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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Magnesium lithospermate B possesses inhibitory activity on Na^+,K^+-ATPase and neuroprotective effects against ischemic stroke显示文摘瞄准:如果镁 lithospermate B (MLB ) 从 Danshen 提取了,检验,鼠尾草植物 miltiorrhiza 的弄干的根,当为经由一样的分子的机制的这繁体中文植物的 cardiactherapeutic 效果负责的一个活跃部件触发了 bycardiac glycosides,可以行动,例如 ouabain 和异羟基洋地黄毒苷。而且,如果,我们想要测试 MLB 对 ischemic 的 provideneuroprotection 可以是为心脏的 glycosides 观察了摸。方法:在 MLB 和 ouabain 之间的类似 inthe 化学药品结构和分子的配置被分析。Na+ 上的 MLB 和 ouabain 的 Theinhibition 力量,一个商业产品的 K+-ATPase 活动,也, asin 从老鼠大脑和心纸巾净化了膜部分,被检验,对 ischemic 击的 MLB 的 compared.Neuroprotective 效果也用一个外皮的基于 brainslice 的试金模型被评估。结果:商业 Na+ 上的剂量依赖者抑制,为 ouabain 的到那的 K+-ATPaseequivalent 为 MLB 被观察近似由重量的半剂量。ouabain 和 MLB 的 Thisrelative 力量也在 Na+ 上为他们的抑制被观察,从老鼠纸巾净化的 K+-ATPase activityof 血浆膜,尽管这 2 个禁止者有点在这些粗略的摘录展出了 lowercompetence。在 ischemic 沙鼠大脑,与 MLB significantlyreduced 处理以后梗塞尺寸,由 2,3,5-triphenyltetrazolium 氯化物染色设想了, byapproximately 55% 什么时候与控制组相比。结论:这些结果显然 suggestthat Danshen 的心脏的治疗学的效果应该部分至少被归因于 Na+ ,由 MLB 的 K+-ATPase,和那 MLB 的 effectiveinhibition 在 gerbilssubjected 提供 anti-ischemic neuroprotection 给焦点的局部缺血和灌注。 | Jason TC TZEN Tzyy-rong JINN Yi-ching CHEN Feng-yin LI Fu-chou CHENG Li-shian SHI Hank KH SHE Balance CM CHEN Vic HSIEH Mu-lin TU | 2007 | Acta Pharmacologica Sinica2007，28，5： | 25 |
| 3 | Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020显示文摘On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of NCIP.These guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing. | Wenxiao Tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng | 2020 | China CDC weekly2020，2，6： | 15 |
| 4 | Electroacupuncture regulates the stress-injury-repair chain of events after cerebral ischemia/reperfusion injury显示文摘Inflammation after stroke is the main cause of cerebral ischemia/reperfusion injury. Cascading events after injury can lead to cell death. Heat shock protein 70 and other endogenous injury-signaling molecules are released by damaged cells, which can lead to systemic stress reactions. Protecting the brain through repair begins with the stress-injury-repair signaling chain. This study aimed to verify whether acupuncture acts through this chain to facilitate effective treatment of ischemic stroke. Rat models of cerebral ischemia/reperfusion injury were established by Zea Longa's method, and injury sites were identified by assessing neurological function, 2,3,5-triphenyltetrazolium chloride staining, and hematoxylin-eosin staining. Electroacupuncture at acupoints Baihui(DU20) and Zusanli(ST36) was performed in the model rats with dilatational waves, delivered for 20 minutes a day at 2–100 Hz and an amplitude of 2 m A. We analyzed the blood serum from the rats and found that inflammatory cytokines affected the levels of adrenotrophin and heat shock protein 70, each of which followed a similar bimodal curve. Specifically, electroacupuncture lowered the peak levels of adrenocorticotrophic hormone and heat shock protein 70. Thus, electroacupuncture was able to inhibit excessive stress, reduce inflammation, and promote the repair of neurons, which facilitated healing of ischemic stroke. | Peng Shi Lin-lin Sun Yi-shuo Lee Ya Tu | 2017 | Neural Regeneration Research2017，12，6： | 14 |
| 5 | Associations of Gonadotropin-Releasing Hormone Receptor (GnRHR) and Neuropeptide Y(NPY) Genes’Polymorphisms with Egg-Laying Traits in Wenchang Chicken显示文摘Single nucleotide polymorphisms(SNP)of chicken gonadotropin-releasing hormone receptor(GnRHR)and neuropeptide Y(NPY)were selected to identify the genotypes of Wenchang(Chinese indigenous breed)chicken with restricton fragment length polymorphisms.The associations of the SNPs with the total egg production(NE),average days of continual laying(ADCL),and number of double-yolked eggs(DYE)traits were analyzed.The frequency of restriction enzyme A/a alleles in the population was for GnRHR 0.69(Bpu1102ⅠA)and 0.31(Bpu1102Ⅰa)and for NPY 0.46(Dra ⅠB)and 0.54(DraⅠb).Trait data from a total of 120 hens,which were purebredintroduced from Hainan Province,China from one generation were recorded.Two significant effects of genes'marker were found:for GnRHR and number of eggs (dominant;t=2.67,df=116)and NPY and number of eggs(additive;t=1.97,df=116).The current research supports the effects of GnRHR and NPY genes on egg-laying traits of chickens. | WU Xu LI Hui-fang YAN Mei-jiao TANG Qing-ping CHEN Kuan-wei WANG Jin-yu GAO Yu- shi TU Yun-jie YU Ya-bo ZHU Wen-qi | 2007 | Agricultural Sciences in China2007，6，4： | 11 |
| 6 | A Fault Diagnosis Method of Power Systems Based on an Improved Adaptive Fuzzy Spiking Neural P Systems and PSO Algorithms显示文摘A new fault diagnosis method based on improved Adaptive fuzzy spiking neural P systems(in short,AFSN P systems) and Particle swarm optimization(PSO)algorithm is presented to improve the efficiency and accuracy of diagnosis for power systems in this paper. AFSN P systems are a novel kind of computing models with parallel computing and learning ability. Based on our previous works, this paper focuses on AFSN P systems inference algorithms and learning algorithms and builds the fault diagnosis model using improved AFSN P systems for diagnosing effectively. The process of diagnosis based on AFSN P systems is expressed by matrix successfully to improve the rate of diagnosis eminently. Furthermore, particle swarm optimization algorithm is introduced into the learning algorithm of AFSN P systems, thus the convergence speed of diagnosis has a big progress. An example of 4-node system is given to verify the effectiveness of this method. Compared with the existing methods, this method has faster diagnosis speed, higher accuracy and strong ability to adapt to the grid topology changes. | WANG Jun PENG Hong TU Min Perez-Jimenez J. Mario SHI Peng | 2016 | Chinese Journal of Electronics2016，25，2： | 10 |
| 7 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 8 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 9 | Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences显示文摘AIM:To evaluate the efficacy of centralized culture and possible influencing factors.METHODS:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(H.pylori) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal endoscopy.Gastric mucosal biopsies were taken from the antrum for culture.These biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 h.The culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 test.An additional 5736 biopsies from H.pylori-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory setting.RESULTS:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the H.pylori-positive quality control specimens.In the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport group.In contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P < 0.001).During transportation,the average natural temperature increased from 4.67 to 29.14℃,while the positive culture rate declined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter H.pylori samples. | Ya-Nan Gong You-Ming Li Ning-Min Yang Hong-Zhang Li Feng Guo Lang Lin Qun-Ying Wang Jia-Kun Zhang Zi-Zhong Ji Ji-Bo Mao Jun-Liang Mao Zheng-Chao Shi Wu-Heng Tang Xin-Jian Zhu Wei Shao Xiao-Feng Zhang Xing-Hua Wang Yue-Feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen Qiu-Long Ding Hong Ouyang Feng-Zhe Jin Yan-Li Xu Jian-Zhong Zhang | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 10 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 11 | Sm-Nd isotopic geochronologyof the Yinachang Fe-Cu-REE deposit at Wuding,Yunnan Province and its genetic significance显示文摘Sm-Nd isotope systematics of ores and fluorites places precise time constraints on REE mineralization of the Yinachang Fe-Cu-REE deposit in Yunnan Province which occur in the Proterozoic Kunyan group. The ore-related fluorites contain high abundant REE, and show a strong enrichment of LREE and a positive Eu anomaly, which is in marked contrast to post-ore fluorites that are HREE en-riched. The Sm-Nd isochron ages of the ores and fluorites are 1539±40 Ma and 1617±100 Ma, respectively, and calculated εNd(t) are ?4.6 and ?3.2. Accurate age determinations of the mineralization demonstrate that the REE mineralization took place during early Mesoproterozoic. Together with other geological evidence from the ore deposit, the primary REE-bearing ore-forming fluids are suggested to have been derived from the Enriched Mantle, and the Yinachang Fe-Cu-REE ore deposit is of volcanic exhalation- hydro-thermal sedimentary origin. This study also imply that the sudden large-scale REE mineralization in the Mesoprotero-zoic epoch may have been induced by alkaline-rich anoro-genic magmatism which occurred at marginal rifts of the continent in the Mesoproterozoic. | YANG Yaomin TU Guanzhi HU Ruizhong SHI Xuefa | 2005 | Chinese Science Bulletin2005，50，18： | 6 |
| 12 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 13 | Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats显示文摘Objective: To evaluate the effect of baicalin on subarachnoid hemorrhage(SAH) in rats and explore the potential mechanisms. Methods: Sprague-Dawley rats underwent experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 and 12 h of SAH. Neurological scores, brain water content, Evans-blue extravasation, and levels of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), myeloperoxidase(MPO), and malondialdehyde(MDA) were measured 24 h after SAH. Expression of nuclear factor erythroid-related factor 2(Nrf2), NAD(P)H: quinone oxidoreductase 1(NQO1), matrix metalloproteinase-9(MMP-9), aquaporin 4(AQP4), occludin, and zonulaoccludens-1(ZO-1) were detected in the brain by Western blot. Heme oxygenase-1(HO-1) was detected by quantitative polymerase chain reaction, and tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were assessed by enzyme-linked immunosorbent assay. Results: Baicalin attenuated EBI 24 h after SAH in rats(P<0.05). Baicalin elevated neurological scores, GSH-Px, SOD, and increased the expression of Nrf2, NQO1, HO-1, occludin, and ZO-1 in SAH rats(P<0.05 or P<0.01). Baicalin reduced MPO, MDA, and the expression of MMP-9, AQP4, TNF-α, and IL-1β(P<0.05 or P<0.01). Conclusion: Baicalin reduced SAH-induced EBI, partially via activation of the Nrf2/HO-1 pathway and inhibition of MMP-9 and AQP4. | ZHANG Hua-bin TU Xian-kun SONG Shi-wei LIANG Ri-sheng SHI Song-sheng | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 5 |
| 14 | Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis显示文摘BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP. | Bo Tu Yue-Ning Zhang Jing-Feng Bi Zhe Xu Peng Zhao Lei Shi Xin Zhang Guang Yang En-Qiang Qin | 2020 | World Journal of Gastroenterology2020，26，29： | 5 |
| 15 | Application of Adaptive Fuzzy Spiking Neural P Systems in Fault Diagnosis of Power Systems显示文摘Adaptive fuzzy spiking neural P systems(AFSN P systems) are a novel kind of computing models with parallel computing and learning ability. Based on our existing works, AFSN P systems are applied to deal with the fault diagnosis problems of power systems and the uncertainty of action messages about protective relays and breakers, and a new fault diagnosis model of power systems is proposed with simple reasoning process and fast speed with parallel processing capabilities. The effectiveness of the fault diagnosis model is verified by some examples of fault diagnosis. Furthermore, the learning ability of AFSN P systems can be applied to adjust the weights in the fault diagnosis model automatically. | TU Min WANG Jun PENG Hong SHI Peng | 2014 | Chinese Journal of Electronics2014，23，1： | 4 |
| 16 | Discrete energetic(~50-200 keV) electron events in the high-altitude cusp/polar cap/lobe显示文摘We identified 28 discrete electron events(DEEs) with enhanced fluxes at ~50-200 keV in the high-altitude cusp/polar cap/lobe,using the electron measurements by the BeiDa Image Electron Spectrometer(BD-IES) instrument onboard an inclined(55°)geosynchronous orbit(IGSO) satellite from October 2015 to January 2016. We find that among the 28 DEEs, 22 occur in the nightside and mostly in the northern cusp/polar cap/lobe, while 6 occur in the dayside and all in the southern cusp; 24 events correspond to an average interplanetary magnetic field(IMF) component B_z>0, 3 correspond to an average IMF B_z<0, and 1 has no OMNI IMF data. In these DEEs, the observed average omnidirectional electron differential flux generally fits well to a power-law spectrum, J^E^(-γ), with the spectral index y ranging from 2.6 to 4.6, while the average electron flux varies over three orders of magnitude from event to event. The spectral index of these cusp DEEs are(strongly) larger than the spectral index of solar wind superhalo electrons(radiation belt electrons) observed by the WIND 3 D Plasma & Energetic Particle instrument(the BD-IES). At^110 keV,the electron flux of DEEs in the cusp/polar cap/lobe shows a weak positive correlation with the solar wind superhalo electron flux but no obvious correlation with the radiation belt electron flux. These results suggest that these DEEs probably originate from transient processes acting on the solar wind superhalo electrons, e.g., the mid/high-latitude reconnection. | WANG LingHua ZONG QiuGang SHI QuanQi WANG YongFu TU ChuanYi HE JianSen TIAN Hui WIMMER-SCHWEINGRUBER Robert F. ZOU Hong | 2017 | Science China(Technological Sciences)2017，60，12： | 4 |
| 17 | Evaluation of acute kidney injury as defined by the risk, injury, failure, loss, and end-stage criteria in critically ill patients undergoing abdominal aortic aneurysm repair显示文摘 | YUE Jia-ning LUO Zhe GUO Da-qiao XU Xin CHEN Bin JIANG Jun-hao YANG Jue SHI Zhen-yu ZHU Ting JU Min-jie TU Guo-wei WANG Yu-qi ZHU Du-ming FU Wei-guo | 2013 | Chinese Medical Journal2013，，3： | 4 |
| 18 | Numerical study of three phase shifts and dual corrugation pitch modulated(CPM) DFB semiconductor lasers based on reconstruction equivalent chirp technology显示文摘A distributed feedback(DFB) semiconductor laser with three phase shifts based on reconstruction equivalent chirp(REC) technology is proposed and investigated numerically.With the combination of multiple phase shifts and corrugation pitch modulated(CPM) structure,we also propose a novel and more complex structure named dual CPM,which has a flatter light power distribution along the laser cavity compared with the true double phase shifts DFB laser diode(LD),while the P-I curves are nearly the same.The proposed dual CPM structure is also designed and analyzed based on REC technology.The simulation results show that,the DFB semiconductor laser with complex structure such as phase shifts,or even arbitrary variation of the grating period can be achieved equivalently and easily by changing the sampling structure.But its external characteristics are almost the same as those DFB lasers with true phase shifts,or true arbitrary variation of the grating period.The key advantage of the REC technology is that it varies only the sampling structure and keeps the seed grating(actual grating in sampling structure) period constant.So its fabrication needs only low-cost and standard holographic exposure technology.Therefore we believe this method can achieve the high-end and low-cost DFB LD for mass production. | SHI YueChun TU XingHua LI SiMin ZHOU YaTing JIA LingHui CHEN XiangFei | 2010 | Chinese Science Bulletin2010，55，35： | 4 |
| 19 | The long non-coding RNA expression profile of Coxsackievirus A16 infected RD cells identified by RNA-seq显示文摘Coxsackievirus A16(CVA16) is one of major pathogens of hand, foot and mouth disease(HFMD) in children. Long non-coding RNAs(Inc RNAs) have been implicated in various biological processes,but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the landscape of Inc RNAs of normal and CVA16 infected rhabdomyosarcoma(RD)cells using RNA-Seq to investigate the functional relevance of Inc RNAs. We showed that a total of 760 Inc RNAs were upregulated and 1210 Inc RNAs were downregulated. Out of these dysregulated Inc RNAs, 43.64% were intergenic, 22.31% were sense, 15.89% were intronic, 8.67% were bidirectional, 5.59% were antisense, 3.85% were s RNA host Inc RNAs and 0.05% were enhancer. Six dysregulated Inc RNAs were validated by quantitative PCR assays and the secondary structures of these Inc RNAs were projected. Moreover, we conducted a bioinformatics analysis of an Inc RNAs(ENST00000602478) to elucidate the diversity of modification and functions of Inc RNAs. In summary, the current study compared the dysregulated Inc RNAs profile upon CVA16 challenge and illustrated the intricate relationship between coding and Inc RNAs transcripts. These results may not only provide a complete picture of transcription in CVA16 infected cells but also provide novel molecular targets for treatments of HFMD. | Yingying Shi Huilin Tu Xiong Chen Yingying Zhang Liujun Chen Zhongchun Liu Jiqun Sheng Song Han Jun Yin Biwen Peng Xiaohua He Wanhong Liu | 2016 | Virologica Sinica2016，31，2： | 4 |
| 20 | Transurethral resection of the prostate is an independent risk factor for biochemical recurrence after radical prostatectomy for prostate cancer显示文摘Biochemical recurrence(BCR)is important for measuring the oncological outcomes of patients who undergo radical prostatectomy(RP).Whether transurethral resection of the prostate(TURP)has negative postoperative effects on oncological outcomes remains controversial.The primary aim of our retrospective study was to determine whether a history of TURP could affect the postoperative BCR rate.We retrospectively reviewed patients with prostate cancer(PCa)who had undergone RP between January 2009 and October 2017.Clinical data on age,prostate volume,serum prostate-specific antigen levels(PSA),biopsy Gleason score(GS),metastasis stage(TNM),D’Amico classification,and American Society of Anesthesiologists(ASA)classification were collected.Statistical analyses including Cox proportional hazard models and sensitivity analyses which included propensity score matching,were performed,and the inverse-probability-of-treatment-weighted estimator and standardized mortality ratio-weighted estimator were determined.We included 1083 patients,of which 118 had a history of TURP.Before matching,the non-TURP group differed from the TURP group with respect to GS(P=0.047),prostate volume(mean:45.19 vs 36.00 ml,P<0.001),and PSA level(mean:29.41 vs 15.11 ng ml?1,P=0.001).After adjusting for age,PSA level,T stage,N stage,M stage,and GS,the TURP group showed higher risk of BCR(hazard ratio[HR]:2.27,95%confidence interval[CI]:1.13–3.94,P=0.004).After matching(ratio 1:4),patients who underwent TURP were still more likely to develop BCR according to the adjusted propensity score(HR:2.00,95%CI:1.05–3.79,P=0.034).Among patients with PCa,those with a history of TURP were more likely to develop BCR after RP. | Kun Jin Shi Qiu Xin-Yang Liao Xiao-Nan Zheng Xiang Tu Lian-Sha Tang Lu Yang Qiang Wei | 2020 | Asian Journal of Andrology2020，22，2： | 4 |
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