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| 1 | Diffusion-weighted magnetic resonance imaging in management of bladder cancer, particularly with multimodal bladder-sparing strategy显示文摘Bladder-sparing strategy for muscle-invasive bladdercancer(MIBC) is increasingly demanded instead ofradical cystectomy plus urinary diversion. Multimodaltherapeutic approaches consisting of transurethralresection, chemotherapy, radiotherapy and/or partialcystectomy improve patients' quality of life by preserv-ing their native bladder and sexual function withoutcompromising oncological outcomes. Because a favor-able response to chemoradiotherapy(CRT) is a prereq-uisite for successful bladder preservation, predictingand monitoring therapeutic response is an essentialpart of this approach. Diffusion-weighted magneticresonance imaging(DW-MRI) is a functional imagingtechnique increasingly applied to various types of can-cers. Contrast in this imaging technique derives fromdifferences in the motion of water molecules among tissues and this information is useful in assessing the biological behavior of cancers. Promising results in pre-dicting and monitoring the response to CRT have been reported in several types of cancers. Recently, growing evidence has emerged showing that DW-MRI can serve as an imaging biomarker in the management of blad-der cancer. The qualitative analysis of DW-MRI can be applied to detecting cancerous lesion and monitoring the response to CRT. Furthermore, the potential role of quantitative analysis by evaluating apparent diffu-sion coefficient values has been shown in character-izing bladder cancer for biological aggressiveness and sensitivity to CRT. DW-MRI is a potentially useful tool for the management of bladder cancer, particularly in multimodal bladder-sparing approaches for MIBC. | Soichiro Yoshida Fumitaka Koga Shuichiro Kobayashi Hiroshi Tanaka Shiro Satoh Yasuhisa Fujii Kazunori Kihara | 2014 | World Journal of Radiology2014，6，6： | 2 |
| 2 | Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer显示文摘Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were investigated.After two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was performed.Formalin-fixed,paraffin-embedded sections were evaluated using immunohistochemistry.PCa with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as reference.Immunoreactively-positive cells were counted in at least three areas in cancer tissue.Labeling indices(LI)were calculated as percentage values.Results:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their biopsies.GT cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT cases.However,there was no significant difference in CD20-positive B cells among the types of case.There were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with GT.Conclusions:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy. | Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu Yoshiki Murakumo Shiro Baba Masatsugu Iwamura | 2021 | Asian Journal of Urology2021，8，3： | 1 |
| 3 | Quantitative Analysis of Right Ventricular Function in Patients With Pulmonary Hypertension Using Three-Dimensional Echocardiography and a Two-Dimensional Summation Method Compared to Magnetic Resonance Imaging显示文摘 | Tomoko Morikawa Mitsushige Murata Shigeo Okuda Hikaru Tsuruta Shiro Iwanaga Mitsuru Murata Toru Satoh Satoshi Ogawa Keiichi Fukuda | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 4 | CT-guided automated cutting needle biopsy by a combined method for accurate Specific diagnosis of focal lung lesions显示文摘 | Shiro Satoh Shinichi Ohdama Osamu Matsubara | 2005 | Radiation Medicine2005，23，1： | 1 |
| 5 | Sliding thin slab, minimum intensity projection imaging forobjective analysis of em- physema显示文摘 | Shiro Satoh Shinichi Ohdama Hitoshi Shibuya | 2006 | Radiat Med2006，24，6： | 1 |
| 6 | The eletrical properties of Zine Selenide heat-treated in controlled partial pressures of constituent elements显示文摘 | Kenzo Igaki Shiro Satoh | 1979 | Jpn J Appi Phys1979，18，： | 1 |
| 7 | Difference in rectal dosimetry between pre-plan and post-implant analysis in transperineal interstitial brachytherapy for prostate cancer显示文摘 | Hiromichi Ishiyama Masashi Kitano Takefumi Satoh Yuzuru Niibe Mineko Uemae Tetsuo Fujita Shiro Baba Kazushige Hayakawa | 2006 | Radiotherapy and Oncology2006，，： | 1 |
| 8 | Quality of life after brachytherpay or radical prostatectomy for localized prostate cancer显示文摘 | Shunichi Namiki Takefumi Satoh Shiro Baba | 2006 | Urology2006，68，6： | 1 |
| 9 | Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy显示文摘AIM: To investigate the time course of testosterone(T) recovery after cessation of androgen deprivation therapy(ADT) in patients treated with brachytherapy. METHODS: One-hundred and seventy-four patients treated between June 1999 and February 2009 were studied. Patients were divided into a short-term usage group(≤ 12 mo, n = 91) and a long-term usage group(≥ 36 mo, n = 83) according to the duration of gonadotropin-releasing hormone agonist therapy. Median follow-up was 29 mo in the short-term group and was 60 mo in the long-term group.RESULTS: Cumulative incidence rates of T recovery to normal and supracastrate levels at 24 mo after cessationwere 28.8% and 74.6%, respectively, in the long-term usage group, whereas these values were 96.4% and 98.8% in the short-term usage group. T recovery to normal and supracastrate levels occurred significantly more rapidly in the short-term than in the long-term usage group(P < 0.001 and P < 0.001, respectively). Five years after cessation, 22.6% of patients maintained a castrate T level in the long-term usage group. On multivariate analysis, lower T levels(< 10 ng/d L) at cessation of ADT was significantly associated with prolonged T recovery to supracastrate levels in the longterm usage group(P = 0.002). CONCLUSION: Lower T levels at cessation of ADT were associated with prolonged T recovery in the longterm usage group. Five years after cessation of longterm ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery. | Hideyasu Tsumura Takefumi Satoh Hiromichi Ishiyama Shuhei Hirano Kenichi Tabata Shinji Kurosaka Kazumasa Matsumoto Tetsuo Fujita Masashi Kitano Shiro Baba Kazushige Hayakawa Masatsugu Iwamura | 2015 | World Journal of Radiology2015，7，12： | 0 |
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