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| 1 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Surveillance on the Immune Effectiveness of Quadrivalent and Trivalent Split Influenza Vaccines—Shenzhen City and Changzhou City,China,2018–2019显示文摘Summary What is already known about this topic?Vaccinations are the most effective way to prevent influenza virus infections and severe outcomes.Influenza vaccine effectiveness can vary by seasons.What is added by this report?This report monitors the antibody level among the population over time after administration of the quadrivalent or trivalent split influenza vaccine.What are the implications for public health practice?Real-time monitoring of serum antibody changes after vaccination provides important data for the development of reasonable and effective strategies for influenza prevention and control. | Liumei Shu Jie Zhang Xiang Huo Cong Chen Shisong Fang Kexin Zong Yuanyuan Guo Yingze Zhao Jun Zhang Changjun Bao Junjie Xia Fengcai Zhu Dayan Wang Guizhen Wu George F.Gao William J.Liu | 2020 | China CDC weekly2020，2，21： | 5 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | In vitro Study of Nucleostemin Gene as a Potential Therapeutic Target for Human Lung Carcinoma显示文摘Objective Nucleostemin (NS) is a GTP-conjugated protein located in the nucleoli of stem cells and some cancer cells,and maintains cell self-renewal.We aimed to evaluate NS as a potential target for lung carcinoma gene therapy by investigating NS gene expression and its effect on A549 cell proliferation.Methods NS mRNA and protein expression in A549,HepG2,SMMC-7721,HeLa,and U251 cells was analyzed by RT-PCR and western blotting following transfection of NS siRNAs and negative control siRNA (NC).The effect on cell proliferation was also analyzed by MTT assays.Results NS mRNA and protein were both expressed in A549 cells and four other tumor cell lines;the relative expression levels were similar in all five cell lines.The three pairs of NS siRNA,either transfected alone or cotransfected into A549 cells,could effectively inhibit the expression of NS mRNA and protein.Moreover,the interference ratio showed an obvious concentration-dependent relationship.NS siRNA treatment resulted in significant inhibition of A549 cell proliferation by 35.7%.Conclusion NS gene was not only highly expressed but also played an important role in A549 cell proliferation.Thus,targeting of NS may be a promising novel strategy for the treatment of lung carcinoma. | GAO Hong Xia GAO Xiu Feng WANG Guo Qing WANG En Shu HUANG Wei HUANG Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 4 |
| 6 | Ameliorating effects of Inonotus obliquus on high fat diet-induced obese rats显示文摘根据从的数据,将在在一年 2030 的世界上有 21.6 亿过重和 11.2 亿个肥胖的个人[1 ] ,它提起多重疾病的风险例如高血压,癌症的糖尿病,心血管的疾病,和几种类型[2,3 ] 。肥胖被看作新陈代谢的混乱,它被高精力吸入主要导致。在哺乳动物,过量精力首先在脂肪质的织物作为 triglyceride (TG ) 被存储。在过去的十年,调整 adipogenesis 的过程的众多的分子很好被记录了。Peroxisome 激活 proliferator 的受体(PPAR-) 为脂肪质的织物的累积被要求并且贡献肥胖[4 ] 。甾醇规章的元素绑定蛋白质(SREBP ) 作为激活胆固醇和丰满的酸合成的全部节目的抄写因素的一个家庭被识别了[5 ] 。Glyceraldehydes 3 磷酸盐 acyltransferase (GPAT ) 和 diacylglycerol acyltransferase (DGAT ) 广泛地在哺乳动物的纸巾被表示并且催化第一并且在 TG 合成的最后的步,分别地[6 ] 。因此,这些分子可以是为肥胖和类脂化合物新陈代谢的评估的大目标。最近,阳光等。[7 ] 证明了在糖尿病的老鼠的类脂化合物的浆液层次显著地与 Inonotus obliquus 的文化肉汤的干燥的事在 3 星期的治疗以后被减少。李和 Hyun [8 ] 证明水摘录从我。obliquus 减少了高脂肪的饮食的胖重量喂的肥胖的老鼠。因此,我们对什么进一步感兴趣,是怎么能我。obliquus 摘录影响类脂化合物新陈代谢并且什么是位于这反肥胖效果下面的可能的机制。在现在的学习,我们造了一个高脂肪的导致食谱的老鼠模型。 | Tao Wu Qingyu Shu Kai Yang Xiaoxian Xie Xia Wang Yangling Wang Anqi Guo Nate Y-uan Binggong Zhao Binbin Chi QiaobeiWu Zhengwei Fu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 7 | IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3显示文摘Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infectionand interferons (IFNs). It inhibits the entry and replication of many viruses, which are independent of receptorusage but dependent on processes that occur in endosomes. In this study, we demonstrate that IFITM3 playsimportant roles in regulating the RNA-virus-triggered production of IFN-β in a negative-feedback manner.Overexpression of IFITM3 inhibited Sendai virus-triggered induction of IFN-β, whereas knockdown of IFITM3 hadthe opposite effect. We also showed that IFITM3 was constitutively associated with IRF3 and regulated thehomeostasis of IRF3 by mediating the autophagic degradation of IRF3. These findings suggest a novel inhibitoryfunction of IFITM3 on the RNA-virus-triggered production of type I IFNs and cellular antiviral responses. | Li-Qun Jiang Tian Xia Yun-Hong Hu Ming-Shun Sun Shuang Yan Cao-Qi Lei Hong-Bing Shu Ji-Hua Guo Yu Liu | 2018 | Cellular & Molecular Immunology2018，15，9： | 4 |
| 8 | New determination of the position of the pulsar B0329+54 with Chinese VLBI network显示文摘We present the first successful CVN (Chinese VLBI Network) phase-referencing observation of the pulsar B0329+54 on October 16, 2008 in S band. A new background source, J0347+5557, 2.5° away from the pulsar was employed as a position reference, which is closer to the pulsar and better for the ‘nodding’ mode than that used in previous observations. The position by fitting image of the pulsar relative to the calibrator is accurately determined at the level of tens of μas, which is comparable with the present differential VLBI astrometric accuracy, proving that CVN will be a potential powerful tool for astrometry and astrophysics.PSR B0329+54, VLBI, CVN, phase | GUO Li1*, ZHENG XingWu2, ZHANG Bo1, WANG WeiHua1, ZHENG WeiMin1, SHU FengChun1, LI JinLing1, YU Yun1, HAO LongFei3, YUAN JianPing4 & XIA Bo1 1Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China 2Department of Astronomy, Nanjing University, Nanjing 210093, China 3Yunnan Astronomical Observatory, National Astronomical Observatory, Chinese Academy of Sciences, Kunming 650011, China 4Urumqi Astronomical Observatory, National Astronom | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，8： | 3 |
| 9 | Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer显示文摘Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity.Dendritic cell(DCs)vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality.Lung cancer is a lethal disease with the highest morbidity and mortality rate in the world.Despite the rapid development of targeted therapy and immune checkpoint inhibitors for lung cancer in recent years,their efficacy is still unsatisfactory overall.Therefore,there is an urgent unmet clinical need for lung cancer treatment.Here,we attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous DC vaccine and conducted a single-arm,2 medical centers,pilot study initiated by the investigator(ChiCTR-ONC 16009100,NCT02956551).The patients enrolled were patients with heavily treated metastatic lung cancer.Candidate neoantigens were derived from whole-exome sequencing and RNA sequencing of fresh biopsy tissues as well as bioinformatics analysis.A total of 12 patients were enrolled in this study.A total of 85 vaccine treatments were administered with a median value of 5 doses/person(range:3-14 doses/person).In total,12-30 peptide-based neoantigens were selected for each patient.AIl treatment-related adverse events were grade 1-2 and there were no delays in dosing due to toxic effects.The objective effectiveness rate was 25%;the disease control rate was 75%;the median progression-free survival was 5.5 months and the median overall survival was 7.9 months.This study provides new evidence for neoantigen vaccine therapy and new therapeutic opportunities for lung cancer treatment. | Zhenyu Ding Qing Li Rui Zhang Li Xie Yang shu Song Gao Peipei Wang Xiaoqing Su Yun Qin Yuelan Wang Juemin Fang Zhongzheng Zhu Xuyang Xia Guochao Wei Hui Wang Hong Qian Xianling Guo Zhibo Gao Yu Wang Yuquan Wei Qing Xu Heng Xu Li Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 3 |
| 10 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 11 | Prevalence of Tuberculosis among Close Contacts of Index Cases in 27 Universities in Beijing,China,2017-2018显示文摘The World Health Organization(WHO)launched the‘End TB Strategy’,which aims to reduce the mortality and incidence rate of tuberculosis(TB)by 95% and 90% by 2035,respectively,compared with the levels in 2015.To achieve these targets and milestones,the strategy set three pillars and 10 indicators,one of which is systematic screening of contacts and high-risk groups[1]. | ZHAO Fei ZHANG Zhi Guo MA Shu Bo YANG Zhen HE Yan Ping WANG Lu Qin OWITI Philip MA Chao LI Tao DU Xin ZHANG Can You CHENG Jun WANG Li Xia HE Guang Xue ZHANG Hui LI Ke Xin | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 12 | Detection of Multi-drug Resistant Acinetobacter Lwoffii Isolated from Soil of Mink Farm显示文摘There were 4 Acinetobacter lwoffii obtained from soil samples.The antimicrobial susceptibility of the strains to 16 antimicrobial agents was investigated using K-B method.Three isolates showed the multi-drug resistance.The presence of resistance genes and integrons was determined using PCR.The aadA 1,aac(3’)-IIc,aph(3’)-VII,aac(6’)-Ib,sul2,cat2,floR,and tet(K)genes were detected,respectively.Three class 1 integrons | SUN Na WEN Yong Jun ZHANG Shu Qin ZHU Hong Wei GUO Li WANG Feng Xue CHEN Qiang MA Hong Xia CHENG Shi Peng | 2016 | Biomedical and Environmental Sciences2016，29，7： | 2 |
| 13 | A Green Synthesis of 2-Ethylanthraquinone by Dehydration of 2-(4'-ethylbenzoyl) benzoic Acid over Solid Acid Catalysts显示文摘The dehydration of 2-(4′-ethylbenzoyl) benzoic acid (BE acid) to 2-ethylanthraquinone (2-EAQ) was investigated over solid acid catalysts. The results showed that H-beta zeolite catalyst modified by dilute HNO3 solution exhibited an excellent performance. In our study, the conversion of BE acid can reach 96.7%, and the selectivity to 2-EAQ is up to 99.6%. | Ren Shu XU Xin Wen GUO Gui Ru WANG Zhu Xia ZHANG | 2005 | Chinese Chemical Letters2005，16，12： | 1 |
| 14 | Determination of complexation capacity of trace metal-organic in natural water显示文摘1IntroductionThechemicalspeciationofheavymetalsintheaquaticenvironmenthasdetermininginfluenceontheirtransport,reactionsandbio... | Yang Yu ying Department of Chemistry, Inner Mongolia Teachers College for Nationalities, Tongliao 028000, China Wu Di, Hong Xia, Guo Bo shu Institute of Environmental Chemistry, Inner Mongolia Normal University, Huhhot 010022, China | 1999 | Journal of Environmental Sciences1999，11，1： | 1 |
| 15 | Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes显示文摘 | Bing Li Chao Gao Jian‐Sheng Diao Da‐Lei Wang Fei‐Fei Chu Yang Li Gang Wang Shu‐Zhong Guo Wei Xia | 2016 | Exp Dermatol2016，，2： | 1 |
| 16 | Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China显示文摘Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very limited.This study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in China.Methods In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h daily.The 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput sequence.Results Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in Guangzhou.Conclusion In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics. | DONG Shi Rui HAN Ya Jing WU Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei WANG Huan Yu GUO Shu JING Chun Xia YANG Guang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 1 |
| 17 | Relationship analysis between September precipitation in western China and 700 hPa wind field in East Asia显示文摘The regional wind index influencing September precipitation in western China has been defined using the 700 hPa u and v components of NCAR/NCEP reanalysis data of 1961 to 2006. There are three regional wind field indices: southwest, southeast, and north, and these indices reflect the change of East Asian monsoon. The relationship between the indices was studied, and results show that they not only have a close relationship, but also have independence. Moreover, there is an obvious relationship between the wind indices and the autumn in particular the September precipitation in western China. The effect of wind indices on rain occurrence is most different: the influenced area of the southwest wind index is larger than that of the southeast wind index, and the southwest wind index is a controlling factor on autumn precipitation in western China. The weakening of southwest wind is the main cause resulting in reduction of autumn precipitation on the east side of the Tibetan Plateau. | ShaoYong Chen Quan Xia JunTin Guo Shu Lin | 2011 | Research in Cold and Arid Regions2011，3，5： | 1 |
| 18 | Pressure control as an effective method to modulate aggregative growth of nanoparticles显示文摘Recent studies suggested that the interactions between particles can induce aggregative nucleation and growth processes beyond those predicted by the traditional LaMer model of nanoparticle formation,but their nucleation and growth processes are still unclear.Here,we report a simple way to control the interaction between nanoparticles by manipulating the oleylamine(OAm)adsorbed on the surface of the nanoparticles.The size distributions of Ag nanoparticles produced at different reaction pressures were monitored as evidence for aggregative growth.From these kinetic data,the aggregative nucleation rate(C)of primary Ag nanoparticles under a 0.01 MPa was demonstrated to be faster than that under atmospheric pressure.This leads to a higher uniformity of Ag nanoparticles in a shorter time(10 min)than that achievable with previous methods.Furthermore,Ag nanoparticles supported on TiO2 exhibited a remarkable performance in the catalytic reduction of 4-nitrophenol(4-NP).After 4 min,4-NP was completely reduced into4-aminophenol(4-AP). | Jian Xu Yuan Shu Qian Xia Yang-Long Guo Guo-Jun Zhou Wang-Cheng Zhan | 2021 | Rare Metals2021，40，7： | 0 |
| 19 | Interaction between N-phosphoryl-α-,β-and γ-amino acids and nucleosides显示文摘四不同的N-的反应( O , O ′-二异丙基) phosphoamino 酸( DIPP-aa )例如N-phosphoryl-l-α-丙氨酸(DIPP-l-α-翼),N-phosphoryl-d-α-丙氨酸(DIPP-d-α-翼),N-phosphoryl-β-丙氨酸(DIPP-β-翼)和N-phosphoryl-γ-氨基的丁酸(DIPP-γ-骆驼毛的织物),和四 nucleosides ,腺苷(A),海鸟粪正弦(G),胞苷(C)和 uridine (U),被电镀物品学习祈祷电离双人脚踏车质谱学( ESI-MS/MS )和 HPLC/ESI-MS 。DIPP-l- α - 翼和 DIPP-d- α - 翼生产了一样的 phosphorylated nucleosides, dinucleotides 和 phosphoroligopeptide。然而, DIPP- β - 翼和 DIPP- γ - 骆驼毛的织物没给相关产品。 | Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao | 2007 | Chinese Chemical Letters2007，18，8： | 0 |
| 20 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi 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Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics 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