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| 1 | Multidisciplinary approach to understand the pathogenesis of gastric cancer显示文摘Gastric carcinoma remains a common disease worldwide with a dismal prognosis. Therefore, it represents a very important health problem. It occurs with a high incidence in Asia and is one of the leading causes of cancer death in the world. Although the incidence and mortality of gastric carcinoma are decreasing in many countries,gastric cancer still represents the second most frequent malignancies in the world and the fourth in Europe. The 5-year survival rate of gastric carcinoma is low. The etiology and pathogenesis are not yet fully known. The study of gastric cancer is important in clinical medicine as well as in public health. Over the past 15 years,integrated research in molecular pathology has clarified the details of genetic and epigenetic abnormalities of cancer-related genes in the course of the development and progression of gastric cancer. Gastric cancer, as all cancers, is the end result of the interplay of many risk factors as well as protective factors. Although epidemiological evidence indicates that environmental factors play a major role in gastric carcinogenesis, the role of immunological, genetic, and immunogenetic factors are thought to contribute to the pathogenesis of gastric carcinoma. Among the environmental factors,diet and Helicobacter pylori are more amenable to intervention aimed at the prevention of gastric cancer.The aim of the present paper is to review and include the most recent published evidence to demonstrate that only a multidisciplinary approach will lead to the advancement of the pathogenesis and prevention of gastric cancer. On the immunogenetic research it is clear that evidence is accumulating to suggest that a genetic profile favoring the proinflammatory response increases the risk of gastric carcinoma. | Juan Shang AS Pe(n|~)a | 2005 | World Journal of Gastroenterology2005，11，27： | 16 |
| 2 | Large-scale rapid oxidation synthesis of SnO, nanoribbons显示文摘 | HUJ Q MA X L SHANG N G er al | 2002 | J Phys Chern B2002，106，15： | 1 |
| 3 | In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice显示文摘 | LIU N SHANG J TIAN F et ol | 2011 | Brain Res2011，1397，1： | 1 |
| 4 | FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis显示文摘 | Shang N Arteaga M Zaidi A | 2015 | Hepatology2015，61，1： | 1 |
| 5 | Hoxcl2 expression pattern in developing and cycling routine hair follicles 显示文摘 | Shang L Pruett N D Awgulewitsch A | 2002 | Mech Dev2002，113，2： | 1 |
| 6 | Catalyst-Free efficient growth, orientation and biosensing prop- erties of Multilayer Graphene Nanoflake Films with sharp edge planes显示文摘 | Shang N G Papakonstantinou P Mcmullan M | 2008 | Advanced Functional Materials2008，18，21： | 1 |
| 7 | Ahierarchical path computation element (PCE)-based k-random-paths routing algorithm inmulti-domain WDM networks 显示文摘 | SHANG S HUA N WANG L | 2011 | OpticalSwitching and Networking2011，8，4： | 1 |
| 8 | Pump-assisted enteral nutrition can prevent aspiration in bedridden percutane~us endoscopic gas- trostomy patients显示文摘 | Shang E Geiger N Sturm JW | 2004 | PEN J Parenter Enteral Nutr2004，28，3： | 1 |
| 9 | Medical Images Water- marking Algorithm Based on Improved DCT显示文摘 | SHANG Y F KANG Y N | 2013 | Jour- nal of Multimedia2013，8，6： | 1 |
| 10 | Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera 显示文摘 | Chignard N Shang S Wang H | 2006 | Gastroenterology2006，130，7： | 1 |
| 11 | Demethylating agent 5 - aza - 2'- de- oxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel 显示文摘 | Shang DH Ito N Kamoto T | 2007 | Urology2007，69，5： | 1 |
| 12 | Uhrathin Al2O3 and HfO2 gate dielectrics on surfaee-nitrided Ge 显示文摘 | CHEN J J BOJARCZUK N A SHANG H | 2004 | IEEE Trans on ED2004，51，9： | 1 |
| 13 | Pump-assisted enteral nutrition can prevent aspiration in bedridden percutaneous endoscopic gastrostomy patients显示文摘 | Shang E Geiger N Sturm JW | 2004 | JPEN J Parenter Enteral Nutr2004，28，3： | 1 |
| 14 | Novel Bi-n-butyltin(Ⅳ) Derivatives:Synthesis, High Levels of Cytotoxicity in Tumorcells and the Induction of Apoptosis in KB Cancer Cells显示文摘 | Shang X M Ding N Xiang G Y | 2012 | Eur J Med Chem2012，48，： | 1 |
| 15 | Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast 显示文摘 | Shang C H Zhu F Li N | 2008 | Biosci Bioteehnol Biochem2008，72，5： | 1 |
| 16 | Effects of glutamine supplementation on innate immune response in rats with gut-derived sepsis显示文摘 | Yeh S L Lai Y N Shang H F | 2004 | Br J Nutr2004，91，3： | 1 |
| 17 | The biotoxicity and color formation results from ozonation of wastwaters containing phenol and aniline 显示文摘 | Shang N Yu Y | 2001 | J Environ Sci2001，36，3： | 1 |
| 18 | 显示文摘 | Hu J Q Ma L X Shang N G | 2002 | Phys Chem B2002，106，15： | 1 |
| 19 | Myeloid expression of cytochrome P450 4F8 is determined by a lineage- specific alter native promoter显示文摘 | Christmas P Carlesso N Shang H | 2003 | J Biol Chem2003，278，25： | 1 |
| 20 | Applicability of bacteriocinogenic Lactobacillus pentosus 31 -1 as a novel functional starter culture or coculture for fermented sau- sage manufacture显示文摘 | Liu G Griffiths M W Shang N | 2010 | Journal of Food Protection2010，73，： | 1 |
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