,facilitating uniform deposition and enhancing rapid kinetics.In contrast,Ru nanoparticles,despite the catalytic activity,induce bulk deposition via a solution-mediated route because the exposed graphene surface shows weak interaction to superoxides,thereby lowering CEs and cyclability.In brief,the atomically-dispersed Ru catalyst endows Na-O_(2)batteries with excellent electrochemical properties via a surface-mediated discharge. | Xin Jin Yangyang Li Shuo Zhang Jiangwei Zhang Zihan Shen Chenlin Zhong Ziqiang Cai Chaoquan Hu Huigang Zhang | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 19 | 3-5 An Experiment Setup for Synergetic Effect of Irradiation and LBE in IMP显示文摘Due to its unique properties, such as favorable neutronic characteristic, low melting point(~125 ?C) and highboiling point (> 1 600 ?C), good natural circulation and chemical inertness with water and air (unlike sodium), etc,lead bismuth eutectic (LBE) has been considered as perspective coolant and spallation target for accelerator drivensystems (ADS)[1;2]. The spallation structural materials of ADS will be long-term irradiated with fast neutrons whilesimultaneous being contact with LBE coolant. In the past few decades, irradiation or LBE corrosion behaviors invarious of materials have been massively investigated for the purpose of developing ADS. However, there are onlya few experiment data on the combined effect of irradiation and LBE corrosion on structural materials due to lackof related experimental setups[3;4]. Such tests are not only essential for ensuring the safety and reliability of ADS,but also necessary for building a database for licensing any materials for use in LBE cooled nuclear systems. | Yao Cunfeng Wang Zhiguang Zhang Hongpeng Sheng Yanbin Chang Hailong Sun Jianrong Wei Kongfang Li Bingsheng Shen Tielong Pang Lilong Zhu Yabin Wang Dong Du Yangyang Wang Ji Cui Minhuan Zhu Huiping Liu Chao Yang Yongwei Fan Deliang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 20 | 3-17 Corrosion Studies of MAX Phase in Liquid Pb-Bi Alloy显示文摘As one of candidates for the fuel cladding or structure material used in fourth generation fission and fusiondemonstrate reactor, MAX phase has the properties of both ceramic and metal, such as high melting point, hightemperaturestability, good erosion resistance and radiation-damage tolerance[1;2]. Max phase is a series of ceramicsof nanolamellar and hexagonal structure. M represents transition element. A represents the third or fourth maingroup element. X represent N and C. In the design of lead-cooled fast reactor, it is required that the materialshould endure the corrosion of liquid Pb-Bi alloy. Therefore, understanding of the oxide layers and their growthmechanisms in LBE is fundamentally important for the development of candidate materials. | Deng Tianyu Sun Jianrong Wang Zhiguang Song Peng Shen Tielong Pang Lilong Zhu Yabin Cui Minghuan Wang Ji Zhu Huiping Wang Dong Du Yangyang He Wenhao | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
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