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	题名	作者	年代	出处	被引量
1	Molecular architecture of mouse and human pancreatic zymogen granules: protein components and their copy numbers显示文摘A molecular model of pancreatic zymogen granule (ZG) is critical for understanding its functions. We haveextensively characterized the composition and membrane topology of rat ZG proteins. In this study, wereport the development of targeted proteomics approaches to quantify representative mouse and humanZG proteins using LC-SRM and heavy isotope-labeled synthetic peptides. The absolute quantities of mouseRab3D and VAMP8 were determined as 1242 ± 218 and 2039±151 (mean ± SEM) copies per ZG. Thesize distribution and the averaged diameter of ZGs 750 ±23 nm (mean ± SEM) were determined byatomic force microscopy. The absolute quantification of Rab3 D was then validated using semi-quantitativeWestern blotting with purified GST-Rab3D proteins as an internal standard. To extend our proteomicsanalysis to human pancreas, ZGs were purified using human acini obtained from pancreatic islet trans-plantation center. One hundred and eighty human ZG proteins were identified for the first time includingboth the membrane and the content proteins. Furthermore, the copy number per ZG of human Rab3 D andVAMP8 were determined to be 1182 ± 45 and 485 ± 15 (mean ± SEM). The comprehensive proteomicanalyses of mouse and human pancreatic ZGs have the potential to identify species-specific ZG proteins.The determination of protein copy numbers on pancreatic ZGs represents a significant advance towardsbuilding a quantitative molecular model of a prototypical secretory vesicle using targeted proteomicsapproaches. The identification of human ZG proteins lays a foundation for subsequent studies of altered ZGcompositions and secretion in pancreatic diseases.	Jin-sook Lee Joseph A. Caruso Garrett Hubbs Patricia Schnepp Jlames Woods Jingye Fang Chunying Li Kezhong ghang Paul M. Stemmer Bhanu P. Jena Xuequn Chen	2018	Biophysics Reports2018，4，2：	2
2	Budesonide inhalation suspension reduces the need for emergency intervention in pediatric asthma: a named-patient case series 显示文摘	Chipps BE Schnepp CM Briscoe M	2003	J Asthma2003，40，8：	1
3	Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys显示文摘	Johnson P R Schnepp B C Zhang J Connell M J Greene S M Yuste E Desrosiers R C Clark K R	2009	Nature Medicine2009，15，8：	1
4	Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2 显示文摘	La P Schnepp R W Petersen C D	2004	Endocrinology2004，145，：	1
5	Mutation of tumor sup- pressor gene Menl acutely enhances proliferation of pancreatic islet cells显示文摘	Schnepp RW Chen YX Wang H	2006	Cancer Res2006，66，11：	1
6	Menin induces apoptosis in murine embryonic fibroblasts 显示文摘	Schnepp R W Mao H Sykes S M	2004	J Biol Chem2004，279，10：	1
7	Functional interaction between tumor suppressor menin and activator of Sphase kinase显示文摘	Schnepp R W Hou Z Wang H	2004	Cancer Res2004，64，：	1
8	Mutation of tumor suppressor gene Men I acutely enhances proliferation of pancreatic islet cells显示文摘	Schnepp R W Chen Y X Wang H	2006	Cancer Res2006，66，：	1
9	Comparison of temperature-and isopropyl-β-D-thiogalacto-pyranoside-indu-ced synthesis of basic fibroblast growth factor in high-cell-density cultures of recombinant Escherichia coli显示文摘	Seeger A Schneppe B McCarthy J E G	1995	Enzyme Microb Technol1995，17，：	1
10	Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation显示文摘	Kaminaga Y Schnepp J Peel G	2006	J Biol Chem2006，281，23：	1
11	Menin associates with FANCD2, a protein involved in repair of DNA damage 显示文摘	Jin S Mao H Schnepp R W	2003	Cancer Res2003，63，：	1
12	Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2显示文摘	LA P SCHNEPP R W D PETERSEN C	2004	Endocrinology2004，145，7：	1
13	Plant phenylacetaldehyde synthase is a hifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation显示文摘	KAMINAGA Y SCHNEPP J PEEL G	2006	J Biol Chem2006，281，23：	1
14	Efficient large scale elee tro-magnetic simulations using dynamically adapted meshes with discontinuous Galerkin method 显示文摘	Schnepp S M Weiland T	2012	Journal of Computational and Applied Mathematics2012，，236：	1
15	Synthesis of highly magnetic iron carbide nanopartieles via a biopolymer route显示文摘	Schnepp Z Wimbush S C Antonietti M	2010	Chem Mater2010，22，18：	1
16	Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development显示文摘	Fabian Chen Hyun Kook Rita Milewski Aaron D. Gitler Min Min Lu Jun Li Ronniel Nazarian Robert Schnepp Kuangyu Jen Christine Biben Greg Runke Joel P. Mackay Jiri Novotny Robert J. Schwartz Richard P. Harvey Mary C. Mullins Jonathan A. Epstein	2002	Cell2002，，6：	1
17	Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys显示文摘	Johnson PR Schnepp BC Zhang J Connell MJ Greene SM Yuste E Desrosiers RC Clark KR	2009	Nat Med2009，15，8：	1
18	Mutation of tumor suppressor gene MEN-1 acutely enhances proliferation of pancreatic islet cells 显示文摘	Schnepp RW Chen YX Wang H	2006	Cancer Res2006，66，11：	1
19	Novel adeno-associated virus vectorr vaccine restricts replication of simian immunodeficiency virus in Macaques显示文摘	JOHNSON PR SCHNEPP BC CONNELL MJ	2005	J Virol2005，79，2：	1
20	Menin induces apoptosis in routine embryonic fibroblasts 显示文摘	Schnepp RW Mao H Sykes SM	2004	J Biol Chem2004，279，10：	1

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