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| 1 | Location-aided and secure routing protocol for heterogeneous multi-hop wireless networks显示文摘Most of the existing routing protocols for heterogeneous multi-hop wireless networks(HWMNs) use on-demand routing protocols owing to their suitability for dynamic topology environments, but it causes wastes of network resources with large number of data packets being broadcast. Furthermore, some nodes in heterogeneous wireless multi-hop networksmay be malicious or selfish nodes which can easily lead to link attacks. A novel routing protocol called trust-based secure routing protocol with auxiliary of nodes' location information(TSRAL) is proposed for the establishment of a secure routing protocol with a lower overhead for HWMNs which combines the location information and trust value of nodes to select the next forwarding nodes. The destination node selects an optimal path from multiple paths according to the total trust value and the hop number of routes. Simulation results demonstrate that TSRAL can not only reduce the number of hops and data packets being broadcast in the process of routing but also ensure the safety of the route. | Bai Yuan Hao Ruimin An Jie Zhang Huibing | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 5 |
| 2 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor显示文摘Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for metabolic disorders and Crohn's disease,respectively.Despite great progress in GLP-1 R structure determination,our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive.Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer.To accommodate GLP-2 rather than GLP-1,GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices(TMs)1,5,7 and extracellular loop 1(ECL1).In contrast to GLP-1,the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.The middle region of GLP-2 engages with TM1 and TM7 more extensively than with ECL2,and the GLP-2 C-terminus closely attaches to ECL1,which is the most protruded among 9 class B G protein-coupled receptors(GPCRs).Functional studies revealed that the above three segments of GLP-2 are essential for GLP-2 recognition and receptor activation,especially the middle region.These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics. | Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang | 2020 | Cell Research2020，30，12： | 4 |
| 3 | Location aided probabilistic broadcast algorithm for mobile Ad-hoc network routing显示文摘On-demand routing protocols are widely used in mobile Ad-hoc network(MANET). Flooding is an important dissemination scheme in routing discovering of on-demand routing protocol. However, in high-density MANET redundancy flooding packets lead to dramatic deterioration of the performance which calls broadcast storm problem(BSP). A location-aided probabilistic broadcast(LAPB) algorithm for routing in MANET is proposed to reduce the number of routing packets produced by flooding in this paper. In order to reduce the redundancy packets, only nodes in a specific area have the probability, computed by location information and neighbor knowledge, to propagate the routing packets. Simulation results demonstrate that the LAPB algorithm can reduce the packets and discovery delay(DD) in the routing discovery phase. | Bai Yuan An jie Zhang Huibing | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，2： | 4 |
| 4 | Spinel-layered integrate structured nanorods with both high capacity and superior high-rate capability as cathode material for lithium-ion batteries显示文摘尖晶石阶段描述 2 O 4 成功地被嵌进单斜晶的阶段 layeredstructured 李 2 MnO 3 nanorods,和这些尖晶石分层集成结构化的 nanorods 为锂离子电池(解放) 作为阴极材料显示出两个高能力和优异高率的能力。太古的李 2 MnO 3 nanorods 被一个简单 rheological 阶段方法作为先锋用 -MnO2 nanowires 综合。尖晶石分层集成结构化的 nanorods 被灵巧的部分减小反应作为 reductant 用硬脂的酸制作。结构的描述和 integrate 的电气化学的性质组织了验证的 nanorods 描述 2 O 4 nanodomains 在太古的李 2 MnO 3 nanorods。当为解放用作阴极材料时,尖晶石分层集成结构化的李 2 MnO 3 nanorods (SL-Li 2 MnO 3) 比太古的分层结构的李 2 MnO 3 nanorods (L-Li2MnO3 ) 。当解除费用时在 20 mAommonly 存在的 i?? | Huibing He Hengjiang Cong Ya Sun Ling Zan Youxiang Zhang | 2017 | Nano Research2017，10，2： | 3 |
| 5 | Threat-Based Declassification and Endorsement for Mobile Computing显示文摘Declassification and endorsement can efficiently improve the usability of mobile applications.However, both declassify and endorse operations in practice are often ad-hoc and nondeterministic, thus, being insecure. From a new perspective of threat assessments,we propose the Threat-based typed security π-calculus(πTBTS) to model declassification and endorsement in mobile computing. Intuitively, when relaxing confidentiality policies and/or integrity policies, we respectively assess threats brought by performing these two relaxes. If these threats are acceptable, the declassification and/or endorsement operations are permitted;Otherwise, they are denied. The proposed assessments have explicit security conditions, results and less open parameters,so our approach solves the problem of the ad-hoc and nondeterministic semantics and builds a bridge between threat assessments and declassification/endorsement. | YIN Lihua GUO Yunchuan ZHANG Huibing HUANG Wenting FANG Binxing | 2019 | Chinese Journal of Electronics2019，28，5： | 2 |
| 6 | Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor显示文摘Dear Editor,Dopamine acts as an essential neurotransmitter whose signaling is conducted through five G protein-coupled receptors(GPCRs),dopamine D1 to D5 receptors(DRD1–DRD5).1 The D1-like receptors,comprising DRD1 and DRD5,primarily couple to the Gs family of G proteins to activate adenylyl cyclase and induce cAMP production.DRD1 is the most abundantly expressed dopamine receptor in the CNS.1 It is the central receptor mediating excitatory dopamine signaling in multiple dopaminergic pathways.Dysregulation of DRD1 signaling has been directly linked to Parkinson’s disease(PD),schizophrenia,and drug abuse. | Youwen Zhuang Brian Krumm Huibing Zhang X.Edward Zhou Yue Wang Xi-Ping Huang Yongfeng Liu Xi Cheng Yi Jiang Hualiang Jiang Cheng Zhang Wei Yi Bryan L.Roth Yan Zhang H.Eric Xu | 2021 | Cell Research2021，31，5： | 2 |
| 7 | Silencing of IKKε using siRNA inhibits proliferation and invasion ofglioma cells in vitro and in vivo显示文摘 | Huibing Li Lingchao Chen Anling Zhang Guangxiu Wang Lei Han Kai Yu Peiyu Pu Chunsheng Kang Qiang Huang | 2012 | International Journal of Oncology2012，，1： | 1 |
| 8 | Molybdenum Oxynitride Atomic Nanoclusters Bonded in Nanosheets of N-Doped Carbon Hierarchical Microspheres for Efficient Sodium Storage显示文摘Transition metal nitrides have attracted considerable attention as great potential anode materials due to their excellent metallic conductivity and high theoretical specific capacity.However,their cycling performance is impeded by their instability caused by the reaction mechanism.Herein,we report the engineering and synthesis of a novel hybrid architecture composed of MoO2.0N0.5 atomic nanoclusters bonded in nanosheets of N-doped carbon hierarchical hollow microspheres(MoO2.0N0.5/NC)as an anode material for sodium-ion batteries.The facile self-templating strategy for the synthesis of MoO2.0N0.5/NC involves chemical polymerization and subsequent one-step calcination treatments.The design is benefi-cial to improve the electrochemical kinetics,buffer the volume variation of electrodes during cycling,and provide more interfacial active sites for sodium uptake.Due to these unique structural and compositional merits,these MoO2.0N0.5/NC exhibits excellent sodium storage performance in terms of superior rate capability and stable long cycle life.The work shows a feasible and effective way to design novel host candidates and solve the long-term cycling stability issues for sodium-ion batteries. | Xiaona Pan Baojuan Xi Huibing Lu Zhengchunyu Zhang Xuguang An Jie Liu Jinkui Feng Shenglin Xiong | 2022 | Nano-Micro Letters2022，14，10： | 1 |
| 9 | Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response显示文摘RIPK1 is a master regulator of multiple cell death pathways,including apoptosis and necroptosis,and inflammation.Importantly,activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis,in animal models of amyotrophic lateral sclerosis(ALS)and Alzheimer's disease(AD),and in human ALS and AD.Rare human genetic carriers of non-cleavable RIPK1 variants(D324V and D324H)exhibit distinct symptoms of recurrent fevers and increased transcription of proinflammatory cytokines.Multiple RIPK1 inhibitors have been advanced into human clinical trials as new therapeutics for human inflammatory and neurodegenerative diseases,such as ALS and AD.However,it is unclear whether and how RIPK1 kinase activity directly mediates inflammation independent of cell death as the nuclear function of RIPK1 has not yet been explored.Here we show that nuclear RIPK1 is physically associated with the BAF complex.Upon RIPK1 activation,the RIPK1/BAF complex is recruited by specific transcription factors to active enhancers and promoters marked by H3K4me1 and H3K27ac.Activated nuclear RIPK1 mediates the phosphorylation of SMARCC2,a key component of the BAF complex,to promote chromatin remodeling and the transcription of specific proinflammatory genes.Increased nuclear RIPK1 activation and RIPK1/BAF-mediated chromati n-remodeling activity were found in cells expressi ng non-cleavable RIPK1,and in creased enrichment of activated RIPK1 on active enhancers and promoters was found in an animal model and human pathological samples of ALS.Our results suggest that RIPK1 kinase serves as a transcriptional coregulator in nucleus that can transmit extracellular stimuli to the BAF complex to modulate chromatin accessibility and directly regulate the transcription of specific genes involved in mediating inflammatory resp onses. | Wanjin Li Bing Shan Chengyu Zou Huibing Wang Meng-Meng Zhang Hong Zhu Masanori Gomi Naito Daichao Xu Vica Jean Manuel Lauren Mifflin Zhaodong Hou John Ravits Junying Yuan | 2022 | Cell Research2022，32，7： | 1 |
| 10 | Cbln1和Cbln4在结构上相似但与GluD2相互作用显著不同显示文摘文章简介本研究以参与突触形成的Cbln家族为研究对象。Cbln家族包含4个成员,其中Cbln1通过在突触间隙中结合Nrxn蛋白和δ-谷氨酸受体参与突触形成;然而,尽管Cbln4与Cbln1有高达74%的序列等同性,文献报道Cbln4不能结合Nrxn蛋白和δ-谷氨酸受体,而是DCC的配体。 | 钟琛 Jinlong Shen Huibing Zhang Guangyi Li Senlin Shen Fang Wang Kuan Hu Longxing Cao Yongning He 丁建平 | 2018 | 科学新闻2018，0，4： | 0 |
| 11 | Luminescent properties of Ce^(3+),Er^(3+) co-doped La_3Si_6N_(11)显示文摘In order to obtain near-infrared phosphor pumped by blue chip with high luminous efficiency, a novel near-infrared phosphor Ce^(3+)/Er^(3+) doped La_3Si_6N_(11) was designed and firstly prepared via conventional solid-state reactions. The structure and morphology of Ce^(3+)/Er^(3+) doped La_3Si_6N_(11) were investigated by X-ray diffraction(XRD) and scanning electron microscopy(SEM). Compared with Er^(3+) doped La_3Si_6N_(11),the emission intensity of the Ce^(3+), Er^(3+) co-doped phosphor can be increased more than 5 times.Meanwhile, the mechanism of energy transfer from Ce^(3+) to Er^(3+) is confirmed according to the excitation,emission spectra and decay lifetimes curve. Above results suggest that La_3 Si_6 N_(11):Ce^(3+),Er^(3+) is a promising near-infrared phosphor for blue pumped LEDs(light-emitting diodes). | Yuan Xue Ronghui Liu Yuanhong Liu Huibing Xu Guantong Chen Xia Zhang Wei Gao Ze Jiang | 2019 | Journal of Rare Earths2019，37，3： | 0 |
| 12 | δ-Calculus:A New Approach to Quantifying Location Privacy显示文摘With the rapid development of mobile wireless Internet and high-precision localization devices,location-based services(LBS)bring more convenience for people over recent years.In LBS,if the original location data are directly provided,serious privacy problems raise.As a response to these problems,a large number of location-privacy protection mechanisms(LPPMs)(including formal LPPMs,FLPPMs,etc.)and their evaluation metrics have been proposed to prevent personal location information from being leakage and quantify privacy leakage.However,existing schemes independently consider FLPPMs and evaluation metrics,without synergizing them into a unifying framework.In this paper,a unified model is proposed to synergize FLPPMs and evaluation metrics.In detail,the probabilistic process calculus(calledδ-calculus)is proposed to characterize obfuscation schemes(which is a LPPM)and integrateα-entropy toδ-calculus to evaluate its privacy leakage.Further,we use two calculus moving and probabilistic choice to model nodes’mobility and compute its probability distribution of nodes’locations,and a renaming function to model privacy leakage.By formally defining the attacker’s ability and extending relative entropy,an evaluation algorithm is proposed to quantify the leakage of location privacy.Finally,a series of examples are designed to demonstrate the efficiency of our proposed approach. | Lihua Yin Ran Li Jingquan Ding Xiao Li Yunchuan Guo Huibing Zhang Ang Li | 2020 | Computers, Materials & Continua2020，，6： | 0 |
| 13 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor显示文摘Melanocortin-4 receptor(MC4R)plays a central role in the regulation of energy homeostasis.Its high sequence similarity to other MC receptor family members,low agonist selectivity and the lack of structural information concerning MC4R-specific activation have hampered the development of MC4R-seletive therapeutics to treat obesity.Here,we report four high-resolution structures of full-length MC4R in complex with the heterotrimeric Gs protein stimulated by the endogenous peptide ligand a-MSH,FDA-approved drugs afamelanotide(Scenesse™)and bremelanotide(Vyleesi™),and a selective small-molecule ligand THIQ,respectively.Together with pharmacological studies,our results reveal the conserved binding mode of peptidic agonists,the distinctive molecular details of small-molecule agonist recognition underlying receptor subtype selectivity,and a distinct activation mechanism for MC4R,thereby offering new insights into G protein coupling.Our work may facilitate the discovery of selective therapeutic agents targeting MC4R. | Huibing Zhang Li-Nan Chen Dehua Yang Chunyou Mao Qingya Shen Wenbo Feng Dan-Dan Shen Antao Dai Shanshan Xie Yan Zhou Jiao Qin Jin-Peng Sun Daniel H.Scharf Tingjun Hou Tianhua Zhou Ming-Wei Wang Yan Zhang | 2021 | Cell Research2021，31，11： | 0 |
| 14 | RHMX:Bus Arrival Time Prediction via Mixed Model显示文摘With the widespread use of information technologies such as IoT and big data in the transportation business,traditional passenger transportation has begun to transition and upgrade into intelligent transportation,providing passengers with a better riding experience.Giving precise bus arrival times is a critical link in achieving urban intelligent transportation.As a result,a mixed model-based bus arrival time prediction model(RHMX)was suggested in this work,which could dynamically forecast bus arrival time based on the input data.First,two sub-models were created:bus station stopping time prediction and interstation running time prediction.The former predicted the stopping time of a running bus at each downstream station in an iterative manner,while the latter projected its running time on each downstream road segment(stations as the break points).Using the two models,a group of time series data on interstation running time and bus station stopping time may be predicted.Following that,the time series data from the two sub-models was fused using long short-term memory(LSTM)to generate an approximate bus arrival time.Finally,using Kalman filtering,the LSTM prediction results were dynamically updated in order to eliminate the influence of aberrant data on the anticipated value and obtain a more precise bus arrival time.The experimental findings showed that the suggested model's accuracy and stability were both improved by 35%and 17%,respectively,over AutoNavi and Baidu. | Fei Jia Huibing Zhang Xiaoli Hu | 2021 | Journal of Electronic Research and Application2021，5，6： | 0 |
| 15 | Thymidylate synthase confers pemetrexed resistance of non-small cell lung cancer cells by EGFR/PI3K/AKT pathway显示文摘Chemotherapy drug resistance is the main cause leading to the relapse and metastasis of non-small cell lung cancer(NSCLC)patients.Our study aimed to investigate the mechanism of pemetrexed resistance in NSCLC.Firstly,the pemetrexed(PEM)-resistant PC-9 and A549 lung adenocarcinoma cell lines(PC-9/PEM and A549/PEM)were established.The expression of thymidylate synthase(TS)in PC-9/PEM,A549/PEM,A549,and PC-9 cells were analyzed by qRT-PCR and western blot.Then,cell viability,colony formation,migration,and invasion were performed on PEM-resistant cells transfected with TS siRNA.The role of EGFR in PEM resistance of PEM-resistant cells was investigated using EGFR siRNA.The effects of gefitinib and EGFR siRNA on EGFR/PI3K/AKT pathway and downstream signaling Cyclin D1 and E2F1 in PEM-resistant cells were analyzed.Results showed that the protein level of TS was significantly increased in A549/PEM and PC-9/PEM.TS knockdown inhibited the potency of proliferation,colony-forming potential,migration,and invasion in PEM-resistant cells.EGFR knockdown abrogated the resistance to PEM of PEM-resistant cells and suppressed the migration and invasion of PEM-resistant cells.Gefitinib treatment and EGFR knockdown respectively inhibited the EGFR/PI3K/AKT pathway and downregulated Cyclin D1 and E2F1 in PEM-resistant cells.Thus,TS might be a predictive marker for PEM resistance in NSCLC.Inhibition of the EGFR pathway abrogated the resistance to PEM and inhibited the EGFR/PI3K/AKT and downstream signaling of PEM-resistant NSCLC cell lines. | DAN ZHANG HAIJING LIU ZHENNAN YI YUANYUAN LU YANYAN CHEN WEIQIANG SU HUIBING LIN ZHIHUI ZHANG WEI LEI | 2021 | BIOCELL2021，45，3： | 0 |
| 16 | Structures of the endogenous peptide-and selective non-peptide agonist-bound SSTR2 signaling complexes显示文摘Dear Editor,Somatostatin,also known as growth hormone-inhibiting hormone,is an important peptide hormone that mediates predominanty neuroendocrine inhibitory effects in the exocrine and endocrine systems,12 Besides,t can also exert potent regulatory effects on cell proliferation and angiogenesis.3 In human,somatostatin exerts its physiological functions through activating five somatostatin receptors(SSTRs),which are class A Gvo protein-coupled receptors,Pharmacologicaly,somatostatin receptors,especially SSTR2,are the primary drug targets for the treatment of pituitary adenomas and neuroendocrine tumors.-s To date,three somatostatin analogs have been approved for clinical use and two of them(lanreotide and octreotide)are sSTR2-selective drugs.3 In addition to peptidic agonists,extensive efforts have also been made to design selective small-molecule agonists,t which will failitate the development of orly active chemotherapeutic agents. | Li-Nan Chen Wei-Wei Wang Ying-Jun Dong Dan-Dan Shen Jia Guo Xuefei Yu Jiao Qin Su-Yu Ji Huibing Zhang Qingya Shen Qiaojun He Bo Yang Yan Zhang Qinglin Li Chunyou Mao | 2022 | Cell Research2022，32，8： | 0 |
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