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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | A Convection-Allowing Ensemble Forecast Based on the Breeding Growth Mode and Associated Optimization of Precipitation Forecast显示文摘A convection-allowing ensemble forecast experiment on a squall line was conducted based on the breeding growth mode(BGM). Meanwhile, the probability matched mean(PMM) and neighborhood ensemble probability(NEP)methods were used to optimize the associated precipitation forecast. The ensemble forecast predicted the precipitation tendency accurately, which was closer to the observation than in the control forecast. For heavy rainfall, the precipitation center produced by the ensemble forecast was also better. The Fractions Skill Score(FSS) results indicated that the ensemble mean was skillful in light rainfall, while the PMM produced better probability distribution of precipitation for heavy rainfall. Preliminary results demonstrated that convection-allowing ensemble forecast could improve precipitation forecast skill through providing valuable probability forecasts. It is necessary to employ new methods, such as the PMM and NEP, to generate precipitation probability forecasts. Nonetheless, the lack of spread and the overprediction of precipitation by the ensemble members are still problems that need to be solved. | xiang li hongrang he chaohui chen ziqing miao shigang bai | 2017 | Journal of Meteorological Research2017，31，5： | 4 |
| 3 | BDNF improves axon transportation and rescues visual function in a rodent model of acute elevation of intraocular pressure显示文摘Optic neuropathies lead to blindness;the common pathology is the degeneration of axons of the retinal ganglion cells. In this study, we used a rat model of retinal ischemia-reperfusion and a one-time intravitreal brain-derived neurotrophic factor(BDNF)injection;then we examined axon transportation function, continuity, physical presence of axons in different part of the optic nerve, and the expression level of proteins involved in axon transportation. We found that in the disease model, axon transportation was the most severely affected, followed by axon continuity, then the number of axons in the distal and proximal optic nerve. BDNF treatment relieved all reductions and significantly restored function. The molecular changes were more minor,probably due to massive gliosis of the optic nerve, so interpretation of protein expression data should be done with some caution.The process in this acute model resembles a fast-forward of changes in the chronic model of glaucoma. Therefore, impairment in axon transportation appears to be a common early process underlying different optic neuropathies. This research on effective intervention can be used to develop interventions for all optic neuropathies targeting axon transportation. | Rui Du Xu Wang Shigang He | 2020 | Science China(Life Sciences)2020，63，9： | 3 |
| 4 | Long-lasting impairments in rodent oxygen-induced retinopathy measured by retinal vessel density and visual function显示文摘In mild or moderate retinopathy of prematurity(ROP), retinal vessels undergo obliteration, proliferation, and regression. Despite complete regression of vessel abnormalities, a variety of visual impairments have been reported. Rodent oxygen-induced retinopathy(OIR) is widely used as a model to study ROP. However, the long-term changes of OIR model remain unclear. The aim of this study is to examine long term changes of retinal vessel and visual function in a rodent OIR model resembling human mild or moderate ROP. In this study, after subjecting the animals to 80% oxygen(O_2) for 5–7 d, the retinal vessel density at postnatal day 12(P12) was approximately 30% lower than that in the age-matched control, but this difference was not significant between the groups. Vessel abnormalities, such as vessel tortuosity, neovascular tufts, and the number of vessels protruding into the vitreous, peaked between P17 and P20. Despite the regression of many abnormalities, vessel density in the OIR group was 36% and 32% lower than that in the control animals at 6 weeks and 4 months, respectively. The visual acuity and contrast sensitivity were impaired in the OIR group when measured at 2, 3 and 4 months. Therefore, the rodent OIR model exhibited long-lasting reduction in retinal vessel density and visual impairments, similar to those observed in mild or moderate human ROP. This study suggests that the rodent OIR model can be used to explore possible interventions for mild and moderate human ROP. | Xu Wang Ke Shen Fang Lu Shigang He | 2019 | Science China(Life Sciences)2019，62，5： | 2 |
| 5 | Properties of mouse retinal ganglion cell dendritic growth during postnatal development显示文摘The property of dendritic growth dynamics during development is a subject of intense interest.Here,we investigated the dendritic motility of retinal ganglion cells (RGCs) during different developmental stages,using ex vivo mouse retina explant culture,Semliki Forest Virus transfection and time-lapse observations.The results illustrated that during development,the dendritic motility underwent a change from rapid growth to a relatively stable state,i.e.,at P0 (day of birth),RGC dendrites were in a highly active state,whereas at postnatal 13 (P13) they were more stable,and at P3 and P8,the RGCs were in an intermediate state.At any given developmental stage,RGCs of different types displayed the same dendritic growth rate and extent.Since the mouse is the most popular mammalian model for genetic manipulation,this study provided a methodological foundation for further exploring the regulatory mechanisms of dendritic development. | YANG XiuLan,SHI XiangMing & HE ShiGang State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China | 2010 | Science China(Life Sciences)2010，53，6： | 2 |
| 6 | Decreasing intraocular pressure significantly improves retinal vessel density,cytoarchitecture and visual function in rodent oxygen induced retinopathy显示文摘We attempted to explore a noninvasive,easily applicable and economically affordable therapy for retinopathy of prematurity(ROP).Rat pups were raised in 80%oxygen from postnatal day 7 to P12,and returned to room air.Travoprost eye drops were administered twice a day for 7 days,to reduce intraocular pressure(IOP)by about 20%.Immunohistochemical staining was performed to visualize vessel endothelial cells,to analyze retinal neurons and cytoarchitecture.Behavioral experiments were carried out to test visual acuity and contrast sensitivity.At the end of the 7-day treatment,the number of vessels extending to the vitreous body was significantly reduced and retinal vessel density increased.This improvement was maintained to the end of the12 th week.In the central retina of the model group,the horizontal cells were completely wiped out,the outer plexiform layer was undetectable,and the rod bipolar cell dendrites sprouted into the outer nuclear layer.The treatment partially reverted these architectural changes.Most importantly,behavioral experiments revealed significantly improved visual acuity and contrast sensitivity in the treated group.Therefore,reducing IOP could potentially serve as a safe and economical measure to treat ROP. | Rui Du Xu Wang Ke Shen Shigang He | 2020 | Science China(Life Sciences)2020，63，2： | 2 |
| 7 | Application of a polycapillary x-ray optics in high pressure XAFS显示文摘 | Yude Li Xiaoyan Lin Shigang Liu Lirong Zheng Jinlong He Fei Guo Tianxi Sun | 2013 | Journal of Optics2013，，7： | 1 |
| 8 | Large-scale morphological survey of mouse retinal ganglion cells显示文摘 | Sun Wenzhi Li Ning He Shigang | 2002 | J Comparative Neurol2002，451，2： | 1 |
| 9 | In situ FTIR spectroscopic studies of CO adsorption on electrodes of nanometer-thin layer of Pt-Ru and Pt-Pd surface alloys显示文摘CO adsorption on nanometer-thin layer of surface alloys of Pt-Ru and Pt-Pd prepared by electrochemical codeposition has been studied using in situ FTIR spectroscopy. Abnormal infrared effects (AIREs) that consist of the enhancement of IR absorption by adsorbed CO on different surface sites and the inversion of IR band direction have been observed on the thin-layer prepared. The results also demonstrate the considerable significance of Pt-Ru and Pt-Pd surface alloys in electrocatalysis applications. | Guoqiang Lu Lirong Cai Shigang Sun Junxiang He | 1999 | Chinese Science Bulletin1999，44，16： | 1 |
| 10 | SCIENCE CHINA In-Sight显示文摘2010 celebrates the 60th anniversary of this journal. From this issue,the journal features a brand new section: ’In-Sight’. Equivalent to the Cutting Edge of Cell,News and Views of | HE ShiGang Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China | 2010 | Science China(Life Sciences)2010，53，1： | 0 |
| 11 | Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag显示文摘Centrifugal blood pumps have become popular for adult extracorporeal membrane oxygenation(ECMO)due to their superior blood handling and reduced thrombosis risk featured by their secondary flow paths that avoid stagnant areas.However,the high rotational speed within a centrifugal blood pump can introduce high shear stress,causing a significant shear-induced hemolysis rate.The Revolution pump,the Rotaflow pump,and the CentriMag pump are three of the leading centrifugal blood pumps on the market.Although many experimental and computational studies have focused on evaluating the hydraulic and hemolytic performances of the Rotaflow and CentriMag pumps,there are few on the Revolution pump.Furthermore,a thorough direct comparison of these three pumps'flow characteristics and hemolysis is not available.In this study,we conducted a computational and experimental analysis to compare the hemolytic performances of the Revolution,Rotaflow,and CentriMag pumps operating under a clinically relevant condition,i.e.,the blood flow rate of 5 L/min and pump pressure head of 350 mmHg,for adult ECMO support.In silico simulations were used to characterize the shear stress distributions and predict the hemolysis index,while in vitro blood loop studies experimentally determined hemolysis performance.Comparative simulation results and experimental data demonstrated that the CentriMag pump caused the lowest hemolysis while the Revolution pump generated the highest hemolysis. | Dong Han Joshua L.Leibowitz Lu Han Shigang Wang Ge He Bartley P.Griffith Zhongjun J.Wu | 2022 | Medicine in Novel Technology and Devices2022，，3： | 0 |
| 12 | Controlling Chaos Using Modified Lyapunov Exponents显示文摘We suggested a method using a small perturbation to modify Lyapunov exponents of the unstable periodic orbit for controlling chaos.The benefit of this control scheme is studied and the effect of noise is discussed.Based on these studies,a more practical control method is recommended,and some experiments can be better understanded. | TAN Yi HE Xiantu CHEN Shigang | 1993 | Chinese Physics Letters1993，10，6： | 0 |
| 13 | Study of Optical-electrical Conversion Interface for Power Supply’s of Ion Source显示文摘The quality of the beam produced by the ion source directly affects the superiority of the cyclotron beam.The 14MeV high dencity cyclotron uses an external multi-cusp ion source.Ion source power supply composes of filament power supply,arc voltage power supply,plasma power supply and puller power supply,which are | WANG Jingfeng HOU Shigang JIA Xianlu LI Pengzhan ZHANG He LIU Zhenwei | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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