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| 1 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 2 | Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers显示文摘 | Shirin H Aeed H Alin A | 2010 | Dig Dis Sci2010，55，2： | 1 |
| 3 | Fuzzy optimal phase balan- cing of radial and meshed distribution networks using BF- PSO algorithm 显示文摘 | RAHMAT A H SHIRIN S | 2012 | IEEE Transactions on Power Sys- tems2012，27，1： | 1 |
| 4 | Childhood mortality due to drowning in rural Matlab of Bangladesh:magnitude of the problem and proposed solutions显示文摘 | Iqbal A Shirin T Ahmed T | 2007 | J Health Popul Nutr2007，25，3： | 1 |
| 5 | The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane显示文摘 | Athar H Chishti Anthony C Kim Shirin M Marfatia Mohini Lutchman Manjit Hanspal Hitesh Jindal Shih-Chun Liu Philip S Low Guy A Rouleau Narla Mohandas Joel A Chasis John G Conboy Phillipe Gascard Yuichi Takakuwa Shu-Ching Huang Edward J Benz Jr Anthony Bret | 1998 | Trends in Biochemical Sciences1998，，8： | 1 |
| 6 | Effects of exercise on memory consolidation and retrieval of passive avoidance learning in young male rats显示文摘 | Hakimeh S Shirin B Naser A | 2010 | Asian J Sports Med2010，1，3： | 1 |
| 7 | Cedecea davisae bacteremia in neutropmie patient with acute myeloid leukemia 显示文摘 | Getahun A Shahab Q Shirin M | 2011 | J Infect2011，63，： | 1 |
| 8 | Determination oI the extraeellular basal levels of glutamate and GA- BA at dentate gyrus of streptozotocin-induced diabetic rats显示文摘 | PARHAM R HOJJATALLAH A SHIRIN B | 2009 | Pathophysiology2009，16，： | 1 |
| 9 | New approach for the elucidation of PCM nanocapsules through miniemulsion polymerization with an acrylic shell 显示文摘 | ABBAS R SHIRIN A ALl R M | 2011 | Macromolecules2011，，44： | 1 |
| 10 | Metformin compared with insulin in the management of gestational diabetes mellitus: A randomized clinical trial 显示文摘 | Shirin N Azin A Fatemeh RS | 2012 | Diabetes Res Clini Pract2012，98，3： | 1 |
| 11 | Helicobacter pylori inhibits the G (1) to S transition in AGS gastric epithelial cells显示文摘 | SHIRIN A H SORDILLO E M OH S H | 1999 | Cancer Res1999，59，10： | 1 |
| 12 | Genistein reduces the production of proinflammatory molecules in human chondrocytes显示文摘 | Shirin H Do Y S Edralin A L | 2007 | Journal of Nutritional Biochemistry2007，18，： | 1 |
| 13 | Rare Benign Tumors of the Liver: Still Rare?显示文摘 | Gaetano Bertino Annalisa Ardiri Shirin Demma Stefano GiuseppeCalvagno Adriana Toro Elisa Basile Davide Campagna Giorgia Ferraro Evelise Frazzetto Maria Proiti Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Michele Malaguarnera Maria Domenica A | 2014 | Journal of Gastrointestinal Cancer2014，，2： | 1 |
| 14 | MADR1, a MAD-related protein that functions in BMP2 signaling pathways 显示文摘 | Pamela A H Theo H Shirin A | 1996 | Cell1996，85，： | 1 |
| 15 | A key cytokine unlocks the door显示文摘 | Smoss H Shirin A Baglin T | 2000 | Immunity2000，7，： | 1 |
| 16 | A key cytokine unlocks the door显示文摘 | Smoss H Shirin A Baglin T | 2000 | Immunity2000，7，： | 1 |
| 17 | Metformin compared with insulin in the management of gestational diabetes mellitus: A randomized clinical trial显示文摘 | Shirin N Azin A Fatemeh RS | 2012 | Res Clin Pract2012，12，10： | 1 |
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