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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury显示文摘Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor,and it may be neuroprotective against cerebral ischemia injury.However,the precise mechanisms of the effects of apelin-13 remain to be elucidated.To investigate the effects of apelin-13 on apoptosis and autophagy in models of cerebral ischemia/reperfusion injury,a rat model was established by middle cerebral artery occlusion.Apelin-13(50μg/kg)was injected into the right ventricle as a treatment.In addition,an SH-SY5Y cell model was established by oxygen-glucose deprivation/reperfusion,with cells first cultured in sugar-free medium with 95%N2 and 5%CO2 for 4 hours and then cultured in a normal environment with sugar-containing medium for 5 hours.This SH-SY5Y cell model was treated with 10-7 M apelin-13 for 5 hours.Results showed that apelin-13 protected against cerebral ischemia/reperfusion injury.Apelin-13 treatment alleviated neuronal apoptosis by increasing the ratio of Bcl-2/Bax and significantly decreasing cleaved caspase-3 expression.In addition,apelin-13 significantly inhibited excessive autophagy by regulating the expression of LC3B,p62,and Beclin1.Furthermore,the expression of Bcl-2 and the phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathway was markedly increased.Both LY294002(20μM)and rapamycin(500 nM),which are inhibitors of the PI3K/Akt/mTOR pathway,significantly attenuated the inhibition of autophagy and apoptosis caused by apelin-13.In conclusion,the findings of the present study suggest that Bcl-2 upregulation and mTOR signaling pathway activation lead to the inhibition of apoptosis and excessive autophagy.These effects are involved in apelin-13-induced neuroprotection against cerebral ischemia/reperfusion injury,both in vivo and in vitro.The study was approved by the Animal Ethical and Welfare Committee of Jining Medical University,China(approval No.2018-JS-001)in February 2018. | Zi-Qi Shao Shan-Shan Dou Jun-Ge Zhu Hui-Qing Wang Chun-Mei Wang Bao-Hua Cheng Bo Bai | 2021 | Neural Regeneration Research2021，16，6： | 35 |
| 3 | Network Pharmacology Evaluation Method Guidance-Draft显示文摘Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the document.Main drafting organizations:Tsinghua University,Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies(WFCMS). | Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan Yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang Hai-Yu Xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang Hai-Yang Yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 32 |
| 4 | Predictive factors improving survival after gastric and hepatic surgical treatment in gastric cancer patients with synchronous liver metastases显示文摘背景为有胃的癌症和同步的肝转移的病人的预后是很 poor.However ,标准治疗学的策略一直不是在为从胃的癌症遗体 controversial.Methods 的肝转移的肝的外科的治疗以后的临床的利益和预示的因素不管肝的外科的治疗经历了 gastrectomy 的 105 个病人记录的井 established.The 因为有在我们在 1995 和 2010 之间的中心的同步肝唯一的转移的胃的癌症 P 0.001 ) .However ,肝的外科的治疗不是为经历了 D1 lymphadenectomy 的病人的一个预示的因素(中部的幸存, 8 个 vs.8 月; P=0.495 ) .For 加肝的外科的治疗经历了 gastrectomy 的 35 个病人, D2 lymphadenectomy ( P 0.001 ),淋巴节点转移( P=-0.015 ),并且肝转移( H1 vs.H2 和 H3 )( P=-0.017 )的程度是独立重要预示的因素因为加肝的外科的治疗的 survival.Conclusions D2 lymphadenectomy 可以为 long-te | Liu Jing Li Jing-hui Zhai Ru-jun Wei Bo Shao Ming-zhe Chen Lin | 2012 | Chinese Medical Journal2012，，2： | 27 |
| 5 | Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach显示文摘瞄准:Nuciferine 是从莲花叶子提取的 aporphine 碱,它是在为重量损失的中国药用的植物的原料。在这研究,我们使用了一条网络药理学途径识别 nuciferine 和内在的 mechanisms.Methods 的反肿瘤活动:nuciferine 的药理学活动和机制通过目标侧面预言被识别,聚类用我们的繁体中文药(TCM ) 的分析和功能的丰富分析网络药理学站台。nuciferine 的反肿瘤活动被验证由在 vitro 并且在 vivo 实验。nuciferine 的反肿瘤机制通过网络目标分析被预言并且验证了由在 vitro experiments.Results:nuciferine 目标侧面与表明小径和生物功能被充实,包括 “脂肪分解酵素 activity” 的规定;, “对 nicotine” 的反应;并且 “房间 proliferation” 的规定;。目标侧面聚类结果建议了那 nuciferine 施加反肿瘤效果。在试验性的确认, nuciferine (0.8 mg/mL ) 显著地在 vitro 禁止了人的 neuroblastoma SY5Y 房间和老鼠 colorectal 癌症 CT26 房间的生存能力,并且 nuciferine (0.05 mg/mL ) 显著地在 vitro 压制了 6 根癌症房间线的侵略。nuciferine 的 Intraperitoneal 注射(9.5 mg/mL, ip,乘为 3 个星期的一个星期的 3 ) 显著地减少了在裸体老鼠的 SY5Y 和 CT26 肿瘤异种皮移植的重量。在 SY5Y 和 CT26 房间的网络目标分析和试验性的确认证明 nuciferine 的反肿瘤效果通过禁止在 SY5Y 和 CT26 cells.Conclusion 表明小径和 IL-1 层次的 PI3K-AKT 被调停:由使用一个 TCM 网络药理学方法, nuciferine 在 vitro 并且在 vivo 对人的 neuroblastoma 和老鼠 colorectal 癌症作为一个反肿瘤代理人被识别,通过禁止表明小径和 IL-1 层次的 PI3K-AKT。 | Quan QI Rui LI Hui-ying LI Yu-bing CAO Ming BAI Xiao-jing FAN Shu-yan WANG Bo ZHANG Shao LI | 2016 | Acta Pharmacologica Sinica2016，37，7： | 23 |
| 6 | Expert consensus on the use of human serum albumin in critically ill patients显示文摘Introduction Human serum albumin(HSA)is a non-glycosylated,negatively charged,single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD.It is synthesized by the liver at a rate of approximately 200 mg·kg^(-1)·day^(-1),with a half-life of 21 days,and subjected to catabolism in the muscles,liver,and kidneys at a rate of 4%per day.[1]Albumin,accounting for 60%of the total plasma protein,has various physiological functions,[2]such as maintaining 70%to 80%of effective plasma colloid osmotic pressure,coordinating vascular endothelial integrity,anti-oxidant and anti-inflammatory activities,maintaining the acidbase balance,and participating in the transport,distribution,and metabolism of a variety of endogenous and exogenous substances. | Yue-Tian Yu Jiao Liu Bo Hu Rui-Lan Wang Xiang-Hong Yang Xiu-Ling Shang Gang Wang Chang-Song Wang Bai-Ling Li Ye Gong Sheng Zhang Xin Li Lu Wang Min Shao Mei Meng Feng Zhu You Shang Qiang-Hong Xu Zhi-Xiong Wu De-Chang Chen | 2021 | Chinese Medical Journal2021，，14： | 22 |
| 7 | Ecosystem vulnerability of China under B2 climate scenario in the 21st century显示文摘This paper applies climate change scenarios in China based on the SRES assumptions with the help of RCMs projections by PRECIS (providing regional climates for impacts studies) system introduced to China from the Hadley Centre for Climate Prediction and Research at a high-resolution (50 km×50 km) over China. This research focuses on B2 scenario of SRES. A biogeochemical model 'Atmosphere Vegetation Integrated Model (AVIM2)' was applied to simulating ecosystem status in the 21st century. Then vulnerability of ecosystems was assessed based on a set of index of mainly net primary production (NPP) of vegetation. Results show that climate change would affect ecosystem of China severely and there would be a worse trend with the lapse of time. The regions where having vulnerable ecological background would have heavier impacts while some regions with better ecological background would also receive serious impacts. Extreme climate even would bring about worse impact on the ecosystems. Open shrub and desert steppe would be the two most affected types. When the extreme events happen, vulnerable ecosystem would extend to part of defoliate broad-leaved forest, woody grassland and evergreen conifer forest. Climate change would not always be negative. It could be of some benefit to cold region during the near-term. However, in view of mid-term to long-term negative impact on ecosystem vulnerability would be enormously. | WU ShaoHong DAI ErFu HUANG Mei SHAO XueMei LI ShuangCheng TAO Bo | 2007 | Chinese Science Bulletin2007，52，10： | 18 |
| 8 | Kinetics in Mg-based hydrogen storage materials:Enhancement and mechanism显示文摘Mg-based materials have been intensively studied for hydrogen storage applications due to their high energy density up to 2600 Wh/kg or 3700 Wh/L.However,the Mg-based materials with poor kinetics and the necessity for a high temperature to achieve 0.1 MPa hydrogen equilibrium pressure limit the applications in the onboard storage in Fuel cell vehicles(FCVs).Over the past decades,many methods have been applied to improve the hydriding/dehydriding(H/D)kinetics of Mg/MgH 2 by forming amorphous or nanosized particles,adding catalysts and employing external energy field,etc.However,which method is more effective and the intrinsic mechanism they work are widely differing versions.The hydrogenation and dehydrogenation behaviors of Mg-based alloys analyzing by kinetic models is an efficient way to reveal the H/D kinetic mechanism.However,some recently proposed models with physical meaning and simple analysis method are not known intimately by researchers.Therefore,this review focuses on the enhancement method of kinetics in Mg-based hydrogen storage materials and introduces the new kinetic models. | Qun Luo Jianding Li Bo Li Bin Liu Huaiyu Shao Qian Li | 2019 | Journal of Magnesium and Alloys2019，7，1： | 15 |
| 9 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 10 | Prophylaxis of chronic kidney disease after liver transplantation-experience from west China显示文摘AIM:To evaluate the prophylaxis of chronic kidney disease (CKD) after liver transplantation (LT) with low-dose calcineurin inhibitor (CNI) and mycophenolate mofetil (MMF).METHODS:From March 1999 to December 2009,a total of 572 patients (478 males and 94 females) underwent LT enrolled in the study.Initial immunosuppression was by triple-drug regimens that included a CNI,MMF,and prednisone.The initial dose of CNI was 0.05-0.10mg/kg per day for tacrolimus (TAC) and 5-10mg/kg per d for cyclosporine A (CSA) respectively,and was gradually reduced based on a stable graft function.The serum trough level of CNI was 6-8 ng/mL for TAC and 120-150 ng/mL for CSA 3-mo post-operation,4-6 ng/mL for TAC and 80-120 ng/mL for CSA 1-year after transplantation was expected with stable liver function.MMF was personalized between 1.0-1.5 g/d.Glomerular filtration rate (GFR) was estimated by an abbreviated Modification of Diet in Renal Disease formula.Risk factors of CKD were examined by univariate and multivariate logistic regression.RESULTS:With a definition of GFR<60 mL/min per 1.73 m 2,the incidence of CKD was 17.3% 5-year after LT.There were 68.3% (293 of 429 cases) patients managed to control their TAC trough concentrations within 8 ng/mL and 58.0% (83 of 143 cases) patients' CSA trough concentrations within 150 ng/mL.Of the 450 recipients followed-up over 1 year,55.5% (183 of 330 cases) of which were treated with TAC had a trough concentration ≤ 6 ng/mL while 65.8% (79 of 120 cases) of which were treated with CSA had a concentration ≤ 120 ng/mL.The incidence of CKD in the groups of lower CNI trough concentrations was significantly lower than the groups with CNI concentrations above the ideal range.Patients with CKD had much higher CNI trough concentrations than that of patients without CKD.MMF was adopted in 359 patients (62.8%).Patients administrated with MMF had a relatively low CNI trough concentrations but with no significant difference.The graft function remained stable during follow-up.No difference was found between different groups of CNI trough concentrations.Pre-LT renal dysfunction,ages,acute kidney injury,high blood trough concentrations of CNI in 3 mo (TAC>8 ng/mL,CSA>150 ng/mL) and hypertension after operation were associated with CKD progression,while male gender and adoption of MMF were protection factors.CONCLUSION:Low dose of CNI combined with MMF managed to prevent CKD after LT with stable graft function. | Zhen-Yong Shao Lu-Nan Yan Wen-Tao Wang Bo Li Tian-Fu Wen Jia-Yin Yang Ming-Qing Xu Ji-Chun Zhao Yong-Gang Wei | 2012 | World Journal of Gastroenterology2012，18，9： | 10 |
| 11 | Enhancement of strength and electrical conductivity for a dilute Al-Sc-Zr alloy via heat treatments and cold drawing显示文摘Developing heat-resistant conductors with high strength and high electrical conductivity is a key issue in the electrical conductor industries, as the ever-increasing power transmission poses higher requirement on the thermal stability of electrical conductor wires. Dilute Al-Sc-Zr alloys are considered as promising candidates due to the excellent heat resistance and high electrical conductivity, but the low strength always limits their application on electrical wires. Yet, few efforts on process design have been made in dilute Al-Sc-Zr alloys to enhance the strength. Here, various kinds of processing paths via combination of cold drawing, ageing and/or annealing were conducted to improve the strength and electrical conductivity of a dilute Al-Sc-Zr alloy. Results show that enhanced strength and electrical conductivity were obtained after cold drawing + ageing or pre-ageing + cold drawing + annealing treatments processes.Optimal properties(194 MPa in ultimate tensile strength and 61% IACS in electrical conductivity) were obtained through cold drawing followed by ageing. Microstructure evolution which affects strength and electrical conductivity was systematically investigated using TEM and 3 DAP. The enhanced strength was mainly attributed to the suitable interactions between strain strengthening and precipitation strengthening. The enhancement in electrical conductivity was caused by precipitation of solute atoms and recovery of defects. These results provide foundations for the processing design of Al-Sc-Zr conducting wires with good properties and push forward their potential application in heat resistant conductor industries. | Li Liu Jian-Tang Jiang Bo Zhang Wen-Zhu Shao Liang Zhen | 2019 | Journal of Materials Science & Technology2019，35，6： | 9 |
| 12 | Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism显示文摘瞄准:在房间的表示上探索雄激素受体(AR ) 的效果周期相关的基因例如 CDKN1A 和 BTG1,在前列腺癌症房间衬里 LNCaP。方法:在 AR 对手 flutamide 治疗和它由阶段对比显微镜和流动血细胞计数的效果的证实以后,房间的微分表示周期相关的基因被 cDNA 分析微数组。对待的房间作为控制作为试验性的组和 LNCaP 房间被设置的 flutamide。分别地,我们通过反向的抄写用 Cy5 和 Cy3 染料标记试验性的组和控制组的 cDNA 探针。然后我们 cDNA 与 cDNA 探查的 hybridized 微数组,它包含了 8 126 个唯一的人的 cDNA 序列和芯片被扫描在每个点上得到 Cy5 和 Cy3 的荧光灯的值。在主要分析以后,反向的抄写聚合酶链反应(RT-PCR ) 测试被执行证实薄片的结果。结果:在 AR 对手 flutamide 治疗以后, 326 基因(3.93%) 表示了差别, 97 下面调整并且 219 起来调整。在他们之中,八起来调整的基因可能是房间周期相关,也就是 CDC10, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKN1A 和 BTG2。CDKN1A 和 BTG1 基因 mRNA 表示被证实在由 RT-PCR 的试验性的组更高,当 p53 mRNA 表示没有重要变化时。结论:在前列腺癌症房间的 Flutamide 治疗力量起来调整 CDKN1A 和 BTG1 表示。CDKN1A 和 BTG1 的蛋白质表情在禁止癌症房间的增长起一个重要作用。CDKN1A 让一个伟人影响前列腺癌症房间的房间周期并且可以在一条 p53 独立的小径在癌症房间起一个作用。前列腺癌症房间可能影响由激活 AR 和 thus 的周期相关的基因打破的房间房间周期控制。 | Yong Wang Chen Shao Chang-Hong Shi Lei Zhang Hong-Hong Yue Peng-Fei Wang Bo Yang Yun-Tao Zhang Fan Liu Wei-Jun Qin He Wang Guo-Xing Shao | 2005 | Asian Journal of Andrology2005，7，4： | 9 |
| 13 | Serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China显示文摘INTRODUCTIONHepatitis G virus(HGV),also known as GB virus C,is arecently cloned virus which may be associated with humannon A-E hepatitis.It is parenterally transmitted andusually coinfected or superinfected with hepatitis B orhepatitis C virus.Some investigations have | De Ying Tian Dao Feng Yang Ning Shao Xia Zheng Gang Zhang Hong Bo Lei Yuan Cheng Huang | 2000 | World Journal of Gastroenterology2000，6，4： | 8 |
| 14 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 15 | Development and validation of an ocean wave retrieval algorithm for VV-polarization Sentinel-1 SAR data显示文摘The purpose is to study the accuracy of ocean wave parameters retrieved from C-band VV-polarization Sentinel-1Synthetic Aperture Radar(SAR) images, including both significant wave height(SWH) and mean wave period(MWP), which are both calculated from a SAR-derived wave spectrum. The wind direction from in situ buoys is used and then the wind speed is retrieved by using a new C-band geophysical model function(GMF) model,denoted as C-SARMOD. Continuously, an algorithm parameterized first-guess spectra method(PFSM) is employed to retrieve the SWH and the MWP by using the SAR-derived wind speed. Forty–five VV-polarization Sentinel-1 SAR images are collected, which cover the in situ buoys around US coastal waters. A total of 52 subscenes are selected from those images. The retrieval results are compared with the measurements from in situ buoys. The comparison performs good for a wind retrieval, showing a 1.6 m/s standard deviation(STD) of the wind speed, while a 0.54 m STD of the SWH and a 2.14 s STD of the MWP are exhibited with an acceptable error.Additional 50 images taken in China's seas were also implemented by using the algorithm PFSM, showing a 0.67 m STD of the SWH and a 2.21 s STD of the MWP compared with European Centre for Medium-range Weather Forecasts(ECMWF) reanalysis grids wave data. The results indicate that the algorithm PFSM works for the wave retrieval from VV-polarization Sentinel-1 SAR image through SAR-derived wind speed by using the new GMF C-SARMOD. | LIN Bo SHAO Weizeng LI Xiaofeng LI Huan DU Xiaoqing JI Qiyan CAI Lina | 2017 | Acta Oceanologica Sinica2017，36，7： | 7 |
| 16 | Real-time Microwave Exposure Induces Calcium Efflux in Primary Hippocampal Neurons and Primary Cardiomyocytes显示文摘Objective To detect the effects of microwave on calcium levels in primary hippocampal neurons and primary cardiomyocytes by the real-time microwave exposure combined with laser scanning confocal microscopy. Methods The primary hippocampal neurons and primary cardiomyocytes were cultured and labeled with probes, including Fluo-4 AM, Mag-Fluo-AM, and Rhod-2, to reflect the levels of whole calcium [Ca^(2+)], endoplasmic reticulum calcium [Ca^(2+)]ER, and mitochondrial calcium [Ca^(2+)]MIT, respectively. Then, the cells were exposed to a pulsed microwave of 2.856 GHz with specific absorption rate(SAR) values of 0, 4, and 40 W/kg for 6 min to observe the changes in calcium levels. Results The results showed that the 4 and 40 W/kg microwave radiation caused a significant decrease in the levels of [Ca^(2+)], [Ca^(2+)]ER, and [Ca^(2+)]MIT in primary hippocampal neurons. In the primary cardiomyocytes, only the 40 W/kg microwave radiation caused the decrease in the levels of [Ca^(2+)], [Ca^(2+)]ER, and [Ca^(2+)]MIT. Primary hippocampal neurons were more sensitive to microwave exposure than primary cardiomyocytes. The mitochondria were more sensitive to microwave exposure than the endoplasmic reticulum. Conclusion The calcium efflux was occurred during microwave exposure in primary hippocampal neurons and primary cardiomyocytes. Additionally, neurons and mitochondria were sensitive cells and organelle respectively. | WANG Hui ZHANG Jing HU Shao Hua TAN Sheng Zhi ZHANG Bo ZHOU Hong Mei PENG Rui Yun | 2018 | Biomedical and Environmental Sciences2018，31，8： | 7 |
| 17 | A User Differential Range Error Calculating Algorithm Based on Analytic Method显示文摘提高完整,有更少的执行时间的一个分析方法(AM ) 被建议计算微分范围错误(UDRE ) 由用户过去常检测潜在的风险的用户。位置推算历和钟修正计算方法首先被介绍。它证明计算 UDRE 的最重要的事情是在服务体积发现最糟的用户地点(WUL ) 。然后,用 AM 的一个 UDRE 算法被描述解决这个问题。由使用错误向量的协变性矩阵,寻找 WUL 被变换成一个分析几何学问题。WUL 的地点能被数学推导直接获得。实验被进行比较在建议 AM 算法和在主人车站使用的彻底的格子搜索(EGS ) 方法之间的表演。AM 算法的正确性能被 EGS 方法和 AM 算法证明的结果表演能在超过 90% 减少计算时间。这个建议算法的计算复杂性从而比 EGS. 的好这个算法对在主人车站计算 UDRE 更合适。 | SHAO Bo LIU Jiansheng ZHAO Ruibin HUANG Zhigang LI Rui | 2011 | Chinese Journal of Aeronautics2011，24，6： | 7 |
| 18 | Accumulation characteristic of protein bodies in different regions of wheat endosperm under drought stress显示文摘The structural characteristics of protein body accumulation in different endosperm regions of hard wheat cultivar(XM33) and soft wheat cultivar(NM13) under drought stress were investigated. Drought stress treatment was implemented from plant regreening to the caryopsis mature stage. Microscope images of endosperm cells were obtained using resin semithin slice technology to observe the distribution and relative area of protein body(PB). Compared with NM13, relative PB area of XM33 was significantly higher in sub-aleurone endosperm region. The amount of accumulation, including the size and relative area of PB, in two wheat cultivars was higher in sub-aleurone region than that in central region at 18 days post anthesis(DPA). Drought stress significantly enhanced the sizes and relative areas of PBs in the dorsal and abdominal endosperms in two wheat cultivars. Particularly for dorsal endosperm, drought stress enhanced the relative PB area at 18 DPA and NM13(5.0% vs. 6.73%) showed less enhancement than XM33(5.49% vs. 8.96%). However, NM13(9.58% vs. 12.02%) showed greater enhancement than XM33(10.25% vs. 11.7%) at 28 DPA. The protein content in the dorsal and abdominal endosperms of the two wheat cultivars decreased at 12 DPA and then increased until 38 DPA. Drought stress significantly increased the protein contents in the two main regions. From 12 to 38 DPA, the amount of PB accumulation and the protein content were higher in XM33 than those in NM13. The results revealed that PB distribution varied in different endosperm tissues and that the amount of PB accumulation was remarkably augmented by drought stress. | CHEN Xin-yu LI Bo SHAO Shan-shan WANG Lei-lei ZHU Xiao-wei YANG yang WANG Wen-jun YU Xu-run XIONG Fei | 2016 | Journal of Integrative Agriculture2016，15，12： | 6 |
| 19 | Inhibition of M2-like macrophages by all-trans retinoic acid prevents cancer initiation and sternness in osteosarcoma cells显示文摘Emerging evidence indicates that M2-polarized tumor-associated macrophages(TAMs)directly participate in tumor initiation,progression and metastasis.However,to date,few studies have investigated novel strategies for inhibiting TAMs in order to overcome osteosarcoma.In this study,we reported that M2 macrophages were enriched in osteosarcoma tissues from patients,and M2-polarized TAMs enhanced cancer initiation and sternness of osteosarcoma cells,thereby establishing M2-polarized TAMs as a therapeutic target for blocking osteosarcoma formation.We also found that all-trans retinoic acid(ATRA)weakened TAM-induced osteosarcoma tumor formation by inhibiting M2 polarization of TAMs in vivo,and inhibited the colony formation,as well as sphereformation capacity of osteosarcoma cells promoted by M2-type macrophages in vitro.Furthermore,M2-type macrophages enhanced cancer stem cells(CSCs)properties as assessed by increasing the numbers of CD117+Stro-1+cells accompanied by the upregulation of CSC markers(CD133,CXCR4,Nanog,and Oct4),which could clearly be reduced by ATRA.Taken together,the results of this study demonstrated the role of M2-polarized TAMs in osteosarcoma initiation and sternness by activating CSCs,and indicated that ATRA treatment is a promising approach for treating osteosarcoma by preventing M2 polarization of TAMs. | Xue-jing Shao Sen-feng Xiang Ying-qian Chen Ning Zhang Ji Cao Hong Zhu Bo Yang Qian Zhou Mei-dan Ying Qiao-jun He | 2019 | Acta Pharmacologica Sinica2019，40，10： | 6 |
| 20 | Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis显示文摘AIM:To test the therapeutic effects of delayed treatment of mesenchymal stem cells(MSCs) in recurrent experimental autoimmune uveitis(r EAU).METHODS: The efficacy of different regimens of MSC administration in r EAU were tested by evaluation of clinical and pathological intraocular inflammation,as well as retinal structural and functional integrity using optical coherence tomography(OCT) and electroretinogram(ERG).The retinal sections were also immunostained with antibodies to glial fibrillary acidic protein(GFAP)and rhodopsin(RHO). RESULTS: Delayed treatment of MSCs effectively alleviated the severity of intraocular inflammation with relative intact of outer retinal structure and function.Moreover,double therapies with longer interval led to an even better clinical evaluation,as well as a trend of decrease in relapse and amelioration of retinal function.MSC therapies also effectively reduced GFAP expression and increased RHO expression in the retina.CONCLUSION: MSC administration can effectively treat developed diseases of rEAU,and multiple therapies can provide additional therapeutic benefits. | Ping-Ting Zhao Ling-Jun Zhang Hui Shao Ling-Ling Bai Bo Yu Chang Su Li-Jie Dong Xun Liu Xiao-Rong Li Xiao-Min Zhang | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 5 |
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