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| 1 | Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation显示文摘AIM:To clarify the strategy for early diagnosis of pancreaticobiliary maljunction(PBM) without biliary dilatation and to pathologically examine gallbladder before cancer develops.METHODS:The anatomy of the union of the pancreatic and bile ducts was assessed by using endoscopic retrograde cholangiopancreatography(ERCP).Patients with a long common channel in which communication between the pancreatic and bile ducts was maintained even during sphincter contraction were diagnosed as having PBM.Of these,patients in which the maximal diameter of the bile duct was less than 10 mm were diagnosed with PBM without biliary dilatation.The process of diagnosing 54 patients with PBM without biliary dilatation was retrospectively investigated.Histopathological analysis of resected gallbladder specimens from 8 patients with PBM without biliary dilatation or cancer was conducted.RESULTS:Thirty-six PBM patients without biliary dilatation were diagnosed with gallbladder cancer after showing clinical symptoms such as abdominal or back pain(n = 16) or jaundice(n = 12).Radical surgery for gallbladder cancer was only possible in 11 patients(31%) and only 4 patients(11%) survived for 5 years.Eight patients were suspected as having PBM without biliary dilatation from the finding of gallbladder wall thickening on ultrasound and the diagnosis was confirmed by ERCP and/or magnetic resonance cholangiopancreatography(MRCP).The median age of these 8 patients was younger by a decade than PBM patients with gallbladder cancer.All 8 patients underwent prophylactic cholecystectomy and bile duct cancer has not occurred.Wall thickness and mucosal height of the 8 resected gallbladders were significantly greater than controls,and hyperplastic changes,hypertrophic muscular layer,subserosal fibrosis,and adenomyomatosis were detected in 7(88%),5(63%),7(88%) and 5(63%) patients,respectively.Ki-67 labeling index was high and K-ras mutation was detected in 3 of 6 patients.CONCLUSION:To detect PBM without biliary dilatation before onset of gallbladder cancer,we should perform MRCP for individuals showing increased gallbladder wall thickness on ultrasound. | Kensuke Takuma Terumi Kamisawa Taku Tabata Seiichi Hara Sawako Kuruma Yoshihiko Inaba Masanao Kurata Goro Honda Koji Tsuruta Shin-ichiro Horiguchi Yoshinori Igarashi | 2012 | World Journal of Gastroenterology2012，18，26： | 13 |
| 2 | Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?显示文摘In immunoglobulin G4(IgG4)-related disease(RD),organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs.Although infiltration of many IgG4-positive plasma cells is detected in the gastric and colonic mucosa and major duodenal papilla of patients with autoimmune pancreatitis,it cannot be diagnosed as a gastrointestinal lesion involved in IgG4-RD,because none of the following is observed in these lesions:a mass-like formation;dense fibrosis;or obliterative phlebitis.Based on our review of the literature,there appear to be two types of IgG4-related gastrointestinal disease.One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach,consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells,which usually show submucosal spreading.The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach,colon,and major duodenal papilla,showing polypoid or mass-like lesions.Most solitary IgG4-related gastrointestinal lesions that are not associated with other IgG4-RD appear to be difficult to diagnose.It is of utmost importance to rule out malignancy.However,these lesions may respond to steroid therapy.To avoid unnecessary resection,IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. | Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Yuka Endo Go Kuwata Koichi Koizumi Tooru Shimosegawa Kazuichi Okazaki Tsutomu Chiba | 2013 | World Journal of Gastroenterology2013，19，35： | 12 |
| 3 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 4 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 5 | Differences between diffuse and focal autoimmune pancreatitis显示文摘AIM:To investigate differences in clinical features between diffuse-and focal-type autoimmune pancreatitis(AIP).METHODS:Based on radiological findings by computed tomography and/or magnetic resonance imaging,we divided 67 AIP patients into diffuse type(D type) and focal type(F type).We further divided F type into head type(H type) and body and/or tail type(B/T type) according to the location of enlargement.Finally,we classified the 67 AIP patients into three groups:D type,H type and B/T type.We compared the three types of AIP in terms of clinical,laboratory,radiological,functional and histological findings and clinical course.RESULTS:There were 34 patients with D-type,19 with H-type and 14 with B/T-type AIP.Although obstructive jaundice was frequently detected in D-typepatients(88%) and H-type patients(68%),no B/T-type patients showed jaundice as an initial symptom(P < 0.001).There were no differences in frequency of abdominal pain,but acute pancreatitis was associated more frequently in B/T-type patients(36%) than in D-type patients(3%)(P = 0.017).Serum immunoglobulin G(IgG)4 levels were significantly higher in D-type patients(median 309 mg/dL) than in B/T-type patients(133.5 mg/dL)(P = 0.042).Serum amylase levels in B/T-type patients(median:114 IU/L) were significantly greater than in H-type patients(72 IU/L)(P = 0.049).Lymphoplasmacytic sclerosing pancreatitis(LPSP) was histologically confirmed in 6 D-type,7 H-type and 4 B/T-type patients;idiopathic duct-centric pancreatitis was observed in no patients.Marked fibrosis and abundant infiltration of CD20-positive B lymphocytes with few IgG4-positive plasma cells were detected in 2 B/T-type patients.Steroid therapy was effective in all 50 patients(31 D type,13 H type and 6 B/T type).Although AIP relapsed during tapering or after stopping steroids in 3 D-type and 3 H-type patients,no patients relapsed in B/T type.During follow-up,radiological features of 6 B/T-type patients were not changed and 1 B/T-type patient improved naturally.CONCLUSION:Clinical features of H-type AIP were similar to those of D-type,but B/T-type differed from D and H types.B/T-type may involve diseases other than LPSP. | Taku Tabata Terumi Kamisawa Kensuke Takuma Seiichi Hara Sawako Kuruma Yoshihiko Inaba | 2012 | World Journal of Gastroenterology2012，18，17： | 6 |
| 6 | Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin显示文摘 | Takahiro Araki Masanori Emoto Megumi Teramura Hisayo Yokoyama Katsuhito Mori Sawako Hatsuda Takaaki Maeno Kayo Shinohara Hidenori Koyama Tetsuo Shoji Masaaki Inaba Yoshiki Nishizawa | 2006 | Metabolism2006，，8： | 5 |
| 7 | Hypothyroidism in patients with autoimmune pancreatitis显示文摘AIM To examine thyroid function and clinical features of hypothyroidism in autoimmune pancreatitis(AIP) patients.METHODS We examined thyroid function in 77 patients with type 1 AIP(50 males, 27 females; median age 68 years, range 33-85) diagnosed according to the Japanese diagnostic criteria for AIP 2011. We compared clinical and serological findings between patients with and without various categories of hypothyroidism. The change in hypothyroidism after steroid therapy was also examined. RESULTS Eight patients(10%) had hypothyroidism of 6 patients had subclinical hypothyroidism with a normal serum free thyroxine(FT4) and high thyroid stimulating hormone(TSH) level, and 2 patients had central hypothyroidism with low serum free triiodothyronine(FT3), FT4 and TSH levels. A significant goiter of the thyroid was not observed in any patient. There were no significant differences in age; male to female ratio; serum concentrations of IgG and IgG 4-related disease(IgG4-RD); presence of antithyroglobulin antibody, antinuclear antigen or rheumatoid factor; or presence of extrapancreatic lesions between the 6 patients with subclinical hypothyroidism and patients with euthyroidism. After steroid therapy, both subclinical and central hypothyroidism improved with improvement of the AIP.CONCLUSION Hypothyroidism was observed in 8(10%) of 77 AIP patients and was subclinical in 6 patients and central in 2 patients. Further studies are necessary to clarify whether this subclinical hypothyroidism is another manifestation of IgG4-RD. | Ryoko Shimizuguchi Terumi Kamisawa Yuka Endo Masataka Kikuyama Sawako Kuruma Kazuro Chiba Taku Tabata Satomi Koizumi | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，2： | 3 |
| 8 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 9 | The association of plasma adiponectin level with carotid arterial stiffness显示文摘 | Takahiro Araki Masanori Emoto Hisayo Yokoyama Takaaki Maeno Sawako Hatsuda Katsuhito Mori Hidenori Koyama Tetsuo Shoji Masaaki Inaba Yoshiki Nishizawa | 2006 | Metabolism2006，，5： | 2 |
| 10 | ABO blood type, long-standing diabetes, and the risk of pancreatic cancer显示文摘AIM: To retrospectively study pancreatic cancer patients with respect to their ABO blood type and diabetes. METHODS: Our analysis included a cohort of 1017 patients with pancreatic ductal cancer diagnosed at our hospital in Tokyo. They were divided into two groups: 114 patients with long-standing type 2 diabetes (DM group, defined as diabetes lasting for at least three years before the diagnosis of pancreatic cancer) and 903 patients without diabetes (non-DM group). Multivariate analysis was performed to identify factors that are associated with long-standing diabetes. The DM group was further divided into three subgroups according to the duration of diabetes (3-5 years, 5.1-14.9 years, and 15 years or more) and univariate analyses were performed. RESULTS: Of the 883 pancreatic cancer patients with serologically assessed ABO blood type, 217 (24.6%) had blood type O. Compared with the non-DM group, the DM group had a higher frequency of blood type B [odds ratio (OR) = 2.61, 95%CI: 1.24-5.47; reference group: blood type A]. Moreover, male (OR = 3.17, 95%CI: 1.67-6.06), older than 70 years of age (OR = 2.19, 95%CI: 1.20-3.98) and presence of a family history of diabetes (OR = 6.21, 95%CI: 3.38-11.36) were associated with long-standing type 2 diabetes. The mean ages were 64.8 ± 9.2 years, 67.1 ± 9.8 years, and 71.7 ± 7.0 years in the subgroups with the duration of diabetes, 3-5 years, 5.1-14.9 years, and 15 years or more, respectively (P = 0.007). A comparison of ABO blood type distribution among the subgroups also showed a significant difference (P = 0.03). CONCLUSION: The association of pancreatic cancer with blood type and duration of diabetes needs to be further examined in prospective studies. | Naoto Egawa Yingsong Lin Taku Tabata Sawako Kuruma Seiichi Hara Ken Kubota Terumi Kamisawa | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 11 | Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated degradation显示文摘 | Yuichi W Sawako T Ken-ichi N | 2008 | Mol Biol Cell2008，19，5： | 1 |
| 12 | Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ul- trasound surgery显示文摘 | Yutaka M Sawako T Hiromi H | 2009 | European Journal of Obstetrics & Gy- necology and Reproductive Biology2009，146，1： | 1 |
| 13 | Involvement of pallidotegmental neurons in methamphetamine- and MK -801 -induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal hy GABAB receptor agonist bacolfen 显示文摘 | Sawako A Kazuhiro T Hiroyuki M | 2008 | Neuropsychopharmacology2008，33，： | 1 |
| 14 | H ydrocellular foam dressings promote wound healing associated with de- crease in inflammation in rat periwound skin and granu- lation tissue, compared with hydrocolloid dressings显示文摘 | Takumi Y Gojiro N Sawako Y | 2015 | Biosci Biotechnol Biochem2015，79，2： | 1 |
| 15 | Amylose synthesis capacity of the three Wx genes of wheat cv. Chinese Spring显示文摘 | Hideho Miura Etsuko Araki Sawako Tarui | 1999 | Euphytica1999，，2： | 1 |
| 16 | Management of postoperative arterial hemorrhage after pancreato-biliary surgery according to the site of bleeding: re-laparotomy or interventional radiology显示文摘 | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Eriko Yamazaki Susumu Kadowaki Makoto Shibuya Sawako Maeno Shigeru Furui Koji Takeshita Yutaka Kotake Tadahiro Takada | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，1： | 1 |
| 17 | Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells显示文摘 | Sawako Kobayashi Shuichi Seki Norifumi Kawada Hiroyasu Morikawa Kazuki Nakatani Naoki Uyama Kazuo Ikeda Yuji Nakajima Tetsuo Arakawa Kenji Kaneda | 2003 | Cell and Tissue Research2003，，3： | 1 |
| 18 | Organohalogen compounds and their metabolites in the blood of Japanese amberjack ( Seriola quinqueradiata ) and scalloped hammerhead shark ( Sphyrna lewini ) from Japanese coastal waters显示文摘 | Kei Nomiyama Yukiko Uchiyama Satoko Horiuchi Akifumi Eguchi Hazuki Mizukawa Sawako Horai Hirata Ryota Shinohara Shinsuke Tanabe | 2011 | Chemosphere2011，，3： | 1 |
| 19 | Improvement of physicochemical stability of highly-concentrated antibodies using cyclodextrin polypseudorotaxane hydrogels显示文摘Recently,a large number of antibodies have been utilized as biodrugs,and their subcutaneous formulations are required to allow the self-administration.However,because of the lower administration capacity of subcutaneous formulation than intravenous ones,highly-concentrated antibody formulations(>100 mg/mL)are desired.Regretfully,highly-concentrated antibodies often cause aggregation during the long-term storage and transportation,resulting in the loss of pharmacological activity and induction of immunogenicity.On the other hand,we previously reported the potential use of polypseudorotaxane(PPRX)hydrogels consisting of polyethylene glycol(PEG,MW 20,000)and cyclodextrins(CyDs)as sustained release systems for protein drugs such as insulin and lysozyme. | Naoko Ohshita Anna Tajima Taishi Higashi Keiichi Motoyama Sawako Koyama Ruriko Iibuchi Shiuhei Mieda Kenji Handa Tomoaki Kimoto Hidetoshi Arima | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 1 |
| 20 | Secondary renal Fanconi syndrome caused by valproate therapy显示文摘 | Toru Watanabe Hideto Yoshikawa Sawako Yamazaki Yuki Abe Tokinari Abe | 2005 | Pediatric Nephrology2005，，6： | 1 |
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