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| 1 | Advances in low-protein diets for swine显示文摘Recent years have witnessed the great advantages of reducing dietary crude protein(CP) with free amino acids(AA)supplementation for sustainable swine industry, including saving protein ingredients, reducing nitrogen excretion, feed costs and the risk of gut disorders without impairing growth performance compared to traditional diets. However, a tendency toward increased fatness is a matter of concern when pigs are fed low-protein(LP) diets. In response, the use of the net energy system and balanced AA for formulation of LP diets has been proposed as a solution. Moreover, the extent to which dietary CP can be reduced is complicated. Meanwhile, the requirements for the first five limiting AA(lysine, threonine, sulfur-containing AA, tryptophan, and valine) that growing-finishing pigs fed LP diets were higher than pigs fed traditional diets, because the need for nitrogen for endogenous synthesis of non-essential AA to support protein synthesis may be increased when dietary CP is lowered. Overall, to address these concerns and give a better understanding of this nutritional strategy, this paper reviews recent advances in the study of LP diets for swine and provides some insights into future research directions. | Yuming Wang Junyan Zhou Gang Wang Shuang Cai Xiangfang Zeng Shiyan Qiao | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 23 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer显示文摘Metformin is a widely prescribed hypoglycemic drug.Many studies have shown its anti-cancer properties.In the present study,we aimed to explore the effect of metformin on breast cancer and clarify the underlying mechanism.Our results showed that metformin induced ferroptosis in MDA-MB-231 cells through upregulating miR-324-3p expression.Overexpression of miR-324-3p inhibited cancer cell viability.miR-324-3p inhibitor promoted cell viability.Further studies showed that the effect of miR-324-3p was mediated by directly targeting glutathione peroxidase 4(GPX4).miR-324-3p bound to the 3ʹ-UTR of GPX4 and led to the downregulation of GPX4.In vivo studies showed that metformin induced ferroptosis by upregulating miR-324-3p in the xenograft model of breast cancer in mice.Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR-324-3p/GPX4 axis.Metformin could act as a potential anti-cancer agent through the induction of ferroptosis. | Yifeng Hou Shuang Cai Shouyang Yu Hui Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 11 |
| 4 | Preliminary molecular analysis of bacterial composition in periapical lesions with primary endodontic infections of deciduous teeth显示文摘 | SHANG Jia-jian YANG Qiu-bo ZHAO Huan-ying CAI Shuang ZHOU Yan SUN Zheng | 2013 | Chinese Medical Journal2013，，16： | 7 |
| 5 | Genetic aberration in primary hepatocellular carcinoma:correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23显示文摘To elucidate the molecular pathology underlying the development of hepatocellular carcinoma (HCC), we used 41 highly polymorphic microsatellite markers to examine 55 HCC and corresponding non-tumor liver tissues on chromosome 9, 16 and 17. Loss-of-heterozygosity (LOH) is observed with high frequency on chromosomal region 17p13 (36/55, 65%), 9p21-p23 (28/55, 51%), 16q21-q23 (27/55, 49%) in tumors. Meanwhile, microsatellite instability is rarely found in these microsatellite loci. Direct sequencing was performed to detect the tentative mutation of tumor suppressor genes in these regions: p53, MTS1/p16, and CDH1/E-cadherin. Within exon 5-9 of p53 gene, 14 out of 55 HCC specimens (24%) have somatic mutations, and nucleotide deletion of this gene is reported in HCC for the first time. Mutation in MTS1/pl6 is found only in one tumor case. We do not find mutations in CDH1/E-cadherin. Furthermore, a statistically significant correlation is present between p53 gene mutation and loss of chromosome region 16q21q23 and 9p21-p23, which indicates that synergism between p53 inactivation and deletion of 16q21-q23 and 9p21-p23 may play a role in the pathogenesis of HCC. Genetic aberration in hepatocellular | WANG GANG CHANG HUI HUANG YAN ZHAO LING CAI YING WANG SHI JIN XIU ZHENG WEN JIANG SHUANG YANG XIN TAI ZHAO WEI HUANG JIAN REN GU | 2000 | Cell Research2000，10，4： | 7 |
| 6 | Research trends, hot spots and prospects for necroptosis in the field of neuroscience显示文摘There are two types of cell death-apoptosis and necrosis. Apoptosis is cell death regulated by cell signaling pathways, while necrosis has until recently been considered a passive mechanism of cell death caused by environmental pressures. However, recent studies show that necrosis can also be regulated by specific cell signaling pathways. This mode of death, termed necroptosis, has been found to be related to the occurrence and development of many diseases. We used bibliometrics to analyze the global output of literature on necroptosis in the field of neuroscience published in the period 2007–2019 to identify research hotspots and prospects. We included 145 necroptosisrelated publications and 2239 references published in the Web of Science during 2007–2019. Visualization analysis revealed that the number of publications related to necroptosis has increased year by year, reaching a peak in 2019. China is the country with the largest number of publications. Key word and literature analyses demonstrated that mitochondrial function change, stroke, ischemia/reperfusion and neuroinflammation are likely the research hotspots and future directions of necroptosis research in the nervous system. The relationship between immune response-related factors, damage-associated molecular patterns, pathogen-associated molecular patterns and necroptosis may become a potential research hotspot in the future. Taken together, our findings suggest that although the inherent limitations of bibliometrics may affect the accuracy of the literature-based prediction of research hotspots, the results obtained from the included publications can provide a reference for the study of necroptosis in the field of neuroscience. | Wei-Tao Yan Shuang Lu Yan-Di Yang Wen-Ya Ning Yan Cai Xi-Min Hu Qi Zhang Kun Xiong | 2021 | Neural Regeneration Research2021，16，8： | 7 |
| 7 | Determination of urinary 8-hydroxy-2′-deoxyguanosine by capillary electrophoresis with molecularly imprinted monolith in-tube solid phase microextraction显示文摘Urinary 8-hydroxy-2'-deoxyguanosine(8-OHdG) is an excellent marker of oxidative DNA damage.In this study,employing guanosine as dummy template a novel molecularly imprinted(MIP) monolithic capillary column had been synthesized,and that was used as medium of in-tube solid phase microextraction(SPME).Coupled with capillary electrophoresis-electrochemical detection(CE-ECD),the system of extraction and detection of 8-OHdG in urinary sample had been developed.Because of its greater phase ratio combined with c... | Zhang, Shao Wen Zou, Cun Jie Luo, Nan Weng, Qian Feng Cai, Ling Shuang Wu, Cai Ying Xing, Jun | 2010 | Chinese Chemical Letters2010，21，1： | 6 |
| 8 | Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer显示文摘AIM:To conduct a meta-analysis to evaluate the prognostic role of hypoxia inducible factor-1α(HIF-1α)expression in gastric cancer.METHODS:The PubMed,EMBASE,and Web of Science databases were searched systematically for all articles published in English before August,2013.Pooled effect was calculated from the available data to evaluate the association between HIF-1αexpression and 5-year overall survival and tumor clinicopathological features in gastric cancer patients.Pooled odds ratios(ORs)with95%CIs were calculated using either a fixed-effects or a random-effects model.RESULTS:Nine studies matched the selection criteria,which reported on 1103 subjects,548 of whom had HIF-1αpositive expression(50%).This meta-analysis indicated that HIF-1αpositive expression in gastric cancer correlated with lower 5-year overall survival(OR=0.36;95%CI:0.21-0.64),worse tumor differentiation(OR=0.38;95%CI:0.23-0.64),deeper invasion(OR=0.42;95%CI:0.32-0.57),higher rates of lymph node metastasis(OR=2.23;95%CI:1.46-3.40),lymphatic invasion(OR=2.50;95%CI:1.46-4.28),and vascular invasion(OR=1.80;95%CI:1.29-2.51),and higher TNM stage(Ⅲ+Ⅳ)(OR=0.31;95%CI:0.15-0.60).CONCLUSION:HIF-1αpositive expression indicates a poor prognosis for patients with gastric cancer.Further studies are required to confirm these results. | Shuang Lin Rui Ma Xue-Yong Zheng Hong Yu Xiao Liang Hui Lin Xiu-Jun Cai | 2014 | World Journal of Gastroenterology2014，20，4： | 6 |
| 9 | Effect of tempering temperature on strain hardening exponent and flow stress curve of 1000MPa grade steel for construction machinery显示文摘To study the effect of tempering temperature on strain hardening exponent and flow stress curve,one kind of 1000 MPa grade low carbon bainitic steel for construction machinery was designed,and the standard uniaxial tensile tests were conducted at room temperature.A new flow stress model,which could predict the flow behavior of the tested steels at different tempering temperatures more efficiently,was established.The relationship between mobile dislocation density and strain hardening exponent was discussed based on the dislocation-stress relation.Arrhenius equation and an inverse proportional function were adopted to describe the mobile dislocation,and two mathematical models were established to describe the relationship between tempering temperature and strain hardening exponent.Nonlinear regression analysis was applied to the Arrhenius type model,hence,the activation energy was determined to be 37.6kJ/mol.Moreover,the square of correlation coefficient was 0.985,which indicated a high reliability between the fitted curve and experimental data.By comparison with the Arrhenius type curve,the general trend of the inverse proportional fitting curve was coincided with the experimental data points except of some fitting errors.Thus,the Arrhenius type model can be adopted to predict the strain hardening exponent at different tempering temperatures. | Yang Yun Qing-wu Cai Bao-sheng Xie Shuang Li | 2017 | Journal of Iron and Steel Research(International)2017，24，9： | 5 |
| 10 | Application of artificial intelligence in preoperative imaging of hepatocellular carcinoma:Current status and future perspectives显示文摘Hepatocellular carcinoma(HCC)is the most common primary malignant liver tumor in China.Preoperative diagnosis of HCC is challenging because of atypical imaging manifestations and the diversity of focal liver lesions.Artificial intelligence(AI),such as machine learning(ML)and deep learning,has recently gained attention for its capability to reveal quantitative information on images.Currently,AI is used throughout the entire radiomics process and plays a critical role in multiple fields of medicine.This review summarizes the applications of AI in various aspects of preoperative imaging of HCC,including segmentation,differential diagnosis,prediction of histo-pathology,early detection of recurrence after curative treatment,and evaluation of treatment response.We also review the limitations of previous studies and discuss future directions for diagnostic imaging of HCC. | Bing Feng Xiao-Hong Ma Shuang Wang Wei Cai Xia-Bi Liu Xin-Ming Zhao | 2021 | World Journal of Gastroenterology2021，27，32： | 4 |
| 11 | Calpain-2 activity promotes aberrant endoplasmic reticulum stress-related apoptosis in hepatocytes显示文摘BACKGROUND Calpain-2 is a Ca^2+-dependent cysteine protease,and high calpain-2 activity can enhance apoptosis mediated by multiple triggers.AIM To investigate whether calpain-2 can modulate aberrant endoplasmic reticulum(ER)stress-related apoptosis in rat hepatocyte BRL-3A cells.METHODS BRL-3A cells were treated with varying doses of dithiothreitol(DTT),and their viability and apoptosis were quantified by 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2-H-tetrazolium bromide and flow cytometry.The expression of ER stress-and apoptosis-related proteins was detected by Western blot analysis.The protease activity of calpain-2 was determined using a fluorescent substrate,Nsuccinyl-Leu-Leu-Val-Tyr-AMC.Intracellular Ca^2+content,and ER and calpain-2 co-localization were characterized by fluorescent microscopy.The impact of calpain-2 silencing by specific small interfering RNA on caspase-12 activation and apoptosis of BRL-3A cells was quantified.RESULTS DTT exhibited dose-dependent cytotoxicity against BRL-3A cells and treatment with 2 mmol/L DTT triggered BRL-3A cell apoptosis.DTT treatment significantly upregulated 78 kDa glucose-regulated protein,activating transcription factor 4,C/EBP-homologous protein expression by>2-fold,and enhanced PRKR-like ER kinase phosphorylation,caspase-12 and caspase-3 cleavage in BRL-3A cells in a trend of time-dependence.DTT treatment also significantly increased intracellular Ca^2+content,calpain-2 expression,and activity by>2-fold in BRL-3A cells.Furthermore,immunofluorescence revealed that DTT treatment promoted the ER accumulation of calpain-2.Moreover,calpain-2 silencing to decrease calpain-2 expression by 85%significantly mitigated DTT-enhanced calpain-2 expression,caspase-12 cleavage,and apoptosis in BRL-3A cells.CONCLUSION The data indicated that Ca^2+-dependent calpain-2 activity promoted the aberrant ER stress-related apoptosis of rat hepatocytes by activating caspase-12 in the ER. | Ru-Jia Xie Xiao-Xia Hu Lu Zheng Shuang Cai Yu-Si Chen Yi Yang Ting Yang Bing Han Qin Yang | 2020 | World Journal of Gastroenterology2020，26，13： | 4 |
| 12 | Heuristics for Online Scheduling on Identical Parallel Machines with Two GoS Levels显示文摘This paper considers the online scheduling problem on m(m≥3)parallel machines(the first k machines with grade 1 and the remaining m-k machines with grade 2)with two Go S levels and makespan as the objective function.The jobs arrive over time with grade 1 or 2 and an arrival job can be assigned to a machine only when the grade of the job is no less than the grade of the machine.Three cases are considered:(i)For k=1,the authors present an online algorithm with competitive ratio of9/5.(ii)For 1 | CAI Shuang LIU Ke | 2019 | Journal of Systems Science & Complexity2019，32，4： | 4 |
| 13 | Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases: a meta-analysis显示文摘 | Chen Jiang Ma Rui Yang Shouzhang Lin Shuang He Shilin Cai Xiujun | 2014 | Chinese Medical Journal2014，，13： | 4 |
| 14 | Study on mode-filtered light sensor for methane detection显示文摘一个新奇过滤模式的轻煤气的传感器被报导了。它被插入 cryptophane A 的薄硅酮 cladding 扔进保险丝硅石的光纤维构造毛状。当甲烷气体的不同集中被介绍给传感器时,过滤模式的轻紧张与甲烷的增加的集中减少了的现象被观察。并且一种线性关系在 0.0 – 的甲烷集中范围以内被获得; 16.0%(v/v ) 。察觉限制是 0.06%(v/v ) 。过滤模式的轻传感器被利用了在房间温度对甲烷气体的各种各样的集中作出回应。 | Suo Zhu Wu Shao Min Shuang Yan Zhang Zhong Ping Li Martin M.E Choi Cai Hong Zhang Chuan Dong | 2009 | Chinese Chemical Letters2009，20，2： | 4 |
| 15 | Wheat straw biochar amendment suppresses tomato bacterial wilt caused by Ralstonia solanacearum: Potential effects of rhizosphere organic acids and amino acids显示文摘Complex interactions based on host plant, rhizosphere microorganisms and soil microenvironment are presumed to be responsible for the suppressive properties of biochar against soil-borne diseases, although the underlying mechanisms are not well understood. This study is designed to evaluate the efficacy of biochar amendment for controlling tomato bacterial wilt caused by Ralstonia solanacearum, and to explore the interactions between biochar-induced changes in rhizosphere compound composition, the pathogen and tomato growth. The results showed that biochar amendment decreased disease incidence by 61–78% and simultaneously improved plant growth. The positive ‘biochar effect' could be associated with enhanced microbial activity and alterations in the rhizosphere organic acid and amino acid composition. Specifically, elevated rhizosphere citric acid and lysine, but reduced salicylic acid, were induced by biochar which improved microbial activity and rendered the rhizosphere unsuitable for the development of R. solanacearum. In addition, nutrients which were either made more available by the stimulated microbial activity or supplied by the biochar could improve plant vigor and potentially enhance tomato resistance to diseases. Our findings highlight that biochar's ability to control tomato bacterial wilt could be associated with the alteration of the rhizosphere organic acid and amino acid composition, however, further research is required to verify these ‘biochar effects' in field conditions. | TIAN Ji-hui RAO Shuang GAO Yang LU Yang CAI Kun-zheng | 2021 | Journal of Integrative Agriculture2021，20，9： | 4 |
| 16 | New role and molecular mechanism of Gadd45a in hepatic fibrosis显示文摘AIM: To investigate the role of Gadd45 a in hepatic fibrosis and the transforming growth factor(TGF)-β/Smad signaling pathway.METHODS: Wild-type male BALB/c mice were treated with CCl_4 to induce a model of chronic liver injury. Hepatic stellate cells(HSCs) were isolated from the liver of BALB/c mice and were treated with small interfering RNAs(si RNAs) targeting Gadd45 a or the pc DNA3.1-Gadd45 a recombinant plasmid. Cellular α-smooth muscle actin(α-SMA), β-actin, type Ⅰ collagen, phosphoSmad2, phospho-Smad3, Smad2, Smad3, and Smad4 were detected by Western blots. The m RNA levels of α-SMA, β-actin, and type Ⅰ collagen were determined by quantitative real-time(q RT)-PCR analyses. Reactive oxygen species production was monitored by flow cytometry using 2,7-dichlorodihydrofluorescein diacetate.Gadd45a, Gadd45 b, anti-Gadd45 g, type Ⅰ collagen, and SMA local expression in liver tissue were measured by histologic and immunohistochemical analyses. RESULTS: Significant downregulation of Gadd45 a, but not Gadd45 b or Gadd45 g, accompanied by activation of the TGF-β/Smad signaling pathways was detected in fibrotic liver tissues of mice and isolated HSCs with chronic liver injury induced by CCl_4 treatment. Overexpression of Gadd45 a reduced the expression of extracellular matrix proteins and α-SMA in HSCs, whereas transient knockdown of Gadd45 a with si RNA reversed this process. Gadd45 a inhibited the activity of a plasminogen activator inhibitor-1 promoter construct and(CAGA)_9 MLP-Luc, an artificial Smad3/4-specific reporter, as well as reduced the phosphorylation and nuclear translocation of Smad3. Gadd45 a showed protective effects by scavenging reactive oxygen species and upregulating antioxidant enzymes.CONCLUSION: Gadd45 a may counteract hepatic fibrosis by regulating the activation of HSCs via the inhibition of TGF-β/Smad signaling. | Liang Hong Qing-Feng Sun Ting-Yan Xu Yang-He Wu Hui Zhang Rong-Quan Fu Fu-Jing Cai Qing-Qing Zhou Ke Zhou Qing-Wei Du Dong Zhang Shuang Xu Ji-Guang Ding | 2016 | World Journal of Gastroenterology2016，22，9： | 3 |
| 17 | Low power and high uniformity of HfO_x-based RRAM via tip-enhanced electric fields显示文摘In this paper, the HfO_x-based resistive random access memory(RRAM) devices with sub-100 nm pyramid-type electrodes were fabricated. With the help of tip-enhanced electric field around the pyramid-type electrodes, it was experimentally demonstrated that the novel devices have better cycle-to-cycle variation control, lower forming/set voltage(1.97/0.7V) and faster switching speed(≤30 ns under 0.9V pulse) as well as better endurance reliability than conventional flat electrode resistive memory devices. In addition,the novel RRAM is experimentally demonstrated with independence of electrode number for the first time to present great potential in scaling down. This novel structure metal-oxide based RRAM will be suitable for the future low-power non-volatile memory application. | Xiaokang LI Baotong ZHANG Bowen WANG Xiaoyan XU Yuancheng YANG Shuang SUN Qifeng CAI Shijie HU Xia AN Ming LI Ru HUANG | 2019 | Science China(Information Sciences)2019，62，10： | 3 |
| 18 | Photocatalytic activity of TiO2 containing anatase nanoparticles and rutile nanoflower structure consisting of nanorods显示文摘A series of TiO2 with diferent crystal phases and morphologies was synthesized via a facile hydrothermal process using titanium n- butoxide and concentrated hydrochloric acid as raw materials. The photocatalytic activity of the samples was evaluated by degradation of Methyl Orange in aqueous solution under UV-Visible light irradiation. On the basis of detailed analysis of the characterizing results of high-resolution transmission electron microscopy, X-ray powder difraction measurements, X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller measurement, it was concluded that the photo-activity of the catalyst is related directly to the 3D morphology and the crystal phase composition. An excellent catalyst should have both a rutile 3D flower-like structure and anatase granulous particles. The 3D flower-like structure could enhance light harvesting, as well as the transfer of reactant molecules from bulk solution to the reactive sites on TiO2. In addition, the optimum anatase/rutile phase ratio was found to be 80:20, which is beneficial to the efective separation of the photogenerated electron–hole pairs. | Zhiqiao He Qiaolan Cai Huiying Fang Gaohua Situ Jianping Qiu Shuang Song Jianmeng Chen | 2013 | Journal of Environmental Sciences2013，25，12： | 3 |
| 19 | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2-and CDKNIA-interacting protein (BCCIP) in cells显示文摘 | Jiaming Su Yi Sui Jian Ding Fuqiang Li Shuang Shen Yang Yang Zeming Lu Fei Wang Lingling Cao Xiaoxia Liu Jingji Jin Yong Cai | 2016 | Protein & Cell2016，7，10： | 3 |
| 20 | Hofmeister Effect-Assisted Strong Natural Biopolymer-Based Hydrogels with Multi-Functions显示文摘Natural biopolymer-based hydrogels have been extensively studied in recent years due to their excellent biocompatibility.However,the preparation of multi-functional and tough natural biopolymer-based hydrogels is still a challenging problem.Herein,a natural biopolymer-based hydrogel is prepared using gelatin and carboxymethyl chitosan(CMCS)through a one-step soaking method.The prepared hydrogel without any synthetic polymers and crosslinking agents has a fully physical crosslinking structure.Due to the hydrophobic interaction brought by the Hofmeister effect,the mechanical properties of soaked hydrogels(tensile stress and strain can reach 3.77 MPa and 1082%)are superior to conventional protein hydrogels.In addition,the prepared gelatin/carboxymethyl chitosan(Gel/CMCS)hydrogels exhibit a variety of appealing properties,including good shape memory,fatigue resistance,electrical conductivity,water retention,drug releasing,antibacterial property,and recyclability.This strategy opens up a new horizon to fabricate hydrogels with excellent mechanical properties and multiple functions,which can extend their applications in the biomedicine area and other related fields. | Yaqian Cai Jiachuan Shi Fangzhe Liu Haichao Li Xinya Man Shuang Guan | 2021 | Chinese Journal of Chemistry2021，39，11： | 3 |
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