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| 1 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 2 | Parkinson's Disease:A Multisystem Disorder显示文摘The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent decades.For a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional light.Today,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ systems.For this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline. | Helena Nunes Costa Ana Raquel Esteves Nuno Empadinhas Sandra Morais Cardoso | 2023 | Neuroscience Bulletin2023，39，1： | 2 |
| 3 | Combined Effect of Two Sustainable Technologies: Self-compacting Concrete (SCC) and Controlled Permeability Formwork (CPF)显示文摘 | Helena Figueiras Sandra Nunes Joana Sousa Coutinho | 2009 | Construction and Building Materials2009，23，： | 1 |
| 4 | Spontaneous Coronary Artery Dissection with Clinical Presentation of Acute Myocardial Infarction显示文摘 | Taísa Godoy Guzzela Luciano de Siqueira Bracci Júnior Mauro Rogério de Barros Wanderley Júnior Sandra Helena Gonsalves de Andrade Mauro Cosme Gomes de Andrade Raony Previtali Paniquar Izabela Guimaraes Falcao Alves Nayrelle de Alencar Ferreira Gomes Jandir Ferreira Gomes Júnior Marcela Lopes Muniz de Andrade Renata London Rodrigues Diego Silveira da Costa Lucila Buriasco de Oliveira Amanda Ribeiro Letícia Trad Martins Costa Diego Braga Filartiga Reiby Caetano Mustafá | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 5 | S Simultaneous determination of copper and lead in seawater using optimised thin-mercury film electrodes in situ plated in thiocyanate media显示文摘 | HELENA M Carapuca Sandra C C Monterroso Luciana S Rocha | 2004 | Talanta2004，64，： | 1 |
| 6 | DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population显示文摘 | Sandra Costa Daniela Pinto Deolinda Pereira Helena Rodrigues Jorge Cameselle-Teijeiro Rui Medeiros Fernando Schmitt | 2007 | Breast Cancer Research and Treatment2007，，2： | 1 |
| 7 | Protein-protein interactions in the extrusion of soya at various temperatures and moisture contents显示文摘 | PRUDENCIO-FERREIRA Sandra Helena ARêAS | 1993 | Journal of Food Science1993，58，2： | 1 |
| 8 | Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients显示文摘 | Beata Shiratori Susan Leano Chie Nakajima Haorile Chagan-Yasutan Toshiro Niki Yugo Ashino Yasuhiko Suzuki Elisabeth Telan Toshio Hattori Sandra Helena Penha Oliveira | 2014 | Mediators of Inflammation2014，，： | 1 |
| 9 | Structural Complexity of the Nitrogen Source and Influence on Yeast Growth and Fermentation显示文摘 | Sandra Helena da Cruz | 2002 | J Inst Brew2002，108，1： | 1 |
| 10 | Ion-exchange and permselectivity properties of poly (sodium4-styrenesulfonate) coatings on glassy carbon: application in the modification of mercury film electrodes for the direct voltammetric analysis of trace metals in estuarine waters 显示文摘 | Sandra C C M Helena M C Armando C D | 2005 | Talanta2005，65，： | 1 |
| 11 | Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer显示文摘 | Edna Maria Vissoci Reiche Helena Kaminami Morimoto Sandra Morimoto Vargas Nunes | 2005 | International Review of Psychiatry2005，，6： | 1 |
| 12 | Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and meta-analysis显示文摘 | Maarten G. Thomeer Cees Gerestein Sandra Spronk Helena C. Doorn Els Ham Myriam G. Hunink | 2013 | European Radiology2013，，： | 1 |
| 13 | Mixture Design of Self-com- pacting Glass Mortar显示文摘 | Nunes Sandra Matos Arm Mafalda Duarte Tiago Figueiras Helena Sousa-Coutinho Joana | 2013 | Cement and Concrete Composites2013，43，： | 1 |
| 14 | 糖代谢物抑制与氮源结构复杂性的相互关系对酵母生长和发酵的影响显示文摘在含有半乳糖、铵盐(磷酸铵)、氨基酸(酪蛋白氨基酸)和多肽(蛋白胨)的培养基中,工业化啤酒酵母生物量和乙醇的产生受到氮源结构复杂性的强烈影响.当半乳糖浓度较低时,可观察到双峰生长现象,且不受氮源的影响.但糖浓度较高时,半乳糖利用的方式有所改变.酵母菌生物量的积累和乙醇的产量依赖于氮源的性质,且面包酵母与Ale酵母、Lager酵母之间的生物量积累和乙醇产量也不同.面包酵母在含有酪蛋白氨基酸的培养基中表现出较高的半乳糖发酵性能.Ale酵母在含有蛋白胨和酪蛋白氨基酸的培养基中积累的生物量很高,而只有在含有酪蛋白氨基酸的培养基中才会大量产生乙醇.相反,Lager酵母在以有蛋白胨为氮源的培养基中积累的生物量较多,且产生较多乙醇.而铵盐却降低了酵母的性能.实验结果表明,以多肽形式存在的氮源对于酵母代谢更加有利,这些结果因半乳糖、葡萄糖和麦芽糖而不同,这说明,在含有不同结构复杂性氮源的培养基中,糖代谢物抑制在酵母性能方面扮演着一个中心角色. | Sandra Helena da Cruz Margareth Batistote Jose Roberto Emandes 林文 杨毅 | 2004 | 啤酒科技2004，，12： | 1 |
| 15 | Structural Complexity of the Nitrogen Source and Influence on Yeast Growth and Fermentation 显示文摘 | | 2002 | J Inst Brew2002，108，1： | 1 |
| 16 | Simultaneous determination of copper and lead inseawater using optimised thin-mercmy film electrodes in situplated in thiocyanate media 显示文摘 | Helena M CarapU9a Sandra C C Monterroso Luciana SRocha | 2004 | Taianta2004，64，： | 1 |
| 17 | PCR-Based Detection and Genotyping of Helicobacter pylori in Endoscopic Biopsy Samples from Brazilian Patients显示文摘 | Silvia M. Ferreira Menoni Sandra Helena Alves Bonon José Murilo Robilota Zeitune Sandra Cecília Botelho Costa Vikram Kate | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 18 | Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer显示文摘 | Edna Maria Vissoci Reiche Helena Kaminami Morimoto Sandra Morimoto Vargas Nunes | 2005 | International Review of Psychiatry2005，，6： | 1 |
| 19 | Influence of Technological Operations in the Dissolved Oxygen Content of Wines显示文摘 | Ana Catarino Sandra Alves Helena Mira | 2014 | Journal of Chemistry and Chemical Engineering2014，8，4： | 0 |
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