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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | Protection against mammary tumor growth by vaccination with full- length,modified human ErbB-2 DNA显示文摘 | Wei WZ Shi WP Galy A | 1999 | Int J Cancer1999，81，5： | 1 |
| 3 | HLA-B*1502 screening and toxic effects of carbamazepine显示文摘 | LIAO WP SHI YW MIN FL | 2011 | N Engl J Med2011，365，7： | 1 |
| 4 | Evidence for circulating bone marrow-derived endothelial cells 显示文摘 | Shi Q Rafii S Hammond WP | 1998 | Blood1998，92，2： | 1 |
| 5 | The low molecular mass subunits of the photosynthetic supracomplex, photosystem II显示文摘 | Shi L X Schroder WP | 2004 | Biochim Biophys Acta2004，48，： | 1 |
| 6 | Identfieation of bla(KPC-2) on different plasmids of three Morganella morganii isolates显示文摘 | Shi DS Wang WP Kuai SG | 2011 | Eur J Clin Microbiol Infect Dis2011，31，5： | 1 |
| 7 | Simultaneously high prevalent es of hepatitis B and C vinls infections in a population in Putian county, China显示文摘 | Lu WP Lin GX Shi S el al | 2012 | J Clin Microbiol2012，50，6： | 1 |
| 8 | Tubular stomach or whole stomach for esophagectomy through cervico-thoraco-abdominal approach: A com- parative clinical study on anastomotic leakage 显示文摘 | Shu YS Sun C Shi WP | 2013 | Ir J Med Sci2013，182，3： | 1 |
| 9 | Selection of fixa-tion devices in proximal femur rotational osteotomy:Clinical complications and finite element analysis显示文摘 | Chen WP Tai CL Shi CH | | 0，，03： | 1 |
| 10 | Association between HLA-B * 1502 allele and cutaneous reactions induced by carbamazepine or lamotrigine in Han Chinese 显示文摘 | Liao WP Shi YW Cheng SH | 2009 | Epilepsia2009，50，2： | 1 |
| 11 | Identification of bla (KPC-2) on different plasmids of three Morganella morganii isolates 显示文摘 | Shi DS Wang WP Kuai SG | 2011 | Eur J Clin Microbiol Infect Dis2011，31，5： | 1 |
| 12 | Tubular stomach or whole stomach for esophagectomy through cervico-thoraco-ahdominal approach : a compar- ative clinical study on anastomotic leakage显示文摘 | Shu YS Sun C Shi WP | 2013 | Ir J Med Sci2013，182，3： | 1 |
| 13 | Influence of stimulus frequency, temperature and Ca2+ on onset of toosendanin paralysis of isolated neuromuscular preparations of rats显示文摘 | Shi YL Yang YQ Wang WP Xu K | 1981 | Acta Physiol Sin(生理学报)1981，33，2： | 1 |
| 14 | A new and improved population-based Canadian reference for birth weight for gestational age显示文摘 | Michael SK RObert WP Shi WW | 2001 | Pediatrics2001，108，2： | 1 |
| 15 | The comparition of bio logical characteristics and multilineage differentiation of bone marrow and adipose derived Mesenchymal stem cells显示文摘 | Zhu XS Shi W Tai WP | 2012 | Cell Tissue Res2012，350，2： | 1 |
| 16 | Partial epilepsy with febrile seizure plus:a subtype of GEFS+ or SME显示文摘 | Liao WP Shi YW Li T | 2007 | Neurol Asia2007，12，1： | 1 |
| 17 | Oxalate accumulation and regulation is independent of glycolate oxidase in rice leaves显示文摘 | Xu HW Ji XM He ZH Shi WP Zhu GH Niu JK Li BS Peng XX | | 0，，： | 1 |
| 18 | Cilostazol, a phosphodiesterase 3 inhibitor, protects mice against acute and late ischemic brain injuries 显示文摘 | Ye YL Shi WZ Zhang WP | 2007 | Eur J Pharmacol2007，557，1： | 1 |
| 19 | Tubular stomach or whole stomach for esophagectomy through cervico-thoraco-abdominal approach: a comparative clinical study on anastomotic leakage 显示文摘 | Shu YS Sun C Shi WP | 2013 | Ir J Med Sci2013，182，3： | 1 |
| 20 | Protection against mmranary tumor growth by vaccination with full- length, modified human ErbB-2 DNA显示文摘 | Wei WZ Shi WP Galy A | 1999 | Int J Cancer1999，81，5： | 1 |
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