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| 1 | Species-specific Response of Photosynthesis to Burning and Nitrogen Fertilization显示文摘The present study was conducted to examine photosynthetic characteristics of three dominant grass species (Agropyron cristatum,Leymus chinensis,and Cleistogenes squarrosa) and their responses to burning and nitrogen fertilization in a semiarid grassland in northern China. Photosynthetic rate (Pn),stomatal conductance (gs),and water use efficiency (WUE) showed strong temporal variability over the growing season. C. squarrosa showed a significantly higher Pn and WUE than A. cristatum and L. chinensis. Burning stimulated Pn of A. cristatum and L. chinensis by 24–59% (P < 0.05) in the early growing season,but not during other time periods. Light-saturated photosynthetic rate (Pmax) in A. cristatum and the maximum apparent quantum yield (Φmax) in A. cristatum and L. chinensis were significantly enhanced by burning (16–67%) in both the fertilized and unfertilized plots. The main effect of burning on Pn,Pmax and Φmax was not significant in C. squarrosa. The burning-induced changes in soil moisture could explain 51% (P =0.01) of the burning-induced changes in Pn of the three species. All three species showed positive responses to N fertilization in terms of Pn,Pmax,and Φmax. The stimulation of Pn under N fertilization was mainly observed in the early growing season when the soil extractable N content was significantly higher in the fertilized plots. The N fertilization-induced changes in soil extractable N content could explain 66% (P = 0.001) of the changes in Pn under N fertilization. The photosynthetic responses of the three species indicate that burning and N fertilization will potentially change the community structure and ecosystem productivity in the semiarid grasslands of northern China. | Yanfang Zhang Shuli Niu Wenhua Xu Yi Han | 2008 | Journal of Integrative Plant Biology2008，50，5： | 8 |
| 2 | Design of Porous Membranes by Liquid Gating Technology显示文摘CONSPECTUS:Porous membranes are playing paramount roles in the areas of wastewater treatment,chemical analysis,energy storage and conversion,flexible devices,and biomedical engineering.Despite their significance in the above fields,the performances of the porous membrane will be weakened due to the inevitable membrane fouling.Solid surfaces or pores of the membranes are easily contaminated or even clogged due to the absorption of small molecules or the accumulation of fine particles,which lower the flux of fluid transport over time,reduce the separation efficiency,shorten the lifetime of the membranes,and increase the operational costs.In addition,the defects in membranes also hinder their applications to some extent.The above-mentioned limitations all arise from the intrinsic properties of the solid surfaces of the membranes.To solve these challenges,liquid gating technology was proposed,which utilizes the capillary-stabilized functional liquid as a pressure-driven,reversible,and reconfigurable gate to fill and seal the pores on demand.Using liquid gating technology,multiphase transportation in the membrane can be modulated with exceptional antifouling and energy-saving manners due to the defect-free molecular-smooth liquid interface.Moreover,the further responsive interface design accelerated the development of liquid gating membranes and their practical applications to a great extent.In recent years,the concept of the liquid gating membrane has become a reality through developing various porous membranes by the rational selection and design of the two essential parts of the composite membranes:the solid porous matrix and the gating liquid.These membranes expand the basic scientific issues of the traditional membranes from the solid−liquid/gas interface to the solid−liquid−liquid/gas interface and bring more possibilities for the applications of porous membranes.With properties and advantages of antifouling,anticorrosion,enhanced transparency,energy-saving,and stability,these porous membranes have shown various applications in multiphase separation,biomedical catheters,chemical detection,mobile valves,microscale flow control,etc.In this Account,we provide a systematic review of our group’s recent progresses in the design and applications of porous membranes with liquid gating technology.First,we give a comprehensive introduction to the liquid gating technology,followed by further details on how to design porous membranes through liquid gating technology and properties and advantages of the porous membranes.Second,we discuss the applications of these porous membranes in the fields of multiphase separation,biomedical catheters,chemical detection,mobile valves,and microscale flow control.Third,we conclude the Account by describing the current challenges and future directions of the field. | Shuli Wang Yunmao Zhang Yuhang Han Yaqi Hou Yi Fan Xu Hou | 2021 | Accounts of Materials Research2021，2，6： | 3 |
| 3 | A novel o-nitrobenzyl-based photocleavable antitumor prodrug with the capability of releasing 5-fluorourail显示文摘An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized.The photolysis properties of the prodrug were investigated by means of1H NMR,HPLC,UV,and MTT methods.The results showed that the toxicity of the anticancer drug was effectively shielded before release.However,the prodrug effectively regained the antitumor capability against cancer cells by release of 5-fluorouracil when it was exposed to ultraviolet irradiation. | Shuli Mo Ying Wen Fengfeng Xue Haichuang Lan Yueyuan Mao Guanglei Lv Tao Yi | 2016 | Science Bulletin2016，61，6： | 2 |
| 4 | Research progress of rare earth separation methods and technologies显示文摘Strategical elements,such as rare earth elements,play a crucial role in the industry,especially in producing high-tech materials.Major global industries have developed a strong dependence on rare earth materials.Every year,there are innovations in industries such as modern technology,green energy,or communications technology,which need more strategic metals to improve investment profitability.This article reviews advances in rare earth separation methods and techniques to guide and recommend the best extractants,depending on leaching conditions and the final target product.Each method for separating and extracting agents is individually revised in terms of the mechanism and interaction of providing rare earth elements.This paper also evaluates past and current trends of these methods and technical extractants and identifies their strengths and weaknesses. | Mory Traore Aijun Gong Yiwen Wang Lina Qiu Yuzhen Bai Weiyu Zhao Yang Liu Yi Chen Ying Liu Huilin Wu Shuli Li Yueyi You | 2023 | Journal of Rare Earths2023，41，2： | 2 |
| 5 | Lanthanides' enhancing absorption of insulin and reduction of blood glucose of rat by pulmonary administration显示文摘To explore the possibility of lanthanides as the enhancer of insulin absorption, the promoting effects of lanthanide ions on the absorption of intrapulmonary delivered insulin and reduction of blood glucose were investigated by means of two approaches, preadministration and coadministration of lanthanide ions with insulin. The results indicate that, compared with the results of those given insulin only, lanthanide ions can effectively enhance the level of insulin and the reduction of glucose level in blood. These effects are dependent on lanthanide species and their concentrations. The mechanism was discussed. | Yi Cheng Zancong Shen Qiang Zhang Rongchang Li Shuli Wei Kui Wang | 2000 | Chinese Science Bulletin2000，45，7： | 1 |
| 6 | Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth显示文摘Glioblastoma(GBM,WHO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal prognosis.The extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,migration,and immune escape.Uridine diphosphate(UDP)-glucose 6-dehydrogenase(UGDH)is the rate-limiting enzyme that catalyzes the biosynthesis of glycosaminoglycans that are the principal component of the CNS ECM.We investigated how targeting UGDH in GBM infuence$the GBM immune microenvironment,including tumor-associated microglia/macrophages(TAMs)and T cells.TAMs are the main im-mune effector cells in GBM and can directly target tumor cells if properly activated.In co-cultures of GBM cells and human primary macrophages,UGDH knockdown in GBM cells pro-moted macrophage phagocytosis and M-like polarization.In orthotropic human GBM xeno-grafts and syngeneic mouse glioma models,targeting UGDH decreased ECM deposition,increased TAM phagocytosis marker expression,reduced M2-like TAMS and inhibited tumor growth.UGDH knockdown in GBM cells also promoted cytotoxic T cell ifltration and activa-tion in orthotopic syngeneic mouse glioma models.The potent and in-human-use small mole-cule GAG synthesis inhibitor 4-methylumbelliferone(4-MU)was found to inhibit GBM cell proliferation and migration in vitro,mimic the macrophage and T-cell responses to UGDH knockdown in vitro and in vivo and inhibit growth of orthotopic murine GBM.Our study shows that UGDH supports GBM growth through multiple mechanisms and supports the development of ECM-based therapeutic strategies to simultaneously target tumor cells and their microenvi-ronment. | Daqian Zhan Fatih Yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye John Laterra Mingyao Ying Hernando Lopez-Bertoni Shuli Xia | 2022 | Genes & Diseases2022，9，3： | 1 |
| 7 | Reconfiguring confined magnetic colloids with tunable fluid transport behavior显示文摘Collective dynamics of confined colloids are crucial in diverse scenarios such as self-assembly and phase behavior in materials science,microrobot swarms for drug delivery and microfluidic control.Yet,fine-tuning the dynamics of colloids in microscale confined spaces is still a formidable task due to the complexity of the dynamics of colloidal suspension and to the lack of methodology to probe colloids in confinement.Here,we show that the collective dynamics of confined magnetic colloids can be finely tuned by external magnetic fields.In particular,the mechanical properties of the confined colloidal suspension can be probed in real time and this strategy can be also used to tune microscale fluid transport.Our experimental and theoretical investigations reveal that the collective configuration characterized by the colloidal entropy is controlled by the colloidal concentration,confining ratio and external field strength and direction.Indeed,our results show that mechanical properties of the colloidal suspension as well as the transport of the solvent in microfluidic devices can be controlled upon tuning the entropy of the colloidal suspension.Our approach opens new avenues for the design and application of drug delivery,microfluidic logic,dynamic fluid control,chemical reaction and beyond. | Zhizhi Sheng Mengchuang Zhang Jing Liu Paolo Malgaretti Jianyu Li Shuli Wang Wei Lv Rongrong Zhang Yi Fan Yunmao Zhang Xinyu Chen Xu Hou | 2021 | National Science Review2021，8，5： | 1 |
| 8 | Discontinuous streaming potential via liquid gate显示文摘Streaming potential is mainly related to electrokinetic energy conversion,which has been considered to show promising potential for advanced technologies,especially sensing.The inherent property of streaming potential is that the energy conversion process is always a continuous state.However,practical applications include many cases of discontinuous states,such as nonlinear sensing.Here,we report a discontinuous streaming potential electrokinetic energy conversion fluid system.Experiments and theoretical calculations reveal that this system exhibits a discontinuous electrokinetic effect and provides a gating liquid slip in micropores,offering the advantages of gating liquid charge coupling and interfacial drag reduction.Moreover,the system is demonstrated in a wearable fall-down alert application.We expect this liquid gating energy conversion system to open up a platform for the design and application of autonomous health monitoring devices,seismic sea wave warning systems,and beyond. | Jian Zhang Kan Zhan Shusong Zhang Yigang Shen Yaqi Hou Jing Liu Yi Fan Yunmao Zhang Shuli Wang Yanbo Xie Xinyu Chen Xu Hou | 2022 | eScience2022，2，6： | 0 |
| 9 | Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry显示文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience. | Bin Liu Xuedong Zhou Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 10 | Detection of T-wave Alternans in ECG Signals Using FRFT and Tensor Decomposition显示文摘T-wave alternans(TWA)refers to the periodic beat-to-beat variation in the amplitude of T-wave in the electrocardiogram(ECG)signal in an ABAB-pattern.TWA has been proven to be a very important indicator of malignant arrhythmia risk stratification.A new method to detect TWA by combining fractional Fourier transform(FRFT)and tensor decomposition is proposed.First,the T-wave vector is extracted from the ECG of each heartbeat,and its FRFT amplitudes at multiple orders are arranged to form a T-wave matrix.Then,a third-order tensor is composed of T-wave matrices of several consecutive heart beats.After tensor decomposition,projection matrices are obtained in three dimensions.The complexity of the projection matrix is measured by Shannon entropy to obtain feature vector to detect the presence of TWA.Results show that the sensitivity,specificity,and accuracy of the algorithm on the MIT-BIH database are 91.16%,94.25%,and 92.68%,respectively.This method effectively utilizes the fractional domain information of ECG,and shows the promising potential of the FRFT in ECG signal processing. | Chuanbin Ge Shuli Zhao Yi Xin | 2021 | Journal of Beijing Institute of Technology2021，30，3： | 0 |
| 11 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 12 | MEF2C ameliorates learning,memory,and molecular pathological changes in Alzheimer’s disease in vivo andin vitro显示文摘Myocyte enhancer factor 2C(MEF2C)is highly expressed in the nervous system,and regulates neuro-development,synaptic plasticity,and inflammation.However,its mechanism in Alzheimer’s disease(AD)is underestimated.In this study,the role and mechanism of MEF2C were investigated in the brain tissue specimens from patients with AD,APPswe/PSEN1dE9 double transgenic(APP/PS1_DT)mice,and SH-SY5Y cells treated withβ-amyloid peptide(Aβ).The results indicated that the expression of MEF2C is significantly reduced,and the expression of MEF2C/Aβin different parts of brain is negatively correlated in patients with AD.Knockdown of MEF2C promotes cell apoptosis and the level ofβ-amyloid precursor protein cleaving enzyme 1(BACE)but reduces BACE2 expression.In addition,knockdown of Mef2c enhances the generation and aggregation of Aβin the cortex of APP/PS1_DT mice,reduces the expression of synaptic proteins,exacerbates the ability of learning and memory of APP/PS1_DT mice,damages the structure of mitochondria,increases the oxidative stress(OS)level,and inhibits the expression levels of members of the Nrf2-ARE signal pathway.In summary,inhibition of MEF2C exacerbates the toxic effect of Aβin vivo and in vitro,damages synaptic plasticity,reduces the ability of learning and memory of APP/PS1 mice,and increases the level of OS via the Nrf2-ARE signal pathway. | Jiamou Ren Shuli Zhang Xiaoling Wang Yuxin Deng Yi Zhao Yan Xiao Jian Liu Liangzhao Chu Xiaolan Qi | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 0 |
| 13 | Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost显示文摘Dear Editor,Pathogenic microorganisms carrying antibiotic resistance genes(ARGs)pose serious challenge to human health worldwide.The major reservoir of ARGs is believed to be the environment(Cao et al.,2020).Some ARGs can be transmitted from the environment into pathogens via horizontal gene transfer(Forsberg et al.,2012). | Jian Cao Fei Liu Shuli Liu Jun Wang Baoli Zhu Yi Shi George Fu Gao | 2021 | Science China(Life Sciences)2021，64，12： | 0 |
| 14 | Mixed invasive pulmonary Mucor and Aspergillus infection:a case report and literature review显示文摘To the Editor:Invasive pulmonary mucormycosis(IPM)is a rare but life-threatening opportunistic fungal disease with a high mortality rate of 40%to 80%.[1]Although IPM accounts for approximately 9.2%of all mucormycosis cases,it has the highest mortality rate(66.6%).A definitive diagnosis of IPM depends on the histopathological findings,regardless of culture results of the respiratory tract specimens or lung tissues. | Peikun Teng Xiudi Han Shuli Zhang Dong Wei Yi Wang Deshun Liu Xuedong Liu | 2022 | Chinese Medical Journal2022，，7： | 0 |
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