|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The recent development of soft x-ray interference lithography in SSRF显示文摘This paper introduces the recent progress in methodologies and their related applications based on the soft x-ray interference lithography beamline in the Shanghai synchrotron radiation facility.Dual-beam,multibeam interference lithography and Talbot lithography have been adopted as basic methods in the beamline.To improve the experimental performance,a precise real-time vibration evaluation system has been established;and the lithography stability has been greatly improved.In order to meet the demands for higher resolution and practical application,novel experimental methods have been developed,such as high-order diffraction interference exposure,high-aspect-ratio and large-area stitching exposure,and parallel direct writing achromatic Talbot lithography.As of now,a 25 nm half-pitch pattern has been obtained;and a cm2 exposure area has been achieved in practical samples.The above methods have been applied to extreme ultraviolet photoresist evaluation,photonic crystal and surface plasmonic effect research,and so on. | Jun Zhao Shumin Yang Chaofan Xue Liansheng Wang Zhaofeng Liang Lei Zhang Yong Wang Yanqing Wu Renzhong Tai | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 2 | Diversity and Bioactivity of Actinomycetes from Marine Sediments of the Yellow Sea显示文摘Among the 116 actinomycetes collected from marine sediments of the Yellow Sea,56 grew slowly and appeared after 2?3 weeks of incubation.Among the 56 strains,only 3 required seawater(SW) for growth,and 21 grew well in the medium prepared with SW rather than distilled water(DW),while the remaining 32 grew well either with SW or with DW.Six representatives with different morphological characteristics,including 1 SW-requiring strain and 5 well-growing with SW strains,were selected for phy-logenetic analysis based on 16S rRNA gene.Two strains belong to Micrococcaceae and Nocardiopsaceae respectively.The other 4 strains belong to the family of Streptomycetaceae.In the analyzed 6 strains,one was related to Nocardiopsis spp.and the other three were related to Streptomyces spp.,representing new taxa.Bioactivity testing of fermentation products from 3 SW-requiring strains and 21 well-growing with SW strains revealed that 17 strains possessed remarkable activities against gram-positive pathogen or/and tumor cells,suggesting that they were prolific resources for natural drug discovery. | ZHANG Shumin YE Liang TANG Xuexi | 2012 | Journal of Ocean University of China2012，11，1： | 2 |
| 3 | A joint water diversion plan for China显示文摘 | Shumin Liang | 2013 | Journal-American Water Works Association2013，105，5： | 1 |
| 4 | Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release显示文摘Time-sensitive and pH-dependent polymers are generally employed to prepare colon-site delivery system, and their coating thickness and order are very important in controlling the drug release. The traditional colon-site delivery systems consist of time-dependent polymers as inner layer and pH-sensitive polymers as outer layer. However, they suffer from low drug-loading rate and immature drug release. In this study, total alkaloids of sophora alopecuroides(TASA)-loaded pellets were prepared by extrusion-spheronization method and coated with Eudragit RS30D and Eudragit S100. Pellets using Eudragit RS30D as inner layer and Eudragit S100 as outer layer were named as ERS-ES100 TCO, while pellets with Eudragit S100 as inner layer and Eudragit RS30D as outer layer were ES100-ERS NCO. Both types of formulations with varying coating ratios and orders of Eudragit S100 and Eudragit RS30D were designed and prepared. The following in vitro drug release and SEM studies indicated that ERS-ES100 TCO(F2) with 12.8% Eudragit RS30D as inner layer and 21% Eudragit S100 as outer layer released up to 42% drug in 5 h. Interestingly, ES100-ERS NCO(F4) coated with 12.8% Eudragit S100 and 14.8% Eudragit RS30D showed optimal drug release in colon. In conclusion, ES100-ERS NCO colonic delivery system achieved reduced coating thickness and improved colonic targeting compared with traditional delivery system(ERS-ES100 TCO). In addition, the similarity factors( f 2) value of sophoridine and matrine for investigated formulation were within 50–100 and > 80, demonstrating that sophoridine and matrine in all formulations achieved a synchronous release. | Lijun Song Liping Liang Xiaoying Shi Honglang Chen Shumin Zhao Wenfeng Chen Ruoxia Zhou Wenchang Zhao | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 1 |
| 5 | The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA PolⅡfrom Binding to HIV-1 LTR显示文摘The CREB-regulated transcriptional co-activators(CRTCs),including CRTC1,CRTC2 and CRTC3,enhance transcription of CREB-targeted genes.In addition to regulating host gene expression in response to cAMP,CRTCs also increase the infection of several viruses.While human immunodeficiency virus type 1(HIV-1)long terminal repeat(LTR)promoter harbors a cAMP response element and activation of the cAMP pathway promotes HIV-1 transcription,it remains unknown whether CRTCs have any effect on HIV-1 transcription and HIV-1 infection.Here,we reported that CRTC2 expression was induced by HIV-1 infection,but CRTC2 suppressed HIV-1 infection and diminished viral RNA expression.Mechanistic studies revealed that CRTC2 inhibited transcription from HIV-1 LTR and diminished RNA PolⅡoccupancy at the LTR independent of its association with CREB.Importantly,CRTC2 inhibits the activation of latent HIV-1.Together,these data suggest that in response to HIV-1 infection,cells increase the expression of CRTC2 which inhibits HIV-1 gene expression and may play a role in driving HIV-1 into latency. | Ling Ma Shumin Chen Zhen Wang Saisai Guo Jianyuan Zhao Dongrong Yi Quanjie Li Zhenlong Liu Fei Guo Xiaoyu Li Pingping Jia Jiwei Ding Chen Liang Shan Cen | 2021 | Virologica Sinica2021，36，4： | 1 |
| 6 | An optimalglobal projection denoising algorithm and its applica-tion to shaft orbit purification 显示文摘 | Hou Shumin Liang Ming Li Yourong | 2011 | Structural HealthMonitoring2011，10，6： | 1 |
| 7 | Discussion on a new paradigm of endogenous security towards 6G networks显示文摘The sixth-generation mobile communication(6G)networks will face more complex endogenous security problems,and it is urgent to propose new universal security theories and establish new practice norms to deal with theªunknown unknownºsecurity threats in cyberspace.This paper first expounds the new paradigm of cyberspace endogenous security and introduces the vision of 6G cyberspace security.Then,it analyzes the security problems faced by the 6G core network,wireless access network,and emerging associated technologies in detail,as well as the corresponding security technology development status and the integrated development of endogenous security and traditional security.Furthermore,this paper describes the relevant security theories and technical concepts under the guidance of the new paradigm of endogenous security. | Xinsheng JI Jiangxing WU Liang JIN Kaizhi HUANG Yajun CHEN Xiaoli SUN Wei YOU Shumin HUO Jing YANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，10： | 1 |
| 8 | A Comparative Study of Supervised Learning as Applied to Acronym Expansion in Clinical Repo 显示文摘 | Mou Shumin Wei Junping Liu Fang Wan Xiuzhi Cao Aimei Liu Yajun Wang Jia Chen Liang Liu Do | 2008 | Sichuan2008，，11： | 1 |
| 9 | Continuous wave operation of GaAsBi microdisk lasers at room temperature with large wavelengths ranging from 1.27 to 1.41 μm显示文摘Submicron-meter size GaAsBi disk resonators were fabricated with the GaAsBi/GaAs single-quantum-well(QW)-structure grown by molecular beam epitaxy. The GaAsBi/GaAs QW revealed very broad photoluminescence signals in the wavelength range of 1100–1400 nm at 300 K. The 750 nm diameter and 220 nm thick disk resonators were optically pumped and exhibited lasing characteristics with continuous wave operation at room temperature.To our knowledge, it is the first demonstration of a lasing wavelength longer than 1.3 μm with a maximum value of 1.4 μm in a GaAsBi/GaAs material system. The lasing wavelength spans about 130 nm by adjusting the disk diameter, covering almost the entire O band. The ultrasmall GaAsBi disk lasers may have great potential for highly dense on-chip integration with large tunability in the O band. | Xiu Liu Lijuan Wang Xuan Fang Taojie Zhou Guohong Xiang Boyuan Xiang Xueqing Chen Suikong Hark Hao Liang Shumin Wang Zhaoyu Zhang | 2019 | Photonics Research2019，7，5： | 1 |
| 10 | Amphiphilic small molecular mates match hydrophobic drugs to form nanoassemblies based on drug-mate strategy显示文摘Nanomedicine has made great progress in the targeted therapy of cancer. Here, we established a novel drug-mate strategy by studying the formulation of nanodrugs at the molecular level. In the drug-mate combination, the drug is a hydrophobic drug that is poorly soluble in water, and the mate is an amphiphilic small molecule (SMA) that has both hydrophilic and lipophilic properties. We proposed that the hydrophobic drug could co-assemble with a suitable SMA on a nanoscale without additive agents. The proof-ofconcept methodology and results were presented to support our hypothesis. We selected five hydrophobic drugs and more than ten amphiphilic small molecules to construct a library. Through molecular dynamic simulation and quantum chemistry computation,we speculated that the formation of nanoassemblies was related to the binding energy of the drug-mate, and the drug-mate interaction must overcome drug-drug interaction.Furthermore, the obtained SF/VECOONa nanoassemblieswas selected as a model, which had an ultra-high drug loading content (46%), improved pharmacokinetics, increased bioavailability, and enhanced therapeutic efficacy. In summary, the drug-mate strategy is an essential resource to design exact SMA for many hydrophobic drugs and provides a reference for the design of a carrier-free drug delivery system. | Leiqiang Han Shuang Liang Weiwei Mu Zipeng Zhang Limin Wang Shumin Ouyang Bufan Yao Yongjun Liu Na Zhang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，1： | 1 |
| 11 | Estimation on wetland loss and its restoration potential in Modern Yellow River Delta,Shandong Province of China显示文摘Wetland is one of the most important ecosystems with varied functions and structures,and its loss has been a major issue.Wetland loss in Modem Yellow River Delta(MYRD) becomes a serious environmental problem,so its restoration attracts a great deal of attention from academia and governments.This article proposes a GIS-based multi-criteria comprehensive evaluation methodology for potential estimation of wetland restoration,using MYRD as an example.The model uses four kinds of data(hydrology,terrain,soil,and land use) and could be adapted by planners for use in identifying the suitability of locations as wetland mitigation sites at any site or region.In the application of the model in the MYRD,the research developed a lost wetland distributed map taking the better wetland situation of 1995 as the reference,and elevated the overall distribution trends of wetland restoration potential based on wetland polygon.The results indicated that the total area of wetland loss from 1995 to 2014 was 568.12 km^2,which includes 188.83 km^2 natural wetland and 21.80 km^2 artificial wetland,respectively.The areas of lost wetland with low,middle,and high resilience ability are 126.82 km^2,259.92 km^2,and 119.59 km^2,occupying 25.05%,51.33%,and 23.62%,respectively.The high-restoration-potential wetland included98.47 km^2 of natural wetland and 21.12 km^2 of artificial wetland,which are mainly bush,reed,and ponds.The highrestoration-potential wetland is mainly distributed in the vicinity of Gudong oil field,the Yellow River Delta protected areas,and the eastern sides of Kenli county and Dongying city. | Baolei Zhang Le Yin Shumin Zhang Kai Liang | 2015 | Chinese Journal of Population,Resources and Environment2015，13，4： | 0 |
| 12 | Targeted drug delivery strategies for the treatment of rheumatoid arthritis显示文摘A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality rates.In addition,the aetiology and pathogenesis of RA have not been fully determined.RA is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010). | Jinxia Zhang Ling Jiang Lihong Sun Ping Wang Suhui Sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui | 2021 | Science China(Life Sciences)2021，64，7： | 0 |
| 13 | Unstable Allotetraploid Tobacco Genome due to Frequent Homeologous Recombination, -. Segmental Deletion, and Chromosome Loss显示文摘 | Shumin Chen Feihong Ren Lei Zhang Yong Liu Xuejun Chen Yuanmei Li Liang Zhang Bin Zhu Pan.Zeng Zaiyun Li Robert M. Larkin Hanhui Kuang | 2018 | Molecular Plant2018，11，7： | 0 |
| 14 | Outage Probability Analysis for D2D-Enabled Heterogeneous Cellular Networks with Exclusion Zone:A Stochastic Geometry Approach显示文摘Interference management is one of the most important issues in the device-to-device(D2D)-enabled heterogeneous cellular networks(HetCNets)due to the coexistence of massive cellular and D2D devices in which D2D devices reuse the cellular spectrum.To alleviate the interference,an efficient interference management way is to set exclusion zones around the cellular receivers.In this paper,we adopt a stochastic geometry approach to analyze the outage probabilities of cellular and D2D users in the D2D-enabled HetCNets.The main difficulties contain three aspects:1)how to model the location randomness of base stations,cellular and D2D users in practical networks;2)how to capture the randomness and interrelation of cellular and D2D transmissions due to the existence of random exclusion zones;3)how to characterize the different types of interference and their impacts on the outage probabilities of cellular and D2D users.We then run extensive Monte-Carlo simulations which manifest that our theoretical model is very accurate. | Yulei Wang Li Feng Shumin Yao Hong Liang Haoxu Shi Yuqiang Chen | 2024 | Computer Modeling in Engineering & Sciences2024，138，1： | 0 |
| 15 | Culture of C6 glioma cells and establishment of model显示文摘Objectives: To establish a simple, reliable, stable rat C6 glioma model, and to provide an operating platform for studying the pathogenesis and prevention and treatment of glioma. Methods: C6 rat glioma cells were cultured in vitro and cultured in the right caudate putamen of SD rats. After implantation, the survival status of rats was observed and the pathological sections were made. HE is dyeing under light microscope. Results: After 6 days of inoculation of C6 glioma cells, the survival status was good at about 7 days, and the intracranial hypertension was more obvious at about 14 days. Most of them were in the endangered state. In the 18 specimens of the rats, except for the accidental death, the other tumor formation rate was 75%. The tumor structure was obviously displaced with the prolongation of the age of the tumor. HE staining was used to observe the formation of glioma in rat brain. Conclusion: The animal model of C6 glioma is reliable and stable. Its tumor growth characteristics and pathological features are similar to those of human glioma, which can be used as an ideal model for clinical study of glioma. | Shumin Liang Yijun Chen Kaifei Wang | 2018 | Anatomical Science2018，1，1： | 0 |
| 16 | Late Quaternary Slip Behavior of the Jinqianghe Fault in the Middle Qilian-Haiyuan Fault Zone,Northeastern Tibetan Plateau显示文摘The Qilian-Haiyuan fault zone in the northeastern Tibetan Plateau has been the source of strong earthquakes in the region.In its middle segment,the Jinqianghe fault is an important active fault within the Tianzhu seismic gap;however,little is known about its slip behavior.To present a new horizontal displacement distribution along this fault,we used WorldView-2 stereo pairs and unmanned aerial vehicle-based photogrammetry to construct digital elevation models to obtain a detailed tectono-geomorphic interpretation and geomorphic offsets.The offset marker measurements yielded 135 geomorphic displacements and 8 offset clusters.Radiocarbon dating was used to establish the regional age sequence of the geomorphic units in offset fluvial terraces at four study sites.The displacements and ages linked the offset clusters with the geomorphic unit sequence;the Holocene strike-slip rate of the Jinqianghe fault was estimated to 4.8-5.6 mm/a at~4-12 ka and 2.9-4.7 mm/a from~4 ka.Three recent earthquakes(with a recurrence interval of~1000 years)represent an active seismic period,revealing the potential seismic hazard along this fault because it has not ruptured in the last 1500 years. | LIANG Shumin ZHENG Wenjun CHEN Gan ZHANG Peizhen ZHANG Dongli BI Haiyun YANG Xue ZHANG Yipeng DUAN Lei LU Bentian | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 0 |
| 17 | Efficient heterogeneous integration of InP/Si and GaSb/Si templates with ultra-smooth surfaces显示文摘Heterogeneous integration of InP and GaS b on Si substrates holds a huge potential interest in near-infrared and mid-infrared optoelectronic devices.In this study,2-inch 180-nm-thick InP and 185-nmthick GaS b thin layers were successfully transferred onto the Si substrates to form high-quality and ultrasmooth InP/Si and GaS b/Si templates using molecular beam epitaxy(MBE)and the ion-slicing technique together with selective chemical etching.The relocation of the implantation-introduced damage in the sacrificial layer enables the transfer of relatively defect-free InP and GaS b thin films.The sacrificial layers were completely etched off by selective chemical etching,leaving ultra-smooth epitaxial surfaces with a roughness of 0.2 nm for the InP/Si template and 0.9 nm for the GaS b/Si template,respectively.Thus,the chemical mechanical polishing(CMP)process was not required to smooth the surface which usually introduces particles and chemical contaminations on the transferred templates.Furthermore,the donor substrate is not consumed and can be recycled to reduce the cost,which provides a paradigm for the sustainable and economic development of the Si integration platform. | Tingting JIN Jiajie LIN Tiangui YOU Xiaolei ZHANG Hao LIANG Yifan ZHU Jialiang SUN Hangning SHI Chaodan CHI Min ZHOU Robert KUDRAWIEC Shumin WANG Xin OU | 2022 | Science China(Information Sciences)2022，65，8： | 0 |
| 18 | Genetic dissection of yield-related traits in response to drought stress in common bean显示文摘Drought stress severely impairs common bean production.For facilitating drought-resistance breeding in common bean,molecular markers were identified in a genome-wide level marker–trait association study.A panel of 210 common bean accessions showed large variation in 11 agronomic traits at the adult stage(plant height,pod number per plant,seed number per pod,seed number per plant,seed yield per plant,pod length,harvest index,pod harvest index,days to maturity,hundred-seed weight,and seed yield)under two water conditions.The coefficient of variation ranged from 6.21% for pod harvest index to51.00% for seed number per plant under well-watered conditions,and from 4.05% for days to maturity to 40.72% for seed number per plant under drought stress.In a genome-wide association study,119quantitative-trait loci were associated with drought resistance,including 41 adjacent to known loci.Among these loci,12 were found to be associated with at least two traits.Three major loci were identified at Pv01 and Pv02.A set of candidate genes were found that encode MYBs,AREBs,WKRYs,and protein kinases.These results reveal promising alleles that control drought resistance,shedding light on the genetic basis of drought resistance and accelerating future efforts for drought resistance improvement in common bean. | Lei Wu Yujie Chang Lanfen Wang Liang Ji Lin Peng Shumin Wang Jing Wu | 2023 | The Crop Journal2023，11，4： | 0 |
| 19 | 颞叶癫痫继发性全身性大发作与下托脑区特异性地存在异常去极化信号通路相关显示文摘文章简介癫痫是一种常见的中枢神经系统疾病,以脑内同步化放电引起的反复且突发性的发作为特征。经典学说认为癫痫发作是由于脑内兴奋—抑制失衡理论引起,因此临床上常用增强脑内抑制性功能的药物治疗癫痫。 | Yi Wang Cenglin Xu Zhenghao Xu Caihong Ji Jiao Liang Ying Wang Bin Chen Xiaohua Wu Feng Gao Shuang Wang Yi Guo Xiaoming Li Jianhong Luo Shumin Duan 陈忠 | 2018 | 科学新闻2018，0，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员