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| 1 | A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings显示文摘In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. | Ziwen Qiao Xueli Lv Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang | 2021 | Bioactive Materials2021，6，9： | 14 |
| 2 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 3 | Research on the Work-rest Scheduling in the Manual Order Picking Systems to Consider Human Factors显示文摘As the status of order picking in the warehousing and distribution system has been raised,the work-rest scheduling of picking becomes particularly important.Although science and technology have developed rapidly,manual picking is still essential and indispensable.However,previous researches focused on the study of the sequencing,ignoring human factors.The paper presents a work-rest schedule model in parts to picker picking system.Two objectives are proposed that include minimizing the picking time and minimizing picking error rate.And workers'fatigue,workload is taken into account in the manual order picking systems because the fatigue can have a large influence on the picking time and the picking error rate.A genetic algorithm is used to solve a multi-objective optimization problem that the model concerns and looking for a Pareto front as the most effective methods for solving this problem.Once the original data is given,the work-rest scheduling model is built and the work sequence,and the number of breaks are determined to be chosen by decision makers.In addition,a case study of the model is used to confirm that the model is effective and it is necessary to consider the human factor in the picking system. | Xiaosong Zhao Na Liu Shumeng Zhao Jinhui Wu Kun Zhang Rui Zhang | 2019 | Journal of Systems Science and Systems Engineering2019，28，3： | 1 |
| 4 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 5 | Customizable Ligand Exchange for Tailored Surface Property of Noble Metal Nanocrystals显示文摘It is highly desirable,while still challenging,to obtain noble metal nanocrystals with custom capping ligands,because their colloidal synthesis relies on specific capping ligands for the shape control while conventional ligand exchange processes suffer from“the strong replaces the weak”limitation,which greatly hinders their applications.Herein,we report a general and effective ligand exchange approach that can replace the native capping ligands of noble metal nanocrystals with virtually any type of ligands,producing flexibly tailored surface properties.The key is to use diethylamine with conveniently switchable binding affinity to the metal surface as an intermediate ligand.As a strong ligand,it in its original form can effectively remove the native ligands;while protonated,it loses its binding affinity and facilitates the adsorption of new ligands,especially weak ones,onto the metal surface.By this means,the irreversible order in the conventional ligand exchange processes could be overcome.The efficacy of the strategy is demonstrated by mutual exchange of the capping ligands among cetyltrimethylammonium,citrate,polyvinylpyrrolidone,and oleylamine.This novel strategy significantly expands our ability to manipulate the surface property of noble metal nanocrystals and extends their applicability to a wide range of fields,particularly biomedical applications. | Qikui Fan Hao Yang Juan Ge Shumeng Zhang Zhaojun Liu Bo Lei Tao Cheng Youyong Li Yadong Yin Chuanbo Gao | 2020 | Research2020，，1： | 1 |
| 6 | Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks显示文摘象通过代的压抑的 histone 修正那样的 epigenetic 信息的忠诚传播或恢复为房间身份的维护是批评的。我们这里报导那 chromodomain 象 Y 一样蛋白质(CDYL ) ,包含 chromodomain 抄写 corepressor,身体上与染色质集会因素 1 被联系(CAF-1 ) 并且 replicative helicase 看建筑群。我们证明 CDYL 衔接 CAF-1 和看,便于在 DNA 复制期间的 histone 转移和免职。我们证明到复制的 CDYL 成员修改 histone 酶 G9a, SETDB1,和 EZH2 分叉,导致最新扔的 histone H3 上的 H3K9me2/3 和 H3K27me2/3 的增加。显著地, CDYL 的弄空阻碍早 S 阶段前进并且敏化房间到 DNA 损坏。我们的数据显示 CDYL 在压抑的 histone 标记的传播 / 恢复起一个重要作用,从而为房间身份的维护保存 epigenetic 风景。 | Yongqing Liu Shumeng Liu Shuai Yuan Huajing Yu Yu Zhang Xiaohan Yang Guojia Xie Zhe Chen Wanjin Li Bosen Xu Luyang Sun Yongfeng Shang Jing Liang | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 7 | The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry显示文摘The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the nucleus.We report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the nucleus.We showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in cyanobacteria.We propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy production.We demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription regulation.Together,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation. | Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 8 | Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection显示文摘Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic capacities.Methods: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular docking.Results: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory profile.Conclusion: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin. | Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren Jiao Xiao Dongmei Wang Xiaoqiu Liu Yingni Pan | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
| 9 | CDYL作为丁烯酰辅酶A水合酶调控组蛋白丁烯酰化及精子发生显示文摘文章简介本研究发现,转录辅抑制因子CDYL具有负调控组蛋白赖氨酸丁烯酰化的功能。有趣的是,CDYL负调控组蛋白丁烯酰化并不是通过直接从底物赖氨酸上去除丁烯酰基的方式实现的,而是利用CDYL的丁烯酰辅酶A水合酶活性。 | Shumeng Liu Huajing Yu Yongqing Liu Xinhua Liu Yu Zhang Chen Bu Shuai Yuan Zhe Chen Guojia Xie Wanjin Li Bosen Xu Jianguo Yang Lin He Tong Jin Yundong Xiong Luyang Sun Xiaohui Liu Chunsheng Han Zhongyi Cheng 梁静 尚永丰 | 2018 | 科学新闻2018，0，4： | 0 |
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