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| 1 | Using Impervious Surfaces to Detect Urban Expansion in Beijing of China in 2000s显示文摘The change of impervious surface area(ISA) can effectively reveal the gradual process of urbanization and act as a key index for monitoring urban expansion. Experiencing rapid growth of the built environment in the 2000 s, urban expansion of Beijing has not been fully characterized through ISA. In this study, Landsat TM images of Beijing in 2001 and 2009 were obtained, and the eight-year urban expansion process in Beijing was analyzed using the ISA extracted by means of the vegetation-imperious surface-soil(V-I-S) model. From the spatial variation in ISA, the ring structure of urban expansion in Beijing was significant during the study period, with decreasing urban density from the city center to the periphery. In the ring road analysis, the most dramatic changes of ISA were found between the fifth ring and the sixth ring. This area has experienced the most new residential development, and is currently the main source of urban expansion. The typical profile lines revealed the directional characteristics of urban expansion. The east-west profile was the most urbanized axes in Beijing, while ISA change in the east-north profile was more significant than in the other five profiles. Moreover, the transition matrix of ISA levels revealed an increase in urban density in the low density built areas; the Moran′s I index showed a clear expansion of the central urban area, which spread contiguously; and the standard deviational ellipse indicated the northeast was the dominant direction of urban expansion. These findings can provide important spatial control guidelines in the next round of national economic and social development planning, overall urban and rural planning, and land use planning. | PENG Jian LIU Yanxu SHEN Hong XIE Pan HU Xiaoxu WANG Yanglin | 2016 | Chinese Geographical Science2016，26，2： | 11 |
| 2 | Research Progress on Evaluation Frameworks of Regional Ecological Sustainability显示文摘As natural ecosystems provide the material basis and fundamental support for regional sustainable devel-opment,the sustainability of natural ecosystems is an important prerequisite and a viable approach for the achievement of regional sustainable development.It is also the final criteria to assess whether sustainable development paradigm is successful.Along with the increasing impacts of human activities on natural ecosystems,the evaluation of regional ecological sustainability has become one of the key issues for research on macro ecology and sustainable development.Based on different unit of indicators,this study firstly groups the evaluation frameworks of regional ecological sus-tainability into three major types:comprehensive index evaluation with dimensionless unit,monetary valuation,and biophysical quantity measurement.We then discuss and compare these types in terms of basic principles,scope of ap-plications,advantages and shortcomings.Finally,drawn on the discussion about characteristics of ecological sustain-ability,we outline the current trend and future directions of regional ecological sustainability evaluation,for instance,transition from sustainable development evaluation to sustainability science,integration of goal-oriented and problem-solving approaches,combination of spatial pattern analysis and ecological sustainability evaluation,and en-hancement of ecological sustainability evaluation at landscape scale. | PENG Jian WANG Yanglin WU Jiansheng SHEN Hong PAN Yajing | 2011 | Chinese Geographical Science2011，21，4： | 9 |
| 3 | Analysis of risk factors associated with endoscopic retrograde cholangiopancreatography for patients with liver cirrhosis: a multicenter, retrospective, clinical study显示文摘Background:Endoscopic retrograde cholangiopancreatography(ERCP)is the endoscopic modality of choice for the treatment of biliary and pancreatic diseases.However,patients with cirrhosis,particularly those with decompensated cirrhosis,are believed to be at increased risk for complications associated with ERCP.There is a paucity of literature describing the outcomes of ERCP for patients with cirrhosis.This study aimed to investigate the outcomes of ERCP for cirrhosis patients,especially adverse events,and evaluated its safety and efficacy.Methods:We performed a multicenter,retrospective study of all patients at Beijing Friendship Hospital affiliated to Capital Medical University,Xijing Hospital affiliated to Air Force Military Medical University,Beijing Youan Hospital affiliated to Capital Medical University,and the Fifth Medical Center of the People’s Liberation Army General Hospital from June 2003 to August 2019.The adverse events of inpatient ERCP for patients with(n=182)and without liver cirrhosis(controls;n=385)were compared.Results:A total of 567 patients underwent ERCP between January 2003 and December 2019 were enrolled in this study.Compared to patients without cirrhosis,patients with cirrhosis were at higher risk for postoperative complications(odds ratio[OR],4.172;95%confidence interval[CI],1.232–7.031;P<0.001)such as postoperative pancreatitis(OR,2.026;95%CI,1.002–4.378;P=0.001)and cholangitis(OR,3.903;95%CI,1.001–10.038;P=0.036).The main indications for ERCP for patients with cirrhosis in this study included choledocholithiasis(101 cases;55.5%),benign bile duct strictures(46 cases;25.3%),and malignant bile duct strictures(28 cases;15.4%).Among them,23 patients(12.6%)underwent balloon dilation and 79 patients(43.4%)underwent sphincterotomy.Of the patients with cirrhosis,delayed bleeding occurred in ten patients(5.5%),postoperative pancreatitis occurred in 80 patients(44.0%),and postoperative cholangitis occurred in 25 patients(13.7%).An additional multivariate analysis showed that the total bilirubin(TBIL)level(OR,4.58;95%CI,2.37–6.70)and Child-Pugh score of C(OR,3.11;95%CI,1.04–5.37)were risk factors for postoperative complications in patients with cirrhosis.Conclusions:Compared with the general population of patients undergoing ERCP,patients with cirrhosis were more prone to postoperative pancreatitis and cholangitis.TBIL levels and Child-Pugh scores were risk factors for postoperative complications in patients with cirrhosis. | Jielin Li Jiexuan Hu Peng Li Yongdong Wu Yongjun Wang Ming Ji Haiyang Hua Wenbin Ran Yanglin Pan Shutian Zhang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 4 | MiR-206 inhibits gastric cancer proliferation in part by repressing CyclinD2显示文摘 | Lin Zhang Xiaodong Liu Haifeng Jin Xuegang Guo Limin Xia Zhangqian Chen Ming Bai Jian Liu Xin Shang Kaichun Wu Yanglin Pan Daiming Fan | 2013 | Cancer Letters2013，，1： | 1 |
| 5 | Phage display selection of peptides that inhibit metastasis ability of gastric cancer cells with high liver-metastatic potential显示文摘 | Shengjuan Hu Xinning Guo Huahong Xie Yulei Du Yanglin Pan Yongquan Shi Jun Wang Liu Hong Shuang Han Dongtao Zhang Dawei Huang Kedong Zhang Feihu Bai Haiping Jiang Huihong Zhai Yongzhan Nie Kaichun Wu Daiming Fan | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 1 |
| 6 | RhoC is essential for the metastasis of gastric cancer显示文摘 | Na Liu Guoyun Zhang Feng Bi Yanglin Pan Yan Xue Yongquan Shi Liping Yao Lina Zhao Yi Zheng Daiming Fan | 2007 | Journal of Molecular Medicine2007，，10： | 1 |
| 7 | Reversal of the maliguantphenotype of gastric cancer cells by inhibition of RhoA expression and activity显示文摘 | Liu Na Bi Feng Pan Yanglin | 2004 | Clin Cancer Res2004，18，1： | 1 |
| 8 | Hydrothermal Conversion of Cellulose to 5-Hydroxymethyl Furfural显示文摘 | Yin Sudong Pan Yanglin Tan Zhongchao | 2011 | International Journal of Green Energy2011，8，2： | 1 |
| 9 | Adenovirus-Mediated Vector of siRNA against VEGFR-2 (KDR) Induced Gene Silencing and Suppressed Tumor Cell Growth in Vitro and in Vivo显示文摘 | Dawei Huang Yanglin Pan Liu Hong Kaichun Wu Lijun Sun Yulei Du Liping Yao Daiming Fan | 2005 | Journal of US-China Medical Science2005，2，4： | 1 |
| 10 | Polysaccharide hemostatic system for hemostasis management in colorectal endoscopic mucosal resection显示文摘 | Rui Huang Yanglin Pan Na Hui Xuegang Guo Linhui Zhang Xiangping Wang Rongchun Zhang Hui Luo Xiong Zhou Qin Tao Zhiguo Liu Kaichun Wu | 2014 | Digestive Endoscopy2014，，1： | 1 |
| 11 | Expression of seven main Rho family members in gastric carcinoma显示文摘 | Yanglin Pan Feng Bi Na Liu Yan Xue Xuebiao Yao Yi Zheng Daiming Fan | 2004 | Biochemical and Biophysical Research Communications2004，，3： | 1 |
| 12 | RhoC is essential for the metastasis of gastric cancer显示文摘 | Na Liu Guoyun Zhang Feng Bi Yanglin Pan Yan Xue Yongquan Shi Liping Yao Lina Zhao Yi Zheng Daiming Fan | 2007 | Journal of Molecular Medicine2007，，10： | 1 |
| 13 | DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation显示文摘Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) cancer.Methods: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published cohorts.Results: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P < 0.001), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and pan-cancer.Conclusions: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions. | Junya Yan Shibo Wang Jing Zhang Qiangqiang Yuan Xianchun Gao Nannan Zhang Yan Pan Haohao Zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao Zhang Abudurousuli Reyila Yu Qi Qiujin Zhang Shundong Cang Yuanyuan Lu Yanglin Pan Yan Kong Yongzhan Nie | 2024 | Cancer Biology & Medicine2024，21，3： | 0 |
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