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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 3 | Constraint regionalization of water environment and the guidance for industrial layout: A case study of Jiangsu Province显示文摘与在在中国的发达区域的经济和社会的高度快的发展一起,随象农业化肥,工业废水和国内污水那样的污染物质分泌物的数量的锋利的增加,水环境连续地被败坏了然后成为一个限制因素到地区性的开发。为加音在经济开发和水环境之间的关系,许多国家一直在尝试浇环境函数 zoning 以便为盆管理提供一个科学基础。然而,主要集中于水身体,这些研究在地区性的工业布局上忽略了在水和土地以及水环境的限制功能之间的空间关系。以前的索引系统因此仅仅适应了环境基因,但是排除了社会经济的开发的压力基因。这篇论文因此,考虑水环境的敏感和压力,讨论水环境的限制区域化的方法包括怎么划分估计的单位,选择并且设法估计的元素。作为案例研究,然后,江苏省被象限分析的方法划分成区域的四种类型,即,高压、高敏感的区域( HP-HS 区域),高压、低敏感的区域( HP-LS 区域),低压、高敏感的区域( LP-HS 区域)和低压、低敏感的区域( LP-LS 区域)。最后,这篇论文分别地论述工业布局和工业发展方向的政策的计划,它是为加音的很重要的底工业发展和水环境的适用的能力。 | SUN Wei CHEN Wen CHEN Cheng GAO Shuang GUO Yao | 2011 | Journal of Geographical Sciences2011，21，5： | 13 |
| 4 | Wrist-ankle acupuncture and Fluoxetine in the treatment of post-stroke depression: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effects of WAA combined with fluoxetine in the clinical treatment of post-stroke depression(PSD).METHODS: In this randomized, controlled and single-blind trial, 105 PSD patients who met the inclusion criteria were randomly divided into three equal groups: Thin wrist-ankle acupuncture(WAA)group(Thin WAA needle + Fluoxetine), Thick WAA group(Thick WAA needle + Fluoxetine), and Sham WAA group(sham WAA needle + Fluoxetine). In this trial, the primary outcome was Hamilton Depression Scale(HAMD), while the secondary outcomes included Zung self-rating depression scale(SDS) and World Health Organization Quality of Life BREF(QQL).RESULTS: Ninety nine PSD patients completed all the treatment. The HAMD scores and SDS scores of all the three groups decreased after treatment(P <0.05);thick WAA group and thin WAA group decreased more obviously than the sham WAA group(P < 0.05). There was no significant difference between the QQL scores of the three groups(P >0.05). There was no significant difference in the scores of the three scales between the thick wrist ankle needles and the thin wrist ankle needles(P >0.05).CONCLUSION: The present study showed that WAA combined with fluoxetine can relieve the symptoms of depression after stroke. WAA therapy could improve the antidepressant effect of fluoxetine. | You Yanli Zhang Tianfang Shu Shi Qian Xiaolu Zhou Shuang Yao Fei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 5 | Reexploring the Possible Roles of Some Genes Associated with Nasopharyngeal Carcinoma Using Microarray-based Detection显示文摘在基因表达介绍,鼻咽的癌( NPC ) 5-8F 房间以他们的高 tumorigenicity 不同于 6-10B 房间,从二种房间类型的变形 ability.Differentiallyexpressed 基因被与 .Theresults 显示出的 MILANO (在 PubMed 基于所有可得到的出版工作的微数组结果的自动特定的注解)结合分析那包括 CTSD , P63 , CSE1L , BPAG1 和 EGR1 ,五基因在出版工作被学习了或提及在上 NPC.Subsequently ,我们 revaluated 在由从 NPC 对 NP 和分享的房间 from5-8F 联合基因芯片的数据的 NPC 的致病的这些基因的角色, 6-10B 和 CNE2 对 NPs.The 结果建议 BPAG1 和 EGR1 的角色与在以前的 NPC 研究报导的那些可能不同。这五基因是可能的涉及基因的 NPC.A 探索的增长, apoptosis,侵略和转移将进一步在 NPC 的致病定义他们的角色。 | Wei-Yi FANG Teng-Fei LIU Wei-Bing XIE Xu-Yu YANG Shuang WANG Cai-Ping REN Xin DENG Qiu-Zhen LIU Zhong-Xi HUANG Xin LI Yan-Qing DING Kai-Tai YAO | 2005 | Acta Biochimica et Biophysica Sinica2005，37，8： | 9 |
| 6 | Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke显示文摘We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined contributions.In the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were included.Participants were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD burden.Cervico-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid ultrasound.We estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression models.During a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic stroke.Severe LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk independently.In multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke. | Fei Han Ding-Ding Zhang Fei-Fei Zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu | 2021 | Science China(Life Sciences)2021，64，9： | 9 |
| 7 | Functional characterization of a Niemann-Pick type C2 protein in the parasitoid wasp Micropfitis mediator显示文摘 | Yao Zheng Shan-Ning Wang Yong Peng Zi-Yun Lu Shuang Shan Ye-Qing Yang Rui-Jun Li Yong-Jun Zhang Yu-Yuan Guo | 2018 | Insect Science2018，25，5： | 8 |
| 8 | Boundedness for Parabolic Singular Integral with Rough Kernels and Its Commutators on Triebel-Lizorkin Spaces显示文摘在这份报纸,作者用不平的核和它的整流器为寓言的单个积分在 Triebel-Lizorkin 空格给固定。 | Shuang Ping TAO Yao Ming NIU | 2011 | Acta Mathematica Sinica,English Series2011，27，9： | 8 |
| 9 | Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits显示文摘Rhododendron molle G.Don is first recorded in Shengnong’s Herbal Classic,and its fruits,which are termed as Liuzhouzi,are often used to treat rheumatoid arthritis in Chinese folk.During our ongoing investigation to develop a safer and potential new arthritis therapy,a process for the preparation of diterpenoid fraction from Rhododendron molle fruits was established.In order to evaluate the main components and the anti-rheumatoid arthritis effect of the diterpenoid fraction,phytochemical and pharmacological experiments were used.As the result,the main components of diterpenoid fraction were identified as rhodojaponinⅢ(1),rhodojaponinⅥ(2),2-O-methylrhodojaponin(3),and 5′-β-D-glucopyranosy-loxyjasmonic acid(4).These four components constitute greater than 95%of diterpenoid fraction using area normalization method of HPLC-ELSD.The results of CIA rat experiment showed that high dose of diterpenoid fraction(0.6 mg·kg^(-1)·d^(-1))significantly alleviated the symptoms of rheumatoid arthritis,similar to tripterygium polyglycosides,an effective RA therapy.Preliminary mechanism studies indicated that diterpenoid fraction significantly inhibited the abnormal proliferation of T and B lymphocytes,and remarkably reduced the levels of pro-inflammatory cytokines IL-6,IL^(-1)βand TNF-α.Overall,our findings may provide a more effective and safe alternative treatment for RA using common clinical Chinese medicines like tripterygium polyglycosides. | HE Yan-Chen YAO Yu-Min XUE Qiu-Wen FANG Xin LIANG Shuang | 2021 | Chinese Journal of Natural Medicines2021，19，3： | 6 |
| 10 | MicroRNA-135a in ABCA1-labeled Exosome is a Serum Biomarker Candidate for Alzheimer’s Disease显示文摘Objective In the present study,the ABCA1 was used as a label to capture specific exosomes,the level of ABCA1-labeled exosomal microRNA-135 a(miR-135 a)was evaluated for the diagnosis of Alzheimer’s disease(AD),especially in patients with early stages of AD.Methods This is a preliminary research focused on the levels of ABCA1 in WBCs,RBCs,HT-22 cells,and neuron cells.The diagnostic value of ABCA1-labeled exosomal miR-135 a was examined using the CSF and serum of APP/PS1 double transgenic mice,and 152 patients with SCD,131 patients with MCI,198 patients with DAT,and 30 control subjects.Results The level of ABCA1 exosomes harvested from HT-22 cells and neuron culture medium was significantly higher compared to that of RBCs and WBCs(P<0.05).The levels of ABCA1-labeled exosomal miR-135 a increased in the CSF of MCI and DAT group compared to those of control group(P<0.05),slightly increased(P>0.05)in the serum of SCD patient group,and significantly increased in MCI and DAT patient groups compared to those of the control group(P<0.05).Conclusion This study outlines a method to capture specific exosomes and detect them using immunological methods,which is more efficient for early diagnosis of AD. | LIU Chen Geng MENG Shuang LI Ying LU Yao ZHAO Yue WANG Pei Chang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 5 |
| 11 | Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats显示文摘The thalamostriatal pathway is implicated in Parkinson's disease(PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease. | Haiyan Zhang Jing Yang Xuenan Wang Xiaomeng Yao Hongyu Han Yunfeng Gao Hongli Chang Tianyu Xiang Shuang Sun Yanan Wang Xiusong Wang Min Wang | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 12 | A model of unsafe behavior in coal mines based on game theory显示文摘Behavior choice, coal mine monitoring, and control intensity are combined in a general mathematical model established from the perspective of a behavioral game. A case study is provided with effective conditions of monitoring provided. This paper defines the expected value difference of control return and behavior cost difference and discusses the measurement and optimization of variable indexes, including the monitoring intensity and costs of control. The results imply that the control of unsafe behavior can be more effective when monitoring and control of coal mines are both improved. Monitoring will be useful when the rewards for displaying safe behavior, and the monitoring of unsafe behavior, are improved to a high level. | Li Shuang Wang Yao Liu Qian | 2013 | International Journal of Mining Science and Technology2013，23，1： | 5 |
| 13 | Determining hydrothermal deactivation mechanisms on Cu/SAPO-34 NH_(3)-SCR catalysts at low-and high-reaction regions:establishing roles of different reaction sites显示文摘Hydrothermal deactivation is a constant chal-lenge in commercial catalytic process aimed at NOx emission control,which may be observed in the low(150-400℃)or high(400-550℃)-reaction regions.To the best of our knowledge,there is a lack of systematic research regarding the correlation between the reaction sites and the mechanism of hydrothermal degradation at various reaction regions.For a targeted investigation of this,Cu/zeolite catalysts have been prepared using different amounts of polyvinyl alcohol for adjusting their redox and acid properties.These catalysts exhibit hydrothermal deactivation in different reaction regions.No change is observed in the reaction mechanism even with hydrother-mal deactivation,but various reaction sites determine the performance deterioration in the low-and high-reaction regions.The redox properties and weak acid sites affect the hydrothermal deactivation in the low-reaction region,whereas the moderate/strong acid sites related to the structure mainly influence the hydrothermal deactivation in the high-reaction region.This work provides several the-oretical insights for optimizing the hydrothermal stabilities of Cu/zeolite catalysts. | Qing-Jin Lin Ming-Ming Pei Pan Yao Shi Xu Shu-Hao Xu Shuang Liu Hai-Di Xu Yi Dan Yao-Qiang Chen | 2022 | Rare Metals2022，41，6： | 4 |
| 14 | Correlation Between Microstructure and Corrosion Behavior of Two 90Cu10Ni Alloy Tubes显示文摘Two kinds of 90Cu10 Ni tubes with different service lives(more than 3 years and only 1 year,respectively)under identical working conditions were studied by an immersion test in a 3.5 wt% NaCl solution and the electron backscattered diffraction(EBSD) technique.The morphology after immersion showed severer corrosion attack at the grain boundaries of the tube with shorter service life compared with the tube with longer service life.The grain boundary characterization distributions(GBCDs) of the two tubes obtained by EBSD revealed more Σ3 boundaries and twins,and larger random boundary meshes in the tube with longer service life.A short immersion test in a modified Livingston's solution was conducted to evaluate the tendency to corrosion attack of different types of the grain boundaries.SEM and AFM were used to characterize the corrosion morphologies of the boundaries.A strong correlation between varying depths of corrosion grooves and types of the grain boundaries was obtained.The influence of deviation angle of low Σ boundaries on corrosion resistance of the grain boundaries was also discussed.It is concluded that a special ‘‘grain boundary engineering''(GBE) treatment has been performed on the tube with longer service life.It is proposed that the optimized GBCD is responsible for the better service performance of the tube. | Aili Ma Shengli Jiang Yugui Zheng Zhiming Yao Wei Ke Shuang Xia | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 4 |
| 15 | CRA-40/Atmosphere—The First-Generation Chinese Atmospheric Reanalysis(1979–2018):System Description and Performance Evaluation显示文摘Atmospheric reanalysis reproduces the past atmospheric conditions through assimilation of historical meteorological observations with fixed version of a numerical weather prediction(NWP)model and data assimilation(DA)system.It is widely used in weather,climate,and even business-related research and applications.This paper reports the development of CMA’s first-generation global atmospheric reanalysis(RA)covering 1979–2018(CRA-40;CRA refers to CMA-RA).CRA-40 is produced by using the Global Spectral Model(GSM)/Gridpoint Statistical Interpolation(GSI)at a 6-h time interval and a TL574 spectral(34-km)resolution with the model top at 0.27 hPa.A large number of reprocessed satellite data and widely collected conventional observations were assimilated during the reanalyzing process,including the reprocessed atmospheric motion vector(AMV)products from FY-2C/D/E/G satellites,dense conventional observations(at about 120 radiosonde and 2400 synoptic stations)over China,as well as MWHS-2 and GNSS-RO observations from FY-3C.The reanalysis fitting to observations is improved over time,especially for surface pressure with root-mean-square error reduced from 1.05 hPa in 1979 to 0.8 hPa,and for upper air temperature from 1.65 K in 1979 to 1.35 K,in 2018.The patterns of global analysis increments for temperature,specific humidity,and zonal wind are consistent with the changes in the observing system.Near surface temperature from the model’s 6-h forecast reflects the global warming trend reasonably.The CRA-40 precipitation pattern matches well with those of GPCP and other reanalyses.CRA-40 also successfully captures the QBO and its vertical and temporal development,hemispherical atmospheric circulation change,and moisture transport by the East Asian summer monsoon.CRA is now operationally running in near real time as a climate data assimilation system in CMA. | Zhiquan LIU Lipeng JIANG Chunxiang SHI Tao ZHANG Zijiang ZHOU Jie LIAO Shuang YAO Jingwei LIU Minyan WANG Huiying WANG Xiao LIANG Zhisen ZHANG Yan YAO Ting ZHU Zhe CHEN Wenhui XU Lijuan CAO Hui JIANG Kaixi HU | 2023 | Journal of Meteorological Research2023，37，1： | 4 |
| 16 | Interventional effect of electroacupuncture combined with medicine on monoamine neurotransmitters in hypothalamus of rats with ulcerative colitis显示文摘BACKGROUND: Ulcerative colitis (UC) is conventionally treated with sulfasalazine and other aminosalicylic acids. The symptoms of UC can be rapidly controlled, but high recurrence, severe adverse reactions and other shortages exist commonly. Whether electroacupuncture combined with medicine can make up these shortages remains unclear. OBJECTIVE: This study was to observe the regulatory effect of electroacupuncture combined with medicine on monoamine neurotransmitter in hypothalamus of rats with ulcerative colitis, and to analyze the pathogenesis of UC and the action pathway of electroacupuncture combined with medicine. DESIGN: A randomized controlled observation. SETTING: Shanghai Institute of Acupuncture and Meridian. MATERIALS: Thirty involved male SD rats of clean grade, weighing (200±20)g, were provided by the Experimental Animal Center, Shanghai University of Traditional Chinese Medicine. Sulfasalazine was produced in the Shanghai Sanwei Pharmaceutical Co., Ltd [certification No. (1995)002083]. METHODS: This study was carried out in the State Laboratory (grade 3) for Acupuncture and Immunology, Shanghai Institute of Acupuncture and Meridian. The involved 30 rats were randomized into 5 groups: normal group, model group, electroacupuncture group, medicine group and electroacupuncture combined with medicine group, with 6 rats in each group. Rats in the latter 4 groups were prepared into models of UC. In the electroacupuncture group, Zusanli(shuang) point was selected. Electro-acupuncture apparatus (G6805Ⅱ type) was connected to the point and used to stimulate it with continuous wave, frequency of 2 Hz, electrical intensity 4 mA, 20 minutes a day, for 14 days successively. In the medicine group, rats were intragastrically administrated with sulfasalazine, twice a day, 3 mL once, for 14 days successively. In the electroacupuncture combined with medicine group, rats were treated with electroacupuncture and medicine simultaneously as described in the previous two groups. Rats in the model group and normal control group were untouched except for being fixed. MAIN OUTCOME MEASURES: The levels of noradrenaline acid tartrate (NE), 3-methoxy-4 hydroxyphenylglycol (MHPG), dopamine hydrochloride (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxytryptamine (5-HT) hydrochloride, homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) of rats in each group were detected by high-performance liquid chromatography (HPLC)-electrochemical method. RESULTS: All the 30 involved rats entered into the stage of final analysis. ①Detection of NE and MHPG levels: After treatment, NE level in the hypothalamus of rats was significantly higher in the electroacupuncture combined with medicine group, electroacupuncture group and medicine group was all significantly higher than that in the model group, respectively (P < 0.01). After treatment, MHPG level in the metabolite of NE was very significantly higher in the electroacupuncture group than in the medicine group (P < 0.01). ②Detection of DA and DOPAC levels: After treatment, DA level in the hypothalamus of rats was very significantly higher in the medicine group than in the model group (P < 0.01). ③Detection of 5-HT, HVA and 5-HIAA levels: After treatment, 5-HIAA level in the hypothalamus of rats was significantly higher in the medicine group than in the model group (P < 0.05). CONCLUSION: The abnormal synthesis and metabolism of monoamine neurotransmitter in the central nervous system is one of pathogenesis of UC. Electroacupuncture combined with medicine might reach its goal of treatment by regulating the monoamine neurotransmitter disorder in the hypothalamus of rats with UC. | Yin Shi Shuang Li Huangan Wu Yi Yao Chen Zhao Zheng Shi Yejing Gong | 2007 | Neural Regeneration Research2007，2，9： | 4 |
| 17 | A New K-Ary Crisp Decision Tree Induction with Continuous Valued Attributes显示文摘The simplicity and interpretability of decision tree induction makes it one of the more widely used machine learning methods for data classification.However,for continuous valued(real and integer) attribute data,there is room for further improvement in classification accuracy,complexity,and tree scale.We propose a new K-ary partition discretization method with no more than K –1 cut points based on Gaussian membership functions and the expected class number.A new K-ary crisp decision tree induction is also proposed for continuous valued attributes with a Gini index,combining the proposed discretization method.Experimental results and non-parametric statistical tests on 19 real-world datasets showed that the proposed algorithm outperforms four conventional approaches in terms of both classification accuracy,tree scale,and particularly tree depth.Considering the number of nodes,the proposed methods decision tree tends to be more balanced than in the other four methods.The complexity of the proposed algorithm was relatively low. | SONG Yan YAO Shuang YU Donghua SHEN Yan HU Yuzhen | 2017 | Chinese Journal of Electronics2017，26，5： | 3 |
| 18 | Vertical Evolution of Boundary Layer Volatile Organic Compounds in Summer over the North China Plain and the Differences with Winter显示文摘The vertical observation of volatile organic compounds(VOCs)is an important means to clarify the mechanisms of ozone formation.To explore the vertical evolution of VOCs in summer,a field campaign using a tethered balloon during summer photochemical pollution was conducted in Shijiazhuang from 8 June to 3 July 2019.A total of 192 samples were collected,23 vertical profiles were obtained,and the concentrations of 87 VOCs were measured.The range of the total VOC concentration was 41-48 ppbv below 600 m.It then slightly increased above 600 m,and rose to 58±52 ppbv at 1000 m.The proportion of alkanes increased with height,while the proportions of alkenes,halohydrocarbons and acetylene decreased.The proportion of aromatics remained almost unchanged.A comparison with the results of a winter field campaign during 8-16 January 2019 showed that the concentrations of all VOCs in winter except for halohydrocarbons were more than twice those in summer.Alkanes accounted for the same proportion in winter and summer.Alkenes,aromatics,and acetylene accounted for higher proportions in winter,while halohydrocarbons accounted for a higher proportion in summer.There were five VOC sources in the vertical direction.The proportions of gasoline vehicular emissions+industrial sources and coal burning were higher in winter.The proportions of biogenic sources+long-range transport,solvent usage,and diesel vehicular emissions were higher in summer.From the surface to 1000 m,the proportion of gasoline vehicular emissions+industrial sources gradually increased. | Shuang WU Guiqian TANG Yinghong WANG Rong MAI Dan YAO Yanyu KANG Qinglu WANG Yuesi WANG | 2021 | Advances in Atmospheric Sciences2021，38，7： | 3 |
| 19 | Solid ion transition route to 3D S-N-codoped hollow carbon nanosphere/graphene aerogel as a metal-free handheld nanocatalyst for organic reactions显示文摘新奇没有金属的体积 nanocatalyst, S-N-codoped 空碳 nanosphere/graphene aerogel (SNC-GA-1000 ) ,成功地用一条灵巧、干净的稳固的离子转变线路被制作了。在这个方法, ZnS 被用作难模板和 S 来源,当 polydopamine 充当一个减少的代理人和碳来源时。在高退火温度, Zn 金属被减少并且蒸发,离开仅仅自由的 S 蒸汽扩散进碳层。有趣地,同样获得的 SNC-GA-1000 比卸掉的赤裸的 S-N-codoped 碳 nanospheres 在器官的减小反应展出许多更高催化的活动。与 ZnS@polydopamine 核心壳 nanospheres (ZnS@PDA ) 装载的 graphene 氧化物表的热水的减小负担得起三维的体积 graphene aerogel。尽管 nanosized 催化剂展出高催化的活动,他们的随后的分离不总是是令人满意的,成为处理以后困难。这条途径完成在活动和可分性之间的一宗交易。更重要地,由于 3D,结构的自然,如此的体积和手持 nanocatalysts 能容易被分开并且再循环。 | Jing Pan Shuyan Song Junqi Li Fan Wang Xin Ge Shuang Yao Xiao Wang Hongjie Zhang | 2017 | Nano Research2017，10，10： | 3 |
| 20 | Gadolinium-hyaluronic acid nanoparticles as an efficient and safe magnetic resonance imaging contrast agent for articular cartilage injury detection显示文摘Accurate detection of cartilage injuries is critical for their proper treatment because these injuries lack the selfhealing ability and lead to joint dysfunction.However,the low longitudinal T1 relaxivity(r1)and non-specificity of contrast agents(such as gadolinium(III)-diethylenetriamine-pentaacetic acid(Gd-DTPA))significantly limit the efficiency of clinical magnetic resonance imaging(MRI)applications.To overcome these drawbacks,we integrated hyaluronic acid(HA)with Gd to synthesize a Gd-DTPA-HA composite,which was subsequently freeze-dried to produce nanoparticles(NPs).The resultant Gd-HA NPs demonstrated a greater r1 value(12.51 mM^-1 s^-1)compared with the bulk Gd-DTPA-HA(8.37 mM^-1 s^-1)and clinically used Gd-DTPA(3.88 mM^-1 s^-1).Moreover,the high affinity of HA to the cartilage allowed these NPs to penetrate deeper beyond the cartilage surface.As a result,Gd-HA NPs considerably increased the quality of cartilage and lesion MR images via their intra-articular injection in vivo.Specifically,2 h after NP administration,the signal-to-noise ratio at the injured cartilage site was 2.3 times greater than the value measured before the injection.In addition,Gd-HA NPs exhibited good biosafety properties due to the absence of adverse effects in the blood or on the main organs.It was also showed that Gd NPs were first metabolized by the kidney and liver and then excreted from the body with urine.Thus,Gd-HA NPs can potentially serve as an efficient MRI contrast agent for improved detection of cartilage injuries. | Rong Lu Yuyang Zhang Hongyue Tao Lu Zhou Huidi Li Tianwu Chen Peng Zhang Yao Lu Shuang Chen | 2020 | Bioactive Materials2020，5，4： | 3 |
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