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| 1 | Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities显示文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. | Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 2 | Inhibiting collagen Ⅰ production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles显示文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells. | Yan Yan Cancan Du Xixi Duan Xiaohan Yao Jiajia Wan Ziming Jiang Zhongyu Qin Wenqing Li Longze Pan Zhuoyu Gu Fazhan Wang Ming Wang Zhihai Qin | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 7 |
| 3 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 4 | Effect of mowing on N2O and CH4 fluxes emissions from the meadow-steppe grasslands of Inner Mongolia显示文摘估计在 N 2 从内部蒙古的草地大草原草地的 O 和 CH 4 流动排出物,中国,二政体被调查:unmown 自从 2005 (嗯) ,并且 mow 的过去分词一次每三年自从 2009 (M3 ) 。所在地的大小在一个整年的时期(到 2012 年 8 月的 2011 年 8 月) 期间连续地被进行。在观察时期期间,三日报周期也被测量。另外,一个指向的实验室实验被进行在冬季补救很少大小。N 2 与结冰融化周期有关的 O 排出物在春天解冻期间在 M3 被观察。结果证明草地大草原为 N 24 和来源作为一个水池起了一个作用 > O。显著地更低的吝啬的 CH 4举起在嗯( 40.3 g C 獡攠慶畬瑡摥?潇摯氠湩慥楲祴??猼灵资???????漠?桴?慣楬牢瑡潩?畣癲獥映牯焠慵瑮晩捩瑡潩?慷?扯慴湩摥漠敶?桴?祤慮業?慲杮?景????朿洿????猯灵?愠摮瀠牥散瑮爠汥瑡癩?瑳湡慤摲搠癥慩楴湯眠獡ㄠ????慥档湩?硥数楲敭瑮猠潨敷?桴瑡挠慹潺慦業?潣汵?潮?敬捡敨?敢潹摮ㄠ?浣漠?潳汩搠灥桴?慍楸畭?潣据湥牴瑡潩?慷?瑡??愠摮ㄠ??浣猠楯?敤瑰??敶慲敧爠'恬碃皵?牦浯猠楯獬映牯楴楦摥愠???? 鄿靗鵌 ? | Zedong LU Rui DU Pengrui DU Ziming LI Zongmin LIANG Yaling WANG Saisai QIN LeiZHONG | 2015 | Frontiers of Earth Science2015，9，3： | 2 |
| 5 | The Ore-Sato Theorem and Shift Exponents in the q-Difference Case显示文摘The authors translate the main results in the paper entitled 'Multiplicative Decomposition of Multivariate q-Hypergeometric Terms' from Chinese into English. The paper is written by Shaoshi Chen, Ruyong Feng, Guofeng Fu and Jing Kang, and published in Journal of Mathematics and Systems Science, 32(8), 1019–1032, 2012. Some minor simpli?cation and modi?cation are made during the translation. Based on the results in the above paper, a special form is derived for q-shift exponents appearing in the q-shift quotients of a q-hypergeometric term. | DU Hao LI Ziming | 2019 | Journal of Systems Science & Complexity2019，32，1： | 2 |
| 6 | Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from?显示文摘Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side. | Yi Du Xingjian Liu Lili Ren Yu Wang Fei Ji Weiwei Guo Ziming Wu | 2023 | Journal of Otology2023，18，2： | 1 |
| 7 | Micropatterns and peptide gradient on the inner surface of a guidance conduit synergistically promotes nerve regeneration in vivo显示文摘Both of the surface topographical features and distribution of biochemical cues can influence the cell-substrate interactions and thereby tissue regeneration in vivo.However,they have not been combined simultaneously onto a biodegradable scaffold to demonstrate the synergistic role so far.In this study,a proof-of-concept study is performed to prepare micropatterns and peptide gradient on the inner wall of a poly(D,L-lactide-co-caprolactone)(PLCL)guidance conduit and its advantages in regeneration of peripheral nerve in vivo.After linear ridges/grooves of 20/40μm in width are created on the PLCL film,its surface is aminolyzed in a kinetically controlled manner to obtain the continuous gradient of amino groups,which are then transferred to CQAASIKVAV peptide density gradient via covalent coupling of glutaraldehyde.The Schwann cells are better aligned along with the stripes,and show a faster migration rate toward the region of higher peptide density.Implantation of the nerve guidance conduit made of the PLCL film having both the micropatterns and peptide gradient can significantly accelerate the regeneration of sciatic nerve in terms of rate,function recovery and microstructures,and reduction of fibrosis in muscle tissues.Moreover,this nerve conduit can also benefit the M2 polarization of macrophages and promote vascularization in vivo. | Deteng Zhang Ziming Li Haifei Shi Yuejun Yao Wang Du Pan Lu Kejiong Liang Liangjie Hong Changyou Gao | 2022 | Bioactive Materials2022，7，3： | 1 |
| 8 | Opimization of Extraction Process for Plysaccharide from Hippophae fhamnoides L显示文摘 | Wang Guowei Cao Ziming Du Guangfen | 2010 | Medicinal plant2010，1，19： | 1 |
| 9 | Identification of differentially expressed microRNAs in nasopharyngeal carcinoma显示文摘 | LI Xiaoxia LI Rui-ping DU Ziming | 2007 | J SUN Yat-sen Univ (Med Sci)2007，28，6： | 1 |
| 10 | Antibacterial hydroxyapatite coatings on titanium dental implants显示文摘Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good biocompatibility.However,their ability to bind to neighboring bone is limited due to the lack of biological activity.At the same time,they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation,eventually resulting in implant failure.The preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these concerns.In this review,the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and reviewed.This review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future. | Ziming Liao Jingxuan Li Yimeng Su Fenyan Miao Xiumei Zhang Yu Gu Jingjing Du Ruiqiang Hang Yan Wei Weiyi Chen Di Huang | 2023 | Frontiers of Materials Science2023，17，1： | 0 |
| 11 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 12 | MiR-4262 regulates differentiation and osteogenesis of humanperiodontal stem cells by targeting suppressor of cytokinesignaling 4显示文摘Periodontitis,as a chronic inflammatory disease,remains unsolved,and the pathogenesis of this disease has not been fully elucidated.In this study,the effect of miR-4262 was investigated in tumor necrosis factor-α(TNF-α)induced human periodontal stem cells(hPDLSCs)for the first time.The gene expression involved in this study was determined using polymerase chain reaction(PCR),the expressions of relevant proteins were determined by western blot analysis,and the levels of IL-1β,IL-6,and MCP-1 were estimated by enzyme-linked immunosorbent assay(ELISA)assay.The luciferase reporter assay was performed for verification of the target gene,alkaline phosphatase(ALP)activity detection was used for differentiation capacity,and alizarin red staining assay was used for mineralization capacity.The inhibition of miRNA-4262,which resulted in the upregulation of suppressor of cytokine signaling 4(SOCS4),showed protective effects,including anti-inflammation and promotional effects on osteogenesis as well as differentiation in TNF-αinduced hPDLSCs.These results provided insights into the roles of miRNAs in regulating the inflammatory response,differentiation,and osteogenesis in hPDLSCs,which may promote the understanding of the mechanisms of periodontitis and find out a better therapeutic application. | ZIMING WEI YARONG WANG MINGYUAN DU MINJIE LI HONG HE | 2020 | BIOCELL2020，44，4： | 0 |
| 13 | 4-29 Step-target Design for High Energy Electron Radiography Research显示文摘High energy proton beam has the long penetration length in solid matter and it could produce the radiographsand indicate the tomography and material properties inside of the specimen. Considering the expensive coststo construct a high energy proton accelerator, the other candidate of high energy electron beam becomes moreacceptable[1??3]. Due to the high spatial and temperal resolution of high energy electron beam. It is a power tool todiagnose the inner structure change during the high energy density matter production and the inertial confinementfusion process. In order to study the density resolution of the high energy electron beam radiography, a step-targetwas designed and produced. The structure and the target pictures are shown in Fig. 1 and the Si targets withdifferent slot-width were produced by using the microetch technics. | Cheng Rui Zhao Yongtao Zhang Ziming Gai Wei Du Yingchao Cao Shuchun Zhou Xianming Zhao Quantang Shen Xiaokang Zong Yang Wang Yangru Xiao Jiahao Li Haixia | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 14 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
| 15 | Analysis of video head impulse test saccades data in patients with vestibular migraine or probable vestibular migraine显示文摘Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their utility in diagnosing VM.To better understand clinical features of VM,it is necessary to understand raw saccades data.Methods:Fourteen patients with confirmed VM,45 patients with probable VM(p-VM)and 14 agematched healthy volunteers were included in this study.Clinical findings related to spontaneous nystagmus(SN),positional nystagmus(PN),head-shaking nystagmus(HSN),caloric test and vHIT were recorded.Raw saccades data were exported and numbered by their sequences,and their features analyzed.Results:VM patients showed no SN,PN or HSN,and less than half of them showed unilateral weakness(UW)on caloric test.The first saccades from lateral semicircular canal stimulation were the most predominant for both left and right sides.Neither velocity nor time parameters were significantly different when compared between the two sides.Most VM patients(86%)exhibited small saccades,around 35%of the head peak velocity,with a latency of 200e400 ms.Characteristics of saccades were similar in patients with p-VM.Only four normal subjects showed saccades,all unilateral and seemingly random.Conclusions:Small saccades involving bilateral semicircular canals with a scattered distribution pattern are common in patients with VM and p-VM. | Yi Du Xingjian Liu Lili Ren Yu Wang Ziming Wu | 2022 | Journal of Otology2022，17，4： | 0 |
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