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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Progress in additive manufacturing on new materials: A review显示文摘Recent efforts and advances in additive manufacturing(AM) on different types of new materials are presented and reviewed. Special attention is paid to the material design of cladding layers, the choice of feedstock materials, the metallurgical behavior and synthesis principle during the AM process, and the resulted microstructures and properties, as well as the relationship between these factors. Thereafter,the trend of development in the future is forecasted, including: Effects of the particles size and size distribution of powders; Approaches for producing fine microstructures; Opportunities for creating new materials by AM; Wide applications in reconditioning of damaged components; Challenges for deep understanding and applications of the AMed new materials. The idea of 'Develop Materials' or 'Create Materials' by AM is highlighted, but a series of scientific, technological and engineering problems remain to be solved in future. | Neng Li Shuai Huang Guodong Zhang Renyao Qin Wei Liu Huaping Xiong Gongqi Shi Jon Blackburn | 2019 | Journal of Materials Science & Technology2019，35，2： | 47 |
| 3 | Study of BESIII trigger efficiencies with the 2018 J/ψ data显示文摘Using a dedicated data sample taken in 2018 on the J/ψpeak,we perform a detailed study of the trigger efficiencies of the BESIII detector.The efficiencies are determined from three representative physics processes,namely Bhabha scattering,dimuon production and generic hadronic events with charged particles.The combined efficiency of all active triggers approaches 100%in most cases,with uncertainties small enough not to affect most physics analyses. | M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.Chelkov D.Y.Chen G.Chen H.S.Chen M.L.Chen S.J.Chen X.R.Chen Y.B.Chen Z.J Chen W.S.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai X.C.Dai A.Dbeyssi R.E.de Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong X.Dong S.X.Du Y.L.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng M.Fritsch C.D.Fu Y.Gao Y.Gao Y.Gao Y.G.Gao I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu Y.T.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris H Hüsken K.L.He F.H.Heinsius C.H.Heinz T.Held Y.K.Heng C.Herold M.Himmelreich T.Holtmann Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad S.Jaeger S.Janchiv Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.B.Jiang X.S.Jiang J.B.Jiao Z.Jiao S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.G.Kurth W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.J.Li J.L.Li J.Q.Li J.S.Li Ke Li L.K.Li Lei Li P.R.Li S.Y.Li W.D.Li W.G.Li X.H.Li X.L.Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang L.Z.Liao J.Libby C.X.Lin B.J.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.L.Liu J.Y.Liu K.Liu K.Y.Liu Ke Liu L.Liu M.H.Liu P.L.Liu Q.Liu Q.Liu S.B.Liu Shuai Liu T.Liu W.M.Liu X.Liu Y.Liu Y.B.Liu Z.A.Liu Z.Q.Liu X.C.Lou F.X.Lu H.J.Lu J.D.Lu J.G.Lu X.L.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo b P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma R.Q.Ma R.T.Ma X.X.Ma X.Y.Ma F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni Y.J.Mao Z.P.Mao S.Marcello Z.X.Meng J.G.Messchendorp G.Mezzadri T.J.Min R.E.Mitchell X.H.Mo Y.J.Mo N.Yu.Muchnoi H.Muramatsu S.Nakhoul Y.Nefedov F.Nerling I.B.Nikolaev Z.Ning S.Nisar S.L.Olsen Q.Ouyang S.Pacetti X.Pan Y.Pan A.Pathak P.Patteri M.Pelizaeus H.P.Peng K.Peters J.Pettersson J.L.Ping R.G.Ping R.Poling V.Prasad H.Qi H.R.Qi K.H.Qi M.Qi T.Y.Qi T.Y.Qi S.Qian W.-B.Qian Z.Qian C.F.Qiao L.Q.Qin X.S.Qin Z.H.Qin J.F.Qiu S.Q.Qu K.H.Rashid K.Ravindran C.F.Redmer A.Rivetti V.Rodin M.Rolo G.Rong Ch.Rosner M.Rump H.S.Sang A.Sarantsev Y.Schelhaas C.Schnier K.Schoenning M.Scodeggio D.C.Shan W.Shan X.Y.Shan J.F.Shangguan M.Shao C.P.Shen P.X.Shen X.Y.Shen H.C.Shi R.S.Shi X.Shi X.D Shi W.M.Song Y.X.Song S.Sosio S.Spataro K.X.Su P.P.Su F.F.Sui G.X.Sun H.K.Sun J.F.Sun L.Sun S.S.Sun T.Sun W.Y.Sun X Sun Y.J.Sun Y.K.Sun Y.Z.Sun Z.T.Sun Y.H.Tan Y.X.Tan C.J.Tang G.Y.Tang J.Tang J.X.Teng V.Thoren I.Uman B.Wang C.W.Wang D.Y.Wang H.J.Wang H.P.Wang K.Wang L.L.Wang M.Wang M.Z.Wang Meng Wang W.Wang W.H.Wang W.P.Wang X.Wang X.F.Wang X.L.Wang Y.Wang Y.D.Wang Y.F.Wang Y.Q.Wang Y.Y.Wang Z.Wang Z.Y.Wang Ziyi Wang Zongyuan Wang D.H.Wei P.Weidenkaff F.Weidner S.P.Wen D.J.White U.Wiedner G.Wilkinson M.Wolke L.Wollenberg J.F.Wu L.H.Wu L.J.Wu X.Wu Z.Wu L.Xia H.Xiao S.Y.Xiao Z.J.Xiao X.H.Xie Y.G.Xie Y.H.Xie T.Y.Xing G.F.Xu Q.J.Xu W.Xu X.P.Xu F.Yan L.Yan W.B.Yan W.C.Yan Xu Yan H.J.Yang H.X.Yang L.Yang S.L.Yang Y.X.Yang Yifan Yang Zhi Yang M.Ye M.H.Ye J.H.Yin Z.Y.You B.X.Yu C.X.Yu G.Yu J.S.Yu T.Yu C.Z.Yuan L.Yuan X.Q.Yuan Y.Yuan Z.Y.Yuan C.X.Yue A.Yuncu A.A.Zafar Y.Zeng B.X.Zhang Guangyi Zhang H.Zhang H.H.Zhang H.Y.Zhang J.J.Zhang J.L.Zhang J.Q.Zhang J.W.Zhang J.Y.Zhang J.Z.Zhang Jianyu Zhang Jiawei Zhang L.Q.Zhang Lei Zhang S.Zhang S.F.Zhang Shulei Zhang X.D.Zhang X.Y.Zhang Y.Zhang Y.H.Zhang Y.T.Zhang Yan Zhang Yao Zhang Yi Zhang Z.H.Zhang Z.Y.Zhang G.Zhao J.Zhao J.Y.Zhao J.Z.Zhao Lei Zhao Ling Zhao M.G.Zhao Q.Zhao S.J.Zhao Y.B.Zhao Y.X.Zhao Z.G.Zhao A.Zhemchugov B.Zheng J.P.Zheng Y.Zheng Y.H.Zheng B.Zhong C.Zhong L.P.Zhou Q.Zhou X.Zhou X.K.Zhou X.R.Zhou A.N.Zhu J.Zhu K.Zhu K.J.Zhu S.H.Zhu T.J.Zhu W.J.Zhu W.J.Zhu Y.C.Zhu Z.A.Zhu B.S.Zou J.H.Zou | 2021 | Chinese Physics C2021，45，2： | 33 |
| 4 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 5 | Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein显示文摘Very recently,a novel coronavirus,2019-nCoV,emerged in Wuhan,China and then quickly spread worldwide,resulting in>17,388 confirmed cases and 361 deaths as of 3 February 2020,thus calling for the development of safe and effective therapeutics and prophylatics.1,2 Similar to severe acute respiratory syndrome(SARS)-CoV,2019-nCoV belongs to lineage B betacoronavirus,and it has the ability to utilize human angiotensin-converting enzyme 2(ACE2)as a receptor to infect human cells. | Shuai Xia Yun Zhu Meiqin Liu Qiaoshuai Lan Wei Xu Yanling Wu Tianlei Ying Shuwen Liu Zhengli Shi Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，7： | 27 |
| 6 | Differences in microstructure and properties between selective laser melting and traditional manufacturing for fabrication of metal parts: A review显示文摘(直线波松) 作为生产技术的添加剂之一,选择激光融化广泛地被调查制作金属部分。在直线波松,部分以一种 layer-by-layer 方式从粉末直接被生产;直线波松也提供几个优点,例如有高三维的精确性的复杂部分的生产,与生产技术的另外的添加剂相比。因此,直线波松能在航空学被使用,航天学,药,并且死并且铸造工业。然而,这种技术不同于传统的方法,例如扔并且前进;例如,前者极大地以产品的微观结构和性质不同。这份报纸通过直线波松在金属材料制造上总结相关研究。基于在 Huazhong 大学 Sci 技术完成的一个工作,快速的 Manuf。中心(HUST-RMC ) 并且与在其它描述的特征相比,直线波松的报导研究,微观结构,性质,维的精确性,和应用被介绍。 | Bo SONG Xiao ZHAO Shuai LI Changjun HAN Qingsong WEI Shifeng WEN Jie LIU Yusheng SHI | 2015 | Frontiers of Mechanical Engineering2015，10，2： | 26 |
| 7 | Microstructure Characteristics of Inconel 625 Superalloy Manufactured by Selective Laser Melting显示文摘Selective laser melting(SLM), an additive manufacturing process, is capable of manufacturing metallic parts with complex shapes directly from computer-aided design(CAD) models. SLM parts are created on a layer-by-layer manner, making it more flexible than traditional material processing techniques. In this paper, Inconel 625 alloy, a widely used material in the aerospace industry, were chosen as the build material. Scanning electron microscopy(SEM), electron back scattering diffraction(EBSD) and X-ray diffraction(XRD) analysis techniques were employed to analyze its microstructure. It was observed that the molten pool was composed of elongated columnar crystal. Due to the rapid cooling speed, the primary dendrite arm space was approximately 0.5 μm and the hardness of SLM state was very high(343 HV). The inverse pole figure(IPF) indicated that the growing orientation of the most grains was<001> due to the epitaxial growth and heat conduction. The XRD results revealed that the austenite structure with large lattice distortion was fully formed. No carbides or precipitated phases were found.After heat treatment the grains grew into two microstructures with distinct morphological characters,namely, rectangular grains and limited in the molten pool, and equiaxed grains along the molten boundaries. Upon experiencing the heat treatment, MC carbides with triangular shapes gradually precipitated. The results also identified that a large number of zigzag grain boundaries were formed. In this study, the grain formation and microstructure, and the laws of the molten pool evolution were also analyzed and discussed. | Shuai Li Qingsong Wei Yusheng Shi Zicheng Zhu Danqing Zhang | 2015 | Journal of Materials Science & Technology2015，31，9： | 24 |
| 8 | Overview of Mechanism and Mitigation Measures on Multi-frequency Oscillation Caused by Large-scale Integration of Wind Power显示文摘In recent years,the large-scale integration of re-newable energy sources represented by wind power and the widespread application of power electronic devices in power systems have led to the emergence of multi-frequency oscillation problems covering multiple frequency segments,which seriously threaten system stability and restrict the accommodation of renewable energy.The oscillation problems related to renewable energy integration have become one of the most popular topics in the field of wind power integration and power system stability research.It has received extensive attention from both academia and industries with many promising research results achieved to date.This paper first analyzes several typical multi-frequency oscillation events caused by large-scale wind power integration in domestic and foreign projects,then studies the multi-frequency oscillation problems,including wind turbine’s shafting torsional oscillation,sub/super-synchronous oscillation and high frequency resonance.The state of the art is systematically summarized from the aspects of oscillation mechanism,analysis methods and mitigation measures,and the future research directions are explored. | Yongning Chi Bingjie Tang Jiabing Hu Xinshou Tian Haiyan Tang Yan Li Sujuan Sun Lei Shi Lei Shuai | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 23 |
| 9 | Facile metagrating holograms with broadband and extreme angle tolerance显示文摘The emerging meta-holograms rely on arrays of intractable meta-atoms with various geometries and sizes for customized phase profiles that can precisely modulate the phase of a wavefront at an optimal incident angle for given wavelengths.The stringent and band-limited angle tolerance remains a fundamental obstacle for their practical application,in addition to high fabrication precision demands.Utilizing a different design principle,we determined that facile metagrating holograms based on extraordinary optical diffraction can allow the molding of arbitrary wavefronts with extreme angle tolerances(near-grazing incidence)in the visible–near-infrared regime.By modulating the displacements between uniformly sized meta-atoms rather than the geometrical parameters,the metagratings produce a robust detour phase profile that is irrespective of the wavelength or incident angle.The demonstration of high-fidelity meta-holograms and in-site polarization multiplexing significantly simplifies the metasurface design and lowers the fabrication demand,thereby opening new routes for flat optics with high performances and improved practicality. | Zi-Lan Deng Junhong Deng Xin Zhuang Shuai Wang Tan Shi Guo Ping Wang Yao Wang Jian Xu Yaoyu Cao Xiaolei Wang Xing Cheng Guixin Li Xiangping Li | 2018 | Light(Science & Applications)2018，7，1： | 17 |
| 10 | Impact of chilling injury and global warming on rice yield in Heilongjiang Province显示文摘这研究为米饭集中于索引在 Heilongjiang 省的寒心的损害在 19602009 期间。第一,我们比较了由与传统的方法种密度的米饭加权的一个新导出的气候数据,并且发现新的是更合理的在庄稼收益上估计气候变化的影响。就在第二,寒心的索引由气象学、国家、国际的层次定义的省寒心的米饭的频率和紧张而言被估计。,结果证明气象学的标准对延期类型损害合适国际的,在阀值(GDDn ) 下面种度白天的所谓的和,描绘的最好为米饭的无菌类型的寒心的损害。当二个独立变量到达了约 92% ,包括两损害的米饭收益时间系列模型的解释能力打字(p < 0.05 ) 。最后,我们断定到米饭收益的人和天气因素的贡献率是大约87.2%和12.8%分别地,并且作为光增加的趋势因为无菌类型的寒心的损害在在最近的年里出发到流动时期期间被发现,为在未来在 Heilongjiang 省种的米饭显示高寒心的风险全球温暖。 | LIU Xiaofei ZHANG Zhao SHUAI Jiabing WANG Pin SHI Wenjiao TAO Fulu CHEN Yi | 2013 | Journal of Geographical Sciences2013，23，1： | 16 |
| 11 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 12 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 13 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 14 | Red and Blue Lights Significantly Affect Photosynthetic Properties and Ultrastructure of Mesophyll Cells in Senescing Grape Leaves显示文摘Light quality significantly affects photosynthetic efficiency in plants. The mechanisms for how light quality affects photosynthesis in grape is poorly understood. Therefore, to investigate the effects of different light qualities on chloroplast ultrastructure and photosynthesis efficiency, two grape cultivars ‘Italia'(slower speed of leaf senescence) and ‘Centennial Seedless'(faster speed of leaf senescence) grown under protected and delayed conditions were used. The three treatments, replicated three times, were control(no supplemental lighting), red light and blue light. Chlorophyll content, net photosynthetic rate, and the ratio of F_v/F_m significantly increased in red light relative to the control. The opposite trend was observed in blue light in the early phase of leaf senescence. At later stages, physiological indexes were gradually higher than that of control, resulting in a delay in leaf senescence. Compared to the control, red and blue light both significantly increased the chlorophyll a/b ratio. Electron microscopy showed that blue light caused severe damage to the fine structure of chloroplasts at early stages of leaf senescence, but effects at later stages of leaf senescence became less severe compared to the control. The degradation of chloroplast ultrastructure was apparently delayed in red light throughout the experimental timeframe compared to other treatments. In this experiment, ‘Italia' showed higher chlorophyll content, net photosynthetic rate, ratios of F_v/F_m, chlorophyll a/b and better preserved chloroplast ultrastructure relative to ‘Centennial Seedless', resulting in a slower rate of leaf senescence. | WANG Shuai WANG Xiaodi SHI Xiangbin WANG Baoliang ZHENG Xiaocui WANG Haibo LIU Fengzhi | 2016 | Horticultural Plant Journal2016，2，2： | 10 |
| 15 | An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius显示文摘新 abietane diterpene12-hydroxy-7-oxo-5,8,11,13-tetraene-18,6-abietanolide 和新自然 sterolstigmasta-7,22-diene-3beta, 5alpha,6alpha-triol 从真菌 Phellinus igniarius.Their 结构的 fruiting 身体被孤立被分光镜的方法包括 2DNMR 技术阐明。 | Ying WANG Su Juan WANG Shun Yan MO Shuai LI Yong Chun YANG Jian Gong SHI | 2006 | Chinese Chemical Letters2006，17，4： | 10 |
| 16 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
| 17 | ^11C-PIBPET和^18F-FDGPET显像诊断阿尔茨海默病与遗忘型轻度认知损害的临床价值显示文摘目的应用11C-PIB PET和18F-FDG PET显像研究阿尔茨海默病和遗忘型轻度认知损害患者β-淀粉样蛋白(Aβ)沉积与葡萄糖代谢之间的关系,联合载脂蛋白E(ApoE)基因型进一步探讨遗忘型轻度认知损害与阿尔茨海默病的相关性。方法利用PET显像对阿尔茨海默病(14例)、遗忘型轻度认知损害(10例)和正常对照者(5例)脑组织Aβ沉积和葡萄糖代谢变化进行分析,采用聚合酶链反应-限制性片段长度多态性方法对ApoE基因型进行分析。结果阿尔茨海默病组患者11C-PIB标准化摄取比值在下顶叶、颞叶外侧、额叶、后扣带回皮质和楔前叶、枕叶和纹状体均高于正常对照组(P<0.05);遗忘型轻度认知损害组患者脑组织11C-PIB结合水平呈双峰形。11C-PIB+aMCI亚组与阿尔茨海默病组、11C-PIB-aMCI亚组与正常对照组之间11C-PIB标准化摄取比值差异均无统计学意义(P>0.05)。18F-FDG PET显像显示,3/5例11C-PIB+aMCI亚组患者双侧顶叶、颞叶和楔前叶代谢减低,其中2例ApoEε4等位基因携带者随访期间进展至阿尔茨海默病;3/5例11C-PIB-aMCI亚组患者双侧额叶和前扣带回代谢减低。结论11C-PIB PET显像是筛查具有阿尔茨海默病病理特点的遗忘型轻度认知损害患者的有效工具。具有阿尔茨海默病病理特征的遗忘型轻度认知损害患者可伴有顶叶、颞叶外侧皮质和楔前叶代谢减低,其中ApoEε4等位基因携带者更易进展至阿尔茨海默病痴呆。 | Shi Zhihong Wang Ying Liu Shuai Liu Shuling Z hou Yuying Wang Jinhuan Cai Li Gao Shuo Ji Yong | 2014 | 中国现代神经疾病杂志2014，14，3： | 8 |
| 18 | Quantum twisted double-slits experiments:confirming wavefunctions'physical reality显示文摘Are quantum states real? This most fundamental question in quantum mechanics has not yet been satisfactorily resolved, although its realistic interpretation seems to have been rejected by various delayedchoice experiments. Here, to address this long-standing issue, we present a quantum twisted double-slit experiment. By exploiting the subluminal feature of twisted photons, the real nature of a photon during its time in flight is revealed for the first time. We found that photons' arrival times were inconsistent with the states obtained in measurements but agreed with the states during propagation. Our results demonstrate that wavefunctions describe the realistic existence and evolution of quantum entities rather than a pure mathematical abstraction providing a probability list of measurement outcomes. This finding clarifies the long-held misunderstanding of the role of wavefunctions and their collapse in the evolution of quantum entities. | Zhi-Yuan Zhou Zhi-Han Zhu Shi-Long Liu Yin-Hai Li Shuai Shi Dong-Sheng Ding Li-Xiang Chen Wei Gao Guang-Can Guo Bao-Sen Shi | 2017 | Science Bulletin2017，62，17： | 8 |
| 19 | Improved Relative-transformation Principal Component Analysis Based on Mahalanobis Distance and Its Application for Fault Detection显示文摘主要部件分析(PCA ) 广泛地在过程工业被使用了,它能维持最大的差错察觉率。尽管许多问题在 PCA 被处理了,一些必要问题仍然保持未解决。这研究以下列方法为差错察觉性能改进 PCA。第一,一个相对转变计划基于 Mahalanobis 距离(MD ) 被介绍消除数据的尺寸的效果而不是无尺寸的标准化,并且改进精确性和差错察觉的即时性能。理论推导证明那相对转变能直接基于 MD 消除尺寸的效果并且在结果显示出的相对空间,分析和模拟给 PCA 的合理解释它的优势和有效性。第二,一个改进摆平的预言错误(SPE ) 统计数值被给改进标准化 PCA 的差错察觉表演,它能使标准化基于 PCA 的差错察觉方法成为对实际工业过程合适的更多。最后,二个改进方法被联合更有效地检测差错。建议方法被使用在热连续滚动过程检测 looper 系统的单个差错和多差错,模拟结果以易感知,精确性和差错察觉的即时性能为差错察觉性能表明这些改进的有效性。 | SHI Huai-Tao LIU Jian-Chang XUE Peng ZHANG Ke WU Yu-Hou ZHANG Li-Xiu TAN Shuai | 2013 | 自动化学报2013，39，9： | 8 |
| 20 | Study on the value of serum miR-106b for the early diagnosis of hepatocellular carcinoma显示文摘AIM To investigate the short-term outcomes and risk factors indicating postoperative death of patients with lesions adjacent to the hepatocaval confluence.METHODS We retrospectively analyzed 54 consecutive patients who underwent hepatectomy combined with inferior vena cava(IVC)and/or hepatic vein reconstruction(HVR)from January 2012 to January 2016 at our liver surgery center.The patients were divided into5 groups according to the range of IVC and hepatic vein involvement.The patient details,indications for surgery,operative techniques,intra-and postoperative outcomes were compared among the 5 groups.Univariate and multivariate analyses were performed to explore factors predictive of overall operative death.RESULTS IVC replacement was carried out in 37(68.5%)patients and HVR in 17(31.5%)patients.Type I2H2 had the longest operative blood loss,operative duration and overall liver ischemic time(all,p<0.05).Three patients of Type I3H1 with totally occluded IVC did not need IVC reconstruction.Total postoperative morbidity rate was40.7%(22 patients)and the operative mortality rate was 16.7%(9 patients).Factors predictive of operative death included IVC replacement(p=0.048),duration of liver ischemia(p=0.005)and preoperative liver function being Child-pugh B(p=0.025). CONCLUSION IVC replacement,duration of liver ischemia and preoperative poor liver function were risk factors predictive of postoperative death.We should be cautious about IVC replacement,especially in Type I2H2.For Type I3H1,it was unnecessary to replace IVC when the collateral circulation was established. | Bao-Min Shi Wen Lu Kun Ji Yu-Feng Wang Shuai Xiao Xiu-Yan Wang | 2017 | World Journal of Gastroenterology2017，23，20： | 8 |
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