|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A misdiagnosed case of caesarean scar pregnancy显示文摘 | Jens Einenkel Patrick Stumpp Sabrina K?sling Lars-Christian Horn Michael H?ckel | 2005 | Archives of Gynecology and Obstetrics2005，，2： | 2 |
| 2 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 3 | Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes显示文摘BACKGROUND Cigarette smoking(CS)is the most common method of consuming tobacco.Deleterious effects on bone integrity,increased incidence of fractures,and delayed fracture healing are all associated with CS.Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and,via the bloodstream,reach the skeletal system.New technologies designed to develop a reduced-risk alternative for smokers are based on electronic nicotine delivery systems,such as e-cigarettes and tobacco heating systems(THS).THS are designed to heat tobacco instead of burning it,thereby reducing the levels of harmful toxic compounds released.AIM To examine the effects of THS on osteoprogenitor cell viability and function compared to conventional CS.METHODS Human immortalized mesenchymal stem cells(n=3)and primary human preosteoblasts isolated from cancellous bone samples from BG Unfall Klinik Tübingen(n=5)were osteogenically differentiated in vitro with aqueous extracts generated from either the THS 2.4“IQOS”or conventional“Marlboro”cigarettes for up to 21 d.Cell viability was analyzed using resazurin conversion assay(mitochondrial activity)and calcein-AM staining(esterase activity).Osteogenic differentiation and bone cell function were evaluated using alkaline phosphatase(AP)activity,while matrix formation was analyzed through alizarin red staining.Primary cilia structure was examined by acetylatedα-tubulin immunofluorescent staining.Free radical production was evaluated with 2’,7’-dichlorofluoresceindiacetate assay.RESULTS Our data clearly show that THS is significantly less toxic to bone cells than CS when analyzed by mitochondrial and esterase activity(P<0.001).No significant differences in cytotoxicity between the diverse flavors of THS were observed.Harmful effects from THS on bone cell function were observed only at very high,non-physiological concentrations.In contrast,extracts from conventional cigarettes significantly reduced the AP activity(by two-fold)and matrix mineralization(four-fold)at low concentrations.Additionally,morphologic analysis of primary cilia revealed no significant changes in the length of the organelle involved in osteogenesis of osteoprogenitor cells,nor in the number of ciliated cells following THS treatment.Assessment of free radical production demonstrated that THS induced significantly less oxidative stress than conventional CS in osteoprogenitor cells.CONCLUSIONTHS was significantly less harmful to osteoprogenitor cells during osteogenesisthan conventional CS. Additional studies are required to confirm whether THS isa better alternative for smokers to improve delays in bone healing followingfracture. | Romina H Aspera-Werz Sabrina Ehnert Monja Müller Sheng Zhu Tao Chen Weidong Weng Johann Jacoby Andreas K Nussler | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 4 | Synthesis,redox behaviourand X-Ray structure of bis-TTF containing a pyridineunit as a potential building block in the construction ofconducting magnetic materials显示文摘 | Sabrina B Katel H Stéphane G | 2003 | New J Chem2003，27，： | 1 |
| 5 | In vitro generation of anti-hepatitis B monoclonal antibodies from a single plasma cell using single-cell RTPCR and cell-free protein synthesis 显示文摘 | SABRINA Y ALI M NAKANO H | 2010 | J Biosci Bioeng2010，109，： | 1 |
| 6 | En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain 显示文摘 | Sabrina FK Susanne B Kamar H | 2010 | Dev Biol2010，340，2： | 1 |
| 7 | Influence of borate complexation on the electrophoretic behavior of carbohydrates in capillary eleetrophoresis显示文摘 | Sabrina Hoffstetter-Kuhn Aran Paulus Ernst Gassmann H Michael Widmer | 1991 | Analytical chemistry1991，63，15： | 1 |
| 8 | Anti-tumor effects of fibroblast growth factor-binding protein(FGF-BP)knockdown in colon carcinoma显示文摘 | Daniel Schulze Philipp Plohmann Sabrina H?bel | 2011 | Mol Cancer2011，10，： | 1 |
| 9 | Post-transcriptional gene silencing and virus resistance in Nicotiana benthamiana expressing a Grapevine virus A minireplicon显示文摘 | Marina B Svetlana S Sabrina H | 2009 | Transgenic Res2009，18，： | 1 |
| 10 | Value of diffusion-weighted MR imaging in the differentiation between benign and malignant cervical lymph nodes 显示文摘 | Konstantin H Sabrina DF Matthias E | 2009 | European Journal of Radiology2009，72，3： | 1 |
| 11 | En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain 显示文摘 | Sabrina F K Susanne B Kamar H | 2010 | Developmental Biol2010，340，2： | 1 |
| 12 | Detection of trace levels of atrazine using surface-enhanced Raman scattering and information visualization显示文摘 | Rafael J G Sabrina A C Pedro H B | 2014 | Colloid and Polymer Science2014，292，： | 1 |
| 13 | Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector显示文摘 | TAMAS L H SABRINA D COLIN B | 2003 | Biochem Phar2003，65，： | 1 |
| 14 | Novel R- ( + )-limonene-based thiosemicarbazones and their an- titumor activity against human tumor cell lines 显示文摘 | Vandresen F Falzirelli H Sabrina A | 2014 | Eur J Med Chem2014，79，： | 1 |
| 15 | The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy显示文摘 | Sabrina P Marta Letizia H Elisabetta F | 2005 | Diabetes2005，54，9： | 1 |
| 16 | Monitoring of tumour progression using bioluminescence imaging and computed tomography scanning in a nude mouse orthotopic model of human small cell lung cancer显示文摘 | Sophie Iochmann Stéphanie Lerondel Claire Bléchet Marion Lavergne Sabrina Pesnel Julien Sobilo Nathalie Heuzé-Vourc’h Alain Le Pape Pascale Reverdiau | 2012 | Lung Cancer2012，，1： | 1 |
| 17 | Age-dependent impairment of endothelial progenitor cells is corrected by growth hormone mediated increase of insulin-like growth factor-1 显示文摘 | Thomas T Sarah H Sabrina F | 2007 | Circ Res2007，100，3： | 1 |
| 18 | Photolysis of fluometuron in the presence of natural water constituents显示文摘 | Sabrina H Amina A K Alexandrater H | 2007 | Chemosphere2007，，69： | 1 |
| 19 | Current activities of the Yersinia effector protein YopM显示文摘 | Sabrina H?fling Benjamin Grabowski Stefanie Norkowski M. Alexander Schmidt Christian Rüter | 2015 | International Journal of Medical Microbiology2015，，： | 1 |
| 20 | APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis显示文摘 | Sabrina Schilling Anita L. DeStefano Perminder S. Sachdev Seung Hoan Choi Karen A. Mather Charles D. DeCarli Wei Wen Peter H?gh Naftali Raz Rhoda Au Alexa Beiser Philip A. Wolf José Rafael Romero Yi-Cheng Zhu Kathryn L. Lunetta Lindsay Farrer Carole Dufou | 2013 | Neurology2013，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员