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| 1 | Global methane and nitrous oxide emissions from terrestrial ecosystems due to multiple environmental changes显示文摘Greenhouse gas(GHG)-induced climate change is among the most pressing sustainability challenges facing humanity today,posing serious risks for ecosystem health.Methane(CH_(4))and nitrous oxide(N_(2)O)are the two most important GHGs after carbon dioxide(CO_(2)),but their regional and global budgets are not well known.In this study,we applied a process-based coupled biogeochemical model to concurrently estimate the magnitude and spatial and temporal patterns of CH_(4)and N_(2)O fluxes as driven by multiple environmental changes,including climate variability,rising atmospheric CO_(2),increasing nitrogen deposition,tropospheric ozone pollution,land use change,and nitrogen fertilizer use.The estimated CH_(4)and N_(2)O emissions from global land ecosystems during 1981-2010 were 144.39±12.90 Tg C/yr(mean 62 SE;1 Tg=1012 g)and 12.52±0.74 Tg N/yr,respectively.Our simulations indicated a significant(P,0.01)annually increasing trend for CH_(4)(0.43±0.06 Tg C/yr)and N_(2)O(0.14±0.02 Tg N/yr)in the study period.CH_(4)and N_(2)O emissions increased significantly in most climatic zones and continents,especially in the tropical regions and Asia.The most rapid increase in CH_(4)emission was found in natural wetlands and rice fields due to increased rice cultivation area and climate warming.N_(2)O emission increased substantially in all the biome types and the largest increase occurred in upland crops due to increasing air temperature and nitrogen fertilizer use.Clearly,the three major GHGs(CH_(4),N_(2)O,and CO_(2))should be simultaneously considered when evaluating if a policy is effective to mitigate climate change. | Hanqin Tian Guangsheng Chen Chaoqun Lu Xiaofeng Xu Wei Ren Bowen Zhang Kamaljit Banger Bo Tao Shufen Pan Mingliang Liu Chi Zhang Lori Bruhwiler Steven Wofsy | 2015 | Ecosystem Health and Sustainability2015，1，1： | 7 |
| 2 | Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity显示文摘The pathophysiology of visceral pain in patients with irritable bowel syndrome remains largely unknown.Our previous study showed that neonatal maternal deprivation(NMD) does not induce visceral hypersensitivity at the age of 6 weeks in rats. The aim of this study was to determine whether NMD followed by adult stress at the age of 6 weeks induces visceral pain in rats and to investigate the roles of adrenergic signaling in visceral pain. Here we showed that NMD rats exhibited visceral hypersensitivity 6 h and 24 h after the termination of adult multiple stressors(AMSs). The plasma level of norepinephrine was significantly increased in NMD rats after AMSs. Whole-cell patch-clamp recording showed that the excitability of dorsal root ganglion(DRG) neurons from NMD rats with AMSs was remarkably increased. The expression of β_2 adrenergic receptors at the protein and mRNA levels was markedly higher in NMD rats with AMSs than in rats with NMD alone. Inhibition of β_2 adrenergic receptors with propranolol or butoxamine enhanced the colorectal distention threshold and application of butoxamine also reversed the enhanced hypersensitivity of DRG neurons. Overall,our data demonstrate that AMS induces visceral hypersensitivity in NMD rats, in part due to enhanced NE-β_2 adrenergic signaling in DRGs. | Wan-Jie Du Shufen Hu Xin Li Ping-An Zhang Xinghong Jiang Shan-Ping Yu Guang-Yin Xu | 2019 | Neuroscience Bulletin2019，35，1： | 5 |
| 3 | Isolation and phylogenetic study of Rift Valley fever virus from the first imported case to China显示文摘Dear Editor,Rift Valley fever(RVF)is an anthropozoonosis caused by Rift Valley fever virus(RVFV).RVFV belongs to the Phlebovirus genus in the family Bunyaviridae,which is circulating among ruminants.Human infection with RVFV is generally asymptomatic,however,minority of patients develop severe RVF diseases like encephalitis | Yongxia Shi Kui Zheng Xiaobo Li Liqiang Li Shufen Li Jinmin Ma Jun Dai Jingkai Ji Shuai Yuan Haorong Lu Jiandong Li Fangfang Sun Xun Xu Jicheng Huang | 2017 | Virologica Sinica2017，32，3： | 4 |
| 4 | Effects of magnesium hydroxide on combustion pruducts of polystyrene 显示文摘 | Hu Yonghua Han Xu Tan Rui Li Shufen | 2007 | Chinese Journal of Chemical Physics2007，20，2： | 1 |
| 5 | Study on adsorption behavior between Cr(Ⅵ) and crosslinked amphoteric starch显示文摘 | Xu Shimei Zhang Shufen Yang Jinzong | 2003 | JAPS2003，89，1： | 1 |
| 6 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 7 | Study on adsorption behavior between Cr(Ⅵ) and crosslinked amphoteric starch显示文摘 | Zhang Shufen Lu Rongwen | 2003 | Journal of Applied Polymer Science2003，89，： | 1 |
| 8 | Transcriptome analysis of the roots at early and late seedling stages using Illumina paired-end sequencing and development of EST-SSR markers in radish显示文摘 | Shufen Wang Xiufeng Wang Qiwei He Xianxian Liu Wenling Xu Libin Li Jianwei Gao Fengde Wang | 2012 | Plant Cell Reports2012，，8： | 1 |
| 9 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 10 | Study on adsorption behavior between Cr (VI) and erosslinked amphoteric starch显示文摘 | Xu Shimei Zhang Shufen Lu Rongwen | 2003 | Journal of Applied Polymer Seienee2003，89，1： | 1 |
| 11 | Chromatographia显示文摘 | Quan Lan Li Shufen Tian Songjiang Xu Hong Lin Anqing Gu Long | 2004 | 59 : 892004，59，： | 1 |
| 12 | An amphoteric semi-IPN nanocomposite hydrogels based on intercala- tion of cationic polyacrylamide into bentonite显示文摘 | Shimei Xu Shufen Zhang Jinzong Yang | 2008 | Materi- als Letters2008，62，： | 1 |
| 13 | Phase control of gain and dispersion in an openV-type system显示文摘 | Fan Xijun Li Jingjuan Tian Shufen Cui Ni Li Hua Li Aiyun Xu Zhizhan | 2005 | J Modern Opt2005，52，12： | 1 |
| 14 | Advances in emission control of diesel vehicles in China显示文摘Diesel vehicles have caused serious environmental problems in China.Hence,the Chinese government has launched serious actions against air pollution and imposed more stringent regulations on diesel vehicle emissions in the latest China VI standard.To fulfill this stringent legislation,two major technical routes,including the exhaust gas recirculation(EGR)and high-efficiency selective catalytic reduction(SCR)routes,have been developed for diesel engines.Moreover,complicated aftertreatment technologies have also been developed,including use of a diesel oxidation catalyst(DOC)for controlling carbon monoxide(CO)and hydrocarbon(HC)emissions,diesel particulate filter(DPF)for particle mass(PM)emission control,SCR for the control of NOx emission,and an ammonia slip catalyst(ASC)for the control of unreacted NH3.Due to the stringent requirements of the China VI standard,the aftertreatment system needs to be more deeply integrated with the engine system.In the future,aftertreatment technologies will need further upgrades to fulfill the requirements of the near-zero emission target for diesel vehicles. | Guangyan Xu Wenpo Shan Yunbo Yu Yulong Shan Xiaodong Wu Ye Wu Shaojun Zhang Liqiang He Shijin Shuai Hailong Pang Xuefeng Jiang Heng Zhang Lei Guo Shufen Wang Feng-Shou Xiao Xiangju Meng Feng Wu Dongwei Yao Yan Ding Hang Yin Hong He | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 15 | Experimental study on the thermal decomposition of 2H-heptafluoropropane显示文摘 | Yonghua Hu Yingbo Xu Tianfang Wang Chenghui Wang Shufen Li | 2010 | Journal of Analytical and Applied Pyrolysis2010，，1： | 1 |
| 16 | Adult Stress Promotes Purinergic Signaling to Induce Visceral Pain in Rats with Neonatal Maternal Deprivation显示文摘Chronic visceral pain is one of the primary symptoms of patients with irritable bowel syndrome(IBS),which affects up to 15%of the population world-wide.The detailed mechanisms of visceral pain remain largely unclear.Our previous studies have shown that neonatal maternal deprivation(NMD)followed by adult multiple stress(AMS)advances the occurrence of visceral pain,likely due to enhanced norepinephrine(NE)-β2 adrenergic signaling.This study was designed to explore the roles of P2X3 receptors(P2X3Rs)in the chronic visceral pain induced by combined stress.Here,we showed that P2X3 Rs were co-expressed inβ2 adrenergic receptor(β2-AR)-positive dorsal root ganglion neurons and that NE significantly enhanced ATP-induced Ca2+signals.NMD and AMS not only significantly increased the protein expression of P2X3Rs,but also greatly enhanced the ATP-evoked current density,number of action potentials,and intracellular Ca2+concentration of colon-related DRG neurons.Intrathecal injection of the P2X3R inhibitor A317491 greatly attenuated the visceral pain and the ATP-induced Ca2+signals in NMD and AMS rats.Furthermore,theβ2-AR antagonist butoxamine significantly reversed the expression of P2X3Rs,the ATP-induced current density,and the number of action potentials of DRG neurons.Overall,our data demonstrate that NMD followed by AMS leads to P2X3R activation,which is most likely mediated by upregulation ofβ2 adrenergic signaling in primary sensory neurons,thus contributing to visceral hypersensitivity. | Shufen Hu Qian Sun Wan-Jie Du Jian Song Xin Li Ping-An Zhang Ji-Tian Xu Guang-Yin Xu | 2020 | Neuroscience Bulletin2020，36，11： | 1 |
| 17 | Blue top-emitting organic light-emitting devices based on wide-angle interference enhancement and suppression of multiple-beam interference显示文摘 | Jun Xie Chunyan Chen Shufen Chen Yang Yang Ming Shao Xu Guo Quli Fan Wei Huang | 2010 | Organic Electronics2010，，2： | 1 |
| 18 | Clinical study on acupuncture treatment of retiaal vein obstruction显示文摘 | Wang Fuchun WeiLijuan Xu Shufen | 2000 | world Je Acu-Mox2000，10，4： | 1 |
| 19 | Sensitization of sodium channels by cystathionine β-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation显示文摘 | Shufen Hu Weiyuan Xu Xiuhua Miao Yanping Gao Liyan Zhu Youlang Zhou Ying Xiao Guang-Yin Xu | 2013 | Experimental Neurology2013，，： | 1 |
| 20 | Study on Carbonate Sequence Stratigraphy of Ordovician in Northern Ordos Basin显示文摘The formation of carbonates is different from that of siliciclastics. The controlling factors, such as the in-situ production of carbonates the transport, local variation in depositional processes and the way of dispersal are unique to carbonates systems, and have resulted in the formation of a wide variety of stratal patterns. The authors believe that all the factors influencing the formation of carbonates, such as the evolution of carbonate platform, transgression and regression, drowning and exposing of the platform, should be taken into consideration during the study of carbonate sequence stratigraphy.This paper attempts to summarize the study procedure in outcrop sequence stratigraphy and to describe the integrated identification of condensed section, first flooding surface and maximum flooding surface, so that the framework of high-resolution sequence stratigraphy can be constructed. During the Sandokan in early Ordovician, a carbonate-siliciclastic ramp was developed in northern Ordos, which changed into a carbonate rimmed shelf or a distally steepened ramp during the Zhuozishan and Kelimoli. It was the break in the Wulalike and Middle Ordovician,changing the sedimentary setting into an aulacogen According to the basin evolution, the authors have established some different idealized models for depositional sequences and systems tracts. | Wei Kuisheng Xu Huaida Ye Shufen (Department of Geology and Energy Resources, China University of Geoscience, Beijing 100083) | 1996 | Journal of Earth Science1996，15，1： | 0 |
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