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| 1 | Effect of dexamethasone on intelligence and hearing in preterm infants: a meta-analysis显示文摘OBJECTIVE: A meta-analysis of published randomized controlled trials investigating the longterm effect of dexamethasone on the nervous system of preterm infants.DATA SOURCES: Online literature retrieval was conducted using The Cochrane Library(from January 1993 to June 2013), EMBASE(from January 1980 to June 2013), MEDLINE(from January 1963 to June 2013), OVID(from January 1993 to June 2013), Springer(from January 1994 to June 2013) and Chinese Academic Journal Full-text Database(from January 1994 to June 2013). Key words were preterm infants and dexamethasone in English and Chinese.STUDY SELECTION: Selected studies were randomized controlled trials assessing the effect of intravenous dexamethasone in preterm infants. The quality of the included papers was evaluated and those without the development of the nervous system and animal experiments were excluded. Quality assessment was performed through bias risk evaluation in accordance with Cochrane Handbook 5.1.0 software in the Cochrane Collaboration. The homogeneous studies were analyzed and compared using Revman 5.2.6 software, and then effect model was selected and analyzed. Those papers failed to be included in the meta-analysis were subjected to descriptive analysis.MAIN OUTCOME MEASURES: Nervous system injury in preterm infants.RESULTS: Ten randomized controlled trials were screened, involving 1,038 subjects. Among them 512 cases received dexamethasone treatment while 526 cases served as placebo control group and blank control group. Meta-analysis results showed that the incidence of cerebral palsy, visual impairment and hearing loss in preterm infants after dexamethasone treatment within 7 days after birth was similar to that in the control group(RR = 1.47, 95%CI: 0.97–2.21; RR = 1.46, 95%CI: 0.97–2.20; RR = 0.80, 95%CI: 0.54–1.18; P > 0.05), but intelligence quotient was significantly decreased compared with the control group(MD =-3.55, 95%CI:-6.59 to-0.51; P = 0.02). Prete rm infants treated with dexamethasone 7 days after birth demonstrated an incidence of cerebral palsy and visual impairment, and changes in intelligence quotient similar to those in the control group(RR = 1.26, 95%CI: 0.89–1.79; RR = 1.37, 95%CI: 0.73–2.59; RR = 0.53, 95%CI: 0.32–0.89; RR = 1.66, 95%CI:-4.7 to 8.01; P > 0.05). However, the incidence of hearing loss was significantly increased compared with that in the control group(RR = 0.53, 95%CI: 0.32–0.89; P = 0.02).CONCLUSION: Dexamethasone may affect the intelligence of preterm infants in the early stages after birth, but may lead to hearing impairment at later stages after birth. More reliable conclusions should be made through large-size, multi-center, well-designed randomized controlled trials. | Ruolin Zhang Tao Bo Li Shen Senlin Luo Jian Li | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 2 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 3 | Cbln1和Cbln4在结构上相似但与GluD2相互作用显著不同显示文摘文章简介本研究以参与突触形成的Cbln家族为研究对象。Cbln家族包含4个成员,其中Cbln1通过在突触间隙中结合Nrxn蛋白和δ-谷氨酸受体参与突触形成;然而,尽管Cbln4与Cbln1有高达74%的序列等同性,文献报道Cbln4不能结合Nrxn蛋白和δ-谷氨酸受体,而是DCC的配体。 | 钟琛 Jinlong Shen Huibing Zhang Guangyi Li Senlin Shen Fang Wang Kuan Hu Longxing Cao Yongning He 丁建平 | 2018 | 科学新闻2018，0，4： | 0 |
| 4 | Striking antibody evasion of SARS-CoV-2 Omicron sub-lineages BQ.1.1,XBB.1 and CH.1.1显示文摘The recent emergence of various B.1.1.529(Omicron)sub-lineages of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)poses an enormous challenge for the prevention and treatment of coronavirus disease 2019(COVID-19)[1,2].BA.2 and BA.5 sub-lineages,with marked antibody evasion,have been dominant in many countries and regions worldwide[3,4]. | Bin Ju Huimin Guo Miao Wang Qing Fan Senlin Shen Xuejiao Liao Jie Jiang Haiyan Wang Fuxiang Wang Zheng Zhang | 2023 | National Science Review2023，10，8： | 0 |
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