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| 1 | Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation显示文摘AIM:To compare the outcomes between doubleguidewire technique(DGT) and transpancreatic precut sphincterotomy(TPS) in patients with difficult biliary cannulation.METHODS:This was a prospective,randomized study conducted in single tertiary referral hospital in Korea.Between January 2005 and September 2010.A total of 71 patients,who bile duct cannulation was not possible and selective pancreatic duct cannulation was achieved,were randomized into DGT(n = 34) and TPS(n = 37) groups.DGT or TPS was done for selective biliary cannulation.We measured the technical success rates of biliary cannulation,median cannulation time,and procedure related complications.RESULTS:The distribution of patients after randomization was balanced,and both groups were comparable in baseline characteristics,except the higher percentage of endoscopic nasobiliary drainage in the DGT group(55.9% vs 13.5%,P < 0.001).Successful cannulation rate and mean cannulation times in DGT and TPS groups were 91.2% vs 91.9% and 14.1 ± 13.2 min vs 15.4 ± 17.9 min,P = 0.732,respectively.There was no significant difference between the two groups.The overall incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis was 38.2% vs 10.8%,P < 0.011 in the DGT group and the TPS group;post-procedure pancreatitis was significantly higher in the DGT group.But the overall incidence of post-ERCP hyperamylasemia was no significant difference between the two groups;DGT group vs TPS group:14.7% vs 16.2%,P < 1.0.CONCLUSION:When free bile duct cannulation was difficult and selective pancreatic duct cannulation was achieved,DGT and TPS facilitated biliary cannulation and showed similar success rates.However,post-procedure pancreatitis was significantly higher in the DGT group. | Young Wook Yoo Sang-Woo Cha Woong Cheul Lee Sae Hee Kim Anna Kim Young Deok Cho | 2013 | World Journal of Gastroenterology2013，19，1： | 25 |
| 2 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 3 | Colonoscopy-induced ischemic colitis in patients without risk factors显示文摘Ischemic colitis is the most common form of intestinal ischemia.It is a condition that is commonly seen in the elderly and among individuals with risk factors for ischemia.Common predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic disorders.Ischemic colitis following colonoscopy is rare.Here,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia. | Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han Dong-Wook Kang | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 4 | Saeng-Kankunbi-Tang(生肝健脾汤) Protects Liver against Oxidative Damage through Activation of ERK/Nrf2 Pathway显示文摘Objective: To investigate the cytoprotective effects of Saeng-kankunbi-tang(生肝健脾汤, SKT), a herbal prescription consisting of Artemisia capillaris and Alisma canaliculatum, and its underlying mechanism involved. Methods: In mice, blood biochemistry and histopathology were assessed in carbon tetrachloride(CCl4)-induced oxidative hepatic injury in vivo. The animal groups included vehicle-treated control, CCl4, SKT 500 mg/(kg·day) CCl4+SKT 200 or 500 mg/(kg·day). In Hep G2 cell, tert-butyl hydroperoxide(t BHP) induced severe oxidative stress and mitochondrial dysfunction in vitro. The cyto-protective effects of SKT were determined by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide(MTT) assay, fluorescence activated cell sorting analysis and western blotting. Results: The administration of SKT prevented liver damage induced by CCl4 in mice, by inhibition of hepatocyte degeneration and inflammatory cell infiltration as well as plasma parameters such as alanine aminotransferase(P<0.01). Moreover, treatment with t BHP induced hepatocyte death and cellular reactive oxygen species production in hepatocyte cell line. However, SKT pretreatment(30–300 μg/m L) reduced this cell death and oxidative stress(P<0.01). More importantly, SKT inhibited the ability of t BHP to induce changes in mitochondrial membrane transition in cell stained with rhodamine 123(P<0.01). Furthermore, treatment with SKT induced extracellular signal-regulated kinases-mediated nuclear factor erythroid-2-related factor 2(Nrf2) activation as well as the expressions of heme oxygenase 1 and glutamate-cystein ligase catalytic, Nrf2 target genes. Conclusion: SKT has the ability to protect hepatocyte against oxidative stress and mitochondrial damage mediated by Nrf2 activation. | In Woo Lee Hee Yoon Choi Ju-Hee Lee Sun-Dong Park Seung Mo Kim Sae Kwang Ku 赵容杰 Sang Chan Kim Young Woo Kim Hong Sik Choi | 2016 | Chinese Journal of Integrative Medicine2016，22，8： | 3 |
| 5 | Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)显示文摘 | Tae Nyun Kim Man Sik Park Kang Il Lim Sae Jeong Yang Hye Jin Yoo Hyun Joo Kang Wook Song Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 6 | Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound显示文摘Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected. | Sang-Woo Cha Sae Hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna Kim Min Koo Lee Hyun Young Han Dong Wook Kang | 2010 | World Journal of Gastroenterology2010，16，8： | 2 |
| 7 | Akt1 phosphorylates Nicastrin to regulate its protein stability and activity显示文摘 | Eun‐Hye Jo Ji‐Seon Ahn Jung‐Soon Mo Ji‐Hye Yoon Eun‐Jung Ann Hyeong‐Jin Baek Hye‐Jin Lee Seol‐Hee Kim Mi‐Yeon Kim Hee‐Sae Park | 2015 | J. Neurochem2015，，： | 1 |
| 8 | The hepatitis B viral X protein activates NF-κB signaling pathway through the up-regulation of TBK1显示文摘 | Hye Rim Kim Sae Hee Lee Guhung Jung | 2009 | FEBS Letters2009，，3： | 1 |
| 9 | Association of Adiponectin, Resistin, and Vascular Inflammation: Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘 | Hae Yoon Choi Sungeun Kim Sae Jeong Yang Hye Jin Yoo Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，4： | 1 |
| 10 | Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘 | Hye Jin Yoo Sungeun Kim Man Sik Park Hae Yoon Choi Sae Jeong Yang Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Clinical Endocrinology and Metabolism2011，，3： | 1 |
| 11 | The Clinical Value of Dual–Time Point 18F-FDG PET/CT for Differentiating Extrahepatic Cholangiocarcinoma From Benign Disease显示文摘 | Eun Kyoung Choi Ie Ryung Yoo Sung Hoon Kim Joo Hyun O Woo Hee Choi Sae Jung Na Sonya Youngju Park | 2013 | Clinical Nuclear Medicine2013，，3： | 1 |
| 12 | Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B显示文摘AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/d.The biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were assessed.RESULTS:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were enrolled.In clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated patients.The cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or rtL180M.There was no virologic breakthrough in the entecavir group.CONCLUSION:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough. | Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie Lee Hyeon Yoong Yang An Na Kim Hee Bok Chae Sae Hwan Lee Hong Soo Kim Tae Hee Lee Young Woo Kang Eaum Seok Lee Seok Hyun Kim Byung Seok Lee Heon Young Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 1 |
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