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| 1 | Gastroenteric tube feeding: Techniques, problems and solutions显示文摘Gastroenteric tube feeding plays a major role in the management of patients with poor voluntary intake,chronic neurological or mechanical dysphagia or gut dysfunction,and patients who are critically ill.However,despite the benefits and widespread use of enteral tube feeding,some patients experience complications.This review aims to discuss and compare current knowledge regarding the clinical application of enteral tube feeding,together with associated complications and special aspects.We conducted an extensive literature search on PubMed,Embase and Medline using index terms relating to enteral access,enteral feeding/nutrition,tube feeding,percutaneous endoscopic gastrostomy/jejunostomy,endoscopic nasoenteric tube,nasogastric tube,and refeeding syndrome.The literature showed common routes of enteral access to include nasoenteral tube,gastrostomy and jejunostomy,while complications fall into four major categories:mechanical,e.g.,tube blockage or removal;gastrointestinal,e.g.,diarrhea;infectious e.g.,aspiration pneumonia,tube site infection;and metabolic,e.g.,refeeding syndrome,hyperglycemia.Although the type and frequency of complications arising from tube feeding vary considerably according to the chosen access route,gastrointestinal complications are without doubt the most common.Complications associated with enteral tube feeding can be reduced by careful observance of guidelines,including those related to food composition,administration rate,portion size,food temperature and patient supervision. | Irina Blumenstein Yogesh M Shastri Jürgen Stein | 2014 | World Journal of Gastroenterology2014，20，26： | 63 |
| 2 | Surgical management of esophagogastric junction tumors显示文摘 | Burkhard HA von Rahden Hubert J Stein J Rüdiger Siewert | 2006 | World Journal of Gastroenterology2006，12，41： | 18 |
| 3 | 热处理豆粕饲喂生长猪的氨基酸消化率显示文摘为测定热处理对豆粕(SBM)表观回肠消化率和标准回肠消化率(SID)的影响,本试验将常规去壳豆粕(48.5%蛋白)分成4组,一份未经额外热处理,一份在125℃下高压蒸汽处理15 min,一份在125℃下高压蒸汽处理30 min,另一份在125℃下烘箱烘干30 min。制定四种豆粕-玉米淀粉型日粮配方,且每个配方只能使用上述四种豆粕中的一种,作为每种日粮中唯一氨基酸来源。用无氮日粮配方来估算基础内源性氨基酸损失。分别在初始体重为(25.3±2.0)kg的10头阉公猪回肠末端安装一个T-型瘘管。采用5×5拉丁方设计法,将试验猪分成5个日粮处理组,5个重复处理周期。每个处理周期持续7 d,在第6天和第7天收集回肠食糜。试验结果表明,随着高压蒸汽处理时间(0~30 min)的延长,蛋白质和所有氨基酸的表观回肠消化率和标准回肠消化率呈线性降低(P<0.01)。糠氨酸含量和豆粕样品的颜色表明高压蒸汽处理导致豆粕产生美拉德反应。然而,125℃烘箱干燥30min并未改变豆粕中蛋白和氨基酸标准回肠消化率,也没有改变SBM的糠氨酸含量(P>0.10),且烘箱处理的样品颜色表明该样品并未受到热处理破坏。总之,热蒸汽处理时间从0 min增至30 min,高压蒸汽处理豆粕的氨基酸消化率呈线性降低,降低原因很可能是由于125℃高压蒸汽处理导致豆粕产生美拉德反应。 | González-Vega J C Kim B G Htoo J K Lemme A Stein H H | 2015 | 中国饲料2015，，24： | 8 |
| 4 | Transepithelial transport of putrescine across monolayers of the human intestinal epithelial cell line, Caco-2显示文摘AIM To study the transepithelial transport characteristics of the polyamine putrescine in human intestinal Caco-2 cell monolayers to elucidate the mechanisms of the putrescine intestinal absorption.METHODS The transepithelial transport and the cellular accumulation of putrescine was measured using Caco 2 cell monolayers grown on permeable filters.RESULTS Transepithelial transport of putrescine in physiological concentrations (>0.5 mM)from the apical to basolateral side was linear. Intracellular accumulation of putrescine was higher in confluent than in fully differentiated Caco-2 cells, but still negligible (less than 0.5%) of the overall transport across the monolayers in apical-to-basolateral direction. EGF enhanced putrescine accumulation in Caco-2 cells by four-fold, as well as putrescine conversion to spermidine and spermine by enhancing the activity of Sadenosylmethionine decarboxylase. However,EGF did not have any significant influence on putrescine flux across the Caco-2 cell monolayers. Excretion of putrescine from Caco-2cells into the basolateral medium did not exceed 50 picomoles, while putrescine passive flux from the apical to the basolateral chamber,contributed hundreds of micromoles polyamines to the basolateral chamber.CONCLUSION Transepithelial transport of putrescine across Caco-2 cell monolayers occurs in passive diffusion, and is not influenced when epithelial cells are stimulated to proliferate by a potent mitogen such as EGF. | Vladan Milovic Lyudmila Turchanowa Jürgen Stein Wolfgang F.Caspary | 2001 | World Journal of Gastroenterology2001，7，2： | 5 |
| 5 | Anemia and iron deficiency in gastrointestinal and liver conditions显示文摘Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice. | Jürgen Stein Susan Connor Garth Virgin David Eng Hui Ong Lisandro Pereyra | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 6 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 7 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 8 | Inflatable composite habitat structures for lunar mars exploration 显示文摘 | CADOGAN D STEIN J GRAHNE M | 1999 | Acta Astronautica1999，44，： | 2 |
| 9 | 铜镍硫化物和海山富钴结壳的Re-Os标准物质研制显示文摘Re-Os同位素系统是研究金属矿床成矿年代和成矿物质来源最直接和有效的方法,该方法的研究及应用,不但可以解决一大批金属矿床的成矿年代问题,而且将对区域成矿理论、成矿规律以及成矿学本身的发展产生深远的影响。另一方面,富钴结壳的年代学是目前结壳地质基础理论研究中的难点和热点之一,由于Os同位素能够提供一些其他同位素如Pb、Nd、Sr所无法给出的重要信息,在示踪物源、古海洋环境、 | 屈文俊 杜安道 Yang G 李超 Stein H J Hannah J L | 2010 | 矿床地质2010，29，S1： | 2 |
| 10 | Robustness with observers 显示文摘 | Doyle J C Stein G | 1979 | IEEE Trans Automat Contr1979，24，8： | 2 |
| 11 | Early Esophageal Cancer: Pattern of Lymphatic Spread and Prognostic Factors for Long-Term Survival After Surgical Resection显示文摘 | Hubert J. Stein Marcus Feith Bjorn L. D. M. Bruecher Jorg Naehrig Mario Sarbia J Rudiger Siewert | 2005 | Annals of Surgery2005，，4： | 2 |
| 12 | Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening显示文摘TO THE EDITORWe read with great interest and a bit of surprise the article by Tonus et al[1]. We would share herein our comments about it. The specifi city of the fecal tumor M2 pyruvate kinase (M2-PK) reported by Tonus et al[1] for diagnosing colorectal cancer (CRC) is 93%. This is considerably higher than in any of the previously published studies. In our work[2], the maximum specificity of fecal M2- | Yogesh M Shastri Jürgen M Stein | 2007 | World Journal of Gastroenterology2007，13，19： | 2 |
| 13 | An ahemative transcript of the S-locus glycoprotein gene in a class Ⅱ pollen recessive self-incompatibility haplotype of Brassica oleracea encodes a membrane anchored protein显示文摘 | TANTIKANJANA T NASRALLAH M E STEIN J C | 1993 | Plant Cell1993，5，： | 1 |
| 14 | Information production and capital allocation: decentralized versus hierarchical firms显示文摘 | STEIN J C | 2002 | The Journal of Finance2002，57，5： | 1 |
| 15 | Avian adipose lipoprotein lipase: cDNA sequence and reciprocal regulation of mRNA levels in adipose and heart显示文摘 | Cooper D A Stein J C Strieleman P J | 1989 | Biochim Biophys Acta1989，1008，1： | 1 |
| 16 | Herd behavior and investment 显示文摘 | Scharfstein D S Stein J C | 1990 | American Economic Review1990，80，3： | 1 |
| 17 | Banks as liquidity pr oviders: An explanation for the co-existence of lending and deposit taking 显示文摘 | Kashy A K Rajan R Stein J C | 2002 | Journal of Finance2002，57，1： | 1 |
| 18 | MACC1 controls Met:what a difference an Sp1 site makes显示文摘 | Stein U Smith J Walther W | 2009 | Cell Cycle2009，8，15： | 1 |
| 19 | Constrained optimization of spatial sampling using continuous simulated annealing 显示文摘 | Van Groenigen J W Stein A | 1998 | Journal of Environmental Quality1998，27，5： | 1 |
| 20 | Not just another BI:faculty-librariancollaboration to guide students through the research process显示文摘 | STEIN L L LAMB J M | 1998 | Research Strategies1998，16，1： | 1 |
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