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| 1 | Emerging approaches and technologies in transplantation:the potential game changers显示文摘Newly emerging technologies are rapidly changing conventional approaches to organ transplantation.In the modern era,the key challenges to transplantation include(1)how to best individualize and possibly eliminate the need for life-long immunosuppression and(2)how to expand the donor pool suitable for human transplantation.This article aims to provide readers with an updated review of three new technologies that address these challenges.First,single-cell RNA sequencing technology is rapidly evolving and has recently been employed in settings related to transplantation.The new sequencing data indicate an unprecedented cellular heterogeneity within organ transplants,as well as exciting new molecular signatures involved in alloimmune responses.Second,sophisticated nanotechnology platforms provide a means of therapeutically delivering immune modulating reagents to promote transplant tolerance.Tolerogenic nanoparticles with regulatory molecules and donor antigens are capable of targeting host immune responses with tremendous precision,which,in some cases,results in donor-specific tolerance.Third,CRISPR/Cas9 gene editing technology has the potential to precisely remove immunogenic molecules while inserting desirable regulatory molecules.This technology is particularly useful in generating genetically modified pigs for xenotransplantation to solve the issue of the shortage of human organs.Collectively,these new technologies are positioning the transplant community for major breakthroughs that will significantly advance transplant medicine. | Anil Dangi Shuangjin Yu Xunrong Luo | 2019 | Cellular & Molecular Immunology2019，16，4： | 3 |
| 2 | Fabrica tion and Characterization of PEO/PPC Polymer Electrolyte for Lithium-ion Battery显示文摘 | Yu Xiaoyuan Xiao Min Wang Shuangjin | 2009 | Journal of Applied Poly mer Science2009，115，： | 1 |
| 3 | Analysis of the Changes in China's Grain Production Costs over the Past Decade显示文摘China's grain production cost has risen constantly since 2003. This paper starts from the grain production cost changes of unit area and unit quality,to analyze the reasons for China's grain production cost change in the last decade. It points out that the direct cause of changes in grain production cost is the steady growth of material and services costs,the fastest growth of labor costs and fast growth of land costs. The indirect cause of grain production high cost is the low efficiency in numerous and dispersive farmer production management,obviously insufficient agricultural infrastructure construction,waste phenomenon grain in production process and low contribution rate of agricultural technology.On this basis,it is recommended to reduce China's grain production cost and improve grain production conditions. | Shuangjin WANG Chen LIANG | 2015 | Asian Agricultural Research2015，7，2： | 1 |
| 4 | The microstructure and formation mechanism of core–shell-like TiAl 3 /Ti 2 Al 20 Ce in melt-spun Al–Ti–B–Re grain refiner显示文摘 | Kui Wang Chunxiang Cui Qian Wang Shuangjin Liu Cunshuai Gu | 2012 | Materials Letters2012，，： | 1 |
| 5 | Application of extended reach well drilling technology in the Pingbei Oilfield显示文摘 | ZHENG Shuangjin HOU Lian LI Liang | 2013 | Journal of Yangtze University(Natural Science Edition)2013，10，7： | 1 |
| 6 | New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma显示文摘 | Shuangjin C Fang F Han L Ming M | 2007 | J Pharm Bi- omed Anal2007，44，5： | 1 |
| 7 | New method for high- performance liquid chromatographic determination of amantadine and its analogues in rat plasma显示文摘 | Shuangjin C Fang F Han L | 2007 | J Pharm Biomed Anal2007，44，： | 1 |
| 8 | Development on manufacturing technology of railway locomotive and rolling stock industry in China显示文摘DevelopmentonmanufacturingtechnologyofrailwaylocomotiveandrollingstockindustryinChina￥WANGKejia(ChinaNationalRailwayLocomotiv... | WANG Kejia (China National Railway Locomotive and Rolling-Stock Industry Corporation (100844 ))SUN Shuangjin (Changchun Railway Car Works) | 1994 | China Welding1994，3，2： | 1 |
| 9 | In situ scanning FTIR microscopy and IR imaging of Pt electrode surface towards CO adsorption显示文摘 | Shigang Sun Shuangjin Hong Shengpei Chen Guoqiang Lu Hongping Dai Xiaoyin Xiao | 1999 | Science in China Series B: Chemistry1999，，3： | 1 |
| 10 | Analysis of the Main Factors Influencing Food Production in China Based on Time Series Trend Chart显示文摘Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effective irrigation area,the affected area,total machinery power,food production cost index,food production price index,financial funds for supporting agriculture,farmers and countryside),and put them into categories of material input,resources and environment,and policy factors. Using the factor analysis,we carry out the multi-angle analysis of these typical influencing factors one by one through the time series trend chart. It is found that application rate of chemical fertilizer,the growing area of food crops and drought-affected area become the key factors affecting food production. On this basis,we set forth the corresponding recommendations for improving the comprehensive food production capacity. | Shuangjin WANG Jianying LI | 2014 | Asian Agricultural Research2014，6，6： | 0 |
| 11 | Regaining Competitive Advantage by Developing E-commerce in Traditional Enterprises显示文摘 | Shuangjin Wang Guiru Gao | 2006 | Chinese Business Review2006，5，4： | 0 |
| 12 | Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis显示文摘The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains unclear.Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease severity.Interestingly,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and GCGR.The data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO mice.Various lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon signaling.These findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment. | Qian Zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
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