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| 1 | Regulation of the SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE genes/microRNA 156 Module by the Homeodomain Proteins PENNYWISE and POUND-FOOLISH in Arabidopsis显示文摘开花期的形态学被调整花说明的时间、空间的事件部分地调整。在 Arabidopsis,一条内长的 flowering 时间小径由 SQUAMOSA 倡导者绑定的一个子集调停了像蛋白质(系统程序设计语言) 包括 SPL3, SPL4,和 SPL5,抄写因素工作由激活花的分裂组织身份基因指定花。在射击开发期间, SPL3, SPL4,和 SPL5 被 microRNA156 (miR156 ) post-transcriptionally 调整。光周期调整了 florigenic 信号, FLOWERING 地点 T (英尺) ,支持花的正式就职,部分地由激活 SPL3, SPL4,和 SPL5。接着,这些系统程序设计语言与英尺同时工作指定花分裂组织。二相关象 BELL1 一样 homeobox 基因 PENNYWISE (PNY ) 并且省小钱吃大亏(PNF ) 在射击表示了顶端的分裂组织绝对为花的分裂组织的说明被要求。基因研究证明英尺的花的说明功能取决于 PNY 和 PNF;然而,在这些 homeodomain 蛋白质和系统程序设计语言之间的相互影响不被知道。在这张手稿,我们证明 SPL3, SPL4,和 SPL5 的花的正式就职是的 photoperiodic 依赖于 PNY 和 PNF。进一步, PNY 和 PNF 也由否定地调整 miR156 控制 SPL3, SPL4,和 SPL5 表示。最后, SPL4 的宫外的表示部分救 pny pnf non-flower-producing 显型,当在 pny pnf 植物的 SPL3 或 SPL5 的 overexpression 是不能的恢复花说明时。这些结果建议那:(1 ) SPL3, SPL4,和 SPL5 功能依赖于 PNY 和 PNF,或(2 ) 多重系统程序设计语言的表示在 pny pnf 植物为花的说明被要求。 | Shruti Lal Leo Bryan Pacis Harley M.S. Smith | 2011 | Molecular Plant2011，4，6： | 13 |
| 2 | Early warning system for shallow landslides using rainfall threshold and slope stability analysis显示文摘A combined cluster and regression analysis were performed for the first time to identify rainfall threshold that triggers landslide events in Amboori, Kerala, India. Amboori is a tropical area that is highly vulnerable to landslides. The 2, 3, and 5-day antecedent rainfall data versus daily rainfall was clustered to identify a cluster of critical events that could potentially trigger landslides. Further, the cluster of critical events was utilized for regression analysis to develop the threshold equations. The 5-day antecedent(xvariable) vs. daily rainfall(y-variable) provided the best fit to the data with a threshold equation of y = 80.7-0.1981 x. The intercept of the equation indicates that if the 5-day antecedent rainfall is zero, the minimum daily rainfall needed to trigger the landslide in the Amboori region would be 80.7 mm. The negative coefficient of the antecedent rainfall indicates that when the cumulative antecedent rainfall increases, the amount of daily rainfall required to trigger monsoon landslide decreases. The coefficient value indicates that the contribution of the 5-day antecedent rainfall is~20% to the landslide trigger threshold. The slope stability analysis carried out for the area, using Probabilistic Infinite Slope Analysis Model(PISA-m), was utilized to identify the areas vulnerable to landslide in the region. The locations in the area where past landslides have occurred demonstrate lower Factors of Safety(FS) in the slope stability analysis. Thus, rainfall threshold analysis together with the FS values from slope stability can be suitable for developing a simple, cost-effective, and comprehensive early-warning system for shallow landslides in Amboori and similar regions. | Shruti Naidu K.S.Sajinkumar Thomas Oommen V.J.Anuja Rinu A.Samuel C.Muraleedharan | 2018 | Geoscience Frontiers2018，9，6： | 12 |
| 3 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 4 | 低VOC涂料用成膜助剂(英文)显示文摘随着环保法规的日益严格和人们环境质量意识的增强,研发新型材料,采用新工艺是降低VOC的有效途径。本文介绍了新型油酸类无溶剂型成膜助剂,能有效降低涂料中的VOC含量以及提高涂料相应性能。 | Shruti Singhal | 2006 | 涂料工业2006，36，9： | 5 |
| 5 | Neuroprotective measures in children with traumatic brain injury显示文摘Traumatic brain injury(TBI) is a major cause of death and disability in children. Severe TBI is a leading cause of death and often leads to life changing disabilities in survivors. The modern management of severe TBI in children on intensivecare unit focuses on preventing secondary brain injury to improve outcome. Standard neuroprotective measures are based on management of intracranial pressure(ICP) and cerebral perfusion pressure(CPP) to optimize the cerebral blood flow and oxygenation, with the intention to avoid and minimise secondary brain injury. In this article, we review the current trends in management of severe TBI in children, detailing the general and specific measures followed to achieve the desired ICP and CPP goals. We discuss the often limited evidence for these therapeutic interventions in children, extrapolation of data from adults, and current recommendation from paediatric guidelines. We also review the recent advances in understanding the intracranial physiology and neuroprotective therapies, the current research focus on advanced and multi-modal neuromonitoring, and potential new therapeutic and prognostic targets. | Shruti Agrawal Ricardo Garcia Branco | 2016 | World Journal of Critical Care Medicine2016，5，1： | 5 |
| 6 | Selective CDK inhibitors:promising candidates for future clinical traumatic brain injury trials显示文摘Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective(Flavopiridol) and selective(Roscovitine and CR-8) cyclin-dependent kinase inhibitors have been shown across multiple experimental traumatic brain injury models and species. Cyclin-dependent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials. | Shruti V.Kabadi Alan I.Faden | 2014 | Neural Regeneration Research2014，9，17： | 4 |
| 7 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 8 | Antioxidant activity and total phenolic content of ethanolic extract of Caesalpinia bonducella seeds显示文摘 | Shruti Shukla Archana Mehta Jinu John Siddharth Singh Pradeep Mehta Suresh Prasad Vyas | 2009 | Food and Chemical Toxicology2009，，8： | 3 |
| 9 | Deciphering the modifiers for phenotypic variability of X-linked adrenoleukodystrophy显示文摘X-linked adrenoleukodystrophy(X-ALD),an inborn error of peroxisomalβ-oxidation,is caused by defects in the ATP Binding Cassette Subfamily D Member 1(ABCD1)gene.X-ALD patients may be asymptomatic or present with several clinical phenotypes varying from severe to mild,severe cerebral adrenoleukodystrophy to mild adrenomyeloneuropathy(AMN).Although most female heterozygotes present with AMN-like symptoms after 60 years of age,occasional cases of females with the cerebral form have been reported.Phenotypic variability has been described within the same kindreds and even among monozygotic twins.There is no association between the nature of ABCD1 mutation and the clinical phenotypes,and the molecular basis of phenotypic variability in X-ALD is yet to be resolved.Various genetic,epigenetic,and environmental influences are speculated to modify the disease onset and severity.In this review,we summarize the observations made in various studies investigating the potential modifying factors regulating the clinical manifestation of X-ALD,which could help understand the pathogenesis of the disease and develop suitable therapeutic strategies. | Shruti V Palakuzhiyil Rita Christopher Sadanandavalli Retnaswami Chandra | 2020 | World Journal of Biological Chemistry2020，11，3： | 2 |
| 10 | The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor显示文摘 | Shruti Setia Bimla Nehru Sankar Nath Sanyal | 2014 | Biomedicine & Pharmacotherapy2014，，6： | 2 |
| 11 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 12 | Rectal ulcers and massive bleeding after hemorrhoidal band ligation while on aspirin显示文摘Endoscopic hemorrhoidal band ligation is a well-established nonoperative method for treatment of bleeding internal hemorrhoids(grade 1 to 3). It is a safe and effective technique with a high success rate. Complications with this procedure are uncommon. Although rectal ulceration due to band ligation is a rare complication, it can cause life-threatening hemorrhage especially when patients are on medications which impair hemostasis like aspirin or non steroidal antiinflammatory drugs. We present 2 cases of massive lower gastro-intestinal bleeding in patients who had a band ligation procedure performed 2 wk prior to the presentation and were on aspirin at home. Both the patients were hemodynamically unstable requiring resuscitation. They required platelet and blood transfusions and were found to have rectal ulcers on colonoscopy done subsequently. The rectal ulcers corresponded to the site of band ligation. The use of aspirin by these patients would have caused defects in the hemostasis and may have predisposed them to massive bleeding in the presence of rectal ulcers occurring after the band ligation procedure. Managing aspirin before and after the ligation may be difficult especially since adequate guidelines are unavailable. Stopping aspirin in all the cases might not be safe and the decision should be individualized. | Shruti Patel Ghulamullah Shahzad Kaleem Rizvon Krishnaiyer Subramani Prakash Viswanathan Paul Mustacchia | 2014 | World Journal of Clinical Cases2014，2，4： | 2 |
| 13 | The Predictors of Postoperative Laryngeal Nerve Paresis in Patients Undergoing Thyroid Surgery:A Pi-lot Study 显示文摘 | Malka C Shruti SJ Steven MM | 2012 | Journal of Voice2012，26，2： | 1 |
| 14 | Acute bacterial meningitis in infants and chil-dren:epidemiology and management显示文摘 | Shruti A Simon N | | 0，，： | 1 |
| 15 | Assessment of liver fibrosis by Transient Elastography in Persons with Hepatitis C Virus Infection or HIV-Hepatitis C Virus Coinfection显示文摘 | Gregory D Kirk Jacquie Astemborski Shruti H Mehta | 2009 | Clin infect Dis2009，48，7： | 1 |
| 16 | 超导系统中玻色模式的量子控制显示文摘玻色模式在多种量子技术中都有重要应用,比如光子常用于量子通信,自旋系综中的磁振子可用于量子信息存储,力学谐振子可用于微波到光波的量子转换.最近的研究表明,玻色模式也可用于进行量子计算,其最具代表性的物理体系是超导量子谐振腔电路.超导系统的玻色模式可以具有较长的相干时间,量子信息可以存储在这些玻色模式的希尔伯特子空间中.对玻色模式进行量子操控的难点在于引入除高斯操控以外的非线性操控.本综述系统介绍了目前对玻色模式进行量子控制的各种理论方法和实验进展,包括幺正控制、量子反馈控制、驱动-耗散控制与和乐量子控制.文章总结的操控方法将对玻色量子计算的进一步发展具有重要的指导意义. | 马稳龙 Shruti Puri Robert J.Schoelkopf Michel H.Devoret S.M.Girvin 蒋良 | 2021 | Science Bulletin2021，66，17： | 1 |
| 17 | Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning显示文摘 | Katherine E. Berry Shruti Waghray Stefanie A. Mortimer Yun Bai Jennifer A. Doudna | 2011 | Structure2011，，10： | 1 |
| 18 | Determination of Red Blood Cell Velocity by Video Shuttering and Image Analysis 显示文摘 | Anadn A P Shruti A J Roland N P | 1999 | Annals of Biomedical Engineering1999，27，3： | 1 |
| 19 | Curcumin alone and in combination with aug-mentin protects against pulmonary inflammation and acute lung injury gener-ated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice显示文摘 | Shruti B Sanjay C | 2010 | J Med Micro2010，59，4： | 1 |
| 20 | Antioxidant activity and total phenolic content of ethanolic extract of Caesalpinia bonducella seeds显示文摘 | Shruti Shukla Archana Mehta Jinu John | 2009 | Food and Chemical Toxicology2009，47，： | 1 |
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