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| 1 | MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma显示文摘 | Shupeng Liu Weixing Guo Jie Shi Nan Li Xiya Yu Jie Xue Xiaohui Fu Kaijian Chu Chongde Lu Jiangsha Zhao Dong Xie Mengchao Wu Shuqun Cheng Shanrong Liu | 2011 | Journal of Hepatology2011，，2： | 2 |
| 2 | Expression of Intercellular Adhesion Molecule 1 by Hepatocellular Carcinoma Stem Cells and Circulating Tumor Cells显示文摘 | Shupeng Liu Nan Li Xiya Yu Xiao Xiao Kai Cheng Jingjing Hu Jiaqi Wang Dandan Zhang Shuqun Cheng Shanrong Liu | 2013 | Gastroenterology2013，，5： | 2 |
| 3 | Experimental study on enhancement of the metastatic potential of portal vein tumor thrombus-originated hepatocellular carcinoma cells using portal vein serum显示文摘Objective: Portal vein metastasis of hepatocellular carcinoma(HCC) results in a poor prognosis and seriously affects the survival rate of patients. The mechanism underlying the formation of portal vein tumor thrombus(PVTT) is complex and is not yet fully understood. This study was conducted to investigate the impact of portal vein blood on the proliferation, metastasis, invasion and apoptosis of PVTT cells and to explore its possible mechanisms, which was expected to lay a foundation for ascertaining the mechanism underlying the portal vein metastasis of HCC.Methods: Peripheral blood and portal vein blood were collected from patients with HCC, and the sera from these two sources were used to culture the PVTT-originated HCC cell line CSQT-2. The cells were collected after 24 h, and flow cytometry was performed to detect cell proliferation, cell cycle stages and apoptosis. Transwell migration and invasion assays were applied to detect the metastasis and invasion of the cells in each group. The changes in the expression of MMP-2 and MMP-9 in cells were detected via Western blotting. The contents of IL-12, IFN-γ, IL-1β, IL-2 and TNF-α in the two groups of sera were quantified using corresponding kits. Results: Compared with the group of cells cultured with peripheral serum, the cells cultured with portal vein serum showed significantly lower apoptosis(P<0.01), significantly enhanced cell metastasis and invasion(P<0.01), whereas cell proliferation and the stages of the cell cycle did not differ significantly(P>0.05). A significantly increased expression level of MMP-2 has been observed in tumor cells treated portal vein serum. In addition, compared with peripheral serum, the content of IL-12 was significantly decreased in portal vein serum(P<0.05), while the contents of IFN-γ, IL-1β, IL-2, and TNF-α did not differ significantly(P>0.05). Conclusions: Portal vein serum from HCC patients could inhibit the apoptosis of PVTT-originated HCC cells and promote cell metastasis and invasion. This effect may be related to the lower level of IL-12 in portal vein serum. | Yufu Tang Hongming Yu Long Zhang Kang Wang Weixing Guo Jie Shi Shupeng Liu Mengchao Wu Hongyang Wang Shuqun Cheng | 2014 | Chinese Journal of Cancer Research2014，26，5： | 2 |
| 4 | Research progress on distribution,sources,identification,toxicity,and biodegradation of microplastics in the ocean,freshwater,and soil environment显示文摘Microplastics(MPs)are distributed in the oceans,freshwater,and soil environment and have become major pollutants.MPs are generally referred to as plastic particles less than 5 mm in diameter.They consist of primary microplastics synthesized in microscopic size manufactured production and secondary microplastics generated by physical and environmental degradation.Plastic particles are long-lived pollutants that are highly resistant to environmental degradation.In this review,the distribution and possible sources of MPs in aquatic and terrestrial environments are described.Moreover,the adverse effects of MPs on natural creatures due to ingestion have been discussed.We also have summarized identification methods based on MPs particle size and chemical bond.To control the pollution of MPs,the biodegradation of MPs under the action of different microbes has also been reviewed in this work.This review will contribute to a better understanding of MPs pollution in the environment,as well as their identification,toxicity,and biodegradation in the ocean,freshwater,and soil,and the assessment and control of microplastics exposure. | Qinghui Sun Juan Li Chen Wang Anqi Chen Yanli You Shupeng Yang Huihui Liu Guibin Jiang Yongning Wu Yanshen Li | 2022 | Frontiers of Environmental Science & Engineering2022，16，1： | 2 |
| 5 | Learning to recognize misaligned hyperfine orbital angular momentum modes显示文摘Orbital angular momentum(OAM)-carrying beams have received extensive attention due to their high-dimensional characteristics in the context of free-space optical communication.However,accurate OAM mode recognition still suffers from reference misalignment of lateral displacement,beam waist size,and initial phase.Here we propose a deep-learning method to exquisitely recognize OAM modes under misalignment by using an alignment-free fractal multipoint interferometer.Our experiments achieve 98.35% recognizing accuracy when strong misalignment is added to hyperfine OAM modes whose Bures distance is 0.01.The maximum lateral displacement we added with respect to the perfectly on-axis beam is about±0.5 beam waist size.This work offers a superstable proposal for OAM mode recognition in the application of free-space optical communication and allows an increase of the communication capacity. | Xiao Wang Yufeng Qian JingJing Zhang Guangdong Ma Shupeng Zhao RuiFeng Liu Hongrong Li Pei Zhang Hong Gao Feng Huang Fuli Li | 2021 | Photonics Research2021，9，4： | 1 |
| 6 | Nonlinear dynamic characteristics of journal bearing-rotor system considering the pitching and roll-ing motion for marine turbo machinery显示文摘 | ZHANG Guanghui LIU Shupeng MA Ruixian | 2015 | Journal of Engineering for the Maritime Environment2015，229，1： | 1 |
| 7 | Value of 18 F-FDG PET/CT in the diagnosis of primary gastric cancer via stomach distension显示文摘 | Quanmei Ma Jun Xin Zhoushe Zhao Qiyong Guo Shupeng Yu Weina Xu Changping Liu Wei Zhai | 2013 | European Journal of Radiology2013，，6： | 1 |
| 8 | Identification of portal vein tumor thrombus with an independent clonal origin in hepatocellular carcinoma via multi-omics data analysis显示文摘Objective: Multiple mechanisms underlying the development of portal vein tumor thrombus(PVTT) in hepatocellular carcinoma(HCC) have been reported recently. However, the origins of PVTT remain unknown. Increasing multi-omics data on PVTTs in HCCs have made it possible to investigate whether PVTTs originate from the corresponding primary tumors(Ts).Methods: The clonal relationship between PVTTs and their corresponding primary Ts was investigated using datasets deposited in public databases. One DNA copy number variations dataset and three gene expression datasets were downloaded for the analyses.Clonality analysis was performed to investigate the clonal relationship between PVTTs and Ts from an individual patient.Differential gene expression analysis was applied to investigate the gene expression profiles of PVTTs and Ts.Results: One out of 19 PVTTs had no clonal relationship with its corresponding T, whereas the others did. The PVTTs with independent clonal origin showed different gene expression and enrichment in biological processes from the primary Ts. Based on the unique gene expression profiles, a gene signature including 24 genes was used to identify pairs of PVTTs and primary Ts without any clonal relationship. Validation in three datasets showed that these types of pairs of PVTTs and Ts can be identified by the 24-gene signature.Conclusions: Our findings show a direct evidence for PVTT origin and consolidate the heterogeneity of PVTTs observed in clinic.The results suggest that PVTT investigation at a molecular level is clinically necessary for diagnosis and treatment. | Shupeng Liu Zaixin Zhou Yin Jia Jie Xue Zhiyong Liu Kai Cheng Shuqun Cheng Shanrong Liu | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 9 | Plant drought tolerance trait is the key parameter in improving the modeling of terrestrial transpiration in arid and semi-arid regions显示文摘陆面过程蒸腾作用的模拟制约着天气,气候降水预测的精确度.近几十年来,为了更好地描述植被蒸腾的水力约束,陆面过程模式发展了基于植物性状的植物水力胁迫方案.然而,我们对于植物性状在蒸腾模拟中的地位仍然缺乏了解,植物性状对蒸腾的重要性仍需进一步量化.本研究利用Morris方法评估植物性状参数在通用陆面模式植物水力胁迫方案(CoLM-P_(50)HS)中的重要性,针对17种植物性状,筛选出最为重要的:耐旱性状(P_(50)),气孔性状,和光合作用性状.在12个FLUXNET站点中,参数的重要性由归一化敏感度来衡量.P_(50)的重要性随着降水的减少而增加,而气孔性状和光合作用性状的重要性则随着降水的减少而减少.在干旱或半干旱地区,P_(50)比气孔性状和光合作用性状更重要,这意味着当植物经常经历干旱时,水力安全策略比植物生长策略更关键.而耐旱性状的巨大变异性进一步暗示了多种植物水力安全策略的共存.忽视P_(50)的变异性可能会对陆面过程模式蒸腾作用的模拟造成严重误差.因此,为了更好地表示植物水力功能的变异性,需要增加对耐旱性状的观测并耦合到陆面模式中. | Xintao Liu Xingjie Lu Shulei Zhang Zhongwang Wei Nan Wei Shupeng Zhang Hua Yuan Wei Shangguan Shaofeng Liu Jianfeng Huang Lu Li Xiulan Ye Jinxuan Zhou Wenke Hu Yongjiu Dai | 2022 | Atmospheric and Oceanic Science Letters2022，15，1： | 1 |
| 10 | Spatial-temporal characteristics in landscape evolution of the Yellow River Delta during 1855- 2000 and a way out for the Yellow River estuary显示文摘基于风景生态学 andGee 信息 Tupu 的图形、量的方法论,这篇论文学习风景黄河三角洲(YRD ) 的空间时间的进化特征,它被黄河(年) 尾部隧道的周期的物理秋千在 1855-2000 期间建立。根据关于 YRDand 年尾部隧道的空间时间的进化的研究,我们断定 Qingshuigou 隧道到达了它的限制,一条新流动隧道迟早多年应该被建立。它建议年隧道的移动应该接受它在以前的隧道之中通过消沉流动的自然规则并且能被人造的努力执行。论文在河口在 YR 流动为淤泥的高内容的处理外面讨论这些问题和交替的方法。 | YE Qinghua CHEN Shenliang CHEN Qi HUANG Chong TIAN Guoliang CHEN Shupeng SHI Yanan LIU Qingshen LIU Gaohuan | 2006 | Chinese Science Bulletin2006，51，B11： | 1 |
| 11 | Up‐regulated microRNA‐143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression显示文摘 | Xiaoying Zhang Shanrong Liu Tingsong Hu Shupeng Liu Ying He Shuhan Sun | 2009 | Hepatology2009，，2： | 1 |
| 12 | Dual functions of PsmiR172b-PsTOE3 module in dormancy release and flowering in tree peony (Paeonia suffruticosa)显示文摘MicroRNAs(miRNAs)are non-coding RNAs that interact with target genes and are involved in many physiological processes in plants.miR172-AP2 mainly plays a role in the regulation of f lowering time and floral organ differentiation.Bud dormancy release is necessary for forcing culture of tree peony in winter,but the mechanism of dormancy regulation is unclear.In this study,we found that a miR172 family member,PsmiR172b,was downregulated during chilling-induced bud dormancy release in tree peony,exhibiting a trend opposite to that of PsTOE3.RNA ligase-mediated(RLM)5-RACE(rapid amplification of cDNA ends)confirmed that miR172b targeted PsTOE3,and the cleavage site was between bases 12(T)and 13(C)within the complementary site to miR172b.The functions of miR172b and PsTOE3 were detected by virus-induced gene silencing(VIGS)and their overexpression in tree peony buds.PsmiR172b negatively regulated bud dormancy release,but PsTOE3 promoted bud dormancy release,and the genes associated with bud dormancy release,including PsEBB1,PsEBB3,PsCYCD,and PsBG6,were upregulated.Further analysis indicated that PsTOE3 directly regulated PsEBB1 by binding to its promoter,and the specific binding site was a C-repeat(ACCGAC).Ectopic expression in Arabidopsis revealed that the PsmiR172b-PsTOE3 module displayed conservative function in regulating f lowering.In conclusion,our results provided a novel insight into the functions of PsmiR172-PsTOE3 and possible molecular mechanism underlying bud dormancy release in tree peony. | Yuxi Zhang Linqiang Gao Yanyan Wang Demei Niu Yanchao Yuan Chunying Liu Xinmei Zhan Shupeng Gai | 2023 | Horticulture Research2023，10，4： | 0 |
| 13 | TaSRO1 interacts with TaVP1 to modulate seed dormancy and pre-harvest sprouting resistance in wheat显示文摘Dormancy is an adaptive trait which prevents seeds from germinating under unfavorable environmental conditions.Seeds with weak dormancy undergo pre-harvest sprouting(PHS)which decreases grain yield and quality.Understanding the genetic mechanisms that regulate seed dormancy and resistance to PHS is crucial for ensuring global food security.In this study,we illustrated the function and molecular mechanism of TaSRO1 in the regulation of seed dormancy and PHS resistance by suppressing TaVP1.The tasro1 mutants exhibited strong seed dormancy and enhanced resistance to PHS,whereas the mutants of tavp1 displayed weak dormancy.Genetic evidence has shown that TaVP1 is epistatic to TaSRO1.Biochemical evidence has shown that TaSRO1 interacts with TaVP1 and represses the transcriptional activation of the PHS resistance genes TaPHS1 and TaSdr.Furthermore,TaSRO1 undermines the synergistic activation of TaVP1 and TaABI5 in PHS resistance genes.Finally,we highlight the great potential of tasro1 alleles for breeding elite wheat cultivars that are resistant to PHS. | Shupeng Liu Li Li Wenlong Wang Guangmin Xia Shuwei Liu | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 14 | An Improved K-Means Algorithm Based on Initial Clustering Center Optimization显示文摘The K-means algorithm is widely known for its simplicity and fastness in text clustering.However,the selection of the initial clus?tering center with the traditional K-means algorithm is some random,and therefore,the fluctuations and instability of the clustering results are strongly affected by the initial clustering center.This paper proposed an algorithm to select the initial clustering center to eliminate the uncertainty of central point selection.The experiment results show that the improved K-means clustering algorithm is superior to the traditional algorithm. | LI Taihao NAREN Tuya ZHOU Jianshe REN Fuji LIU Shupeng | 2017 | ZTE Communications2017，15，B12： | 0 |
| 15 | E®ect of laser acupuncture combined with electrical stimulation on recovery from exercise fatigue in mice显示文摘In sports events,the rapid recovery after high-intensity training or sport competition performance is very important for athletes'performance and health.The aim of this study is to evaluate the effect of laser acupuncture and electrical stimulation on the recovery from exercise fatigue,using mice with swimming fatigue as experimental model and the electromyography(EMG)and the Raman spectroscopy of blood as evaluation indicators.Root mean square(RMS)and mean power frequency(MPF)of EMG were analyzed after laser acupuncture and electrical stimulation.The amplitude frequency combined analysis(JASA)showed that the proportion of muscles in the fatigue recovery area of the control group,the laser acupuncture group,the multi-channel laser acupuncture group and the laser combined with electrical stimulation group were 34.78%,39.13%,39.13%and 43.48%,respectively.Raman spectroscopy of the mice blood during fatigue recovery showed there is a significant difference between the multi-channel laser acupuncture group and the laser combined with electric stimulation group compared with the recovery period and fatigue period(P<0:05)at the peak of 997 cm^(-1) and the laser combined electrical stimulation group had a statistical difference in the recovery period compared with the fatigue period(P<0.05)at the peak of 1561 cm^(-1).The results showed that laser acupuncture combined with electrical stimulation was beneficial to fatigue recovery in mice,and had the potential value in sports fatigue recovery. | Shupeng Liu Yudan Xia Zehai Hou Haotian Hong Na Chen Taihao Li Chunlei Shan Heng Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 16 | PsRGL1 negatively regulates chilling- and gibberellin-induced dormancy release by PsF-box1-mediated targeting for proteolytic degradation in tree peony显示文摘Tree peony bud endodormancy is a common survival strategy similar to many perennial woody plants in winter,and the activation of the GA signaling pathway is the key to breaking endodormancy.GA signal transduction is involved in many physiological processes.Although the GA-GID1-DELLA regulatory module is conserved in many plants,it has a set of specific components that add complexity to the GA response mechanism.DELLA proteins are key switches in GA signaling.Therefore,there is an urgent need to identify the key DELLA proteins involved in tree peony bud dormancy release.In this study,the prolonged chilling increased the content of endogenously active gibberellins.PsRGL1 among three DELLA proteins was significantly downregulated during chilling-and exogenous GA3-induced bud dormancy release by cell-free degradation assay,and a high level of polyubiquitination was detected.Silencing PsRGL1 accelerated bud dormancy release by increasing the expression of the genes associated with dormancy release,including PsCYCD,PsEBB1,PsEBB3,PsBG6,and PsBG9.Three F-box protein family members responded to chilling and GA3 treatments,resulting in PsF-box1 induction.Yeast two-hybrid and BiFC assays indicated that only PsF-box1 could bind to PsRGL1,and the binding site was in the C-terminal domain.PsF-box1 overexpression promoted dormancy release and upregulated the expression of the dormancy-related genes.In addition,yeast two-hybrid and pull-down assays showed that PsF-box1 also interacted with PsSKP1 to form an E3 ubiquitin ligase.These findings enriched the molecular mechanism of the GA signaling pathway during dormancy release,and enhanced the understanding of tree peony bud endodormancy. | Linqiang Gao Demei Niu Tianyu Chi Yanchao Yuan Chunying Liu Shupeng Gai Yuxi Zhang | 2023 | Horticulture Research2023，10，5： | 0 |
| 17 | Numerical Simulations of Hydrodynamics of Nematic Liquid Crystals:Effects of Kinematic Transports显示文摘In this paper,we investigate the effects of kinematic transports on the nematic liquid crystal system numerically and theoretically.The model we used is a'1+2'elastic continuum model simplified from the Ericksen-Leslie system.The numerical experiments are carried out by using a Legendre-Galerkin spectral method which can preserve the energy law in the discrete form.Based on this highly accurate numerical approach we find some interesting and important relationships between the kinematic transports and the characteristics of the flow.We make some analysis to explain these results.Several significant scaling properties are also verified by our simulations. | Shupeng Zhang Chun Liu Hui Zhang | 2011 | Communications in Computational Physics2011，9，4： | 0 |
| 18 | Corporate Power for Poverty Alleviation: Evidence from the Poverty Alleviation Results of Chinese Listed Companies显示文摘Government-led poverty alleviation faces multiple constraints and limitations fighting poverty,and it is urgent to mobilize social forces as many as possible,especially the involvement of corporate forces.To figure out whether corporate participation is effective to poverty alleviation and whether regional differences have an impact on it,this paper probes into results of corporate involvement in poverty alleviation,based on corporate social responsibility report information released by A-share listed companies in 2010-2017.The findings are as follows.(1)Companies in the western region,companies directly contacting consumers and large companies with good business performance are more willing to involve in poverty alleviation.(2)The participation of enterprises in poverty alleviation can increase the per capita income of rural residents,which is even better in underdeveloped areas.This revealed that social forces represented by companies have responded to China’s call of targeted poverty alleviation and fulfilled corporate social responsibilities,which will indeed help consolidate the achievements of poverty alleviation and lift underdeveloped areas out of poverty.From the perspective of corporate involvement in poverty alleviation,this paper extends related research on social forces and another participant in poverty alleviation,and enrich the literature on social benefits brought by companies performing social responsibilities. | Liya Liu Shupeng Zhou Yuanchen Pang Xuehan Guo | 2022 | China Finance and Economic Review2022，11，2： | 0 |
| 19 | The effect of laser acupuncture on hypoxia tolerance and inflammation reaction in mice with optical fiber acupuncture needle intra body显示文摘Hypoxia is a disorder in which the tissues are not oxygenated adequately.The lack of oxygen may cause irreversible damage to the major organs such as the brain,heart and lungs.In severe cases,coma,seizures,and death may happen.In addition to the routine medication,acupuncture.treatment has been applied as a complementary treatment to counter hypoxia.In this paper,the optical fiber acupuncture needle was fabricated using the optical fiber imbedding into the metal capillary tube with needle tip,therefore made it easy to insert into the body for the laser treatment.The laser optical fiber needle treatment to the ST36 acupoint conducted with the laser.irradiation intra body.The normobaric hypoxia tolerance test results in mice show that the optical fber needle treatment to the ST36 acupoint with laser acupuncture appears to improve the tolerance to hypoxia.The mice treated with laser acupuncture expressed high level of IL-1βin serum.Our results suggest that laser optical fiber needle acupuncture may serve as a potential treatment for hypoxia. | Shupeng Liu Minmin Xu Xiumei Cao Junyi Hou Na Chen Fufei Pang Zhenyi Chen Xiangfei Yang Tingyun Wang Jianshe Yan | 2017 | Journal of Innovative Optical Health Sciences2017，，2： | 0 |
| 20 | Phase-Locked Loop Based Cancellation of ECG Power Line Interference显示文摘Power line(PL)interference is one significant artifact in electrocardiography(ECG)that needs to be reduced to ensure accurate recording of cardiac signals.Because PL interference is non-stationary and has varying frequency,phase,and amplitude in ECG measurement,adaptive techniques are often necessary to track and cancel the interference.In this paper we present a phase-locked loop(PLL)-based adaptive filter to cancel PL interference.The PLL obtains the reference signal that is fed into the adaptive filter to remove the PL interference at the central frequency of 50 Hz.It is found that the technique can effectively cancel PL interference in real ECG signals and,when compared with some existing techniques such as least mean squares(LMS)adaptive filter,the new technique produces better results in terms of signal-to-interference ratio(SIR). | LI Taihao ZHOU Jianshe LIU Shupeng SHI Jinsheng REN Fuji | 2018 | ZTE Communications2018，16，1： | 0 |
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