|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Danshen: a phytochemical and pharmacological overview显示文摘Danshen, the dried root or rhizome of Salvia miltiorrhiza Bge., is a traditional and folk medicine in Asian countries, especially in China and Japan. In this review, we summarized the recent researches of Danshen in traditional uses and preparations, chemical constituents, pharmacological activities and side effects. A total of 201 compounds from Danshen have been reported, including lipophilic diterpenoids, water-soluble phenolic acids, and other constituents, which have showed various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-tumor, anti-atherogenesis, and anti-diabetes. This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization. | MEI Xiao-Dan CAO Yan-Feng CHE Yan-Yun LI Jing SHANG Zhan-Peng ZHAO Wen-Jing QIAO Yan-Jiang ZHANG Jia-Yu | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 43 |
| 3 | Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase显示文摘目的: 调查 resveratrol (RSV ) 是否能改进非酒精的脂肝疾病(NAFLD ) 并且发现可能的 mechanism.Methods : 老鼠喂了一本高脂肪的食谱与 RSV.The 肝组织学被对待 observed.Hyperinsulinemic euglycemic clamp 被执行估计胰岛素敏感度。胖累积在 HepG2 细胞被导致,并且细胞与 激活RSV.AMP 的蛋白质激酶( AMPK )被对待磷酸化层次在动物学习和细胞 study.Results 两个都被决定:老鼠喂了一本高脂肪的食谱发达腹的肥胖, NAFLD ,和抗胰岛素性(红外),它显著地到 10 星期 RSV administration.RSV 处理被改进在与葡萄糖和胰岛素的高集中被孵化的 HepG2 细胞的阻止的 triacylglycerol ( TG )累积。在活体内和在试管内研究证明 RSV 处理能支持 AMPK 的磷酸化,它在这学习,压制了 2 脂肪的开始基因表情,贡献 NAFLD 和 IR.Conclusion 的改进:结果由减少 TG 累积和改善红外显示了那, RSV 能保护肝免受 AMPK 的 NAFLD.The 激活的伤害涉及 mechanism.RSV 为阻止或对待 NAFLD 和红外相关的新陈代谢的混乱有治疗学的潜力。 | Jing SHANG Lu-lu CHEN Fang-xi XIAO Hui SUN Hong-cheng DING Hu XIAO | 2008 | Acta Pharmacologica Sinica2008，29，6： | 32 |
| 4 | The roles of heterogeneous chemical processes in the formation of an air pollution complex and gray haze显示文摘Urban and regional air pollutions are characterized by high concentrations of secondary pollutants such as photo-oxidants (mainly ozone) and fine particulate matter,which are formed through chemical reactions of the primary pollutants emitted from various sources.The accumulation of these pollutants under stagnant meteorological conditions results in the formation of gray haze,reducing visibility and causing major impacts on human health and climate.In an air pollution complex,the coexistence of high concentrations of primary and secondary gaseous and particulate pollutants provides a large amount of reactants for heterogeneous reactions on the surface of fine particles;these reactions change the oxidizing capacity of the atmosphere,as well as chemical compositions along with the physicochemical and optical properties of particulate matter,thereby accelerating formation of the air pollution complex and gray haze.Using in situ technologies,such as diffuse reflectance infrared Fourier-transform spectroscopy and single-particle Raman spectroscopy,we systematically investigated the reaction kinetics and mechanisms of gaseous pollutants (i.e.,NO2,SO2,O3,and formaldehyde) on the surfaces of the major components of atmospheric particles such as CaCO3,kaolinite,montmorillonite,NaCl,sea salt,Al2O3,and TiO2.We found that the main reaction products were sulfate,nitrate,or formate,which can change the hygroscopicity and light extinction parameters of those particles significantly.By analyzing the reaction kinetics of these heterogeneous reactions,we identified synergetic mechanisms of the three ternary reaction systems,i.e.,NO2-particlesH2O,SO2-particles-O3,and organics/SO2-particles–UV illumination.These synergetic mechanisms can provide experimental and theoretical bases for understanding the feedback mechanisms and nonlinear processes in the formation of an air pollution complex and gray haze. | ZHU Tong,SHANG Jing & ZHAO DeFeng State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China | 2011 | Science China Chemistry2011，54，1： | 24 |
| 5 | Lithofacies palaeogeography of the Carboniferous and Permian in the Qinshui Basin, Shanxi Province, China显示文摘The Qinshui Basin in the southeastern Shanxi Province is an important area for coalbed methane(CBM) exploration and production in China, and recent exploration has revealed the presence of other unconventional types of gas such as shale gas and tight sandstone gas. The reservoirs for these unconventional types of gas in this basin are mainly the coals, mudstones, and sandstones of the Carboniferous and Permian; the reservoir thicknesses are controlled by the depositional environments and palaeogeography. This paper presents the results of sedimentological investigations based on data from outcrop and borehole sections, and basin-wide palaeogeographical maps of each formation were reconstructed on the basis of the contours of a variety of lithological parameters. The palaeogeographic units include the depositional environments of the fluvial channel, flood basin(lake), upper delta plain, lower delta plain, delta front, lagoon, tidal flat, barrier bar, and carbonate platform.The Benxi and Taiyuan Formations are composed mainly of limestones, bauxitic mudstones,siltstones, silty mudstones, sandstones, and economically exploitable coal seams, which were formed in delta, tidal flat, lagoon, and carbonate platform environments. The Shanxi Formation consists of sandstones, siltstones, mudstones, and coals; during the deposition of the formation, the northern part of the Qinshui Basin was occupied mainly by an upper delta plain environment, while the central and southern parts were mainly occupied by a lower delta plain environment and the southeastern part by a delta front environment. Thick coal zones occur in the central and southern parts, where the main depositional environment was a lower delta plain. The thick coal zones of the Taiyuan Formation evidently occur in the sandstone-rich belts, located mainly in the lower delta plain environment in the northern part of the basin and the barrier bar environments in the southeastern part of the basin. In contrast, the thick coal zones of the Shanxi Formation extend over the mudstone-rich belts, located in the areas of the lower delta plain environments of the central and southern parts of the Basin.The Xiashihezi, Shangshihezi, and Shiqianfeng Formations consist mainly of red mudstones with thick-interbedded sandstones. During the deposition of these formations, most areas of the basin were occupied by a fluvial channel, resulting in palaeogeographic units that include fluvial channel zones and flood basins. The fluvial channel deposits consist mainly of relatively-thick sandstones, which could have potential for exploration of tight sandstone gas. | Long-Yi Shao Zhi-Yu Yang Xiao-Xu Shang Zheng-Hui Xiao Shuai Wang Wen-Long Zhang Ming-Quan Zheng Jing Lu | 2015 | Journal of Palaeogeography2015，4，4： | 21 |
| 6 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 7 | Endometriosis Fertility Index for Predicting Pregnancy after Endometriosis Surgery显示文摘 | Xin Li Cheng Zeng Ying-Fang Zhou Hui-Xia Yang Jing Shang Sai-Nan Zhu Qing Xue | 2017 | Chinese Medical Journal2017，，16： | 15 |
| 8 | A meta-analytic review of ERCC1/MDR1 polymorphism and chemosensitivity to platinum in patients with advanced non-small cell lung cancer显示文摘 | WEI Hai-bo HU Jing SHANG Li-hua ZHANG Yun-yan LU Fei-fei WEI Min YU Yan | 2012 | Chinese Medical Journal2012，，16： | 14 |
| 9 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
| 10 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 11 | Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome显示文摘Background: Estradiol, as an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization embryo transfer (IVF-ET) cycles. The aim of this retrospective study was to evaluate the association between elevated serum estradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and IVF-ET pregnancy and birth outcomes. Methods: A total of 1771 infertile patients with their first fresh IVF-ET cycles were analyzed retrospectively between January 2011 and January 2016 in Peking University First Hospital. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels < 1000 pg/mL, n = 205), group 2 (serum E2 levels 1001-2000 pg/mL, n = 457), group 3 (serum E2 levels 2001-3000 pg/mL, n = 425), group 4 (serum E2 levels 3001-4000 pg/mL, n = 310), group 5 (serum E2 levels 4001- 5000 pg/mL, n = 237), and group 6 (serum E2 levels > 5000 pg/mL, n — 137). The retrieved oocyte and Mil oocyte numbers and implantation and clinical pregnancy rates of the groups were compared as the first objective of the study. For the 360 women with singleton births among all patients, the area under the corresponding receiver operating characteristic curve (ROC curve) was calculated to assess the predictive value of the E2 change for the probability of low birth weight (LBW) infants as the second objective. Results: The retrieved oocyte and Mil oocyte numbers and implantation and clinical pregnancy rates gradually increased from groups 1 to 5 but decreased in group 6. The parameters of group 1 were statistically worse than those of the other groups, from group 2 to group 6 (the number of retrieved oocytes, t = 13.096, t = 23.307, t = 23.086, t = 26.376, t = 19.636, P < 0.003;the number of retrieved Mil oocytes, t = 10.856, t = 20.868, t = 21.874, t = 23.374, t = 19.092, P < 0.003;the implantation rate,χ^2= 12.179,χ^2= 22.239,χ^2= 23.993,χ^2= 23.344,χ^2= 16.758, P < 0.003;the clinical pregnancy rate,χ^2= 16.415,χ^2= 28.074,χ^2= 35.387,χ^2= 37.025,χ^2= 24.590, P < 0.003). ROC analysis revealed that when a serum peak E2 of 3148 pg/mL was used to predict LBW. Conclusions: The results indicate that serum E2 levels have a concentration-dependent effect on clinical outcomes. The optimal range of the E2 level during a fresh IVF-ET cycle is 1000 to 3148 pg/mL. | Xin Li Cheng Zeng Jing Shang Sheng Wang Xue-Lian Gao Qing Xue | 2019 | Chinese Medical Journal2019，，10： | 12 |
| 12 | Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019显示文摘As a representative drug for the treatment of severe community-acquired pneumonia and sepsis,Xuebijing(XBJ)injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019(COVID-19),but its treatment mechanism for COVID-19 is still unclear.Therefore,this study aims to explore the potential mechanism of XBJ injection in the treatment of COVID-19 employing network pharmacology and molecular docking methods.The corresponding target genes of 45 main active ingredients in XBJ injection and COVID-19 were obtained by using multiple database retrieval and literature mining.102 overlapping targets of them were screened as the core targets for analysis.Then built the PPI network,TCM-compound-target-disease,and disease-target-pathway networks with the help of Cytoscape 3.6.1 software.After that,utilized DAVID to perform gene ontology(GO)function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to predict the action mechanism of overlapping targets.Finally,by applying molecular docking technology,all compounds were docked with COVID-193 CL protease(3 CLpro),spike protein(S protein),and angiotensin-converting enzyme II(ACE2).The results indicated that quercetin,luteolin,apigenin and other compounds in XBJ injection could affect TNF,MAPK1,IL6 and other overlapping targets.Meanwhile,anhydrosafflor yellow B(AHSYB),salvianolic acid B(SAB),and rutin could combine with COVID-19 crucial proteins,and then played the role of anti-inflammatory,antiviral and immune response to treat COVID-19.This study revealed the multiple active components,multiple targets,and multiple pathways of XBJ injection in the treatment of COVID-19,which provided a new perspective for the study of the mechanism of traditional Chinese medicine(TCM)in the treatment of COVID-19. | XING Yan HUA Ying-Rong SHANG Jing GE Wei-Hong LIAO Jun | 2020 | Chinese Journal of Natural Medicines2020，18，12： | 11 |
| 13 | Review of the fabrication and application of porous materials from silicon-rich industrial solid waste显示文摘Porous materials have promise as sound insulation, heat barrier, vibration attenuation, and catalysts. Most industrial solid wastes, such as tailings, coal gangue, and fly ash are rich in silicon. Additionally, a high silicon content waste is a potential raw material for the syn- thesis of silicon-based, multi-porous materials such as zeolites, mesoporous silica, glass-ceramics, and geopolymer foams. Representative sil- icon-rich industrial solid wastes (SRISWs) are the focus of this mini review of the processing and application of porous silicon materials with respect to the physical and chemical properties of the SRISW. The transformation methods of preparing porous materials from SRISWs are summarized, and their research status in micro-, meso-, and macro-scale porous materials are described. Possible problems in the application of SRISWs and in the preparation of functional porous materials are analyzed, and their development prospects are discussed. This review should provide a typical reference for the recycling and use of industrial solid wastes to develop sustainable “green materials.” | Chao Miao Lixing Liang Fan Zhang Shumei Chen Kaixuan Shang Jinlong Jiang Yi Zhang Jing Ouyang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 10 |
| 14 | Genome-Wide Analysis of the Sus Gene Family in Cotton显示文摘蔗糖 synthase (怀疑) 是在植物蔗糖新陈代谢的关键酶。在棉花,怀疑(EC 2.4.1.13 ) 是降级的主要的酶从种子上衣的韧皮部进口进棉花纤维的蔗糖。这研究示威了 Gossypium arboreum L. 的染色体, G。raimondii Ulbr,和 G。hirsutum L. ,包含了 8, 8,和 15 分别地怀疑基因。他们的结构的组织,种系发生的关系,和表示侧面被描绘。genomic 和编码序列的比较识别了哪个高度被保存在之间的多重 introns,数字和位置双并且 allotetraploid 棉花种类。大多数种系发生的 clades 从所有三种包含了序列,建议 tetraploid G 的 Sus 基因。hirsutum 它的双祖先源于那些。一个人怀疑组(怀疑我) 在棉花期间经历了扩大进化。表示分析显示大多数怀疑基因差别在各种各样的纸巾被表示并且在棉花纤维房间有发展依赖者表示侧面。一样的 orthologous 组的成员在所有三种有很类似的表示模式。这些结果提供新卓见进棉花的进化在纤维生长和开发期间怀疑基因家庭,和卓见进它的成员的生理的功能。 | Changsong Zou Cairui Lu Haihong Shang Xinrui Jing Hailiang Cheng Youping Zhang Guoli Song | 2013 | Journal of Integrative Plant Biology2013，55，7： | 10 |
| 15 | Clinical Significance of Pelvic Peritonization in Laparoscopic Dixon Surgery显示文摘 | Zi-Kuo Wang Jing Xu Cong-Cong Shang Yong-Jie Zhao Shuai Zhang | 2018 | Chinese Medical Journal2018，，3： | 9 |
| 16 | Tetrahydrobiopterin Protects against Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes显示文摘 | Zheng-Yi Zhang Yi Li Rui Li An-An Zhang Bo Shang Jing Yu Xiao-Dong Xie | 2016 | Chinese Medical Journal2016，，22： | 9 |
| 17 | Prevention and control of HIV/AIDS in China:lessons from the past three decades显示文摘In the past 37 years,human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)has undergone various major transmission routes in China,with the world most complex co-circulating HIV-1 subtypes,even the prevalence is still low.In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection,China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing,which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection.China has been providing free antiretroviral therapy(ART)since 2003,which covered>80%of the identified patients and achieved a viral suppression rate of 91%.To bend the curve of increasing the disease burden of HIV and finally end the epidemic,China should consider constraining HIV spread through sexual transmission,narrowing the gaps in identifying HIV cases,and the long-term effectiveness and safety of ART in the future. | Jun-Jie Xu Meng-Jie Han Yong-Jun Jiang Hai-Bo Ding Xi Li Xiao-Xu Han Fan Lv Qing-Feng Chen Zi-Ning Zhang Hua-Lu Cui Wen-Qing Geng Jing Zhang Qi Wang Jing Kang Xiao-Lin Li Hong Sun Ya-Jing Fu Ming-Hui An Qing-Hai Hu Zhen-Xing Chu Ying-Jie Liu Hong Shang | 2021 | Chinese Medical Journal2021，，23： | 9 |
| 18 | Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey显示文摘 | Yi Yang Jian-Feng Xie Kai-Jiang Yu Chen Yao Jian-Guo Li Xiang-Dong Guan Jing Yan Xiao-Chun Ma Yan Kang Cong-Shan Yang Xiao-Qing Yao Hong-Cai Shang Hai-Bo Qiu | 2016 | Chinese Medical Journal2016，，24： | 8 |
| 19 | Heterogeneous reaction of SO_2 on TiO_2 particles显示文摘The heterogeneous reaction of SO2 on TiO2 particles was studied using in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS).The influences of the oxygen concentration,relative humidity (RH),and ultraviolet (UV) light illumination (λ=365 nm) intensity on the reaction were investigated.The main product of the heterogeneous reaction of SO2 on TiO2 particles was sulfate with UV illumination and sulfite without it.The production of sulfate was promoted significantly with UV illumination or water,and there was a synergistic effect when both were present.In the dry system without UV,the heterogeneous reaction of SO2 on TiO2 particles was found to be second-order for SO2 and the initial uptake coefficient,BET,was determined to be 1.94 × 10-6.With UV and RH=40%,the reaction order was first-order and the initial uptake coefficient was 1.35 × 10-5. | SHANG Jing,LI Jia & ZHU Tong State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China | 2010 | Science China Chemistry2010，53，12： | 8 |
| 20 | Activation and coreceptor expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients显示文摘Background At the end of 2005, 650 000 people lived with human immunodeficiency virus type-1 (HIV-1) in China, of whom 75 000 were AIDS patients. Many AIDS patients received highly active antiretroviral therapy (HAART) supported by the “China CARES” program but the immune responses of HAART were seldom reported. This study investigated the effect of HAART on the activation and coreceptor expression of T lymphocytes in Chinese HIV/AIDS patients and evaluated its effect on immune reconstitution. Methods Seventeen HIV/AIDS patients were enrolled and three-color-flow cytometry was used to detect the activation of HLA-DR CD38 and the coreceptor CCR5, CXCR4 expression on T lymphocytes in whole blood samples taken from the patients before and after 3- or 6-month HAART. Results The activation percents of CD4+, CD8+ T lymphocytes were significantly higher before therapy than the normal controls (HLA-DR/CD4: 40.47±18.85 vs 11.54±4.10; CD38/CD4: 81.34±10.86 vs 53.34±11.44; HLA-DR/CD8: 63.94±12.71 vs 25.67±9.18; CD38/CD8: 86.56±11.41 vs 58.84±6.16, all P<0.01). After 6-month combined antiretroviral treatment, the activation of T lymphocytes in HIV/AIDS patients was significantly decreased (HLA-DR/CD4: 28.31±13.48; CD38/CD4: 69.88±12.64; HLA-DR/CD8: 46.56±18.64; CD38/CD8: 70.17±14.54, all P<0.01 compared with the pre-treatment values). Before the treatment, CCR5 expression on CD8+ T lymphocytes was up-regulated while CXCR4 expression on CD8+ T lymphocytes downregulated in HIV/AIDS patients compared with the normal controls (CD8/CCR5: 70.91±10.03 vs 52.70± 7.68; CD8/CXCR4: 24.14±11.08 vs 50.05±11.68, all P<0.01). After 6-month HAART, CCR5 expression on CD8+ T lymphocytes significantly decreased (56.35±12.96, P<0.01), while CXCR4 expression on CD8+ T lymphocytes increased (36.95±9.96, P<0.05) compared with the pre-treatment and the normal controls. A significant statistical relationship was observed between the expression of activation markers, CCR5 and the CD4+ T lymphocyte counts after HAART (P<0.05). Conclusions Reduced activation of T lymphocytes and a normalization of coreceptor expression were observed in Chinese HIV/AIDS patients after HAART. Immunity can be restored in HIV/AIDS patients receiving HAART. | ZHANG Zi-ning SHANG Hong JIANG Yong-jun LIU Jing DAI Di DIAO Ying-ying GENG Wen-qing JIN Xin WANG Ya-nan | 2006 | Chinese Medical Journal2006，，23： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员