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| 1 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 2 | Taking out the garbage:cathepsin D and calcineurin in neurodegeneration显示文摘Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to maintain cellular health over decades. Thus, a functional decline of processes contributing to protein degradation such as autophagy and general lysosomal proteolytic capacity is connected to several age-associated neurodegenerative disorders, including Parkinson's, Alzheimer's and Huntington's diseases. These so called proteinopathies are characterized by the accumulation and misfolding of distinct proteins, subsequently driving cellular demise. We recently linked efficient lysosomal protein breakdown via the protease cathepsin D to the Ca^(2+)/calmodulin-dependent phosphatase calcineurin. In a yeast model for Parkinson's disease, functional calcineurin was required for proper trafficking of cathepsin D to the lysosome and for recycling of its endosomal sorting receptor to allow further rounds of shuttling. Here, we discuss these findings in relation to present knowledge about the involvement of cathepsin D in proteinopathies in general and a possible connection between this protease, calcineurin signalling and endosomal sorting in particular. As dysregulation of Ca^(2+) homeostasis as well as lysosomal impairment is connected to a plethora of neurodegenerative disorders, this novel interplay might very well impact pathologies beyond Parkinson's disease. | Andreas Aufschnaiter Verena Kohler Sabrina Büttner | 2017 | Neural Regeneration Research2017，12，11： | 3 |
| 3 | Freeze drying of pharmaceutical excipients close to collapse temperature:Influence of the process conditions on process time and product quality显示文摘 | ANTONELLO A B SABRINA G DAVIDE F | 2009 | Drying Technology2009，27，： | 1 |
| 4 | Impairment of CD8^+ T suppressor cell function in patients with active systemic lupus erythematosus显示文摘 | Gilberto F Sabrina B | 2001 | J Immunol2001，166，： | 1 |
| 5 | Synthesis,redox behaviourand X-Ray structure of bis-TTF containing a pyridineunit as a potential building block in the construction ofconducting magnetic materials显示文摘 | Sabrina B Katel H Stéphane G | 2003 | New J Chem2003，27，： | 1 |
| 6 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 7 | Association of V617F Jak2 mutation with the risk of thrombosis among patients with essential thrombocythaemia or idiopathic myelofibrosis: A systematic review显示文摘 | Federico Lussana Sabrina Caberlon Chiara Pagani Pieter W. Kamphuisen Harry R. Büller Marco Cattaneo | 2009 | Thrombosis Research2009，，4： | 1 |
| 8 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 9 | 显示文摘 | Franck D Gregorio C Sabrina B | 2005 | Carbohydrate Poly- mers2005，60，1： | 1 |
| 10 | Barrett's esophagus:an update显示文摘 | Massimo C Gabriella L Sabrina B | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 11 | Modeling the structure and variability of the southern Benguela upwelling using QuickSCAT wind forcing 显示文摘 | BRUNO B SABRINA S ABDERRAHIM B | 2005 | Journal of Geophysical Research2005，110，： | 1 |
| 12 | En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain 显示文摘 | Sabrina FK Susanne B Kamar H | 2010 | Dev Biol2010，340，2： | 1 |
| 13 | Human hepa- tocyte morphology and functions in a multibore fiber bioreactor显示文摘 | Loredana D B Sabrina M Maria R | 2007 | Macromol Biosci2007，7，： | 1 |
| 14 | Rapid and sensitive solid phase extraction-large volume injection-gas chromatography for the analysis of mineral oil saturated and aromatic hydrocarbons in cardboard and dried foods显示文摘 | SABRINA M LAURA B GIORGIA P | 2012 | Journal of Chromatography A2012，1243，12： | 1 |
| 15 | Electrochemical characterisation of a martensitic stainless steel in a neutral chloride solution显示文摘 | Sabrina Marcelin Nadine Pébère Sophie Régnier | 2013 | Electrochimica Acta2013，，： | 1 |
| 16 | Membrane-parti- cle interactions in an asymmetric flow field flow fractionation channel studied with titanium dioxide nanopartieles 显示文摘 | NINA B SABRINA L CHRISTIAN A | 2014 | J Chro- matogrA2014，1334，： | 1 |
| 17 | The K121Q polymorphism of the ENPP1/PC - 1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction 显示文摘 | Simonetta B Ornella L Sabrina P | 2005 | Diabetes2005，54，10： | 1 |
| 18 | Post-transcriptional gene silencing and virus resistance in Nicotiana benthamiana expressing a Grapevine virus A minireplicon显示文摘 | Marina B Svetlana S Sabrina H | 2009 | Transgenic Res2009，18，： | 1 |
| 19 | Poly(ethylene terephthalate)(PET)degradation during the Zn catalyzed transesterification with dibutyl maleate functionalized polyolefins显示文摘 | MARIA-BEATRICE C SABRINA B MAURO A | 2007 | Polymer2007，48，5： | 1 |
| 20 | Argonaute2, a link between genetic and biochmical analyses of RNAi显示文摘 | Scott MH Sabrina B Amy AC | 2001 | Science2001，293，： | 1 |
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