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| 1 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 2 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 4 |
| 3 | Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘 | Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，3： | 3 |
| 4 | Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening显示文摘 | Susumu Aikou Yasukazu Ohmoto Toshiaki Gunji Nobuyuki Matsuhashi Hiroshi Ohtsu Hirona Miura Kensuke Kubota Yukinori Yamagata Yasuyuki Seto Atsushi Nakajima James R. Goldenring Michio Kaminishi Sachiyo Nomura | 2011 | Gastroenterology2011，，3： | 2 |
| 5 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 2 |
| 6 | Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H显示文摘 | Fumitaka Suzuki Norio Akuta Yoshiyuki Suzuki Hiromi Yatsuji Hitomi Sezaki Yasuji Arase Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Hiromitsu Kumada | 2007 | Journal of Clinical Virology2007，，2： | 2 |
| 7 | Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b显示文摘 | Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yuya Seko Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saito Yasuji Arase Kenji Ikeda Mariko Kobayashi Rie Mineta Sachiyo Watahiki Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Clinical Virology2012，，4： | 2 |
| 8 | A two-stage operation for thoracic esophageal cancer: esophagectomy and subsequent reconstruction by a free jejunal flap显示文摘 | Yasuhiro Okumura Kazuhiko Mori Yukinori Yamagata Takashi Fukuda Ikuo Wada Nobuyuki Shimizu Sachiyo Nomura Takuya Iida Makoto Mihara Yasuyuki Seto | 2014 | Surgery Today2014，，2： | 1 |
| 9 | Transient learning impairment of adult rats fed zinc deficient diet显示文摘 | Atsushi T Sachiyo TS | 2000 | Brain Res2000，859，2： | 1 |
| 10 | Current status of insec- ticide resistance in the small brown planthopper,laodelphax striat- ellus in Japan, Taiwan and Vietnam 显示文摘 | SACHIYO S M SH1NJI S REIKO O | 2011 | Appl Entomol Zoo12011，46，1： | 1 |
| 11 | Studies on the sesquiterpenes from Ambrosia elatior Linn6 显示文摘 | Taichi O Keiji I Sachiyo N | 1987 | Chem Pharm Bull1987，35，6： | 1 |
| 12 | Identification of distinctive volatile compounds in fish sauce 显示文摘 | Fukami K Sachiyo I Hitoshi Y | 2002 | J Agric Food Chem2002，50，19： | 1 |
| 13 | Home care nursing in Japan,a challenge for providing good care at home 显示文摘 | Sachiyo M Satoko N Joan KM | 2002 | Public Health nurse2002，19，2： | 1 |
| 14 | Identification of distinctive volatile compounds in fish sauce 显示文摘 | Katsuya F Sachiyo I Hitoshi Y | 2002 | J Agr Food Chem2002，50，19： | 1 |
| 15 | Exploring the ideal combination of activity satisfaction and burden among health promotion volunteers : a cross - section- al study in Japan显示文摘 | Hiroshi Murayama Atsuko Taguchi Sachiyo Murashima | 2013 | BMC Public Health2013，，3： | 1 |
| 16 | Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia显示文摘 | Christian W Tohru F Sachiyo T | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 17 | Analysis of short tandem (STR)polymorphisms by the powerplex 16 system and capillary electrophoresis : application to forensic practise 显示文摘 | OSAMU Oka-moto YUJI Yama-moto SACHIYO Lnagaki | 2003 | Acta Medical Okayama2003，57，2： | 1 |
| 18 | The Effectiveness of the Around the-Clock In-Home Care System:Did It Prevent the Institutionalization of Frail Elderly显示文摘 | Sachiyo Murashima Kiyomi Asahara | | 0，，01： | 1 |
| 19 | Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: Two-year follow-up显示文摘 | Hiromi Yatsuji Fumitaka Suzuki Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Satoshi Saitoh Yasuji Arase Kenji Ikeda Sachiyo Watahiki Satomi Iwasaki Mariko Kobayashi Hiromitsu Kumada | 2008 | Journal of Hepatology2008，，6： | 1 |
| 20 | Pleiotrophin promotes functional recovery after neural transplantation in rats显示文摘 | Hideki Hida Tadashi Masuda Toyohiro Sato Tae-Sun Kim Sachiyo Misumi Hitoo Nishino | 2007 | NeuroReport2007，，2： | 1 |
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