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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | The growth mechanism of hydrotalcite crystal显示文摘From the point of growth units, the growth mechanism of hydrotalcite (HT) crystal is investigated in this paper. Results show that the growth morphology of HT is consistent with the model of anion coordination polyhedron growth units. The Raman shift of growth solutions of HT, Cu-HTlc, and Cu-Zn-HTlc are monitored using Raman spectroscopy. In the experiment, the growth units of Mg-Al-hydrotalcite are [Mg-(OH)6]4- and [Al-(OH)6]3-, and the growth units of Cu-Htlc and Cu-Zn-HTlc are [Mg-(OH)6]4- and [Al-(OH)6]3-, respectively. The growth process of hydrotalcite is as follows: growth units first incorpo- rate into metal layers, then metal layers adsorb An- and H2O, and the growth units incorporate into layer compounds according to this rule. Growth units will have different incorporations and growth morphologies caused by different growth surroundings. Furthermore, the reason why Cu-HTlc is difficult to synthesize is also interpreted in this paper. | WU JianSong XIAO YingKai WAN JianYu WEN LiRong | 2012 | Science China(Technological Sciences)2012，55，4： | 15 |
| 3 | An Atypical Thioredoxin Imparts Early Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Qingqing Liu Huanhuan Liu Yangqing Gong Yongfu Tao Lu Jiang Weiliang Zuo Qin Yang Jianrong Ye Jinsheng Lai Jianyu Wu Thomas Lubberstedt Mingliang Xu | 2017 | Molecular Plant2017，10，3： | 14 |
| 4 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 5 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 6 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 7 | Quantitative trait locus mapping with background control in genetic populations of clonal F_1 and double cross显示文摘In this study, we considered five categories of molecular markers in clonal F_1 and double cross populations,based on the number of distinguishable alleles and the number of distinguishable genotypes at the marker locus. Using the completed linkage maps, incomplete and missing markers were imputed as fully informative markers in order to simplify the linkage mapping approaches of quantitative trait genes. Under the condition of fully informative markers, we demonstrated that dominance effect between the female and male parents in clonal F_1 and double cross populations can cause the interactions between markers. We then developed an inclusive linear model that includes marker variables and marker interactions so as to completely control additive effects of the female and male parents, as well as the dominance effect between the female and male parents. The linear model was finally used for background control in inclusive composite interval mapping(ICIM) of quantitative trait locus(QTL). The ef ficiency of ICIM was demonstrated by extensive simulations and by comparisons with simple interval mapping, multiple-QTL models and composite interval mapping. Finally, ICIM was applied in one actual double cross population to identify QTL on days to silking in maize. | Luyan Zhang Huihui Li Junqiang Ding Jianyu Wu Jiankang Wang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 4 |
| 8 | Highly Ordered Thermoplastic Polyurethane/Aramid Nanofiber Conductive Foams Modulated by Kevlar Polyanion for Piezoresistive Sensing and Electromagnetic Interference Shielding显示文摘Highly ordered and uniformly porous structure of conductive foams is a vital issue for various functional purposes such as piezoresistive sensing and electromagnetic interference(EMI) shielding. With the aids of Kevlar polyanionic chains, thermoplastic polyurethane(TPU) foams reinforced by aramid nanofibers(ANF) with adjustable pore-size distribution were successfully obtained via a nonsolvent-induced phase separation. In this regard, the most outstanding result is the in situ formation of ANF in TPU foams after protonation of Kevlar polyanion during the NIPS process. Furthermore, in situ growth of copper nanoparticles(Cu NPs) on TPU/ANF foams was performed according to the electroless deposition by using the tiny amount of pre-blended Ti_(3)C_(2)T_(x) MXene as reducing agents. Particularly, the existence of Cu NPs layers significantly promoted the storage modulus in 2,932% increments, and the well-designed TPU/ANF/Ti_(3)C_(2)T_(x) MXene(PAM-Cu) composite foams showed distinguished compressive cycle stability. Taking virtues of the highly ordered and elastic porous architectures, the PAM-Cu foams were utilized as piezoresistive sensor exhibiting board compressive interval of 0–344.5 kPa(50% strain) with good sensitivity at 0.46 kPa^(-1). Meanwhile,the PAM-Cu foams displayed remarkable EMI shielding effectiveness at 79.09 dB in X band. This work provides an ideal strategy to fabricate highly ordered TPU foams with outstanding elastic recovery and excellent EMI shielding performance, which can be used as a promising candidate in integration of satisfactory piezoresistive sensor and EMI shielding applications for human–machine interfaces. | Kunpeng Qian Jianyu Zhou Miao Miao Hongmin Wu Sineenat Thaiboonrod Jianhui Fang Xin Feng | 2023 | Nano-Micro Letters2023，15，6： | 4 |
| 9 | Precise time frequency synchronization technology for bistatic radar显示文摘A complete method of synchronization technology of bistatic radar using global position system (GPS) is presented. The pulse per second signal (1PPS) is elaborately modified to increase the time synchronization precision and keep loop locking. A very high time synchronization precision is achieved. Using the modified 1PPS to discipline the local OCXO, the reference frequency signal achieves both high long term stability (LTS) and short term stability (STS) properties. An algorithm, named phase abrupt change CFAR is presented to restrain the 1PPS phase abrupt change and keep loop locking. The experimental results indicate that this time and frequency synchronization method is effective and the time synchronization precision of the synchronization system can be improved from ±100 ns to ±25 ns. In addition, the phase noise is improved to 20 dB. | Huang Yulin Yang Jianyu Wu Junjie Xiong Jintao | 2008 | Journal of Systems Engineering and Electronics2008，19，5： | 4 |
| 10 | A Nonresonant Hybridized Electromagnetic-Triboelectric Nanogenerator for Irregular and Ultralow Frequency Blue Energy Harvesting显示文摘As a promising renewable energy source,it is a challenging task to obtain blue energy,which is irregular and has an ultralow frequency,due to the limitation of technology.Herein,a nonresonant hybridized electromagnetic-triboelectric nanogenerator was presented to efficiently obtain the ultralow frequency energy.The instrument adopted the flexible pendulum structure with a precise design and combined the working principle of electromagnetism and triboelectricity to realize the all-directional vibration energy acquisition successfully.The results confirmed that the triboelectric nanogenerator(TENG)had the potential to deliver the maximum power point of about 470μW while the electromagnetic nanogenerator(EMG)can provide 523 mW at most.The conversion efficiency of energy of the system reached 48.48%,which exhibited a remarkable improvement by about 2.96 times,due to the elastic buffering effect of the TENG with the double helix structure.Furthermore,its ability to collect low frequency wave energy was successfully proven by a buoy in Jialing River.This woke provides an effective candidate to harvest irregular and ultralow frequency blue energy on a large scale. | Weibo Xie Lingxiao Gao Lingke Wu Xin Chen Fayang Wang Daqiao Tong Jian Zhang Jianyu Lan Xiaobin He Xiaojing Mu Ya Yang | 2021 | Research2021，，1： | 4 |
| 11 | Formation of the front-gradient bandgap in the Ag doped CZTSe thin films and solar cells显示文摘The graded bandgap of kesterite based absorber layer is an important way to achieve high efficiency solar cells. Incorporation of Ag into CZTSSe thin films can adjust the bandgap and thus reduce the VOC-deficit and improve the quality of crystallization. However, the distribution of Ag is difficult to control due to the quick diffusion of Ag under the high temperature. In this study, we achieve the front Ag-gradient in kesterite structured compound films by prealloying followed by selenization process at 550 °C. AgZn3,Ag3Sn, and Sn–Ag–Cu alloy phases were formed during prealloying stage at 250 °C. After prealloying process, Ag tends to distribute at the front surface of the ACZTSe thin films. Combining the results of experiment and SCAPS simulation, the significantly VOCimprovement of devices is ascribed to the formation of the front Ag-gradient bandgap structure in the absorber layer. This facile prealloying selenization process affords a feasible method to design the graded bandgap structure absorber layers, which will promote the fabrication of high efficient graded bandgap structure solar cells. | Dongxiao Wang Jianyu Wu Xiyu Liu Li Wu Jianping Ao Wei Liu Yun Sun Yi Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 12 | MicroRNAs Are Involved in Maize Immunity Against Fusarium verticillioides Ear Rot显示文摘Fusarium ear rot(FER)caused by Fusarium verticillioides is one of the most common diseases affecting maize production worldwide.FER results in severe yield losses and grain contamination with health-threatening mycotoxins.Although most studies to date have focused on comprehensive analysis of gene regulation in maize during defense responses against F.verticillioides infection,less is known about the role of micro RNAs(mi RNAs)in this process.We used deep sequencing to compare small RNA libraries from the maize kernels of susceptible(N6)or resistant(BT-1)inbred lines from uninfected plants and upon F.verticillioides infection.We found that pathogen exposure was accompanied by dynamic alterations in expression levels of multiple mi RNAs,including new members of previously annotated mi RNA families.A combination of transcriptomic,degradomic,and bioinformatics analyses revealed that F.verticillioides-responsive mi RNAs and their potential target genes displayed opposite expression patterns in the susceptible and resistant genotypes.Functional category analysis uncovered preferential enrichment of the pathogen-responsive mi RNAs and their targets in the phenylpropanoid metabolic processes,plant–pathogen interactions,and plant phytohormone signal transduction pathways.Furthermore,transgenic maize plants overexpressing mi R408 b exhibited reduced resistance to F.verticillioides infection in a susceptible maize line.These findings provide new insights into the regulatory roles of mi RNAs in maize immunity against FER and new resources for breeding disease resistance into maize. | Zijian Zhou Yan Cao Tao Li Xinghao Wang Jiafa Chen Hang He Wen Yao Jianyu Wu Huiyong Zhang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，3： | 3 |
| 13 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 14 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population显示文摘 | Yanli Li Shen-Chih Chang Binh Y. Goldstein William L. Scheider Lin Cai Nai-Chieh Y. You Heather P. Tarleton Baoguo Ding Jinkou Zhao Ming Wu Qingwu Jiang Shunzhang Yu Jianyu Rao Qing-Yi Lu Zuo-Feng Zhang Lina Mu | 2011 | Cancer Epidemiology2011，，4： | 2 |
| 15 | A feature extraction method for synthetic aperture radar(SAR) automatic target recognition based on maximum interclass distance显示文摘Synthetic aperture radar(SAR) automatic target recognition is an important application in SAR.How to extract features has restricted the application of SAR technology seriously.In this paper,a new feature extraction method for SAR automatic target recognition based on maximum interclass distance is proposed,which integrates class and neighborhood information.This method can reinforce discriminative power using maximum interclass distance,so it can improve recognition rate effectively. | WANG Bing HUANG YuLin YANG JianYu WU JunJie | 2011 | Science China(Technological Sciences)2011，54，9： | 2 |
| 16 | Silencing of ER-resident oxidoreductase PDIA3 inhibits malignant biological behaviors of multidrug-resistant gastric cancer显示文摘Glycosylation is a common posttranslational modification of proteins,which plays a role in the malignant transformation,growth,progression,chemoresistance,and immune response of tumors.Disulfide isomerase family A3(PDIA3)specifically acts on newly synthesized glycoproteins to promote the correct folding of sugar chains.Studies have shown that PDIA3 participates in multidrug-resistant gastric cancer(MDR-GC).In this study,we performed western blot analysis and immunohistochemistry to identify PDIA3 expression.Cell proliferation was assessed by CCK-8 assay.Transwell assays were used to detect the migration and invasion abilities of cells.Immunoprecipitation coupled to mass spectrometry(IP-MS)analysis was employed to identify PDIA3-interacting proteins and the associated pathways in MDR-GC cells.Glycoprotein interactions and translocation were detected by immunofluorescence assay.The results showed that PDIA3 knockdown significantly inhibited the proliferation,invasion,and migration abilities of MDR-GC cells.Kyoto Encyclopedia of Genes and Genomes analysis of the IP-MS results showed that PDIA3 was closely associated with focal adhesion pathways in MDR-GC cells.Additionally,important components of focal adhesion pathways,including fibronectin-1(FN1)and integrinα5(ITGA5),were identified as pivotal PDIA3-binding glycoproteins.Knockdown of PDIA3 altered the cellular locations of FN1 and ITGA5,leading to abnormal accumulation.In conclusion,our results suggest that knockdown of PDIA3 inhibited the malignant behaviors of MDR-GC cells and influenced the translocation of FN1 and ITGA5. | Danyang Song Meng Guo Kaichu Wu Jianyu Hao Yongzhan Nie Daiming Fan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 17 | Uranium enrichment determination by high-energy photon interrogation显示文摘Uranium enrichment determination by non-destructive assay is an important method in authenticating the nuclear warhead or uranium component in deep nuclear reduction verifications.In this paper,the feasibility of applying the high-energy photon interrogation to determine the uranium enrichment is studied.Simplified models are presented which were simulated by particle Monte Carlo transport code.The results indicate that the relation curves of the released neutrons and the enrichment of uranium objects are almost linear.For a uranium object of a given shape,the uranium enrichment can be obtained with the relation curves,which could be got in advance by calibration experiments or simulations. | ZHU JianYu ZHANG SongBai WU Jun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 1 |
| 18 | Specific cross-dimerization of terminal alkynes via Pd/TMEDA catalysis显示文摘The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,and organic functional materials,etc.However,due to the inherent issues of the stereo-,regio-,and chemoselectivity,the strategy is less explored and remains problematic in substrate scope,selectivity,and screening of catalytic system,etc.Herein,a specific cross-dimerization of terminal alkynes is developed under Pd/TMEDA catalysis,which produces a series of gem-1,3-enynes(58 examples)in totally moderate to high yields with outstanding functional group tolerance.A cyclopalladium compound might be the key imtermediate,which performs anti-addition-carbometallation,and leads to the exclusive cross-selectivity.The unprecedented features of the reaction,such as anti-addition-carbometallation,easy control of selectivity,wide range of the donor alkynes,and very simple catalytic conditions,allow it not only a facile and functionally diverse synthesis of 1,3-enynes,but also a substantial progress for the textbook reaction. | Lixin Liu Jianyu Dong Zuqi Fu Lebin Su Shaofeng Wu Qian Shang Shuang-Feng Yin Yongbo Zhou | 2022 | Science China Chemistry2022，65，12： | 1 |
| 19 | Nonreciprocal coherent coupling of nanomagnets by exchange spin waves显示文摘Nanomagnets are widely used to store information in non-volatile spintronic devices.Spin waves can transfer information with low-power consumption as their propagations are independent of charge transport.However,to dynamically couple two distant nanomagnets via spin waves remains a major challenge for magnonics.Here we experimentally demonstrate coherent coupling of two distant Co nanowires by fast propagating spin waves in an yttrium iron garnet thin film with sub-50 nm wavelengths.Magnons in two nanomagnets are unidirectionally phase-locked with phase shifts controlled by magnon spin torque and spin-wave propagation.The coupled system is finally formulated by an analytical theory in terms of an effective non-Hermitian Hamiltonian.Our results are attractive for analog neuromorphic computing that requires unidirectional information transmission. | Hanchen Wang Jilei Chen Tao Yu Chuanpu Liu Chenyang Guo Song Liu Ka Shen Hao Jia Tao Liu Jianyu Zhang Marco A.Cabero Z Qiuming Song Sa Tu Mingzhong Wu Xiufeng Han Ke Xia Dapeng Yu Gerrit E.W.Bauer Haiming Yu | 2021 | Nano Research2021，14，7： | 1 |
| 20 | Assessment of Arctic sea ice simulations in CMIP5 models using a synthetical skill scoring method显示文摘The Arctic sea ice cover has declined at an unprecedented pace since the late 20th century. As a result, the feedback of sea ice anomalies for atmospheric circulation has been increasingly evidenced. While climatic models almost consistently reproduced a decreasing trend of sea ice cover, the reported results show a large distribution. To evaluate the performance of models for simulating Arctic sea ice cover and its potential role in climate change, this study constructed a reasonable metric by synthesizing both linear trends and anomalies of sea ice. This study particularly focused on the Barents Sea and the Kara Sea, where sea ice anomalies have the highest potential to affect the atmosphere. The investigated models can be grouped into three categories according to their normalized skill scores. The strong contrast among the multi-model ensemble means of different groups demonstrates the robustness and rationality of this method. Potential factors that account for the different performances of climate models are further explored. The results show that model performance depends more on the ozone datasets that are prescribed by the model rather than on the chemical representation of ozone. | Liping Wu Xiao-Yi Yang Jianyu Hu | 2019 | Acta Oceanologica Sinica2019，38，9： | 1 |
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