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| 1 | Implications of hepatic dysfunction in Kawasaki disease:Time-related changes in aspartate aminotransferase, alanine aminotransferase,total bilirubin,and C-reactive protein levels显示文摘Importance:The cause of the hepatic dysfunction that commonly accompanies Kawasaki disease(KD)remains unclear.Objective:We tried to clarify the cause of the hepatic dysfunction.Methods:A total of 381 consecutive patients with acute KD,who had undergone inpatient treatment with intravenous immunoglobulin until the 7th day of illness,were divided into a group of 199 patients with an alanine aminotransferase(ALT)level≥40 IU/L on admission(group I),a group of 52 patients with an ALT level≥40 IU/L at some point after admission(group II),and a group of 130 patients with ALT levels consistently<40 IU/L throughout hospitalization(group III).Aspartate aminotransferase(AST),ALT,total bilirubin(T-Bil),and C-reactive protein(CRP)levels were analyzed over time,and time-courses were compared.results:In the initial stage of illness,in group I,AST,ALT,T-Bil peaked on days 1-3,and AST tended to improve significantly on the 4th day(P<0.001).T-Bil improved on day 5(P<0.01),and ALT improved significantly on day 6(P<0.001).CRP increased every day up to day 6(P<0.001).In group II,AST and ALT increased after admission,and thereafter CRP increased,then decreased.The frequency of use of aspirin and aspirin doses did not differ significantly in the three groups.Interpretation:Recovery from liver dysfunction occurred in the initial stage of illness in group I-within the period of CRP exacerbation,which is an indicator of systemic inflammation. | Yasuhiko Tomita Takashi Fukaya Yasuko Yamaura Rie Tsujiguchi Haruko Muratani Maki Shimaya | 2019 | Pediatric Investigation2019，3，1： | 3 |
| 2 | CMOS/SIMOX devices having a radiation hardness of 2Mrad(Si)显示文摘 | Ohno T Izumi K Shimaya M | 1987 | Electron Lett1987，23，： | 1 |
| 3 | The novel hypoglycemic agent YM440 normalizes hypergly- cemia without changing body fat weight in diabetic db/ db mice 显示文摘 | SHIMAYA A KUROSAKI E NAKANO R | 2000 | Metabolism2000，49，3： | 1 |
| 4 | Rheumatoid arthritis and simultaneous aortic, mitral, and tricuspid valve incompetence显示文摘 | Shimaya K Kurihashi A Masago R etal | 1999 | Int J Cardiol1999，71，2： | 1 |
| 5 | Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion显示文摘 | Hirotsugu Tanaka Shigeru Yoshida Hideaki Minoura Kenji Negoro Akiyoshi Shimaya Teruhiko Shimokawa Masayuki Shibasaki | 2013 | Life Sciences2013，，： | 1 |
| 6 | Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect显示文摘 | Koga H Shimaya M Muneta T | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 7 | Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer显示文摘 | S. Matsui H. Shiozaki M. Inoue S. Tamura Y. Doki T. Kadowaki T. Iwazawa K. Shimaya T. Mori A. Nagafuchi S. Tsukita | 1994 | Virchows Archiv1994，，4： | 1 |
| 8 | Predictability of in vivo chemosensitivity by in vitro MTT assay with reference to the clonogenic assay显示文摘 | Qvist V Laurberg L | 1989 | J Surg Oncol1989，42，4： | 1 |
| 9 | Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer显示文摘 | S. Matsui H. Shiozaki M. Inoue S. Tamura Y. Doki T. Kadowaki T. Iwazawa K. Shimaya T. Mori A. Nagafuchi S. Tsukita | 1994 | Virchows Archiv1994，，4： | 1 |
| 10 | Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor γ and its transactivation显示文摘 | Eiji Kurosaki Ryosuke Nakano Akiyoshi Shimaya Shigeru Yoshida Motoko Ida Takayuki Suzuki Masayuki Shibasaki Hisataka Shikama | 2002 | Biochemical Pharmacology2002，，5： | 1 |
| 11 | The novel hypoglycemic agent YM440 normalizes hyperglyee mia without changing bodyfat weight in diabetic db/db mice显示文摘 | Shimaya A Kurosaki E Nakano R | 2000 | Metabolism2000，49，3： | 1 |
| 12 | Effects of the novel Foxol inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice显示文摘 | Tanaka H Nagashima T Shimaya A | 2010 | Eur J Pharmacol2010，645，13： | 1 |
| 13 | Structural changes in wood pulp treated by 55wt% aqueous calcium thiocyanate solution显示文摘 | Hattori Makiko Shimaya Yoshihiko | 1998 | Polymer Journal1998，30，1： | 1 |
| 14 | Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist显示文摘 | TANAKA H SHIMAYA A KISO T | 2011 | Life Sci2011，88，1112： | 1 |
| 15 | Differential ef- fects of YM440 a hypoglycemic agent on binding to a peroxisome proliferators activated receptor gamma and its transactivation 显示文摘 | Kurosaki E Nakano R Shimaya A | 2003 | Biochem Pharmacol2003，65，： | 1 |
| 16 | Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferatot-activated receptor gamma and its transactivation 显示文摘 | Kurosaki E Nakano R Shimaya A | 2003 | Biochem Pharmacol2003，65，5： | 1 |
| 17 | Antagonism of PPARr prevents high - fat diet - induced obesity in vivo 显示文摘 | Nakano R kurasaki E Shimaya A | 2006 | Biochemical pharmacology2006，72，1： | 1 |
| 18 | Differential effects of YM440: a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation显示文摘 | Kurosaki E Nakano R Shimaya A | 2003 | Biochem Pharmacol2003，65，5： | 1 |
| 19 | Interface-trap generation at ultrathin SiO2(4-6nm)–Si inter-faces during negative-bias temperature aging显示文摘 | OGAWA S SHIMAYA M SHIONO N | 1995 | JAppl Phys1995，77，3： | 1 |
| 20 | Solubility and dissolved cellulose in aqueous calcium and sodillm-thiocyanateso- lution显示文摘 | Hattori M Shimaya Y Saito M | 1998 | Polymer Journal1998，30，1： | 1 |
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