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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Electrical sensitive behavior of poly ( vinyl alcohol )/poly ( diallydimethlammonium chloride) IPN hydrogel 显示文摘 | SEON J K SEOUNG G Y SANG M L | 2003 | Sensors and Actuators B2003，，88： | 1 |
| 3 | Identification of a novelhuman voltage-gated sodium channel a subunit gene,SCN12A显示文摘 | Seon Y J Jun G Hideji H | 2000 | Biochem Biophy Res Commun2000，267，： | 1 |
| 4 | Characteristics of electri- cal responsive alginate/poly( diallyldim -ethylammonium chloride) IPN hydrogel in HCI solutions 显示文摘 | SEON J K SEOUNG G Y SANG M L | 2003 | Sensors and Actuators B2003，30，96： | 1 |
| 5 | Electrical behavior of polymer hydrogel composed of poly( vinyl alcohol)-hyaluronic acid in solution 显示文摘 | SEON J K SEOUNG G Y YOUNG M L | 2004 | Biosensors and Bioelectronics2004，10，19： | 1 |
| 6 | Effect of heat treatment on precipitation behavour in a Cu-Ni-Si-P alloy显示文摘 | YONG G K TAE Y SEON J | 1986 | Journal of Materials Science1986，21，4： | 1 |
| 7 | Simulation of damage in composites based on solid finite elements显示文摘 | Nikishkov Y Makeev A Seon G | 2010 | Journal of the Amerieal Helicopter Society2010，55，04： | 1 |
| 8 | Failure predictions for car- bon/epoxy tape laminates with wavy plies显示文摘 | Makeev A Seon G Lee E | 2010 | Journal of Composite Materials2010，44，1： | 1 |
| 9 | High electrical performance of wet-processed indium zinc oxide thin-film transistors显示文摘 | Park K B Seon J B Kim G H | | 0，，04： | 1 |
| 10 | Riiaximin plus levofoxacin- based rescue regimen for the eradication of Helieobacter pylori显示文摘 | Yun S P Seon H G Ok C S | 2012 | Gut Liver2012，6，4： | 1 |
| 11 | Direct Medical Costs of Constipation From Childhood to Early Adulthood: A Population-based Birth Cohort Study显示文摘 | Rok Seon Choung Nilay D Shah Denesh Chitkara Megan E Branda Miranda A Van Tilburg William E Whitehead Slavica K Katusic G Richard Locke Nicholas J Talley | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，1： | 1 |
| 12 | Simultaneous bi - lateral total knee arthroplasty with robotic and conventional tech niques: a prospective, randomized study显示文摘 | Song g K Seon J K Park S J | 2011 | Knee Surg Sports Traumatol Arthrosc2011，19，10： | 1 |
| 13 | Bactericidal Activity in Whole Blood as a Potential Surrogate Marker of Immunity after Vaccination against Tuberculosis显示文摘 | Seon - Hee Cheon Beate Kampmann Amy G Hise | 2002 | Clinical and Diagnostic Laboratory Immunology2002，9，4： | 1 |
| 14 | Hydrogen production by immobilized cells in the nozzle loop bioreactor显示文摘 | SEON Y H LEE C G PARK D H | 1993 | Biotechnol Lett1993，15，12： | 1 |
| 15 | Studies of starch esterification: reactions with alkenylsuccinates in aqueous slurry systems 显示文摘 | Young- Seon J Arvind V L Richard A G | 1999 | Starch/Starke1999，51，23： | 1 |
| 16 | Swelling and electroresponsive characteristic of interpenetrating polymer network hydrogels 显示文摘 | Seoung G Y In Y K Seon J K | 2005 | Polym Int2005，54，8： | 1 |
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