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| 1 | MiRNA-218, a new regulator of HMGB1, suppresses cell migration and invasion in non-small cell lung cancer显示文摘基因表示的否定管理者在癌症转移包含了的 MicroRNAs (miRNAs ) 功能。这研究的目的是在非小的房间肺癌症调查 miR-218 的潜在的角色并且验证它的规定机制。功能的研究证明 miR-218 overexpression 禁止了房间移植和侵略,但是没在房间生存能力上有效果。提高的绿色荧光灯蛋白质记者试金,即时聚合酶链反应和西方的污点分析证实 miR-218 由直接指向它的 3-untranslated 区域压制了高活动性组 box-1 (HMGB1 ) 的表示。因此,在房间移植和侵略上与 miR-218 的效果给予的 HMGB1 的 silencing,和 HMGB1 的 overexpression 能恢复被 miR-218 减少的房间移植和侵略。在结论,这些调查结果证明 miR-218 在肺癌症作为肿瘤 suppressor 工作。而且, miR-218 可以为变形的肺癌症病人充当潜在的治疗学的 biomarker。 | Cailian Zhang Shengli Ge Cailian Hu Ning Yang Jinran Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 14 |
| 2 | Holocene environmental change inferred from the loess–palaeosol sequences adjacent to the floodplain of the Yellow River, China显示文摘 | Chun Chang Huang Jiangli Pang Hongxia Su Shengli Li Benwei Ge | 2009 | Quaternary Science Reviews2009，，25： | 2 |
| 3 | Measuremnet of diffusion coefficient of heavy oil in fluidizcd catalylic cracking (FCC) catalysts显示文摘 | Liu Ziyuan Chen Shengli Ge Xiujun | 2010 | Energy & Fuels2010，24，5： | 1 |
| 4 | MAVS Regulates Apoptotic Cell Death by Decreasing K48-Linked Ubiquitination of Voltage-Dependent Anion Channel 1显示文摘 | Kai Guan Zirui Zheng Ting Song Xiang He Changzhi Xu Yanhong Zhang Shengli Ma Ying Wang Quanbin Xu Ye Cao Jia Li Xiaoli Yang Xiaoxing Ge Congwen Wei Hui Zhong | 2013 | Molecular and Cellular Biology2013，，16： | 1 |
| 5 | Effect of Temperature on the Properties and Microstructures of Carbon Refractories for Blast Furnace显示文摘 | Xilai Chen Yawei Li Yuanbing Li Shengli Jin Lei Zhao Shan Ge | 2009 | Metallurgical and Materials Transactions A2009，，7： | 1 |
| 6 | High phosphorylated cyclin-dependent kinase 2 expressionindicates poor prognosis of luminal androgen receptortriple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a highly aggressive breast cancer subtype characterized by a lack of estrogen receptorα(ER)and progesterone receptor(PR)expression and the absence of HER2 overexpression or amplification. | Zining Jin Qingfu Zhang Chunyu Wang Shengli Wang Lin Lin Renlong Zou Ge Sun Kai Zeng Baosheng Zhou Yuxin Tong Bo Chen Yue Zhao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 7 | Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19显示文摘COVID-19 remains a serious emerging global health problem,and little is known about the role of oropharynx commensal microbes in infection susceptibility and severity.Here,we present the oropharyngeal microbiota characteristics identified by shotgun metagenomic sequencing analyses of oropharynx swab specimens from 31 COVID-19 patients,29 influenza B patients,and 28 healthy controls.Our results revealed a distinct oropharyngeal microbiota composition in the COVID-19 patients,characterized by enrichment of opportunistic pathogens such as Veillonella and Megasphaera and depletion of Pseudopropionibacterium,Rothia,and Streptococcus.Based on the relative abundance of the oropharyngeal microbiome,we built a microbial classifier to distinguish COVID-19 patients from flu patients and healthy controls with an AUC of 0.889,in which Veillonella was identified as the most prominent biomarker for COVID-19 group.Several members of the genus Veillonella,especially Veillonella parvula which was highly enriched in the oropharynx of our COVID-19 patients,were also overrepresented in the BALF of COVID-19 patients,indicating that the oral cavity acts as a natural reservoir for pathogens to induce co-infections in the lungs of COVID-19 patients.We also found the increased ratios of Klebsiella sp.,Acinetobacter sp.,and Serratia sp.were correlated with both disease severity and elevated systemic inflammation markers(neutrophil-lymphocyte ratio,NLR),suggesting that these oropharynx microbiota alterations may impact COVID-19 severity by influencing the inflammatory response.Moreover,the oropharyngeal microbiome of COVID-19 patients exhibited a significant enrichment in amino acid metabolism and xenobiotic biodegradation and metabolism.In addition,all 26 drug classes of antimicrobial resistance genes were detected in the COVID-19 group,and were significantly enriched in critical cases.In conclusion,we found that oropharyngeal microbiota alterations and functional differences were associated with COVID-19 severity. | Shengli Ma Fan Zhang Fengxia Zhou Hui Li Wenyu Ge Rui Gan Huan Nie Biao Li Yindong Wang Meng Wu Duo Li Dongmei Wang Zheng Wang Yuhong You Zhiwei Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 0 |
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