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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction显示文摘 | Kai Qu Nai-ying Shen Xin-sen Xu Hai-bo Su Ji-chao Wei Ming-hui Tai Fan-di Meng Lei Zhou Yue-lang Zhang Chang Liu | 2013 | Acta Pharmacologica Sinica2013，34，9： | 11 |
| 3 | Effects of Cinnamon Acid on Respiratory Rate and Its Related Enzymes Activity in Roots of Seedlings of Malus hupehensis Rehd.显示文摘This paper studied the effects of cinnamon acid treatments on the respiratory rate and related enzymes activity in the seedling roots of Malus hupehensis Rehd.It would provide information for understanding the mechanisms of inhibition damage caused by continuous cultivation of apple tree.20 mL of solution containing different concentrations of cinnamon acid was added into container with the tested seedlings.After treatment,the samples were taken periodically and the respiratory rates were measured by OXY-LAB oxygen electrodes under 25°C stable temperature and then the activities of related enzymes were measured.The rates of total respiration and other 2 pathways [tricarboxylic acid cycle (TCA) and pentose phosphate pathway (PPP)] appeared initially an increasing treads and late (on the 3rd d) began to decline.However,they again appeared an increase trend at the end period,on the contrast,the respiratory rate of embden-meyer- hot-parnas (EMP) pathway appeared a stead decline tread but it had a recover on the last day.The respiratory rate of total and 3 pathways were decreased under 125 mg kg-1 (soil).The dynamic trends of the enzymes activities of pyrophosphate-dependent phosphofructokinase (PFK),glucose-6-phosphate dehydrogenase (G-6-PDH) and malate dehydrogenase (MDH) showed similarly.In conclusion,treatments of certain concentration of cinnamon acid would inhibit the respiratory rate and related enzymes activity of roots of M.hupehensis Rehd.And the inhibition degrees were positively related with concentration of cinnamon acid treatments. | GAO Xiang-bin,ZHAO Feng-xia,SHEN Xiang,HU Yan-li,HAO Yun-hong,YANG Shu-quan,SU Li-tao and MAO Zhi-quan State Key Laboratory of Crop Biology/College of Horticultural Science and Engineering,Shandong Agricultural University,Tai’an 271018,P.R.China | 2010 | Agricultural Sciences in China2010，9，6： | 9 |
| 4 | Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells:comparison of vasorelaxant effects of verapamil and phentolamine显示文摘Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of mitochondrial fission in smooth muscle cells was associated with arterial relaxation. Here, we used the typical vasorelaxants, verapamil and phentolamine, to further confirm the coupling between arterial constriction and mitochondrial fission in rat aorta. Results showed that phentolamine but not verapamil induced vasorelaxation in phenylephrine(PE)-induced rat thoracic aorta constriction. Verapamil, but not phentolamine, induced vasorelaxation in high K^+(KPSS)-induced rat thoracic aorta constriction. Pre-treatment with phentolamine prevented PEbut not KPSS-induced aorta constriction and pre-treatment with verapamil prevented both PE-and KPSSinduced aorta constriction. Transmission electron microscopy(TEM) results showed that verapamil but not phentolamine inhibited KPSS-induced excessive mitochondrial fission in aortic smooth muscle cells,and verapamil prevented both PE-and KPSS-induced excessive mitochondrial fission in aortic smoothmuscle cells. Verapamil inhibited KPSS-induced excessive mitochondrial fission in cultured vascular smooth muscle cells(A10). These results further demonstrate that arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells. | Jing Jin Xin Shen Yu Tai Shanliang Li Mingyu Liu Changlin Zhen Xiuchen Xuan Xiyue Zhang Nan Hu Xinzi Zhang Deli Dong | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 5 |
| 5 | ASICla contributes to the symptom of pain in a ra' model of chronic prostatitis显示文摘 | Song Fan Zong-Yao Hao Li Zhang Jun Zhou Yi-Fei Zhang Shen Tai Xian-Sheng Zhang Chao-Zhao Liang | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
| 6 | Monitoring Value of Multimodal Magnetic Resonance Imaging in Disease Progression of Amyotrophic Lateral Sclerosis: A Prospective Observational Study显示文摘Background: Ongoing efforts have been made to identify new neuroimaging markers to track amyotrophic lateral sclerosis (ALS) progression. This study aimed to explore the monitoring value of multimodal magnetic resonance imaging (MRI) in the disease progression of ALS. Methods: From September 2015 to March 2017, ten patients diagnosed with ALS in Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Multimodal MRI analyses, including gray matter (GM) volume measured by voxel-based morphometry;cerebral blood flow (CBF) evaluated by arterial spin labeling;functional connectivity, including low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), measured by resting-state functional MRI;and integrity of white-matter (WM) fiber tracts evaluated by diffusion tensor imaging, were performed in these patients. Comparisons of imaging metrics were made between baseline and follow-up using paired t-test. Results: In the longitudinal comparisons, the brain structure (GM volume of the right precentral gyri, left postcentral gyri, and right thalami) and perfusion (CBF of the bilateral temporal poles, left precentral gyri, postcentral gyri, and right middle temporal gyri) in both motor and extramotor areas at follow-up were impaired to different extents when compared with those at baseline (all P < 0.05, false discovery rate adjusted). Functional connectivity was increased in the motor areas (fALFF of the right precentral gyri and superior frontal gyri, and ReHo of right precentral gyri) and decreased in the extramotor areas (fALFF of the bilateral middle frontal gyri and ReHo of the right precuneus and cingulate gyri) (all P < 0.001, unadjusted). No significant changes were detected in terms of brain WM measures. Conclusion: Multimodal MRI could be used to monitor short-term brain changes in ALS patients. | Dong-Chao Shen Yin-Yan Xu Bo Hou Hong-Fei Tai Kang Zhang Shuang-Wu Liu Zhi-Li Wang Feng Feng Ming-Sheng Liu Li-Ying Cui | 2018 | Chinese Medical Journal2018，，24： | 4 |
| 7 | Alteration of oncogenic IGF-II gene methylation status associates with hepatocyte malignant transformation显示文摘Background: Oncogenic insulin-like growth factor-II(IGF-II) is overexpressed in hepatocellular carcinoma(HCC). The present study aimed to analyze the dynamic alteration of IGF-II CpG site methylation status and its molecular mechanism in HCC progression. Methods: IGF-II alterations were observed in rat hepatocarcinogenesis models induced by 2-acetylaminofluorene. Liver IGF-II expression was compared by immunohistochemistry or tissue IGF-II specific concentration(nmol/mg protein). Status of human IGF-II promoter 3(P3) or rat IGF-II P2 CpG site methylation was amplified by methylation-specific polymerase chain reaction(MSP). Serum IGF-II levels were quantitatively detected by an enzyme-linked immunosorbent assay. Results: The levels of hepatic IGF-II expression were significantly elevated in the HCC group( P < 0.001). The unmethylation rate of IGF-II P3 CpG sites was 100% in the HCC-, 52.5% in the paracancerous-, and none(0%) in the distal noncancerous-tissues. Abnormal IGF-II expression was related to differentiation degree, tumor invasion, and positive HBV-DNA(all P < 0.001), with a negative correlation between P3 methylation degree and IGF-II expression. There was a positive correlation between liver IGF-II specific concentration and circulating IGF-II level( r = 0.97, P < 0.001). Significantly negative correlation was found between IGF-II P2 CpG site methylation and circulating IGF-II( r s =-0.89, P < 0.001) or liver IGF-II level( r s =-0.84, P < 0.001). Conclusions: The increase of serum IGF-II and the alteration of oncogenic gene IGF-II methylation may be biomarkers for HCC diagnosis and DNA methylation may be the therapeutic target of HCC. | Bo-Jun Tai Min Yao Wen-Jie Zheng Yu-Cheng Shen Li Wang Jian-Ying Sun Meng-Na Wu Zhi-Zhen Dong Deng-Fu Yao | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 3 |
| 8 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 9 | Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury显示文摘在 somatostatin 类似物之中, octreotide (10 月) 是通常经由静脉内或下的注射在诊所过去常治疗生长荷尔蒙, gastrin 或胰岛素的增加的分泌物引起的各种各样的疾病的大多数。以便 assesse 开发 10 月的口头的明确的表达的可行性,我们在几个动物模型进行了 10 月的系统的 pharmacokinetic 和 pharmacodynamic 分析。在老鼠的 pharmacokinetic 研究证明 10 月的 intragastric 管理有极其低的 bioavailability (<0.5%) ,但是它能明确地在老鼠胃由于 somatostatin 受体 2 的高表示(SSTR2 ) 散布到胃的 mucosa。pharmacodynamic 研究表明 10 月的 intragastric 管理 dose-dependently 带着胃的溃疡,它比得上那些由 10 月的静脉内的注射完成了的导致 WIRS 的老鼠在老鼠免于胃的 mucosal 损害(GMI ) ,并且这效果被 CYN-154806 的合作管理显著地稀释, SSTR2 的一个对手。在幽门的导致结扎的溃疡老鼠,我们进一步证明那个 10 月显著地减少了胃的酸的分泌物经由下面调整 gastrin 的水平,它为对 GMI 的 10 月的保护的效果负责。总的来说,我们为最重要地开发10月的口头的明确的表达的可行性提供了 pharmacokinetic 和 pharmacodynamic 证据,10月的 pharmacokinetics 和药效学上的 SSTR2 的影响建议10月的口头的明确的表达可能为另外的临床的指示是适用的,在这些肿瘤房间上由于 SSTR2 的 overexpression 包括 neuroendocrine 瘤和垂体腺瘤。 | Xi-nuo LI Tai RAO Yang-fan XU Kang-rui HU Zhang-pei ZHU Hao-feng LI Dian KANG Yu-hao SHAO Bo-yu SHEN Xiao-xi YIN Lin XIE Guang-ji WANG Yan LIANG | 2018 | Acta Pharmacologica Sinica2018，39，8： | 3 |
| 10 | Transcriptome analysis of the influence of CPPU application for fruit setting on melon volatile content显示文摘In fruit production,the application of the plant growth regulator 1-(2-chloro-4-pyridyl)-3-phenylurea(CPPU)dulls the fruit aroma.Gas chromatography-mass spectrometry and transcriptome analyses were performed on CPPU-treated and pollinated fruits to determine how CPPU affects the production of aroma in melon fruit.The results showed that the contents of two important esters(benzyl acetate and phenethyl acetate)in the CPPU-treated fruits were significantly lower than those in the pollinated fruits.Transcriptome sequencing data revealed that most differentially expressed genes were involved in“phenylalanine metabolism”pathway,and their expression was significantly decreased in the CPPU-treated fruits.Further analysis showed that the phenylalanine content in the CPPU-treated fruits was significantly higher than that in the pollinated fruits.In summary,CPPU application interferes with phenylalanine metabolism in melon fruits and affects the production of aromatic esters. | CHENG Jin-tao CHEN Hai-wen DING Xiao-chen SHEN Tai PENG Zhao-wen KONG Qiu-sheng HUANG Yuan BIE Zhi-long | 2021 | Journal of Integrative Agriculture2021，20，12： | 2 |
| 11 | A review on computer vision systems in monitoring of poultry: A welfare perspective显示文摘Monitoring of poultry welfare-related bio-processes and bio-responses is vital in welfare assessment and management of welfare-related factors.With the current development in information technologies,computer vision has become a promising tool in the real-time automation of poultry monitoring systems due to its non-intrusive and non-invasive properties,and its ability to present a wide range of information.Hence,it can be applied to monitor several bio-processes and bio-responses.This review summarizes the current advances in poultrymonitoring techniques based on computer vision systems,i.e.,conventional machine learning-based and deep learning-based systems.A detailed presentation on the machine learning-based system was presented,i.e.,pre-processing,segmentation,feature extraction,feature selection,and dimension reduction,and modeling.Similarly,deep learning approaches in poultry monitoring were also presented.Lastly,the challenges and possible solutions presented by researches in poultry monitoring,such as variable illumination conditions,occlusion problems,and lack of augmented and labeled poultry datasets,were discussed. | Cedric Okinda Innocent Nyalala Tchalla Korohou Celestine Okinda Jintao Wang Tracy Achieng Patrick Wamalwa Tai Mang Mingxia Shen | 2020 | Artificial Intelligence in Agriculture2020，，1： | 2 |
| 12 | Plasticity of urinary bladder reflexesevoked by stimulation of pudendal afferent nerves after chronic spinalcord injury in cats显示文摘 | Tai C Chen M Shen B | 2011 | Exp Neurol2011，228，1： | 1 |
| 13 | Effects of Channel Width on Electrical Characteristics of Polysilicon TFTs with Multiple Nanowire Channels 显示文摘 | Wu Yung-Chun Chang Ting-Chang Liu Po-Tsun Chen Chi- Shen Tu Chun-Hao Zan Hsiao-Wen Tai Ya-Hsiang Chang Chun-Yen | 2005 | Electron Devices IEEE Transactions on2005，52，10： | 1 |
| 14 | Development of test bench of elec- tric power steering system for electric bus显示文摘 | Shen R W Tai X H Han J G | 2013 | Applied Mechanics and Materials2013，347，3： | 1 |
| 15 | Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma显示文摘 | YEH C T SHEN C H TAI D I | 2000 | Oncogene2000，19，46： | 1 |
| 16 | A multilevel perspective on the relationship between interpersonal justice and negative feedback‐seeking behaviour显示文摘 | Aichia Chuang Chun‐Yang Lee Chi‐Tai Shen | 2014 | Can J Adm Sci2014，，1： | 1 |
| 17 | Electrospun Ti()2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients 显示文摘 | Zhang N Deng Y Tai Q Cheng B Zhao L Shen Q He R Hong L Liu W Guo S | 2012 | Advanced Materials2012，24，20： | 1 |
| 18 | Intrathecal etanercept partially restores morphine's antinociception in morphine-tolerant rats via attenuation of the glutamatergic transmission 显示文摘 | Shen CH Tsai RY Tai YH | 2011 | Anesth Analg2011，113，1： | 1 |
| 19 | Detection of alkaline phosphatase by competitive indirect ELISA using immunoglobulin in yolk (IgY) specific against bovine milk alkaline phosphatase显示文摘 | CHAO-CHENG CHEN YU-CHANG TAI SZU- CHUAN SHEN | 2006 | Food Chemistry2006，95，2： | 1 |
| 20 | Efficient purification of native recombinant proteins using proteases immobilized on cellulose显示文摘 | Dongming Lan Yan Tai Yanfei Shen Fanghua Wang Bo Yang Yonghua Wang | 2011 | Journal of Bioscience and Bioengineering2011，，4： | 1 |
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