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| 1 | Removal of sulfamethazine antibiotics by aerobic sludge and an isolated Achromobacter sp.S-3显示文摘Removal characteristics of sulfamethazine(SMZ) by sludge and a bacterial strain using an aerobic sequence batch reactor(ASBR) were studied.Operating conditions were optimized by varying the reaction time and sludge retention time(SRT).An Achromobacter sp.(S-3) with the ability to remove SMZ was isolated from the ASBR.The effects of different operating parameters(pH and temperature) on the biodegradation of SMZ by S-3 were determined.The results indicate that,between 0.5 and 4 hr,reaction time of the ASBR had a significant effect on the SMZ removal efficiency in the system.The SMZ removal efficiency also increased from 45% to 80% when SRT was prolonged from 5 to 25 days,although longer SRT had no impact on SMZ removal.The SMZ adsorption rate decreased with increasing temperature,which fitted Freundlich isotherm well.The removal of SMZ in the ASBR was due to the combined effects of adsorption and degradation,and degradation played a leading role. | Manhong Huang Shixuan Tian Donghui Chen Wei Zhang Jun Wu Liang Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 12 |
| 2 | Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer显示文摘颈的癌为本地侵略和淋巴节点转移与高倾向被联系。然而,驾驶颈的癌症的前进和转移的分子的改变仍然保持不清楚。细胞的老朽作为机制被建议了保护一个有机体免于癌症前进和转移。另外,扭动,一个基本 helix-loop-helix 抄写因素,因为它是在人的癌症的许多类型的 overexpressed,作为 oncogene 被建议了。这基因也在调整侵略和转移展出积极功能。在这研究,扭曲强烈并且断然在正常织物,有鳞的房间癌(SCC ) IAIIA,和 SCC IIBIIIB 被表示(4.3% , 44% ,和 88.9% ,分别地) 。老朽标记 CBX3 的强壮的积极表情分别地是 39.1% , 32% ,和 15.6% 。在 SCC 组与或没有淋巴节点转移的扭曲的强壮的积极表情是 80.8% 和 50% 。为 CBX3,如此的表情分别地是 7.7% 和 29.5% 。结果也证明扭曲的表示相反地与 CBX3 的被相关。而且,有在 SiHa 的目标 siRNA 的扭曲击倒触发了细胞的老朽 CBX3 和联系老朽的牛乳糖活动的染色质标记的正式就职。我们的结果建议扭曲的表示在颈的癌症的前进和转移期间增加了。而且,导致扭曲的老朽绕过在这个过程是重要的。 | Tian Wang Yan Li Abidan Tuerhanjiang Wenwen Wang Zhangying Wu Ming Yuan Shixuan Wang | 2014 | Frontiers of Medicine2014，8，1： | 4 |
| 3 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 4 | Twist2 contributes to cisplatin?resistance of ovarian cancer throughthe AKT/GSK?3β signaling pathway显示文摘 | Tian Wang Yan Li Abidan Tuerhanjiang Wenwen Wang Zhangying Wu Ming Yuan Mayinuer Maitituoheti Shixuan Wang | 2014 | Oncology Letters2014，，： | 1 |
| 5 | Correlation of TWIST2 up-regulation and epithelial–mesenchymal transition during tumorigenesis and progression of cervical carcinoma显示文摘 | Yan Li Wei Wang Wenwen Wang Runfeng Yang Tian Wang Tiefen Su Danhui Weng Tao Tao Wei Li Ding Ma Shixuan Wang | 2011 | Gynecologic Oncology2011，，1： | 1 |
| 6 | The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome–lysosome fusion显示文摘Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in autophagy.Two SNAP29-containing SNARE complexes have been extensively studied in starvation-induced bulk autophagy,while the relevant SNARE complexes in other types of autophagy occurring under non-starvation conditions have been overlooked.Here,we found that autophagosome–lysosome fusion in selective autophagy under non-starvation conditions does not require SNAP29-containing SNARE complexes,but requires the STX17-SNAP47-VAMP7/VAMP8 SNARE complex.Further,the STX17-SNAP47-VAMP7/VAMP8 SNARE complex also functions in starvation-induced autophagy.SNAP47 is recruited to autophagosomes following concurrent detection of ATG8s and PI(4,5)P2 via its Pleckstrin homology domain.By contrast,SNAP29-containing SNAREs are excluded from selective autophagy due to inactivation by O-GlcNAcylation under non-starvation conditions.These findings depict a previously unknown,default SNARE complex responsible for autophagosome–lysosome fusion in both selective and bulk autophagy,which could guide research and therapeutic development in autophagy-related diseases. | Fenglei Jian Shen Wang Rui Tian Yufen Wang Chuangpeng Li Yan Li Shixuan Wang Chao Fang Cong Ma Yueguang Rong | 2024 | Cell Research2024，34，2： | 0 |
| 7 | Real- and momentum-indirect neutral and charged excitons in a multi-valley semiconductor显示文摘Excitons dominate the photonic and optoelectronic properties of a material.Although significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still limited.Here,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent photoluminescence.Together with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum origin.Remarkably,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics. | Zhiheng Huang Yuhui Li Tao Bo Yanchong Zhao Fanfan Wu Lu Li Yalong Yuan Yiru Ji Le Liu Jinpeng Tian Yanbang Chu Xiaozhou Zan Yalin Peng Xiuzhen Li Yangkun Zhang Kenji Watanabe Takashi Taniguchi Zhipei Sun Wei Yang Dongxia Shi Shixuan Du Luojun Du Guangyu Zhang | 2023 | National Science Open2023，2，4： | 0 |
| 8 | Application of Nanopore Single Molecule Detection Technology in Analysis of Xylan Dissolved in Ionic Liquid显示文摘Xylan is the most abundant hemicellulose in nature. As a new type of green organic solvent, ionic liquid shows good preservation ability for the functional groups of hemicellulose. In this paper, a single molecule detection technology based on glass nanopore was established to analyze xylan dissolved in ionic liquid. Arabino-xylan (AX) and beech xylan (BX) are respectively taken as the representatives of heterogeneous xylan and homogeneous xylan. Firstly, unmodified glass nanopore was used to detect the dissolved xylan in ionic liquid, and then poly(ethylene imine) (PEI) was used to modify the nanopore to change the surface charge in the nanopore and further enhance the interaction between the nanopore and the xylan molecule. It was found that before and after nanopore modification, at negative voltage and low positive voltage, AX didn't generate current blocking signal. On the contrary, BX didn't generate current blocking signal at positive voltage. This phenomenon may be due to the current disturbance driven by electrophoresis and electroosmosis of xylan molecules with weak negative charge. After statistics analysis, the current blocking signal of AX showed that the modified nanopore showed multiple peaks. It indicates that heterogeneous xylan and PEI modified nanopore had stronger interaction. The results show that the nanopore detection technology can show the structural difference of heterogenous branched chain and homogeneous straight chain based on the single characteristic current blocking signal and statistical information, providing a research basis for the structural analysis of water insoluble polysaccharides. | Wanyi Xie Shaoxi Fang Bohua Yin Rong Tian Liyuan Liang Shixuan He Deqiang Wang | 2023 | Chinese Journal of Chemistry2023，41，14： | 0 |
| 9 | Helium-ion-beam nanofabrication: extreme processes and applications显示文摘Helium ion beam(HIB)technology plays an important role in the extreme fields of nanofabrication.This paper reviews the latest developments in HIB technology as well as its extreme processing capabilities and widespread applications in nanofabrication.HIB-based nanofabrication includes direct-write milling,ion beam-induced deposition,and direct-write lithography without resist assistance.HIB nanoscale applications have also been evaluated in the areas of integrated circuits,materials sciences,nano-optics,and biological sciences.This review covers four thematic applications of HIB:(1)helium ion microscopy imaging for biological samples and semiconductors;(2)HIB milling and swelling for 2D/3D nanopore fabrication;(3)HIB-induced deposition for nanopillars,nanowires,and 3D nanostructures;(4)additional HIB direct writing for resist,graphene,and plasmonic nanostructures.This paper concludes with a summary of potential future applications and areas of improvement for HIB extreme nanofabrication technology. | Shixuan He Rong Tian Wei Wu Wen-Di Li Deqiang Wang | 2021 | International Journal of Extreme Manufacturing2021，3，1： | 0 |
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