|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Building an IPv6 address generation and traceback system with NIDTGA in Address Driven Network显示文摘In the design and construction process of Next Generation Internet, it is important to identify the source of each IP packet forwarding accurately, especially for the support of precise fine-grained management,control, traceability and improving the trustworthiness of the Internet. This paper designed a scalable Network Identity(NID) scheme for the Internet users, proposed NIDTGA(Network Identity and Time Generated Address), an IPv6 address generation algorithm embedded NID and time information, then designed and implemented an IPv6 address generation and traceback system based on NIDTGA. The design of NIDTGA, which reflects the length, time and owner attributes of the IP address, can be a good support to ADN(Address Driven Network). At the same time, by embedding the key elements of user identity and time in the IPv6 address,and by taking into account both the traceability and privacy, NIDTGA can provide a technical basis for the establishment of the network trust mechanism, and achieve the traceability of security event. | LIU Ying REN Gang WU JianPing ZHANG ShengLin HE Lin JIA YiHao | 2015 | Science China Chemistry2015，58，12： | 7 |
| 2 | Sustainable and invisible anti-counterfeiting inks based on waterborne polyurethane and upconversion nanoparticles for leather products显示文摘Counterfeit leather products infringe the intellectual property rights of the business,cause enormous economic loss,and negatively influence the business enthusiasm for innovation.However,traditional anti-counterfeiting materials for leather products suffer from complicated fabrication procedures,photobleaching,and high volatile organic com-pound(VOC)emissions.Here,a sustainable and invisible anti-counterfeiting ink composed of waterborne polyure-thane and water-dispersible lanthanide-doped upconversion nanoparticles(UCNPs)featuring ease of preparation,high photostability,non-toxicity,low VOC emissions,and strong adhesion strength for leather products is designed and synthesized.After decorating on the surface of leather products,the obtained patterns are invisible under normal light conditions.Upon irradiation at 808 nm,the invisible patterns can be observed by naked eyes due to the visible light emitted by 808 nm excited UCNPs.Our approach described here opens a new pathway to realize the long-term,stable anti-counterfeiting function of leather products. | Jun Xiang Jianxun Lin Zhonghui Wang Shenglin Zhou Zhenya Wang Qiang Yan Yidong Liu Haojun Fan | 2021 | Journal of Leather Science and Engineering2021，3，1： | 4 |
| 3 | In Situ Regeneration of Mo/MCM-22 with 1%O_2 at Reaction Temperature显示文摘 | BAI Jie, XIE Sujuan, LIU Shenglin, XU Longya, LIN Liwu (State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning, China) | 2003 | 催化学报2003，24，11： | 4 |
| 4 | HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway显示文摘Osteosarcoma is the most common primary malignant bone tumor,which occurs in adolescents.As reported by our previous studies,HER4 indicates a poor prognosis of primary osteosarcoma.However,its mechanisms in the pathogenesis of osteosarcoma have not yet been studied.The purpose of this study was to investigate the role of HER4 in osteosarcoma and whether the PI3K/AKT pathway is involved.In this study,western blot analysis was used to investigate the expression of HER4 protein in osteosarcoma tissues and cell lines.CCK8 and transwell assays were used to detect the effects of HER4 on the proliferation,migration,and invasion of osteosarcoma cells in vitro.The effects of HER4 on the growth and metastasis of osteosarcoma in vivo were detected by tumor formation and immunofluorescence in nude mice.The role of the PI3K/AKT pathway in HER4 regulation of the growth and metastasis of osteosarcoma was examined by western blot analysis and immunofluorescence assay.We found that HER4 protein was highly expressed in clinical osteosarcoma specimens and osteosarcoma cells.HER4 markedly promoted the proliferation,migration,and invasion of osteosarcoma cells in vitro as well as the growth and metastasis of osteosarcoma in vivo.HER4 overexpression upregulated the expression of phosphorylated protein kinase B(pAKT),proliferation marker antigen Ki67,and metastasis cell marker matrix metalloproteinase 9(MMP9).Notably,PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT,Ki67,and MMP9.Moreover,LY294002 markedly blocked the effects of HER4-induced upregulation of tum or malignancy.The present study suggests that HER4 may promote the growth and metastasis of osteosarcoma via the PI3K/AKT pathway.The HER4/PI3K/AKT pathway could serve as a potential target for the treatment of osteosarcoma. | Xiaodong Li Qingshan Huang Shenglin Wang Zhen Huang Fengqiang Yu Jianhua Lin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 3 |
| 5 | Shape Selectivity in Methane Dehydroaromatization Over Mo/MCM-22 Catalysts During a Lifetime Experiment显示文摘 | J. Bai Shenglin Liu Sujuan Xie Longya Xu Liwu Lin | 2003 | Catalysis Letters (-)2003，，3： | 1 |
| 6 | Reduction of biogenic amine accumulation in silver carp sausage by an amine- negative Lactobacillus plantarum 显示文摘 | Qilin Zhang Shenglin Lin Xiaohua Nie | 2013 | Food Control2013，32，2： | 1 |
| 7 | Typhoon effects on litterfall in a subtropical forest显示文摘 | Lin Kuochuan Steven P H Tang Shenglin | 2003 | Canadian Journal of Forest Research2003，33，11： | 1 |
| 8 | Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway显示文摘Osteosarcoma(OS),the most common malignant bone tumor with high metastatic potential,frequently affects children and adolescents.Epidermal growth factor receptor(EGFR)-targeted tyrosine kinase inhibitors exhibit encouraging anti-tumor activity for patients with solid tumors,whereas their effects on OS remain controversial.In the present study,we aimed to elucidate the anti-tumor activity of gefitinib for OS,as well as to explore the underlying mechanisms.Gefitinib inhibits cell viability,tumor growth,cell migration,and invasion and promotes cell apoptosis and G1 cycle arrest in OS at a relatively high concentration via suppressing the PI3K/Akt and ERK pathways.However,gefitinib treatment results in the feedback activation of signal transducer and activator of transcription 3(STAT3)induced by interleukin 6(IL-6)secretion.Combined treatment with gefitinib and stattic,an inhibitor for STAT3 phosphorylation,engenders more evident inhibitory effects on cell proliferation,migration,and invasion and promotive effects on cell apoptosis and G1 phase arrest in OS,compared with the single exposure to gefitinib or stattic.Western blot analysis demonstrates that stattic treatment in gefitinib-treated OS abrogates the IL-6-induced STAT3 activation and subsequently further restrains the activities of EGFR,Akt,and ERK pathways in tumor cells.This study confirms that the EGFR inhibitor of gefitinib has moderate anti-tumor effects on OS through IL-6 secretion-mediated STAT3 activation.Additional administration of stattic in EGFR-targeted therapies may contribute to improve the efficacy for OS. | Shenglin Wang Yunqing Wang Zhen Huang Hongxiang Wei Xinwen Wang Rongkai Shen Wenbin Lan Guangxian Zhong Jianhua Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 9 | Thermal property evaluation of a 2.5D integration method with device level microchannel direct cooling for a high-power GaN HEMT device显示文摘Gallium nitride high electron mobility transistor(GaN HEMT)devices have become critical components in the manufacturing of high-performance radio frequency(RF)or power electronic modules due to their superior characteristics,such as high electron saturation speeds and high power densities.However,the high heat characteristics of GaN HEMTs make device level cooling a critical problem to solve since performance degradation or even failure may occur under high temperatures.In this paper,we proposed a 2.5D integration method with devicelevel microchannel direct cooling for a high-power GaN HEMT device.To demonstrate this technological concept,a multigate GaN HEMT device featuring a gate length/width/source drain spacing of 0.5μm/300μm/6μm that underwent in-house backside thinning and metallization was used as the test vehicle.A high-resistivity silicon(HR Si)interposer embedded with four-layer microchannels was designed,having widths/pitches of 30μm/30μm at the top microchannel.The high-power GaN HEMT device was soldered on a Si interposer embedded with open microchannels for heat dissipation.A pair of GSG Pad chips was soldered simultaneously to display the capacity for the heterogeneous integration of other chip types.Thermal property evaluation was conducted with experiments and simulations.The test results showed that the maximum surface temperature of the GaN HEMT device decreased to 93.8°C when it experienced a heat dissipation density of 32 kW/cm^(2) in the gate finger area and an average heat dissipation density of 5 kW/cm^(2) was found in the active area with the DI water coolant at a flow rate of 3 mL/min.To our knowledge,among recently reported works,this finding was the best cooling capacity of heterogeneously integrated microchannels for GaN HEMT devices.In addition,this technology was scalable regarding the numbers of gate fingers or GaN HEMT devices. | Tingting Lian Yanming Xia Zhizheng Wang Xiaofeng Yang Zhiwei Fu Xin Kong Shuxun Lin Shenglin Ma | 2022 | Microsystems & Nanoengineering2022，8，6： | 0 |
| 10 | Epidermal growth factor receptor promotes tumor progression and contributes to gemcitabine resistance in osteosarcoma显示文摘Osteosarcoma(OS)is the most common type of primary malignant tumors that originate in the bone.Resistance to chemotherapy confers a poor prognosis on OS patients.Dysregulation of the epidermal growth factor receptor(EGFR)signaling has been reported in sarcomas.However,the functional contribution of EGFR hyperactivation to the tumor biology and chemoresistance remains largely unexplored in OS.In this study,we aimed to investigate the role of EGFR in OS progression and in the response of OS to gemcitabine treatment.The EGFR expression was found to be upregulated in fibroblastic OS cell lines.EGFR knockdown suppressed OS cell proliferation,migration,and invasion in vitro and tumor formation in vivo.Conversely,EGFR overexpression promoted the growth and motility of OS cells.In terms of mechanism,the levels of phospho-Akt and phospho-ERK were decreased upon EGFR knockdown but increased as a result of EGFR overexpression,implying a possible involvement of PI3K/Akt and ERK pathways in mediating the effects of EGFR on OS cells.Moreover,the level of phospho-EGFR was increased in OS cells when exposed to gemcitabine treatment.A more profound proliferative inhibition and a higher rate of apoptosis were obtained in OS cells via inducing cell cycle arrest at G1 phase upon gemcitabine treatment combined with EGFR knockdown,as compared to gemcitabine alone.On the contrary,EGFR overexpression counteracted the growth-inhibiting and pro-apoptotic effects of gemcitabine in OS cells.The present study suggests that EGFR promotes tumor progression and contributes to gemcitabine resistance in OS. | Shenglin Wang Hongxiang Wei Zhen Huang Xinwen Wang Rongkai Shen Zhaoyang Wu Jianhua Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 0 |
| 11 | Behavioral Differentiation between Anas poecilorhyncha and Domestic Duck显示文摘 | Shenglin Yang Lin Zhou Wei Lin Xiaomeng Li Man Lu Chenggang Liu | 2016 | Journal of Agricultural Science and Technology(A)2016，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员