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| 1 | Th22 cells are associated with hepatocellular carcinoma development and progression显示文摘Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma(HCC). The study aimed to determine the biological function of Th22 cells and its effector IL-22 in HCC patients.Methods: Forty-five HCC patients and 19 healthy controls were recruited and their peripheral blood was collected. The fresh HCC tissues, adjacent HCC tissues and ten normal liver tissues were also collected. Flow cytometry analysis was used to determine the frequencies of circulating Th22 cells and Th17 cells. Serum IL-22 levels were tested by enzyme-linked immunosorbent assay(ELISA). Immunohistochemical staining and real-time polymerase chain reaction(PCR) were used to detect IL-22 protein and mRNA in tissues specimens, respectively.Results: Circulating Th22 cells, Th17 cells and serum IL-22 levels were significantly elevated in HCC patients compared with those of healthy controls(P<0.001). Th22 cells were showed to be positively correlated with IL-22 in HCC patients(P<0.05), but not in healthy controls. No significant differences were found in HCC patients with HBeAg positivity or negativity in term of Th22 cells and serum IL-22 levels. The expression of IL-22 protein and mRNA was highest in HCC tissues, followed by adjacent HCC tissues and normal liver tissues. Furthermore, Th22 cells, serum IL-22 levels and IL-22 mRNA were elevated at stage III-IV compared with stage I-II of HCC(P<0.05).Conclusions: Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention. | Shanyu Qin Shijia Ma Xiaoli Huang Donghong Lu You Zhou Haixing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 25 |
| 2 | A New Critical Nitrogen Dilution Curve for Rice Nitrogen Status Diagnosis in Northeast China显示文摘In-season diagnosis of crop nitrogen(N) status is crucial for precision N management. Critical N(N_c) dilution curve and N nutrition index(NNI) have been proposed as effective methods to diagnose N status of different crops. The N_c dilution curves have been developed for indica rice in the tropical and temperate zones and japonica rice in the subtropical-temperate zone, but they have not been evaluated for short-season japonica rice in Northeast China. The objectives of this study were to evaluate the previously developed N_c dilution curves for rice in Northeast China and to develop a more suitable N_c dilution curve in this region. A total of17 N rate experiments were conducted in Sanjiang Plain, Heilongjiang Province in Northeast China from 2008 to 2013. The results indicated that none of the two previously developed N_c dilution curves was suitable to diagnose N status of the short-season japonica rice in Northeast China. A new N_c dilution curve was developed and can be described by the equation N_c = 27.7 W^(-0.34) if W ≥ 1 Mg dry matter(DM) ha^(-1) or N_c = 27.7 g kg^(-1) DM if W < 1 Mg DM ha^(-1), where W is the aboveground biomass. This new curve was lower than the previous curves. It was validated using a separate dataset, and it could discriminate non-N-limiting and N-limiting nutritional conditions. Additional studies are needed to further evaluate it for diagnosing N status of different rice cultivars in Northeast China and develop efficient non-destructive methods to estimate NNI for practical applications. | HUANG Shanyu MIAO Yuxin CAO Qiang YAO Yinkun ZHAO Guangming YU Weifeng SHEN Jianning YU Kang Georg BARETH | 2018 | Pedosphere2018，28，5： | 10 |
| 3 | Effects of Artificial Aging on Physiological Characteristics of Rice Seeds with Different Dormancy Characteristics显示文摘In this study,two indica varieties with different dormancy characteristics [4 K58( II-32 B dormant),4 K59( II-32 B) ] and their F2 seeds( C178,C179) obtained through hybridization with sterile line( II-32 A) were used as materials. Different aged seeds( 0,3,6 and 9 d) of these four varieties were acquired by artificial accelerated aging method. Effects of artificial aging on malondialdehyde( MDA) content and catalase( CAT),ascorbate peroxidase( APX),peroxidase( POD) and superoxide dismutase( SOD) activity were investigated. The results showed that with the prolongation of aging time,MDA contents of these four rice varieties increased significantly,while the activity of antioxidant enzymes decreased dramatically. Besides,MDA contents and SOD,CAT and APX activity of the two inbred lines were significantly lower than those of the hybrid varieties. In addition,the activity of antioxidant enzymes in 4 K58 and C178 was significantly lower than that in 4 K59 and C179,respectively. This study indicated that artificial aging treatment significantly inhibited the activity of antioxidant system in seeds,improved membrane lipid peroxidation degree,and thus aggravated the deterioration of seeds. In addition,it also suggested that rice seeds with dormant property were more intolerant to storage. | Dongdong CAO Shanyu CHEN Yutao HUANG Yebo QIN Guanhai RUAN | 2019 | Agricultural Biotechnology2019，8，1： | 5 |
| 4 | Identification of banana fusarium wilt using supervised classification algorithms with UAV-based multi-spectral imagery显示文摘The disease of banana Fusarium wilt currently threatens banana production areas all over the world.Rapid and large-area monitoring of Fusarium wilt disease is very important for the disease treatment and crop planting adjustments.The objective of this study was to evaluate the performance of supervised classification algorithms such as support vector machine(SVM),random forest(RF),and artificial neural network(ANN)algorithms to identify locations that were infested or not infested with Fusarium wilt.An unmanned aerial vehicle(UAV)equipped with a five-band multi-spectral sensor(blue,green,red,red-edge and near-infrared bands)was used to capture the multi-spectral imagery.A total of 139 ground sample-sites were surveyed to assess the occurrence of banana Fusarium wilt.The results showed that the SVM,RF,and ANN algorithms exhibited good performance for identifying and mapping banana Fusarium wilt disease in UAV-based multi-spectral imagery.The overall accuracies of the SVM,RF,and ANN were 91.4%,90.0%,and 91.1%,respectively for the pixel-based approach.The RF algorithm required significantly less training time than the SVM and ANN algorithms.The maps generated by the SVM,RF,and ANN algorithms showed the areas of occurrence of Fusarium wilt disease were in the range of 5.21-5.75 hm2,accounting for 36.3%-40.1%of the total planting area of bananas in the study area.The results also showed that the inclusion of the red-edge band resulted in an increase in the overall accuracy of 2.9%-3.0%.A simulation of the resolutions of satellite-based imagery(i.e.,0.5 m,1 m,2 m,and 5 m resolutions)showed that imagery with a spatial resolution higher than 2 m resulted in good identification accuracy of Fusarium wilt.The results of this study demonstrate that the RF classifier is well suited for the identification and mapping of banana Fusarium wilt disease from UAV-based remote sensing imagery.The results provide guidance for disease treatment and crop planting adjustments. | Huichun Ye Wenjiang Huang Shanyu Huang Bei Cui Yingying Dong Anting Guo Yu Ren Yu Jin | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 3 |
| 5 | Covert voice over internet protocol communications based on spatial model显示文摘This paper presents a new spatial steganography model for covert communications over voice over internet protocol(Vo IP), providing a solution to the issue of increasing the capacity of covert Vo IP channels without compromising the imperceptibility of the channels. Drawing from Orthogonal Modulation Theory in communications, the model introduced two concepts, orthogonal data hiding features and data hiding vectors, to covert Vo IP communications. By taking into account the variation characteristics of Vo IP audio streams in the time domain, a hiding vector negotiation mechanism was suggested to achieve dynamic self-adaptive steganography in media streams. Experimental results on Vo IP steganography show that the proposed steganographic method effectively depicted the spatial and temporal characteristics of Vo IP audio streams, and enhanced robustness against detection of steganalysis tools, thereby improving the security of covert Vo IP communications. | HUANG YongFeng TANG ShanYu | 2016 | Science China(Technological Sciences)2016，59，1： | 2 |
| 6 | Steganogra-phy in inactive frames of VoIP streams encoded by source codec显示文摘 | Huang Yongfeng Yuan Jian Tang Shanyu | 2011 | IEEE Transactions on Information Forensics and Security2011，6，2： | 1 |
| 7 | Active canopy sensor-based precision N management strategy for rice显示文摘 | Yinkun Yao Yuxin Miao Shanyu Huang Lei Gao Xiaobo Ma Guangming Zhao Rongfeng Jiang Xinping Chen Fusuo Zhang Kang Yu Martin Gnyp Georg Bareth Cheng Liu Liqin Zhao Wen Yang Huamin Zhu | 2012 | Agronomy for Sustainable Development2012，，4： | 1 |
| 8 | Low-voltage Electromagnetic Compaction of Powder Materials显示文摘 | Wu Yanchun Huang Shanyu Chang Zhihua | 2002 | J Wuhan Univ Tech-Mater Sci Ed2002，17，4： | 1 |
| 9 | Steganography in inactive frames of VoIP streams encoded by source codec显示文摘 | Huang Yongfeng Tang Shanyu Yuan Jian | 2011 | IEEE Trans on Information Forensics and Security2011，6，2： | 1 |
| 10 | Steganography integration into a low-bit rate speech codec显示文摘 | Huang Yongfeng Liu Chenghao Tang Shanyu | 2012 | IEEE Trans on Information Forensics and Security2012，7，6： | 1 |
| 11 | Hyperspectral canopy sensing of paddy rice aboveground biomass at different growth stages显示文摘 | Martin L. Gnyp Yuxin Miao Fei Yuan Susan L. Ustin Kang Yu Yinkun Yao Shanyu Huang Georg Bareth | 2014 | Field Crops Research2014，，： | 1 |
| 12 | Stegano-graphy in inactive frames of VoIP streams encoded by source codec 显示文摘 | Yong Feng Huang Shanyu Tang Jian Yuan | 2011 | IEEE Trans on Information Forensics and Securky2011，6，2： | 1 |
| 13 | HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19显示文摘Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a major pathological feature of Coronavirus Disease 2019(COVID-19)and a crucial determinant in COVID-19 prognosis.Understanding the mechanism underlying the SARS-CoV-2-induced cytokine storm is critical for COVID-19 control.Here,we identify that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α(HIF-1α)play key roles in the virus infection and pro-inflammatory responses. | Mingfu Tian Weiyong Liu Xiang Li Peiyi Zhao Muhammad Adnan Shereen Chengliang Zhu Shanyu Huang Siyu Liu Xiao Yu Miaomiao Yue Pan Pan Wenbiao Wang Yongkui Li Xulin Chen Kailang Wu Zhen Luo Qiwei Zhang Jianguo Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 14 | Steganography in inactive frames of VolP streams encoded by source codec 显示文摘 | Huang Yongfeng Tang Shanyu Yuan Jian | 2011 | IEEE Transactions on Information Forensics and Security2011，6，2： | 1 |
| 15 | Steganography in Inactive Frames of VoIP Streams Encoded by Source Codec显示文摘 | Huang Yongfeng Tang Shanyu Yuan Jian | | 0，，02： | 1 |
| 16 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 17 | Preparation of Mycobacterium smegmatis porin A (MspA) nanopores for single molecule sensing of nucleic acids显示文摘Mycobacterium smegmatis porin A(MspA),possessing a short(~0.6 nm)and narrow(~1.2 nm)constriction that enables its high spatial resolution of sensing,has emerged as an optimum choice for nanopore sequencing and nano-reactive sensing.However,prepared MspA nanopores cannot be obtained from any commercial vendors.We here provide a highly simplified protocol for MspA preparation.The protocol yields~10 mg fully oligomerized protein per liter of culture and is straightforward to follow.With the prepared MspA nanopores,discrimination of immobilized ssDNA oligonucleotides can be performed,which serves as a demo application to demonstrate core procedures of single molecule sensing using MspA.This method is also in principle compatible with all other MspA mutants,which might merit the need to develop a variety of MspA based nano-reactive sensors. | Yuqin Wang Pingping Fan Shanyu Zhang Shuanghong Yan Shuo Huang | 2021 | Biophysics Reports2021，7，5： | 0 |
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