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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Upregulation of collagen messenger RNA expression occurs immediately after lung damage显示文摘 | Deheinzelin D Jatene F B Saldiva P H | 1997 | Chest1997，112，： | 2 |
| 3 | Pulmonary func- tional and morphological damage after exposure to tripoli dust显示文摘 | Machado MN Schmidt AC Saldiva PH | 2014 | Respir Physiol Neurobio12014，196，： | 1 |
| 4 | PM 2.5 induces acute electrocardiographic alterations in healthy rats显示文摘 | Dolores Helena Rodriguez Ferreira Rivero Carolina Sassaki Geraldo Lorenzi-Filho Paulo Hilário Nascimento Saldiva | 2004 | Environmental Research2004，，2： | 1 |
| 5 | The relationship between low birth weight and exposure to inhalable particulate matter显示文摘 | Romlo R Pereira LA Saldiva PH | 2013 | Cad Saude Publica2013，29，6： | 1 |
| 6 | The effects of systemic hormonal replacement therapy on the skin of postmenopausal women显示文摘 | A.V.D Sauerbronn A.M Fonseca V.R Bagnoli P.H Saldiva J.A Pinotti | 2000 | International Journal of Gynecology and Obstetrics2000，，1： | 1 |
| 7 | The relationship between low birth weight and exposure to inhalable particulate matter 显示文摘 | Romao R Pereira LA Saldiva PH | 2013 | Cademos de Saude Publica2013，29，6： | 1 |
| 8 | Large cell carcinoma of the lung: ultra structural and immunohistochemical features 显示文摘 | Delmonte VC Alberti O Saldiva PHN | 1986 | Chest1986，90，4： | 1 |
| 9 | Air pollution and mortality in elderly people: a time series study in Sao Paulo, Brazil显示文摘 | SALDIVA P H POPE C A SCHWARTZ J | 1995 | Arch Environ Health1995，50，2： | 1 |
| 10 | Air Pollution and Mortality in Elderly People: A Time - Series Study in Sao Paulo, Brazil 显示文摘 | Saldiva P H N Pope C A Ⅲ Doekery D W Schwartz J | 1995 | Archives of Environmental Health1995，50，2： | 1 |
| 11 | Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats显示文摘 | Batalha JR Saldiva PH Clarke RW | 2002 | Environ Health Perspect2002，110，12： | 1 |
| 12 | Evaluation of the air quality benefits of the subway system in Sao Paulo,Brazil显示文摘 | Silva C B P D Saldiva P H N Amato-Louren.o L F | | 0，，： | 1 |
| 13 | Morphological changes of carotid bodies in acute respiratory distress syndrome:a morphometric study in humans显示文摘 | Vinhaes EN Dolhnikoff M Saldiva PH | 2002 | Braz J Med Biol Res2002，35，10： | 1 |
| 14 | Morphological changes of carotid bodies in acute respiratory distress syndrome:a morphometric study in humans显示文摘 | VINHAES E N DOLHNIKOFF M SALDIVA P H | 2002 | Braz J Med Biol Res2002，35，10： | 1 |
| 15 | Electrocar- diographic changes during exposure to residual oil fly ash ( ROFA ) particles in a rat model of myocardial infarction 显示文摘 | WELLENIUS G A SALDIVA P H BATATHA J R | 2002 | Toxicol Sci2002，66，2： | 1 |
| 16 | Air pollution and mortality in elderly people: a time-series study in Sao Paulo, Brazil显示文摘 | SALDIVA PH POPE CA 3rd SCHWARTZ J | 1995 | Arch Environ Health1995，50，2： | 1 |
| 17 | Amaranth protein presents cholesterol-lowering effect显示文摘 | MENDONCA S SALDIVA P H CRUZ R J | 2009 | Food Chemistry2009，116，3： | 1 |
| 18 | Concentrat ed ambient air particles induce vasoconstriction of small pulmonary art eries in rats显示文摘 | Batalha R F Saldiva P H N Clark R W | 2002 | Environ Health Perspect2002，110，12： | 1 |
| 19 | Air pollution and mortality in elderly people: a time- series study in Sao Paulo, Brazil 显示文摘 | SALDIVA P | 1995 | Arch Environ Health1995，40，1： | 1 |
| 20 | Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction显示文摘 | Wellenius GA Saldiva PH Batalha JR | 2002 | Toxicol Sci2002，66，： | 1 |
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