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| 1 | Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation显示文摘AIM:To compare the outcomes between doubleguidewire technique(DGT) and transpancreatic precut sphincterotomy(TPS) in patients with difficult biliary cannulation.METHODS:This was a prospective,randomized study conducted in single tertiary referral hospital in Korea.Between January 2005 and September 2010.A total of 71 patients,who bile duct cannulation was not possible and selective pancreatic duct cannulation was achieved,were randomized into DGT(n = 34) and TPS(n = 37) groups.DGT or TPS was done for selective biliary cannulation.We measured the technical success rates of biliary cannulation,median cannulation time,and procedure related complications.RESULTS:The distribution of patients after randomization was balanced,and both groups were comparable in baseline characteristics,except the higher percentage of endoscopic nasobiliary drainage in the DGT group(55.9% vs 13.5%,P < 0.001).Successful cannulation rate and mean cannulation times in DGT and TPS groups were 91.2% vs 91.9% and 14.1 ± 13.2 min vs 15.4 ± 17.9 min,P = 0.732,respectively.There was no significant difference between the two groups.The overall incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis was 38.2% vs 10.8%,P < 0.011 in the DGT group and the TPS group;post-procedure pancreatitis was significantly higher in the DGT group.But the overall incidence of post-ERCP hyperamylasemia was no significant difference between the two groups;DGT group vs TPS group:14.7% vs 16.2%,P < 1.0.CONCLUSION:When free bile duct cannulation was difficult and selective pancreatic duct cannulation was achieved,DGT and TPS facilitated biliary cannulation and showed similar success rates.However,post-procedure pancreatitis was significantly higher in the DGT group. | Young Wook Yoo Sang-Woo Cha Woong Cheul Lee Sae Hee Kim Anna Kim Young Deok Cho | 2013 | World Journal of Gastroenterology2013，19，1： | 25 |
| 2 | Distinction of white,beige and brown adipocytes derived from mesenchymal stem cells显示文摘Adipose tissue is a major metabolic organ, and it has been traditionally classified as either white adipose tissue(WAT) or brown adipose tissue(BAT). WAT and BAT are characterized by different anatomical locations, morphological structures, functions, and regulations. WAT and BAT are both involved in energy balance. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides, whereas BAT specializes in dissipating energy as heat during cold- or diet-induced thermogenesis. Recently, brownlike adipocytes were discovered in WAT. These brownlike adipocytes that appear in WAT are called beige or brite adipocytes. Interestingly, these beige/brite cells resemble white fat cells in the basal state, but they respond to thermogenic stimuli with increased levels of thermogenic genes and increased respiration rates. In addition, beige/brite cells have a gene expressionpattern distinct from that of either white or brown fat cells. The current epidemic of obesity has increased the interest in studying adipocyte formation(adipogenesis), especially in beige/brite cells. This review summarizes the developmental process of adipose tissues that originate from the mesenchymal stem cells and the features of these three different types of adipocytes. | Anna Park Won Kon Kim Kwang-Hee Bae | 2014 | World Journal of Stem Cells2014，6，1： | 15 |
| 3 | Colonoscopy-induced ischemic colitis in patients without risk factors显示文摘Ischemic colitis is the most common form of intestinal ischemia.It is a condition that is commonly seen in the elderly and among individuals with risk factors for ischemia.Common predisposing conditions for ischemic colitis are major vascular occlusion,small vessel disorder,shock,some medications,colonic obstructions and hematologic disorders.Ischemic colitis following colonoscopy is rare.Here,we report two cases of ischemic colitis after a routine screening colonoscopy in patients without risk factors for ischemia. | Sang Ok Lee Sae Hee Kim Sung Hee Jung Chan Woong Park Min Ji Lee Jin A Lee Hyun Cheol Koo Anna Kim Hyun-Young Han Dong-Wook Kang | 2014 | World Journal of Gastroenterology2014，20，13： | 9 |
| 4 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 5 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 6 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 7 | Reliable and explainable machine-learning methods for accelerated material discovery显示文摘Despite ML’s impressive performance in commercial applications,several unique challenges exist when applying ML in materials science applications.In such a context,the contributions of this work are twofold.First,we identify common pitfalls of existing ML techniques when learning from underrepresented/imbalanced material data.Specifically,we show that with imbalanced data,standard methods for assessing quality of ML models break down and lead to misleading conclusions.Furthermore,we find that the model’s own confidence score cannot be trusted and model introspection methods(using simpler models)do not help as they result in loss of predictive performance(reliability-explainability trade-off).Second,to overcome these challenges,we propose a general-purpose explainable and reliable machine-learning framework.Specifically,we propose a generic pipeline that employs an ensemble of simpler models to reliably predict material properties.We also propose a transfer learning technique and show that the performance loss due to models’simplicity can be overcome by exploiting correlations among different material properties.A new evaluation metric and a trust score to better quantify the confidence in the predictions are also proposed.To improve the interpretability,we add a rationale generator component to our framework which provides both model-level and decision-level explanations.Finally,we demonstrate the versatility of our technique on two applications:(1)predicting properties of crystalline compounds and(2)identifying potentially stable solar cell materials.We also point to some outstanding issues yet to be resolved for a successful application of ML in material science. | Bhavya Kailkhura Brian Gallagher Sookyung Kim Anna Hiszpanski T.Yong-Jin Han | 2019 | npj Computational Materials2019，，1： | 3 |
| 8 | Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods显示文摘 | Anna Floegel Dae-Ok Kim Sang-Jin Chung Sung I. Koo Ock K. Chun | 2011 | Journal of Food Composition and Analysis2011，，7： | 2 |
| 9 | Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound显示文摘Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected. | Sang-Woo Cha Sae Hee Kim Hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna Kim Min Koo Lee Hyun Young Han Dong Wook Kang | 2010 | World Journal of Gastroenterology2010，16，8： | 2 |
| 10 | An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘 | George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman | 2012 | Investigational New Drugs2012，，1： | 2 |
| 11 | Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma显示文摘 | Anna S. Lok Richard K. Sterling James E. Everhart Elizabeth C. Wright John C. Hoefs Adrian M. Di Bisceglie Timothy R. Morgan Hae–Young Kim William M. Lee Herbert L. Bonkovsky Jules L. Dienstag | 2010 | Gastroenterology2010，，2： | 2 |
| 12 | Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance显示文摘 | Jonathan W. Weinsaft Han W. Kim Dipan J. Shah Igor Klem Anna Lisa Crowley Rhoda Brosnan Olga G. James Manesh R. Patel John Heitner Michele Parker Eric J. Velazquez Charles Steenbergen Robert M. Judd Raymond J. Kim | 2008 | Journal of the American College of Cardiology2008，，2： | 1 |
| 13 | Isoform-specific alanine aminotransferase measurement can distinguishhepatic from extrahepatic injury in humans显示文摘 | Ingalill Rafter Truls Gr?berg Anna Kotronen Lovisa Str?mmer C. Mattson Ray Kim Ewa Ehrenborg H?kan Andersson Hannele Yki-J?rvinen Ina Schuppe-Koistinen Bj?rn Ekblom Ian Cotgreave Bj?rn Glinghammar | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 14 | FIGO stage IIIC endometrial carcinoma: Prognostic factors and outcomes显示文摘 | Anna V. Hoekstra Robert J. Kim William Small Alfred W. Rademaker Irene B. Helenowski Diljeet K. Singh Julian C. Schink John R. Lurain | 2009 | Gynecologic Oncology2009，，2： | 1 |
| 15 | Rate dependence of swelling in lithium-ion cells显示文摘 | Ki-Yong Oh Jason B. Siegel Lynn Secondo Sun Ung Kim Nassim A. Samad Jiawei Qin Dyche Anderson Krishna Garikipati Aaron Knobloch Bogdan I. Epureanu Charles W. Monroe Anna Stefanopoulou | 2014 | Journal of Power Sources2014，，： | 1 |
| 16 | Type-Selective Benefits of Medications in Treatment of Acute Aortic Dissection (from the International Registry of Acute Aortic Dissection [IRAD])显示文摘 | Toru Suzuki Eric M. Isselbacher Christoph A. Nienaber Reed E. Pyeritz Kim A. Eagle Thomas T. Tsai Jeanna V. Cooper James L. Januzzi Alan C. Braverman Daniel G. Montgomery Rossella Fattori Linda Pape Kevin M. Harris Anna Booher Jae K. Oh Mark Peterson Vija | 2012 | The American Journal of Cardiology2012，，1： | 1 |
| 17 | Valproate protects cells from ER stress-induced lipidaccumulation and apoptosis by inhibiting glycogen synthase kinase-3 显示文摘 | Anna J Kim Yuan-yuan Shi Richard C Austin | 2004 | J Cell Sci2004，118，1： | 1 |
| 18 | Endogenous Control of Immunity against Infection: Tenascin-C Regulates TLR4-Mediated Inflammation via MicroRNA-155显示文摘 | Anna M. Piccinini Kim S. Midwood | 2012 | Cell Reports2012，，4： | 1 |
| 19 | Sensing of lead ions by a carboxylate-substituted PPE: Multivalency effects显示文摘 | Ik-Bum Kim Anna Dunkhorst | 2005 | Macromolecules2005，38，11： | 1 |
| 20 | Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes显示文摘 | Dong Min Kim Hye-Ryung Choi Anna Park Sang-Mo Shin Kwang-Hee Bae Sang Chul Lee Il-Chul Kim Won Kon Kim | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 1 |
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