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| 1 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 2 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 3 | The Sequence of Magmatic-Tectonic Events and Orogenic Processes of the Yanshan Belt, North China显示文摘This paper emphasizes that the interactive constraints of geology and isotopic dating is the best approach to construct the geological event sequence, and has compiled 106 data of reasonable isotopic ages for the igneous rocks of the Yanshan belt. We propose a sequence of mgmatic-tectonic events in the Jurassic-Cretaceous Yanshan orogen of North China. Five orogenic episodes are divided, (1) pre-and initial orogenic episode (Early Jurassic); (2) early orogenic episode (Middle Jurassic); (3) peak orogenic episode (Late Jurassic); (4) late orogenic episode (early Early Cretaceous),and (5) post-orogenic episode. Each episode is a short cycle, all of the orogenic processes construct a longer cycle, and they, in general, followed a counter-clockwise (ccw) PTt path. Finally, it is suggested that the Yanshanian movement was so intensive that the magmatism and tectonic deformation had involved all the lithosphere thickness and the lateAchaean-formed cratonic lithosphere had been significantly reworked. | DENG Jinfu, SU Shangguo, MO Xuanxue, ZHAO Guochun, XIAO Qinghiu, JI Guangyi,QIU Ruizhao, ZHAO Hailing, LUO Zhaohua, WANG Yang and LIU Cui China University of Geosciences, Beijing 100083 and Key Laboratory of Lithospheric Tectonics and Lithoprobe Techniques, Ministry of Education of China | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 35 |
| 4 | Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy显示文摘Although many studies have investigated intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC),sample sizes in the reported studies are usually small and different in outcomes in different T and N subgroups are seldom analyzed.Herein,we evaluated the outcomes of NPC patients treated with IMRT and further explored treatment strategy to improve such outcome.We collected clinical data of 865 NPC patients treated with IMRT alone or in combination with chemotherapy,and classified all cases into the following prognostic categories according to different TNM stages:early stage group (T1-2N0-1M0),advanced local disease group (T3-4N0-1M0),advanced nodal disease group (T1-2N2-3M0),and advanced locoregional disease group (T3-4N2-3M0).The 5-year overall survival (OS),local relapse-free survival (LRFS),and distant metastases-free survival (DMFS) were 83.0%,90.4%,and 84.0%,respectively.The early disease group had the lowest treatment failure rate,with a 5-year OS of 95.6%.The advanced local disease group and advanced nodal disease group had similar failure pattern and treatment outcomes as well as similar hazard ratios for death (4.230 and 4.625,respectively).The advanced locoregional disease group had the highest incidence of relapse and death,with a 5-year DMFS and OS of 62.3% and 62.2%,respectively,and a hazard ratio for death of 10.402.Comparing with IMRT alone,IMRT in combination with chemotherapy provided no significant benefit to locoregionally advanced NPC.Our results suggest that the decision of treatment strategy for NPC patients should consider combinations of T and N stages,and that IMRT alone for early stage NPC patients can produce satisfactory results.However,for advanced local,nodal,and locoregional disease groups,a combination of chemotherapy and radiotherapy is recommended. | Sheng-Fa Su 1,2,3,Fei Han 1,2,Chong Zhao 1,2,Ying Huang 1,2,Chun-Yan Chen 1,2,Wei-Wei Xiao 1,2,Jia-Xin Li 1,2 and Tai-Xiang Lu 1,2 1 State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China 2 Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China 3 Department of Oncology,Guiyang Medical College Hospital,Tumor Hospital of Guizhou,Guiyang,Guizhou 550003,P.R.China. | 2011 | Chinese Journal of Cancer2011，30，8： | 40 |
| 5 | Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study显示文摘背景尽管在中国的死亡的第一个领先的原因是恶意的瘤(死亡, 374.1 每 100000 人年),因为关于学习试图在 PBT.Methods 的流行上报导一个全面评价的大脑 tumors.This 的流行病的特征有一些很好记录的报告,保健系统上的主要大脑肿瘤( PBT )的完整的影响完全没被描述 multicenter 大脑肿瘤( MCSBT )上的代表性的学习在里面中国在五地区性的 c 被开始59 岁;女性: 45 岁) .Conclusions 年龄标准化了 PBT 的流行是 22.52 每 100 000 (95% CI , 13.22~31.82 )为所有人口, 17.64 每 100 000 (95% CI , 9.41~25.87 )为人,和 27.94 同等 100 000 (95% CI , 17.58~38.30 )为有 PBT.Our 流行的 304 954 个案例的一张估计的人口估计的到中国产出的 2010 人口的 women.Age 标准化提供计划护理服务并且为 surviving.In 开发编程的策略的一个保守基础未来,它将是 | JIANG Tao TANG Gen-fu LIN Yi PENG Xiao-xia ZHANG Xiao ZHAI Xiu-wei PENG Xiang YANG Jin-qing HUANG Hong-er WU Nai-feng CHEN Xiao-jun XING Hou-xun SU Tong-yong WANG Zhong-cheng | 2011 | Chinese Medical Journal2011，，17： | 40 |
| 6 | Inhibition of Dual Specific Oncolytic Adenovirus on Esophageal Cancer via Activation of Caspases by a Mitochondrial-dependent Pathway显示文摘We investigated the anti-tumor effects of dual cancer specific-oncolytic adenovirus Ad-VP on esophageal cancer(EC).The anti-tumor activity of Ad-VP was compared with that of the control recombinant adenoviruses(Ad-GP,Ad-Apoptin,Ad-EGFP) in human esophageal cancer cell EC-109 and human normal liver cell L02 in vitro.In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays,the growth of EC-109 cells was slightly inhibited by Ad-GP,Ad-Apoptin and Ad-EGFP.However,Ad-VP induced a significant cytotoxic effect.Infection of EC-109 cells with Ad-VP resulted in a significant induction of apoptosis of them in vitro,detected by 4',6-diamidino-2-phenylindole(DAPI) or acridine orange and ethidium bromide staining.The results of Western blot and flow cytometric assay indicate the loss of mitochondrial membrane potential(ΔΨ m),the release of cytochrome c and the activation of caspase-3,6 and 7 in Ad-VP infected EC-109 cells.In contrast,all these assays show almost no effects of the recombinant adenoviruses on L02 cells.These results demonstrate that the treatment of tumors with Ad-VP selectively inhibits tumor growth and induces apoptosis of esophageal cancer cells.Ad-VP may provide a novel and powerful strategy for cancer gene therapy. | SU Jia-qiang CHI Bao-rong LI Xiao LIU Lei LIU Li-ming QI Yan-xin WANG Zhuo-yue JIN Ning-yi | 2012 | Chemical Research in Chinese Universities2012，28，3： | 38 |
| 7 | Oceanic plate subduction history in the western Pacific Ocean:Constraint from late Mesozoic evolution of the Tan-Lu Fault Zone显示文摘The NE-to NNE-striking Tan-Lu Fault Zone(TLFZ) is the largest fault zone in East China, and a typical representative for the circum-Pacific tectonics. Its late Mesozoic evolution resulted from subduction of the Paleo-Pacific Plate,and can be used for indication to the subduction history. The TLFZ reactivated at the end of Middle Jurassic since its origination in Middle Triassic. This phase of sinistral motion can only be recognized along the eastern edge of the Dabie-Sulu orogenis,and indicates initiation of the Paleo-Pacific(Izanagi) Plate subduction beneath the East China continent. After the Late Jurassic standstill, the fault zone experienced intense sinistral faulting again at the beginning of Early Cretaceous under N-S compression that resulted from the NNW-ward, low-angle, high-speed subduction of the Izanagi Plate. It turned into normal faulting in the rest of Early Cretaceous, which was simultaneous with the peak destruction of the North China Craton caused by backarc extension that resulted from rollback of the subducting Izanagi Plate. The TLFZ was subjected to sinistral, transpressive displacement again at the end of Early Cretaceous. This shortening event led to termination of the North China Craton destruction. The fault zone suffered local normal faulting in Late Cretaceous due to the far-field, weak backarc extension. The late Mesozoic evolution of the TLFZ show repeated alternation between the transpressive strike-slip motion and normal faulting. Each of the sinistral faulting event took place in a relatively short period whereas every normal faulting event lasted in a longer period, which are related to the subduction way and history of the Paleo-Pacific Plates. | Guang ZHU Cheng LIU Chengchuan GU Shuai ZHANG Yunjian LI Nan SU Shiye XIAO | 2018 | Science China Earth Sciences2018，61，4： | 38 |
| 8 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 9 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 10 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 11 | Heavy metal contamination and source in arid agricultural soil in central Gansu Province,China显示文摘铜( Cu )的集中,铅( Pb ),铬( Cr ),水银( Hg ),和砷(作为)在在 Daba 村庄, Shajiawuan 村庄, Gangou 村庄和 Sifangwu 村庄里收集的干旱农业、灌溉的农业土壤被测量,在中央 Gansu 省定位了,除了 Hg 和 Pb 的 China.Concentrations 比在在选择干旱农业 soils.Pb 集中的灰石灰性土壤的背景价值由结果显示出的72.46% .These 在中国超过干旱农业土壤的阀值低有有 Pb 的确实严肃的污染,为在 Daba 村庄里的灌溉农业土壤的另外的选择金属的一个细微污染问题。种量分析(PCA ) 被用来估计土壤数据,使用有凯撒正规化的 varimax 旋转。结果证明灌溉因素,农业因素和人为的因素都贡献了在选择化学特性之间的关系。Cu 的累积的主要因素, Pb, Cr, Hg 并且这是石版印刷在干旱农业区域的逻辑因素。有 Cu 的起源的惹人注目的不同, Pb, Cr, Hg 并且作为在在 irrigate 农业和干旱农业之间的农业土壤。 | LI Yu GOU Xin WANG Gang ZHANG Qiang SU Qiong XIAO Guoju | 2008 | Journal of Environmental Sciences2008，20，5： | 27 |
| 12 | Microstructure and Mechanical Properties of C/C-ZrC-SiC Composites Fabricated by Reactive Melt Infiltration with Zr,Si Mixed Powders显示文摘To meet the increasing demand for advanced materials capable of operation over 2000℃for future thermal protection systems application,C/C—ZrC—SiC composites were fabricated by reactive melt infiltration(RMI) with Zr,Si mixed powders as raw materials.The structural evolution and formation mechanism of the C/C—ZrC -SiC composites were discussed,and the mechanical property of the as-prepared material was investigated by compression test.The results showed that after the RMI process,a special structure with ZrC-SiC multi-coating as outer layer and ZrC-SiC-PyC ceramics as inner matrix was formed.ZrC and SiC rich areas were formed in the composites and on the coating surface due to the formation of Zr-Si intermetallic compounds in the RMI process.Mechanical tests showed that the average compression strength of the C/C-ZrC-SiC composites was 133.86 MPa,and the carbon fibers in the composites were not seriously damaged after the RMI process. | Xin Yang Zhean Su Qizhong Huang Xiao Fang Liyuan Chai | 2013 | Journal of Materials Science & Technology2013，29，8： | 25 |
| 13 | RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation显示文摘RANKL signaling is essential for osteoclastogenesis. Its role in osteoblastic differentiation and bone formation is unknown. Here we demonstrate that RANK is expressed at an early stage of bone marrow mesenchymal stem cells(BMSCs) during osteogenic differentiation in both mice and human and decreased rapidly. RANKL signaling inhibits osteogenesis by promoting β-catenin degradation and inhibiting its synthesis. In contrast, RANKL signaling has no significant effects on adipogenesis of BMSCs.Interestingly, conditional knockout of rank in BMSCs with Prx1-Cre mice leads to a higher bone mass and increased trabecular bone formation independent of osteoclasts. In addition, rank^(flox/flox): Prx1-Cre mice show resistance to ovariectomy-(OVX) induced bone loss. Thus, our results reveal that RANKL signaling regulates both osteoclasts and osteoblasts by inhibition of osteogenic differentiation of BMSCs and promotion of osteoclastogenesis. | Xiao Chen Xin Zhi Jun Wang Jiacan Su | 2018 | Bone Research2018，6，4： | 24 |
| 14 | Subchondral bone microenvironment in osteoarthritis and pain显示文摘Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain,causing disability and economic burden.The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trends.Basic and clinical research on osteoarthritis has been carried out for decades,but many questions remain unanswered.The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear.Accumulating evidence shows that subchondral bone lesions,including bone marrow edema and angiogenesis,develop earlier than cartilage degeneration.Clinical interventions targeting subchondral bone have shown therapeutic potential,while others targeting cartilage have yielded disappointing results.Abnormal subchondral bone remodeling,angiogenesis and sensory nerve innervation contribute directly or indirectly to cartilage destruction and pain.This review is about bone-cartilage crosstalk,the subchondral microenvironment and the critical role of both in osteoarthritis progression.It also provides an update on the pathogenesis of and interventions for osteoarthritis and future research targeting subchondral bone. | Yan Hu Xiao Chen Sicheng Wang Yingying Jing Jiacan Su | 2021 | Bone Research2021，9，3： | 24 |
| 15 | Study on early warning index of spatial deformation for high concrete dam显示文摘Owing to the deficiency in early warning for high concrete dam,a formula was established to characterize the deformation behavior of high concrete dam as a whole.The early warning index of spatial deformation was calculated by low probability principle on the basis of the deformation entropy formula proposed.The steps were as follows.Firstly,the probability method was utilized to define the degree of order and degree of chaos for each survey point.Secondly,the weight distribution among the survey points was calculated by projection pursuit analysis.Thirdly,the formula of holistic deformation entropy,which can represent the degree of order of high concrete dam,was established on the basis of synergetics and information entropy.Lastly,the early warning index of deformation entropy was computed by low probability method based on series of calculated deformation entropy values.An example showed that the dynamic property of deformation entropy is in accordance with both environmental variables and deflection deformation.Moreover,deformation entropy can be used to improve warning ability and safety management for high concrete dam. | LEI Peng CHANG XiaoLin XIAO Feng ZHANG GuiJin SU HuaiZhi | 2011 | Science China(Technological Sciences)2011，54，6： | 23 |
| 16 | A method to estimate concentrations of surface-level particulate matter using satellite-based aerosol optical thickness显示文摘We propose a new method to estimate surface-level particulate matter(PM)concentrations by using satellite-retrieved Aerosol Optical Thickness(AOT).This method considers the distribution and variation of Planetary Boundary Layer(PBL)height and relative humidity(RH)at the regional scale.The method estimates surface-level particulate matter concentrations using the data simulated by an atmospheric boundary layer model RAMS and satellite-retrieved AOT.By incorporation MODIS AOT,PBL height and RH simulated by RAMS,this method is applied to estimate the surface-level PM 2.5 concentrations in North China region.The result is evaluated by using 16 ground-based observations deployed in the research region,and the result shows a good agreement between estimated PM 2.5 concentrations and observations,and the coefficient of determination R2 is 0.61 between the estimated PM 2.5 concentrations and the observations.In addition,surface-level PM 2.5 concentrations are also estimated by using MODIS AOT,ground-based LIDAR observations and RH measurements.A comparison between the two estimated PM 2.5 concentrations shows that the new method proposed in this paper is better than the traditional method.The coefficient of determination R2 is improved from 0.32 to 0.62. | TAO JinHua ZHANG MeiGen CHEN LiangFu WANG ZiFeng SU Lin GE Cui HAN Xiao ZOU MingMin | 2013 | Science China Earth Sciences2013，56，8： | 20 |
| 17 | The growth mechanism of the basic magnesium chloride whisker显示文摘Based on the theoretical model of anion coordination polyhedron growth units, the growth mechanism of the basic magnesium chloride whisker was discussed in this paper.It was found that the basic magnesium chloride whisker habits were related to the different environments in which anion coordination polyhedra grew. The growth units of basic magnesium chloride whiskers are [Mg - (OH) 4]2 -and [Mg - Cl 4]2 -. The growth process is the incorporation process of growth units. Growth units will have different incorporations and orientations caused by different system characters or heating. Furthermore, the formation mechanism of basic magnesium chloride whiskers was also interpreted using anion coordination polyhedron growth units. | WU JianSong XIAO YingKai SU JingYun DENG TingTing FENG JieRong MO YuYing ZENG Mei | 2011 | Science China(Technological Sciences)2011，54，3： | 18 |
| 18 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 19 | Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors显示文摘 | SU Li-li MA Wei-xia YUAN Jian-feng SHAO Yang XIAO Wei JIANG Shu-juan | 2012 | Chinese Medical Journal2012，，22： | 18 |
| 20 | Transforming growth factor-β1 gene polymorphisms associated with chronic obstructive pulmonary disease in Chinese population显示文摘Aim: To determine the frequencies of polymorphism and haplotype in the transforming growth factor-beta 1 (TGF-β1) gene promoter in the Chinese population and to investigate the susceptibility of this population to chronic obstructive pulmonary disease (COPD). Methods: The target fragments of the TGF-β1 gene promoter were amplified and analyzed by polymerase chain reaction-restriction fragment length polymorphism technique in 84 COPD patients and 97 age-and sex-matched healthy controls. The test for Hardy-Weinberg equilibrium was performed using HWE program of the LINKUTIL package and statistical analysis was carded out with the SPSS statistical package. An expectation maximization algorithm was used for the pairwise linkage disequilibrium test and haplotype analysis. Results: More carriers of the -800A allele, or fewer carders of the -509T allele, were detected in the COPD patients compared with the non-symptomatic control subjects [for the -800A allele, 29.8% vs 14.4%, respectively, χ^2=6.257,degrees of freedom (df)=l, P=0.012; for the-509T allele, 27.3% vs 44.3%, respectively, χ^2=5.582, df=1, P=0.018]. The prevalence of the-800A allele was significantly higher in the COPD patients than in control subjects (P=0.009), whereas the frequency of the-509T allele was significantly higher in control subjects than in the COPD patients (P=0.008). In addition, this distribution tendency for the-800A or-509T allele was similar in heavy smokers (smoking history≥20 pack years);(number of packs of cigarettes per day multiplied by the number of years of smoking)χ^2=7.235, P=0.007, and χ^2=5.636, P=0.018, respectively). The linkage disequilibrium was found between-800 G→A and-509 C→T (D>0.60, P<0.0001), and the frequency of the AC haplotype, consisting of the least common base at -800 and the most common base at -509, was significantly higher in patients with COPD than in controls (0.056 vs 0.021, P<0.05). Conclusions: The single nucleotide polymorphism (SNP) in the TGF-β1 gene promoter might be associated with COPD,and the -800A/-509C haplotype is possibly one of the susceptibility factors for COPD. | Zhi-guang SU~2, Fu-qiang WEN, Yu-lin FENG, Min XIAO, Xiao-ling WU Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University Key Laboratory of Biotherapy of Human Disease, Ministry of Education, Chengdu 610041, China | 2005 | Acta Pharmacologica Sinica2005，26，6： | 17 |
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