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| 1 | Neoadjuvant chemoradiotherapy followed by D2 gastrectomy in locally advanced gastric cancer显示文摘AIM:To investigate the efficacy of neoadjuvant chemoradiotherapy(NACRT) for resectability of locally advanced gastric cancer(LAGC).METHODS:Between November 2007 and January 2014,29 patients with LAGC(clinically T3 with distal esophagus invasion/T4 or bulky regional node metastasis) that were treated with NACRT followed by D2 gastrectomy were included in this study.Resectability was evaluated with radiologic and endoscopic exams before and after NACRT.Using threedimensional conformal radiotherapy,patients received 45 Gy,with a daily dose of 1.8 Gy.The entire tumor extent and the regional metastatic lymph nodes were included in the gross tumor volume.Patients presenting with a resectable tumor after NACRT received a total or subtotal gastrectomy with D2 dissection.The pathologic tumor response was evaluated using Japanese Gastric Cancer Association histologic evaluation criteria.Postoperative morbidity was evaluated using the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4.0.Overall survival(OS) and progression-free survival(PFS) rates were estimated using a Kaplan-Meier analysis and compared using the log-rank test.RESULTS:All patients were assessed as unresectable cases.Twenty-four patients(24/29; 82.8%) showed LAGC on positron emission tomography-computed tomography(CT) and contrast-enhanced CT,whereas four patients(4/29; 13.8%) with vague invasion orabutment to an adjacent organ underwent diagnostic laparoscopy.One patient(1/29; 3.4%),initially assessed as a resectable case,underwent an 'open and closure' after the tumor was found to be unresectable.Abutment to an adjacent organ(34.5%) was the most common reason for NACRT.The clinical response rate one month after NACRT was 44.8%.After NACRT,69%(20/29) of patients had a resectable tumor.Of the 20 patients with a resectable tumor,18 patients(62.1%) underwent a D2 gastrectomy.The R0 resection rate was 94.4% and two patients(2/18; 11.1%) showed a complete response.The median follow-up duration was 13.5 mo.The one-year OS and PFS rates were 72.4 and 48.9%,respectively.The one-year OS,PFS,local failure-free survival,and distant metastasis-free survival were higher in patients with a resectable tumor after NACRT(P < 0.001,P < 0.001,P < 0.001,and P =0.078,respectively).No grade 3-4 late treatment-related toxicities or postoperative mortalities were observed.CONCLUSION:NACRT with D2 gastrectomy showed a high rate of R0 resection and promising local control,which may increase the R0 resection opportunity resulting in survival benefit. | Mi Sun Kim Joon Seok Lim Woo Jin Hyung Yong Chan Lee Sun Young Rha Ki Chang Keum Woong Sub Koom | 2015 | World Journal of Gastroenterology2015，21，9： | 15 |
| 2 | Patterns of regional recurrence after curative D2 resection for stage III (N3) gastric cancer: Implications for postoperative radiotherapy显示文摘 | Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Chang Geol Lee Woong Sub Koom | 2012 | Radiotherapy and Oncology2012，，3： | 4 |
| 3 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 2 |
| 4 | Phase II study of the safety and efficacy of temsirolimus in east asian patients with advanced renal cell carcinoma 显示文摘 | YAN SUNI SUN RHA SE-HOON LEE | 2012 | Jpn J Clin Oncol2012，42，9： | 1 |
| 5 | Growth inhibitory effects of trastuzumab and chemotherapeutic drugs in gastric cancer cell lines显示文摘 | Soo Jung Gong Choon Jo Jin Sun Young Rha Hyun Cheol Chung | 2004 | Cancer Letters2004，，2： | 1 |
| 6 | Phase II study of thesafety and efficacy of temsirolimus in East Asian pa-tients with advanced renal cell carcinoma显示文摘 | Sun Y Rha S Lee SH | 2012 | Jpn J ClinOncol2012，42，9： | 1 |
| 7 | Defining the target volume for post-operative radiotherapy after D2 dissection in gastric cancer by CT-based vessel-guided delineation<!-- CT-based vessel-guided target volume delineation -->显示文摘 | Hong In Yoon Jee Suk Chang Joon Seok Lim Sung Hoon Noh Woo Jin Hyung Ji Yeong An Yong Chan Lee Sun Young Rha Kyung Hwan Kim Woong Sub Koom | 2013 | Radiotherapy and Oncology2013，，： | 1 |
| 8 | Cranofacial osteosarcoma: Single institutional experience in K orea显示文摘 | Seungtaek Lim Soohyeon Lee Sun Young Rha Jae Kyung Rho | 2016 | Asia‐Pac J Clin Oncol2016，，： | 1 |
| 9 | Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced solid tumors显示文摘 | Han Sang Kim Sang Joon Shin Sang Cheol Kim Surim An Sun Young Rha Joong Bae Ahn Byoung Chul Cho Hye Jin Choi Joo Hyuk Sohn Hyo Song Kim Hyun Cheol Chung Joo Hang Kim Jae Kyung Roh Soohyeon Lee | 2013 | Supportive Care in Cancer2013，，6： | 1 |
| 10 | The and general anesthe system and bioavaila in patients surgery 显示文摘 | Shin S Sun J bined epidural nomic oxide nervous B Rha K H | 2013 | Surgical effects of the of n com- auto- itric undergoing laparoscopic pelvic Endoscopy2013，27，3： | 1 |
| 11 | A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation显示文摘 | Nam Kyu Kim Seung Hyuk Baik Byung Soh Min Hong Ryull Pyo Yun Jung Choi Hogeun Kim Jinsil Seong Ki Chang Keum Sun Young Rha Hyun Cheol Chung | 2007 | International Journal of Radiation Oncology Biology Physics2007，，1： | 1 |
| 12 | Gastrointestinal Stromal Tumor of the Rectum: An Analysis of Seven Cases显示文摘 | Seung Hyuk Baik Nam Kyu Kim Chung Ho Lee Kang Young Lee Seung Kook Sohn Chang Hwan Cho Hoguen Kim Hong Ryull Pyo Sun Young Rha Hyun Cheol Chung | 2007 | Surgery Today2007，，6： | 1 |
| 13 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 14 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 1 |
| 15 | A pilot study of S-1 plus cisplatin versus 5-fluorouracil plus cisplatin for postoperative chemotherapy in histological stage IIIB-IV (M0) gastric cancer显示文摘 | Sung Sook Lee Hei-Cheul Jeung Hyun Cheol Chung Sung Hoon Noh Woo Jin Hyung Ji Yeong Ahn Sun Young Rha | 2012 | Investigational New Drugs2012，，1： | 1 |
| 16 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 17 | Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer显示文摘 | Keun Seok Lee Hyun Cheol Chung Seock Ah Im Yeon Hee Park Chul Soo Kim Sung-Bae Kim Sun Young Rha Min Young Lee Jungsil Ro | 2008 | Breast Cancer Research and Treatment2008，，2： | 1 |
| 18 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 19 | Gd-EOB-DTPA-Enhanced MRI is Better than MDCT in Decision Making of Curative Treatment for Hepatocellular Carcinoma显示文摘 | Sun Hong Yoo Jong Young Choi Jeong Won Jang Si Hyun Bae Seung Kew Yoon Dong Goo Kim Young Kyoung Yoo Sung Eun Rha Young Joon Lee Eun Sun Jung | 2013 | Annals of Surgical Oncology2013，，9： | 1 |
| 20 | Phase II study of the safety and efficacy of temsirolimus in east asian patients with advanced renal cell carcino- ma显示文摘 | Sun Y Rha S Lee SH | 2012 | Jpn J Clin 0ne012012，42，9： | 1 |
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