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| 1 | Multidisciplinary approach to understand the pathogenesis of gastric cancer显示文摘Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cancer death in the world. Although the incidence and mortality of gastric carcinoma are decreasing in many countries,gastric cancer still represents the second most frequent malignancies in the world and the fourth in Europe. The 5-year survival rate of gastric carcinoma is low. The etiology and pathogenesis are not yet fully known. The study of gastric cancer is important in clinical medicine as well as in public health. Over the past 15 years,integrated research in molecular pathology has clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of the development and progression of gastric cancer. Gastric cancer, as all cancers, is the end result of the interplay of many risk factors as well as protective factors. Although epidemiological evidence indicates that environmental factors play a major role in gastric carcinogenesis, the role of immunological, genetic, and immunogenetic factors are thought to contribute to the pathogenesis of gastric carcinoma. Among the environmental factors,diet and Helicobacter pylori are more amenable to intervention aimed at the prevention of gastric cancer.The aim of the present paper is to review and include the most recent published evidence to demonstrate that only a multidisciplinary approach will lead to the advancement of the pathogenesis and prevention of gastric cancer. On the immunogenetic research it is clear that evidence is accumulating to suggest that a genetic profile favoring the proinflammatory response increases the risk of gastric carcinoma. | Juan Shang AS Pe(n|~)a | 2005 | World Journal of Gastroenterology2005，11，27： | 16 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Blade row interaction effects on compressor measurement 显示文摘 | Shang T Epstein A H Giles M B | 1993 | Journal of Propulsion and Power1993，9，4： | 2 |
| 4 | Increased neureglobin levels in the cerebral cortex and serum after ischemia-reperfusian insuits显示文摘 | Shang A Zhou D Wang L Gao Y | 2006 | Brain Res2006，1078，1： | 1 |
| 5 | FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis显示文摘 | Shang N Arteaga M Zaidi A | 2015 | Hepatology2015，61，1： | 1 |
| 6 | Hoxcl2 expression pattern in developing and cycling routine hair follicles 显示文摘 | Shang L Pruett N D Awgulewitsch A | 2002 | Mech Dev2002，113，2： | 1 |
| 7 | A transhipment model for the optimization of steam levels of total site utility system for multi-period op- eration显示文摘 | Shang Z Kokossis A | 2004 | Computers & Chemical Engineering2004，28，9： | 1 |
| 8 | Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminer- gic neurons and glia via BMP signaling显示文摘 | Chalazonitis A Tang A A Shang Y | 2011 | J Neurosci2011，31，13： | 1 |
| 9 | First-principles calculations of the elastic, phonon and thermodynamic properties of Al12Mg17 显示文摘 | ZHANG H SHANG S L WANG Y SAENGDEEJING A CHEN L Q LIU Z K | 2010 | Acta Materialin2010，58，11： | 1 |
| 10 | Overex-pression of Hoxcl3 in differentiatingkeratinocytes resultsin downregulation of a novel hair keratin gene cluster andalopecia显示文摘 | Tkatchenko A V Visconti R P Shang L | 2001 | Development2001，128，： | 1 |
| 11 | Mechanism of escherichia coli inactivation on palladium-modified nitrogen-doped Titanium dioxide显示文摘 | Wu P G Imlay J A Shang J K | 2010 | Biomaterials2010，31，29： | 1 |
| 12 | Investigation of cata- strophic ground collapse in Xingtai gypsum mines inChina显示文摘 | Wang J A Shang X C Ma H T | 2008 | International Journal of Rock Mechanics and Mining Sciences2008，45，8： | 1 |
| 13 | Increased neuroglobin levels in the cerebral cortex and serum after ischemia - reperfusion insults 显示文摘 | Shang A Zhou D Wang L | 2006 | Brain Res2006，1078，1： | 1 |
| 14 | Opting for Families: Recent Trends in The Fertility of Highly Educated Women显示文摘 | QINGYAN SHANG BRUCE A Weinberg | 2013 | Journal of Population Economics2013，26，： | 1 |
| 15 | Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and pseudomonas aeruginosa 显示文摘 | DAVIES T A SHANG W C BUSH K | 2008 | Antimicrob Agents Chemother2008，52，4： | 1 |
| 16 | Tetrahymena thermophila contains a conventional γ-tubulin that is differentially required for the maintenance of different MTOCs 显示文摘 | Shang Y Li B Gorovsky M A | 2002 | J Ceil Biol2002，158，7： | 1 |
| 17 | Molecular cloning and sequence analysis of the gene encoding LipL41,a surface-exposed lipoprotein of pathogenic Leptospira species显示文摘 | Shang E S Summers T A Haake D A | 1996 | Infect Immun1996，64，6： | 1 |
| 18 | Investigation of catastrophic ground collapse in Xingtai gypsum mines in China显示文摘 | Wang J A Shang X C Ma H T | 2008 | International Journal of Rock Mechanics and Mining Sciences2008，45，8： | 1 |
| 19 | A transhipment model for the optimisation of steam levels of total site utility system for muhiperiod operation 显示文摘 | Z Shang A Kokossis | 2004 | Computers & chemical engineering2004，28，9： | 1 |
| 20 | Relationship between cation exchange selectivity and crystalline swelling in expanding 2:1 phyllosilicates 显示文摘 | LAIRD D A SHANG C | 1997 | Clays Clay Miner1997，45，5： | 1 |
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