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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | Autonomic and sensory nerve dysfunction in primary biliary cirrhosis显示文摘AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using sensitive methods in patients with primary biliary cirrhosis (PBC). METHODS: Twenty-four AMA M2 positive female patients with clinical, biochemical and histological evidence of PBC and 20 age matched healthy female subjects were studied. Five standard cardiovascular reflex tests and 24-h heart rate variability (HRV) analysis were performed to define autonomic function. Peripheral sensory nerve function on median and peroneal nerves was characterized by current perception threshold (CPT), measured by a neuroselective diagnostic stimulator (Neurotron, Baltimore, MD). RESULTS: Fourteen of 24 patients (58%) had at least one abnormal cardiovascular reflex test and thirteen (54%) had peripheral sensory neuropathy. Lower heart rate response to deep breathing (P=0.001), standing (P=0.03) and Valsalva manoeuvre (P=0.01), and more profound decrease of blood pressure after standing (P=0.03) was found in PBC patients than in controls. As a novel finding we proved that both time domain and frequency domain parameters of 24-h HRV were significantly reduced in PBC patients compared to controls. Each patient had at least one abnormal parameter of HRV. Lower CPT values indicated hyperaesthesia as a characteristic feature at peroneal nerve testing at three frequencies (2000 Hz: P=0.005; 250 Hz: P=0.002; 5 Hz: P=0.004) in PBC compared to controls. Correlation of autonomic dysfunction with the severity and duration of the disease was observed. Lower total power of HRV correlated with lower CPT values at median nerve testing at 250 Hz (P = 0.0001) and at 5 Hz (P=0.002), as well as with those at peroneal nerve testing at 2000 Hz (P=0.01). CONCLUSION: Autonomic and sensory nerve dysfunctions are frequent in PBC. Twenty-four-hour HRV analysis is more sensitive than standard cardiovascular tests for detecting of both parasympathetic and sympathetic impairments. Our novel data suggest that hyperaesthesia is a characteristic feature of peripheral sensory neuropathy and might contribute to itching in PBC. Autonomic dysfunction is related to the duration and severity of PBC. | Katalin Keresztes lldikó Istenes Aniko Folhoffer Peter L Lakatos Andrea Horvath Timea Csak Peter Varga Peter Kempler Ferenc Szalay | 2004 | World Journal of Gastroenterology2004，10，20： | 2 |
| 4 | Exogenous 4-hydroxybenzoic acid and salicylic acid modulate the effect of short-term drought and freezing stress on wheat plants 显示文摘 | Horváth E Pál M Szalai G Páldi E Janda T | 2007 | Biologia Plantarum2007，51，3： | 1 |
| 5 | Pathophysiology of ischemia - reperfusion injury 显示文摘 | Kaszaki J Wolfard A Szalay L | 2006 | Transplant Proc2006，38，3： | 1 |
| 6 | Circulating S100B Is Increased after Bilateral Femur Fracture without Brain Injury in the Rat显示文摘 | PELINKA LE SZALAY L JAFARMADAR M | 2003 | Br J Anaesthesia(S0007-0912)2003，91，4： | 1 |
| 7 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 8 | C3α expressed in the central nervous system protects against LPS-induced shock 显示文摘 | Boos L Szalai AJ Barnum SR | 2005 | Neurosci Lett2005，387，2： | 1 |
| 9 | On the diophantine equation(2^n- 1)(3^n-1) =x^2显示文摘 | Szalay L | 2000 | Publ Math Debreeen2000，57，1： | 1 |
| 10 | On the diophantine equations (2^n - 1 ) (6^n - 1 ) = x^2 and ( α^n - 1 ) (α^kn - 1 ) = x^2 显示文摘 | HAJDU L SZALAY L | 2000 | Period Math Hungar2000，40，： | 1 |
| 11 | On the diophantine equation (2^n-1)(6^n-1) = x^2 and (a^n-1)(b^kn-1) = x^2显示文摘 | HAJDU L SZALAY L | 2000 | Per Math Hungarica2000，40，20： | 1 |
| 12 | On the diophantine equation (2^n-1)(3^n -1) = x^2显示文摘 | SZALAY L | 2000 | Publ Math Debrecen2000，57，： | 1 |
| 13 | On the diophantine equations (2^n - 1 )(3^n - 1 ) = x^2 显示文摘 | SZALAY L | 2000 | Publ Math Debrecen2000，57，： | 1 |
| 14 | Intraoperative and postoperative corneal thickness change after collagen crosslinking therapy显示文摘 | Hassan Z Modis L Jr Szalai E | 2014 | Eur J Ophthalmol2014，24，2： | 1 |
| 15 | Imaging of light emission from the expression of luciferases in living cells and organisms:a review显示文摘 | Greer L F Szalay A A | 2002 | Luminescence2002，17，1： | 1 |
| 16 | A role of PPARgamma in and rostenediol-mediated salutary effects on cardiac function fol- lowing trauma-hemorrhage显示文摘 | Shimizu T Szalay L Hsieh YC | 2006 | Ann Surg2006，244，1： | 1 |
| 17 | Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis 显示文摘 | Suzuki T Shimizu T Szalay L | 2006 | Cytokine2006，34，12： | 1 |
| 18 | Imaging of light emission from the expression of luciferases in living cells and organisms : a review 显示文摘 | Greer L F 3rd Szalay A A | 2002 | Luminescence2002，17，43： | 1 |
| 19 | Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein e*3-leiden transgenic mice显示文摘 | Verschuren L Kleemann R Offerman EH Szalai AJ Emeis SJ Princen HM | 2005 | Arterioscler Thromb2005，25，： | 1 |
| 20 | Hemorrhagic shock induces an S 100 B increase associated with shock severity显示文摘 | PELINKA LE BAHRAMI S SZALAY L | 2003 | Shock2003，19，5： | 1 |
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