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| 1 | Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer显示文摘在红外线附近(NIR ) photothermal 治疗在最近的年里很快速发展了。然而,它的临床的应用程序被许多实际问题妨碍,例如在在 vivo 的肿瘤,高激光力量密度和高 biotoxicity 的低累积。此处,用 ultrasmall Pd nanosheets (SPNS ) 为癌症治疗把化疗与 photothermal 治疗相结合的一个万用的系统被开发了。SPNS 能担任 pH 应答的药搬运人高效地交付纪录影片进癌症房间和肿瘤。在另一方面,在 SPNS 上的纪录影片的同等的装载在肿瘤织物提高它的累积。我们能高效地因此用低紧张的激光放射切除肿瘤。与 ultrasmall 尺寸(4.4 nm ) ,重要地,有减少的谷胱甘肽(GSH ) 的 SPNS surface-functionalized 能通过肾的系统从身体被清除进尿。这癌症治疗学的 nanosystem,展出重要 synergistic 效果和低全身的毒性,为临床的应用程序有大潜力。 | Shaoheng Tang Mei Chen Nanfeng Zheng | 2015 | Nano Research2015，8，1： | 14 |
| 2 | Effect of glutathione on in vivo biodistribution and clearance of surface-modified small Pd nanosheets显示文摘Plasmonic Pd nanosheets have been emerging as promising materials for application in near-infrared(NIR) photothermal therapy(PTT) of cancer. However, animal in mice studies indicated that the original synthesized poly(vinylpyrrolidone)(PVP)-protected small Pd nanosheets(Pd-PVP) and some further surface-modified small Pd nanosheets such as Pd-PEG(SH) easily accumulated in reticuloendothelial system(RES) organs(liver, spleen, etc.) and were difficult to be cleared from these organs quickly. In the work, we surprisingly found that glutathione(GSH) could promote the clearance of surface-modified small Pd nanosheets(e.g. Pd-PVP, Pd-PEG(SH) and Pd-GSH) from the RES organs efficiently. The effects of GSH on the biodistribution and clearance of different surface-modified Pd nanosheets were investigated. Our results indicated that these surface-modified Pd nanosheets with or without GSH added caused no morbidity at target primary organs, and GSH can promote the clearance of different surface-modified Pd nanosheets in the order of Pd-PVP≈Pd-PEG(SH)>Pd-GSH. This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems(RES). | Yizhuan Huang Xiaolan Chen Saige Shi Mei Chen Shaoheng Tang Shiguang Mo Jingping Wei Nanfeng Zheng | 2015 | Science China Chemistry2015，58，11： | 3 |
| 3 | Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles显示文摘在 nanomedicine 的主要临床的翻译挑战是在主要机关与举起和非可能减解的 nanoparticles (NP ) 的长期的保留联系的毒性的潜力。经历肾的清理的无机的 NP 的发展能潜在地解决这颗重要 biosafety 担心。然而,能被肾排泄的无机的 NP 是否仍然保持能够与差的渗透指向肿瘤,仍然保持不清楚。Glioblastoma multiforme,最恶意的 orthotopic 大脑肿瘤,因为血大脑障碍和反应 microglia 和 macroglia 的柔韧的血肿瘤障碍,在肿瘤微型环境为 NP 交货提出唯一的挑战。此处,我们使用了 orthotopic 调查在直径的 3 nm 的谷胱甘肽涂的金 nanoparticles (AuNPs ) 的被动指向的鼠科的 glioma 模型经历没能经历肾的清理的肾的清理和 18-nm AuNPs。显著地,我们报导 3-nm AuNPs 能与更高的效率指向 intracranial 肿瘤纸巾(2.3ver 在 1.0 妈骑车的 100 | Chuanqi Peng Xiaofei Gao Jing Xu Bujie Du Xuhui Ning Shaoheng Tang Robert M. Bachoo Mengxiao Yu Woo-Ping Ge Jie Zheng | 2017 | Nano Research2017，10，4： | 3 |
| 4 | Integrative genomic analyses on IL28RA, the common receptor of interferon-λ1,-λ2 and -λ3显示文摘 | Liming Yang Yuming Luo Jifu Wei Shaoheng He | 2010 | International Journal of Molecular Medicine2010，，5： | 1 |
| 5 | Growth and electron field emission of ZnO nanorods on diamond films显示文摘 | Dandan Sang Hongdong Li Shaoheng Cheng | 2011 | Applied Surface Science2011，，： | 1 |
| 6 | Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke显示文摘 | Hongao Zheng Yuening Liu Tian Huang Zheman Fang Guishuang Li Shaoheng He | 2009 | Toxicology Letters2009，，3： | 1 |
| 7 | Development and assessment of human adenovirus type Ⅱ as a gene transfer vector显示文摘 | Daniel Stone Shaoheng Ni Zong-Yi Li | 2005 | J Virol2005，79，8： | 1 |
| 8 | Epitaxial growth of ZnO nanorods on diamond and negative differential resistance of n-ZnO nanorod/p-diamond heterojunction显示文摘 | Hongdong Li Dandan Sang Shaoheng Cheng Jing Lu Xiuhua Zhai Lixue Chen Xiao-qiang Pei | 2013 | Applied Surface Science2013，，： | 1 |
| 9 | Freestanding palladium nanosheets with plasmonic and catalytic properties 显示文摘 | Xiaoqing Huang Shaoheng Tang Nanfeng Zheng | 2010 | Nnano2010，，： | 1 |
| 10 | Comments on robust stabilition of a class of time-delay nonlinear systems显示文摘 | Zhou Shaoheng Feng Gang Nguang S K | 2002 | IEEE Trans Automat Control2002，47，9： | 1 |
| 11 | Phenylpropanoid glycoside inhibition of pepsin, trypsin and α-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens显示文摘 | Xuli Wu WenPu Wang Tian Zhu Ting Liang FangQi Lu Weiyi He Haiping Zhang Zhigang Liu ShaoHeng He Kaiping Gao Zhendan He | 2013 | Food Research International2013，，2： | 1 |
| 12 | Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats显示文摘 | Zhang Shaoheng Guo Jingxuan Zhang Ping | 2004 | Life Sciences2004，74，23： | 1 |
| 13 | Synthesis of Novel Thiazoline Catalysts and Their Application in Michael Addition Reaction显示文摘 | WANG Hongyue WANG Ze LI Shaoheng QIU Yuntao LIU Bowen SONG Zhiguang LIU Zhihui | 2016 | Chemical Research in Chinese Universities2016，32，3： | 1 |
| 14 | Activation of Human Mast Cells: Modulation of Histamine Release by Tryptase and Inhibitors of Tryptase显示文摘 | Marianna D A Ga a | 1998 | J Pharmacol and Experi Therap1998，286，： | 1 |
| 15 | Increased heme oxygenase - 1 expression in infarcted rat hearts following human bone marrow mesenchymal cell transplantation 显示文摘 | Shaoheng Z Shun L Junbo G | 2005 | MICROVASC RES2005，69，： | 1 |
| 16 | BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression显示文摘 | Wei Ren Xiaoxiao Sun Ke Wang Honglei Feng Yuehong Liu Chang Fei Shaoheng Wan Wei Wang Jinyong Luo Qiong Shi Min Tang Guowei Zuo Yaguang Weng Tongchuan He Yan Zhang | 2014 | Molecular Biology Reports2014，，3： | 1 |
| 17 | MTHFR C677T polymorphism contributes to the risk for gastric cancer显示文摘 | Shushan Yan Donghua Xu Pingping Wang Ping Wang Chengcheng Liu Changjiang Hua Tao Jiang Bin Zhang Zengcai Li Lei Lu Xianzhong Liu Bingji Wang Donghua Zhang Rongsheng Zhang Shaoheng He Beicheng Sun Xuan Wang | 2014 | Tumor Biology2014，，3： | 1 |
| 18 | Madingneideyuyangongnengguanheyuyanjingjiyuanze马丁内的语言功能观和语言经济原则[AfunctionalviewandeconomicprinciplesoflanguagebyMartinet]显示文摘 | Zhou Shaoheng(周绍珩) | 1980 | 国外语言学1980，4，： | 1 |
| 19 | Induction of interleukin-6 release from monocytes by serine proteinases and its potential mechanisms 显示文摘 | Tao LI Haoyang WANG Shaoheng HE | 2006 | Scand J Immunol2006，64，1： | 1 |
| 20 | A method for 3D structured data sets regu-lation based on image显示文摘 | HE Tao LONG Pengcheng ZHOU Shaoheng | 2012 | Electrical Engineering2012，126，： | 1 |
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