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| 1 | Hepatic encephalopathy:An approach to its multiple pathophysiological features显示文摘Hepatic encephalopathy(HE)is a neuropsychiatric complex syndrome,ranging from subtle behavioral abnormalities to deep coma and death.Hepatic encephalopathy emerges as the major complication of acute or chronic liver failure.Multiplicity of factors are involved in its pathophysiology,such as central and neuromuscular neurotransmission disorder,alterations in sleep patterns and cognition,changes in energy metabolism leading to cell injury,an oxidative/nitrosative state and a neuroinflammatory condition.Moreover,in acute HE,a condition of imminent threat of death is present due to a deleterious astrocyte swelling.In chronic HE,changes in calcium signaling,mitochondrial membrane potential and long term potential expression,N-methyl-D-aspartate-cGMP and peripheral benzodiazepine receptors alterations,and changes in the mRNA and protein expression and redistribution in the cerebral blood flow can be observed.The main molecule indicated as responsible for all these changes in HE is ammonia.There is no doubt that ammonia,a neurotoxic molecule,triggers or at least facilitates most of these changes.Ammonia plasma levels are increased two-to three-fold in patients with mild to moderate cirrhotic HE and up to ten-fold in patients with acute liver failure. Hepatic and inter-organ trafficking of ammonia and its metabolite,glutamine(GLN),lead to hyperammonemic conditions.Removal of hepatic ammonia is a differentiated work that includes the hepatocyte,through the urea cycle,converting ammonia into GLN via glutamine synthetase.Under pathological conditions,such as liver damage or liver blood bypass,the ammonia plasma level starts to rise and the risk of HE developing is high. Knowledge of the pathophysiology of HE is rapidly expanding and identification of focally localized triggers has led the development of new possibilities for HE to be considered.This editorial will focus on issues where, to the best of our knowledge,more research is needed in order to clarify,at least partially,controversial topics. | Juan Carlos Perazzo Silvina Tallis Amalia Delfante Pablo Andrés Souto Abraham Lemberg Francisco Xavier Eizayaga Salvador Romay | 2012 | World Journal of Hepatology2012，4，3： | 16 |
| 2 | Evaluation of IGL-1 preservation solution using an orthotopic liver transplantation model显示文摘AIM: To compare, in a pig liver transplantation model, the protective effect of UW with that of IGL-1, a high-sodium preservation solution containing polyethylene glycol (PEG) as an oncotic supply. METHODS: All livers were harvested and grafted orthotopically according to standard techniques. The livers were washed out and preserved for 7 h in IGL-1 (n = 6) or in UW solution (n = 7) at 4℃. In a sham group (n = 4), the livers underwent a 60-min warm ischemia at 37℃. The hepatocellular injury was assessed in organ preservation solution washed out from the graft at the end of ischemic storage (before revascularization), and in serum 2 h after reperfusion and daily for up to 6 d. RESULTS: Livers preserved in IGL-1 solution released markedly less AST than that preserved in the UW solution before and after revascularization (P < 0.05). Besides, the activity of creatine kinase-BB, a marker of sinusoidal lining cells injury, was higher in the UW group than in the IGL-1 group (P < 0.05). Histological results showed less necrotic regions in livers preserved in IGL-1 solution; however, no difference was observed for in? ammation. CONCLUSION: IGL-1 liquid effectively protects parenchymal and non-parenchymal cells against prese-rvation-reperfusion injuries. | Hassen Ben Abdennebi Ziad Elrassi Jean-Yves Scoazec Jean-Paul Steghens Silvina Ramella-Virieux Olivier Boillot | 2006 | World Journal of Gastroenterology2006，12，33： | 5 |
| 3 | Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn’s disease in mice显示文摘 | Jean Guy LeBlanc Silvina del Carmen Anderson Miyoshi Vasco Azevedo Fernando Sesma Philippe Langella Luis G. Bermúdez-Humarán Laurie Watterlot Gabriela Perdigon Alejandra de Moreno de LeBlanc | 2010 | Journal of Biotechnology2010，，3： | 2 |
| 4 | Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?显示文摘 | Silvina B. Lotito Balz Frei | 2006 | Free Radical Biology and Medicine2006，，12： | 2 |
| 5 | Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions显示文摘 | Silvina G. Castro Sergio F. Sanchez Bruni Lucí a P. Urbizu Alejandra Confalonieri Laura Ceballos Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2013 | Pharmaceutical Development and Technology2013，，2： | 2 |
| 6 | Improved Albendazole Dissolution Rate in Pluronic 188 Solid Dispersions显示文摘 | Silvina G. Castro Sergio Sanchez Bruni Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2010 | AAPS PharmSciTech2010，，4： | 2 |
| 7 | The westward lithospheric drift,its role on the subduction and transform zones surrounding Americas:Andean to cordilleran orogenic types cyclicity显示文摘We investigate the effect of the westerly rotation of the lithosphere on the active margins that surround the Americas and find good correlations between the inferred easterly-directed mantle counterflow and the main structural grain and kinematics of the Andes and Sandwich arc slabs.In the Andes,the subduction zone is shallow and with low dip,because the mantle flow sustains the slab;the subduction hinge converges relative to the upper plate and generates an uplifting doubly verging orogen.The Sandwich Arc is generated by a westerly-directed SAM(South American) plate subduction where the eastward mantle flow is steepening and retreating the subduction zone.In this context,the slab hinge is retreating relative to the upper plate,generating the backarc basin and a low bathymetry single-verging accretionary prism.In Central America,the Caribbean plate presents a more complex scenario:(a) To the East,the Antilles Arc is generated by westerly directed subduction of the SAM plate,where the eastward mantle flow is steepening and retreating the subduction zone.(b) To the West,the Middle America Trench and Arc are generated by the easterly-directed subduction of the Cocos plate,where the shallow subduction caused by eastward mantle flow in its northern segment gradually steepens to the southern segment as it is infered by the preexisting westerly-directed subduction of the Caribbean Plateau.In the frame of the westerly lithospheric flow,the subduction of a divergent active ridge plays the role of introducing a change in the oceanic/continental plate’s convergence angle,such as in NAM(North American)plate with the collision with the Pacific/Farallon active ridge in the Neogene(Cordilleran orogenic type scenario).The easterly mantle drift sustains strong plate coupling along NAM,showing at Juan de Fuca easterly subducting microplate that the subduction hinge advances relative to the upper plate.This lower/upper plate convergence coupling also applies along strike to the neighbor continental strike slip fault systems where subduction was terminated(San Andreas and Queen Charlotte).The lower/upper plate convergence coupling enables the capture of the continental plate ribbons of Baja California and Yakutat terrane by the Pacific oceanic plate,transporting them along the strike slip fault systems as para-autochthonous terranes.This Cordilleran orogenic type scenario,is also recorded in SAM following the collision with the Aluk/Farallon active ridge in the Paleogene,segmenting SAM margin into the eastwardly subducting Tupac Amaru microplate intercalated between the proto-LiquineOfqui and Atacama strike slip fault systems,where subduction was terminated and para-autochthonous terranes transported.In the Neogene,the convergence of Nazca plate with respect to SAM reinstalls subduction and the present Andean orogenic type scenario. | Eugenio Aragon Fernando D'Eramo Marco Cuffaro Carlo Doglioni Eleonora Ficini Lucio Pinotti Silvina Nacif Manuel Demartis Irene Hernando Tomas Fuentes | 2020 | Geoscience Frontiers2020，11，4： | 2 |
| 8 | Recombinant canarypox virus expressing the VP2 protein of infectious bursal disease virus induces protection in vaccinated SPF chickens显示文摘Dear Editor,Infectious bursal disease virus(IBDV)causes infectious bursal disease,a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry worldwide.IBDV replicates mainly in actively dividing B lymphocytes within the bursa of Fabricius(BF),leading to immunosuppression in affected flocks(Mahgoub et al.,2012).Viral protein 2(VP2),the only structural component of the | Flavia Adriana Zanetti Romina Cardona Carlos Rodolfo Federico Silvina Chimeno-Zoth Gabriela Calamante | 2016 | Virologica Sinica2016，31，3： | 2 |
| 9 | Cigarette smoking, dietary habits and genetic polymorphisms in GSTT1, GSTM1 and CYP1A1 metabolic genes: A case-control study in oncohematological diseases显示文摘AIM To analyze the association between oncohematological diseases and GSTT1 /GSTM1 /CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control study.METHODS This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. Deletions in GSTT1 and GSTM1 (null genotypes) were addressed by PCR. CYP1A1 MspI polymorphism was detected by PCR-RFLP. Odds ratio(OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological disease.RESULTS Women showed lower risk of disease compared to men(OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education(> 12 years) were significantly associated with an increased risk, compared to complete primary school or less(OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease(OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk(OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 and CYP1A1 polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found. CONCLUSION We reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer. | María Belén Cerliani Walter Pavicic Juan Antonio Gili Graciela Klein Silvia Saba Silvina Richard | 2016 | World Journal of Clinical Oncology2016，7，5： | 1 |
| 10 | Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: Preventive effects of metformin显示文摘 | María José Tolosa Sara Rocío Chuguransky Claudia Sedlinsky León Schurman Antonio Desmond McCarthy María Silvina Molinuevo Ana María Cortizo | 2013 | Diabetes Research and Clinical Practice2013，，2： | 1 |
| 11 | Design and basehne characteristics of the soy phytoestrogens as replacement e- strogen (SPARE)study-A clincal trial of the effects of soy isoflavones in menopausal women显示文摘 | Silvina Levis Nancy Strickman-Stein Daniel R Doerge | 2010 | Contemporary Clinical Trials2010，31，： | 1 |
| 12 | Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats显示文摘 | Claudia Sedlinsky María Silvina Molinuevo Ana María Cortizo María José Tolosa Juan Ignacio Felice María Laura Sbaraglini Leon Schurman Antonio Desmond McCarthy | 2011 | European Journal of Pharmacology2011，，3： | 1 |
| 13 | Hydrolysis of pork muscle sarcoplasmie protdns by Laetobaeillus curvatus and lactobacillus sake显示文摘 | SILVINA F YOLANDA S GRACIELA V | 1999 | Appt Environ Micro1999，65，： | 1 |
| 14 | The effect of whey protein concentrates and hedrocolloids on the texture and colour char- acteristics of chicken sausages显示文摘 | Silvina Andles Noemi Zaritzky Alicia Califano | 2006 | International Journal of Food Sci- ence &Technology2006，41，8： | 1 |
| 15 | Gas phase hydrogenation of maleic anhydride at low pres- sure over silica-supported cobalt and nickel catalysts 显示文摘 | Meyer Camilo I Regenhardt Silvina A Marchi Alberto J | 2012 | Applied Catalysis A: General2012，，： | 1 |
| 16 | Social inequality in Pap smear coverage:identifying under-users of cervical cancer screening in Argentina显示文摘 | Silvina A Silvina R Melisa P | 2008 | Reprod Health Matters2008，16，32： | 1 |
| 17 | Characlerizalion of muscle sarcoplasrnic and myofibrillar protein hydrolysis caused by Lactobacillus plantarum显示文摘 | SILVINA F YOLANDA S GRACIELA V | 1999 | Appl Environ Micro1999，65，： | 1 |
| 18 | Hydrolysis of pork muscle sarcoplasmic proteins by Lactobacillus curvatus and Lactobacillus sake显示文摘 | SILVINA F YOLANDA S GRACIELA V | 1999 | Appl Environ Micro1999，65，： | 1 |
| 19 | Hydrolysis of muscle myofibrillar proteins by Lactobacillus curvatus and Lactobacillus sake显示文摘 | YOLANDA S SILVINA F GRACIELA V | | 0，，2： | 1 |
| 20 | Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas显示文摘 | Jorge Humberto Mukdsi Ana Lucía De Paul Silvina Gutiérrez Félix Daniel Roth Agustín Aoki Alicia Inés Torres | 2005 | Journal of Molecular Histology (-)2005，，8： | 1 |
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