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| 1 | Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China显示文摘Objective This study was conducted to investigate the viral and bacterial etiology and epidemiology of patients with acute febrile respiratory syndrome(AFRS) in Qinghai using a commercial routine multiplex-ligation-nucleic acid amplification test(NAT)-based assay. Methods A total of 445 nasopharyngeal swabs specimens from patients with AFRS were analyzed using the RespiFinderSmart22 kit(PathoFinder BV, Netherlands) and the LightCycler 480 real-time PCR system. Results Among the 225(225/445, 51%) positive specimens, 329 positive pathogens were detected, including 298(90.58%) viruses and 31(9%) bacteria. The most commonly detected pathogens were influenza virus(IFV;37.39%;123/329), adenovirus(AdV;17.02%;56/329), human coronaviruses(HCoVs;10.94%;36/329), rhinovirus/enterovirus(RV/EV;10.03%;33/329), parainfluenza viruses(PIVs;8.51%;28/329), and Mycoplasma pneumoniae(M. pneu;8.51%;28/329), respectively. Among the co-infected cases(17.53%;78/445), IFV/AdV and IFV/M. pneu were the most common co-infections. Most of the respiratory viruses were detected in summer and fall. Conclusion In our study, IFV-A was the most common respiratory pathogen among 22 detected pathogens, followed by AdV, HCoV, RV/EV, PIV, and M. pneu. Bacteria appeared less frequently than viruses, and co-infection was the most common phenomenon among viral pathogens. Pathogens were distributed among different age groups and respiratory viruses were generally active in July, September, and November. Enhanced surveillance and early detection can be useful in the diagnosis, treatment, and prevention of AFRS, as well as for guiding the development of appropriate public health strategies. | LIU Gao Shan LI Hong ZHAO Sheng Cang LU Rou Jian NIU Pei Hua TAN Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，6： | 8 |
| 2 | Molecular Characterization of Human Respiratory Adenovirus Infection in Children from November 2016 to October 2017 in Xining City, China显示文摘Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4]. | YU Juan LI Hong LU Nan Nan LEI You Ju JIANG Shuang Ying ZHAO Sheng Cang RAO Hua Xiang | 2019 | Biomedical and Environmental Sciences2019，32，1： | 3 |
| 3 | Nitrous Oxide‐Oxygen Mixture During Burn Wound Dressing: A Double‐Blind Randomized Controlled Study显示文摘 | Yu‐Xiang Li Wen‐Jun Han Hong‐Tai Tang Yin‐Sheng Wu Lu Tang Jian‐Qiang Yu Yan‐Cang Li Zhao‐Fan Xia Ji‐Jun Zhao | 2013 | CNS Neurosci Ther2013，，： | 1 |
| 4 | Effect of Intraoperative Amino Acid Infusion on Blood Glucose under General Anesthesia Combined with Epidural Block显示文摘 | Zhong Jing Ge Sheng Jin Zhuang Xiao Feng Cang Jing Xue Zhang Gang | 2012 | Annals of Nutrition & Metabolism2012，，1： | 1 |
| 5 | The hospitals performance management, and effective human capital 显示文摘 | Zhang Bo Deng Shi-han Cang Sheng | 2008 | Chinese Medicine2008，5，32： | 1 |
| 6 | A Novel Method for Modification of SMPU by Micro-phase显示文摘A novel method of controlling the shape memory properties of shape memory polyurethane (SMPU) by addition of micro-phase separation promoters including 1-octadecanol (ODO) and liquid paraffin (LP) is reported. The results indicate that the strain recovery temperature and the strain modulus rate (Eg/Er) were increased significantly with addition of small amount of micro-phase separation promoters. Thus it can increase the shape memory fixity rate and other shape memory behaviors of SMPU. | Shao Jun CHEN Jing Cang SU Peng Sheng LIU | 2005 | Chinese Chemical Letters2005，16，9： | 1 |
| 7 | Damage Layer Evolution of a Breakwater Under Seawater Attack: Testing and Modeling显示文摘This paper presents experimental and theoretical methods to study the damage layer evolution of a breakwater made with concrete hollow squares in marine environment.Wetting time was directly related to the performance degradation of the breakwater by observation.The thickness of damage layer was detected by means of ultrasonic testing.Meanwhile,some samples drilled from concrete hollow squares were analyzed by SEM and XRD in order to illustrate the damage mechanism.Subsequently,a theoretical model containing wetting time ratio was established to simulate the damage layer evolution based on Fick’s second law,which could be suggested to predict the service life of concrete structures in marine environment. | Sheng Cang Yizhan Yang Jiankang Chen | 2020 | Acta Mechanica Solida Sinica2020，33，1： | 1 |
| 8 | DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation显示文摘Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) cancer.Methods: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published cohorts.Results: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P < 0.001), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and pan-cancer.Conclusions: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions. | Junya Yan Shibo Wang Jing Zhang Qiangqiang Yuan Xianchun Gao Nannan Zhang Yan Pan Haohao Zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao Zhang Abudurousuli Reyila Yu Qi Qiujin Zhang Shundong Cang Yuanyuan Lu Yanglin Pan Yan Kong Yongzhan Nie | 2024 | Cancer Biology & Medicine2024，21，3： | 0 |
| 9 | Lineage-specific evolution of flavin-containing monooxygenases involved in aliphatic glucosinolate side-chain modification显示文摘 | Wei Cang Yu-Xin Sheng Ejiroghene Ruona Evivie Wen-Wen Kong Jing Li | 2018 | Journal of Systematics and Evolution2018，56，2： | 0 |
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